Introduction to Special Issue on 'Physiological and PA Evolutionary Mechanisms of Aging'

Exp Gerontol. 2023 Nov 6:112324. doi: 10.1016/j.exger.2023.112324. Online ahead of print.ABSTRACTWhat are the structural components and physiological mechanisms determining the aging process? Can the different mechanisms described in aging biology converge into a core of coordinated aging effectors? Why some human beings, for instance, can reach 115-122 years of age while rats can live at best a maximum of 4 years? Can the aging rate be modified? How much can human lifespan be extended? Is aging a programmed or non-programmed process? This special issue includes invited articles to explore the physiological mechanisms of aging, and both classical and updated hypotheses on the evolutionary meaning of aging. Breakthroughs in aging-related research are currently unveiling longevity factors highly conserved during evolution of animal species and are discovering details on how and why molecular and cellular processes decline during physiologically normal aging. Investigations in model organisms and humans are uncovering potential approaches to extend not only mean individual survival but also species maximum (from here on) longevity. Experimental Gerontology presents this Special Issue (SI) highlighting recent advances in the mechanistic understanding of longevity, aging and interventions that extend lifespan. This SI includes invited articles to address most of the reasonably well known physiological mechanisms of aging, and tries to evaluate the available evidence supporting or ...
Source: Experimental Gerontology - Category: Geriatrics Authors: Source Type: research