The oxytocin receptor is essential for the protective effect of pair housing on post-stroke depression in mice

In conclusion, pair housing protects against the development of PSD depending on OXT and OXTR in the brain, with no significant divergence based on sex. These findings provide valuable insights into the potential of social interaction and oxytocin as therapeutic targets for PSD. Further research into the underlying mechanisms of these effects may contribute to the development of novel treatments for PSD.PMID:38614224 | DOI:10.1016/j.exger.2024.112432

Source: Experimental Gerontology - April 13, 2024 Category: Geriatrics Authors: Su-Ting Jiang Shu-Ying Lian Yao-Huan Sun Mei-Bo Pan Bin Wang Hui Wang Jun Hua Yi-Chen Wang Qiu-Ling Wang Yin-Feng Dong Source Type: research