Increased circulatory IL-6 during 8-week fluoxetine treatment is a risk factor for suicidal behaviors in youth - Amitai M, Taler M, Ben-Baruch R, Lebow M, Rotkopf R, Apter A, Fennig S, Weizman A, Chen A.
OBJECTIVE: Selective serotonin reuptake inhibitors (SSRIs) are commonly used to treat anxiety and/or depression in pediatric populations. However, the response rates are low (approximately 50%). Moreover, SSRI use is frequently associated with adverse even... (Source: SafetyLit)
Source: SafetyLit - January 1, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Using antidepressants while pregnant can increase the risk of autism in newborns – study
(Natural News) Pregnant women can add antidepressants to their laundry list of things to avoid during pregnancy. The results of a recent study revealed that babies exposed to the pharmaceutical drug fluoxetine in the womb could develop autistic-like behavior later on. The study, published in the journal Molecular Brain, also identified a potential therapy for the problem,... (Source: NaturalNews.com)
Source: NaturalNews.com - December 3, 2019 Category: Consumer Health News Source Type: news

Amendments to Serious Shortage Protocols for fluoxetine 30mg capsules (England)
The Serious Shortage Protocols (SSP) for fluoxetine 30mg capsules has been varied... (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - November 20, 2019 Category: Drugs & Pharmacology Source Type: news

Amendments to Serious Shortage Protocols for fluoxetine 40mg capsules (England)
The Serious Shortage Protocols (SSP) for fluoxetine 40mg capsules ... (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - November 8, 2019 Category: Drugs & Pharmacology Source Type: news

Amendments to Serious Shortage Protocols for fluoxetine 30mg and 40mg capsules (England)
The Serious Shortage Protocols (SSP) for fluoxetine 30mg capsules and fluoxetine 40mg capsules are being varied to extend the end date, which was previously 31 October 2019. (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - October 30, 2019 Category: Drugs & Pharmacology Source Type: news

Withdrawal of Serious Shortage Protocol for fluoxetine 10mg capsule (England)
The Department of Health and Social Care (DHSC) has issued information about the withdrawal of Serious Shortage Protocol (SSP) for fluoxetine 10mg. (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - October 25, 2019 Category: Drugs & Pharmacology Source Type: news

Effect of Fluoxetine on Repetitive Behaviors in ASD Youth Unclear
WEDNESDAY, Oct. 23, 2019 -- Treatment with fluoxetine results in significantly lower scores for obsessive compulsive behaviors at 16 weeks among children and adolescents with autism spectrum disorder (ASD), according to a study published in the Oct.... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 23, 2019 Category: Pharmaceuticals Source Type: news

What are the effects of fluoxetine treatment in overweight or obese adults?
Fluoxetine is a medicine used for the treatment of depression, which reduces appetite as a side effect. Therefore, it is suspected that fluoxetine could be used as a treatment for overweight or obese people. In this group of people administration of fluoxetine means an off-label treatment which means it is not licensed for treating obesity.The authors identified 19 randomised controlled trials (clinical studies where people are randomly put into one of two or more treatment groups) evaluating mainly women receiving different doses of fluoxetine. A total of 1280 overweight or obese participants received fluoxetine and 936 p...
Source: Cochrane News and Events - October 17, 2019 Category: Information Technology Authors: Katie Abbotts Source Type: news

Featured review: What are the effects of fluoxetine treatment in overweight or obese adults?
Fluoxetine is a medicine used for the treatment of depression, which reduces appetite as a side effect. Therefore, it is suspected that fluoxetine could be used as a treatment for overweight or obese people. In this group of people administration of fluoxetine means an off-label treatment which means it is not licensed for treating obesity.The authors identified 19 randomised controlled trials (clinical studies where people are randomly put into one of two or more treatment groups) evaluating mainly women receiving different doses of fluoxetine. A total of 1280 overweight or obese participants received fluoxetine and 936 p...
Source: Cochrane News and Events - October 17, 2019 Category: Information Technology Authors: Katie Abbotts Source Type: news

Serious shortage protocols (SSPs) for Fluoxetine (England)
The Department of Health and Social Care has agreed the October serious shortage protocols for the following items... (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - October 3, 2019 Category: Drugs & Pharmacology Source Type: news

First Serious Shortage Protocols issued
The Government has authorised the first Serious Shortage Protocols (SSP), for the antidepressant fluoxetine, enabling pharmacists in England to supply an alternative strength or pharmaceutical form of (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - October 3, 2019 Category: Drugs & Pharmacology Source Type: news

Drug Supply issues: Provera100mg tablets and fluoxetine capsules
Information from the Department of Health and Social Care (DHSC) regarding the following supply issues... (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - September 20, 2019 Category: Drugs & Pharmacology Source Type: news

Study shows how serotonin and a popular anti-depressant affect the gut ’s microbiota
In this study, we were interested in finding out why they might do so,” said Hsiao, UCLA assistant professor of integrative biology and physiology, and of microbiology, immunology and molecular genetics in the  UCLA College; and of digestive diseases in the David Geffen School of Medicine at UCLA.Hsiao and her research group reported in the journal Cell in 2015 that in mice, a specific mixture of bacteria, consisting mainly of  Turicibacter sanguinis and Clostridia, produces molecules that signal to gut cells to increase production of serotonin. When Hsiao’s team raised mice without the bact...
Source: UCLA Newsroom: Health Sciences - September 6, 2019 Category: Universities & Medical Training Source Type: news

Psychotherapy Alone First Line of Treatment for Depressed Youth
Adding fluoxetine to cognitive behavioral therapy did not further reduce depressive symptoms (Source: The Doctors Lounge - Psychiatry)
Source: The Doctors Lounge - Psychiatry - August 12, 2019 Category: Psychiatry Tags: Family Medicine, Pediatrics, Pharmacy, Psychiatry, Journal, Source Type: news

The addition of fluoxetine to cognitive behavioural therapy for youth depression (YoDA-C): a randomised, double-blind, placebo-controlled, multicentre clinical trial - Davey CG, Chanen AM, Hetrick SE, Cotton SM, Ratheesh A, Amminger GP, Koutsogiannis J, Phelan M, Mullen E, Harrison BJ, Rice S, Parker AG, Dean OM, Weller A, Kerr M, Quinn AL, Catania L, Kazantzis N, McGorry PD, Berk M.
BACKGROUND: Medication is commonly used to treat youth depression, but whether medication should be added to cognitive behavioural therapy (CBT) as first-line treatment is unclear. We aimed to examine whether combined treatment with CBT and fluoxetine was ... (Source: SafetyLit)
Source: SafetyLit - August 4, 2019 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

How a popular antidepressant drug could rewire the brain
(American Chemical Society) Prozac ® , the trade name for the drug fluoxetine, was introduced to the US market for the treatment of depression in 1988. Thirty years later, scientists still don't know exactly how the medication exerts its mood-lifting effects. Now, researchers report that, in addition to the drug's known action on serotonin receptors, fluoxetine could rearrange nerve fibers in the hippocampus of mouse brains. They report their results in ACS Chemical Neuroscience. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 10, 2019 Category: International Medicine & Public Health Source Type: news

fluoxetine (Prozac, Sarafem, Prozac Weekly)
Title: fluoxetine (Prozac, Sarafem, Prozac Weekly)Category: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 7/3/2019 12:00:00 AM (Source: MedicineNet Depression General)
Source: MedicineNet Depression General - July 3, 2019 Category: Psychiatry Source Type: news

Zoloft (sertraline) vs. Prozac (fluoxetine)
Title: Zoloft (sertraline) vs. Prozac (fluoxetine)Category: MedicationsCreated: 6/26/2019 12:00:00 AMLast Editorial Review: 6/26/2019 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - June 26, 2019 Category: Drugs & Pharmacology Source Type: news

AMP-Activated Protein Kinase: Potential Target for TNBC AMP-Activated Protein Kinase: Potential Target for TNBC
Metformin, fluoxetine, and other AMPK agonists significantly inhibit TNBC. Will targeted therapy finally become an option for this aggressive disease?Breast Cancer Research (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 26, 2019 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Lupin launches generic antidepressant tablets in US
The company has launched its Fluoxetine tablets USP in the strength of 60mg after having received an approval from the United States Food and Drug Administration. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - April 10, 2019 Category: Pharmaceuticals Source Type: news

A commonly-used antidepressant doesn't improve recovery after stroke
The antidepressant fluoxetine works no better than placebo to reduce disability after a stroke, lowering hopes that had been raised by other smaller studies. After a six month trial including more than 3,000 adult stroke patients recruited at 103 UK hospitals, researchers concluded that fluoxetine should not be used to promote recovery from stroke-related disability, or routinely prescribed to prevent depression after stroke. Several smaller studies and animal trials had found promising results from the use of fluoxetine after stroke. However, this trial of fluoxetine 20mg daily for six months found no improvement in funct...
Source: Current Awareness Service for Health (CASH) - February 18, 2019 Category: Consumer Health News Source Type: news

Effects of Antidepressants Span Three Generations in Fish
Fluoxetine dampened stress responses in zebrafish embryos exposed to the drug--and their descendants. (Source: The Scientist)
Source: The Scientist - December 10, 2018 Category: Science Tags: News & Opinion Source Type: news

New Drug Option Fails for Rare Polio-Like Virus in Kids New Drug Option Fails for Rare Polio-Like Virus in Kids
Despite initial hope, fluoxetine failed to improve outcomes in children with acute flaccid myelitis and in some cases was linked to a worsening of the disorder, which can cause permanent paralysis in children.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 14, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

No Efficacy Signal for Fluoxetine in EV-D68 Acute Flaccid Myelitis
TUESDAY, Nov. 13, 2018 -- The antiviral agent fluoxetine is well tolerated but is not effective for patients with proven or presumptive enterovirus D68-associated acute flaccid myelitis (AFM), according to a study published online Nov. 9 in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 13, 2018 Category: Pharmaceuticals Source Type: news

Prozac No Help In Polio-Like Illness
Researchers have been searching for possible treatments for acute flaccid myelitis, or AFM. Lab tests showed that fluoxetine had antiviral effects against a virus associated with the disorder, so some experts had suggested that the antidepressant might be a possible treatment for the disorder. (Source: WebMD Health)
Source: WebMD Health - November 9, 2018 Category: Consumer Health News Source Type: news

Some Researchers Thought This Drug Could Treat the Polio-Like Illness Sickening Children. A New Study Says It Probably Doesn ’t
Health officials are scrambling for answers — and cures — as a rare, polio-like illness called acute flaccid myelitis (AFM) spreads across the country. Some researchers thought the antidepressant fluoxetine, which is often sold under the brand name Prozac and has some antiviral properties, could work against AFM, a mysterious illness that strikes some children and can cause muscle weakness, breathing issues, paralysis and even death. A new study published Friday in Neurology, however, provides disappointing results: In a small, non-randomized retrospective study, fluoxetine did not seem to restore patients&rsqu...
Source: TIME: Health - November 9, 2018 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Drugs healthytime onetime Source Type: news

Fluoxetine for Acute Flaccid Myelitis? (CME/CE)
(MedPage Today) -- Anti-enteroviral activity in vitro, but did not improve neurological outcomes in children (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - November 9, 2018 Category: American Health Source Type: news

Dead End for Treatment of Polio-Like Disorder Striking Kids
FRIDAY, Nov. 9, 2018 -- The antidepressant fluoxetine (Prozac) is ineffective in treating a rare, polio-like disorder that can cause muscle weakness and paralysis in children, researchers are reporting. In the United States, there have been 219... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 9, 2018 Category: General Medicine Source Type: news

Fluoxetine, Riluzole or Amiloride No Benefit in Progressive MS Fluoxetine, Riluzole or Amiloride No Benefit in Progressive MS
A new trial with an innovative multiarm design testing three drugs at the same time has shown no therapeutic benefit for any of them in secondary progressive MS.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 23, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Why depression pills could be fuelling the rise of superbugs  
Research suggests that an ingredient in the commonly prescribed antidepressant fluoxetine — or Prozac — causes a mutation in some bacteria, making them resistant to antibiotics. (Source: the Mail online | Health)
Source: the Mail online | Health - September 25, 2018 Category: Consumer Health News Source Type: news

Book Review: Understanding Antidepressants
One in five Americans will have a major depressive episode in their lives and many will seek help from a mental health provider, which may include treatment with medication. As with all medication, there is no one-size-fits-all treatment plan when it comes to antidepressants. The terminology alone is confusing. There are SSRIs, tricyclics, and other drugs that have off-label uses. For those who take antidepressants, it is a challenge to find the right one. Some work better than others for individuals, and family members may not understand why it is difficult to find something that “works.” In Understanding Anti...
Source: Psych Central - September 23, 2018 Category: Psychiatry Authors: Tina Arnoldi Tags: Antidepressants Book Reviews Depression Disorders General Medications Psychology Treatment book on antidepressants understanding antidepressants Source Type: news

Prozac may be driving the antibiotic-resistance crisis
Researchers from the University of Queensland found that when E.coli is exposed to the antidepressant fluoxetine it undergoes mutations that stop it responding to common antibiotics. (Source: the Mail online | Health)
Source: the Mail online | Health - September 10, 2018 Category: Consumer Health News Source Type: news

Open water swimming as a treatment for major depressive disorder - van Tulleken C, Tipton M, Massey H, Harper CM.
A 24-year-old woman with symptoms of major depressive disorder and anxiety had been treated for the condition since the age of 17. Symptoms were resistant to fluoxetine and then citalopram. Following the birth of her daughter, she wanted to be medication-f... (Source: SafetyLit)
Source: SafetyLit - August 24, 2018 Category: International Medicine & Public Health Tags: Program and Other Evaluations, Effectiveness Studies Source Type: news

Antidepressant restores youthful flexibility to aging inhibitory neurons in mice
(Picower Institute at MIT) Inhibitory neurons in the aging brain show reduced growth and plasticity, likely contributing to declines in brain function. In a new study in mice researchers at the Picower Institute at MIT show that treatment with fluoxetine restored substantial growth and plasticity. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 20, 2018 Category: International Medicine & Public Health Source Type: news

Medical News Today: What is fluoxetine?
Fluoxetine oral capsule is a prescription medication used to treat conditions such as depression, obsessive-compulsive disorder (OCD), eating disorders, and panic attacks. It comes as the brand-name drugs Prozac and Prozac Weekly, and as a generic drug. Learn about side effects, warnings, dosage, and more. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 12, 2018 Category: Consumer Health News Tags: Pharmacy / Pharmacist Source Type: news

My OCD story: evidence-based medicine to the rescue!
Karen Morley blogs about her experience of seeking help for her Obsessive-Compulsive Disorder (OCD) and how finding and using Cochrane evidence was a turning point. This blog post was originally published onEvidently Cochrane.Without knowing what it was, I had experienced episodes of Obsessive-Compulsive Disorder (OCD) since I was an adolescent, usually when I was particularly stressed. But it was when I was caring full time for my mother, who had multiple conditions including dementia, that I had an unusually distressing episode of contamination-related OCD. When I took to the internet I was amazed to discover that the ob...
Source: Cochrane News and Events - June 27, 2018 Category: Information Technology Authors: Muriah Umoquit Source Type: news

My OCD story: evidence-based medicine to the rescue!
Karen Morley blogs about her experience of seeking help for her Obsessive-Compulsive Disorder (OCD) and how finding and using Cochrane evidence was a turning point. This blog post was originally published onEvidently Cochrane.Without knowing what it was, I had experienced episodes of Obsessive-Compulsive Disorder (OCD) since I was an adolescent, usually when I was particularly stressed. But it was when I was caring full time for my mother, who had multiple conditions including dementia, that I had an unusually distressing episode of contamination-related OCD. When I took to the internet I was amazed to discover that the ob...
Source: Cochrane News and Events - June 27, 2018 Category: Information Technology Authors: Muriah Umoquit Source Type: news

The Drugs That Changed Our Minds by Lauren Slater – review
Twenty years after hailing antidepressants in her memoir Prozac Diary, a now jaded, sceptical Lauren Slater revisits the psychopharmacological industry – with uneven resultsInProzac Diary (1998), Lauren Slater wrote powerfully of the way fluoxetine had transformed her previously chaotic life. While the author recorded a handful of negative side-effects – a profound loss of libido, for instance – the reader was left with the sense that Prozac had pieced back together the shards of Slater’s existence. In some ways,The Drugs That Changed Our Minds is a sequel to that book. Slater is now in her mid-50s,...
Source: Guardian Unlimited Science - April 1, 2018 Category: Science Authors: Alex Preston Tags: Autobiography and memoir Science and nature Books Medical research Depression Society Culture Source Type: news

Antidepressants do work – but children need someone to talk to
Young people in mental distress need – and deserve – faster access to support services, as well as pillsNearly a decade ago I found myself perched on the edge of a hard chair in a dark doctor ’s office. I was 13 and struggling a lot with self harm, body image, and the simple task of keeping myself alive. Shuffling my feet and wondering how I ended up here, I remember not fully understanding what was happening when I was handed a little green prescription for Fluoxetine – an antidepre ssant drug often better known as Prozac.Back then, my frame of reference for mental illness was pretty minimal. All I...
Source: Guardian Unlimited Science - March 4, 2018 Category: Science Authors: Alice Gibbs Tags: Depression Mental health Psychiatry Society Drugs Science Source Type: news

Fluoxetine Capsules (New - Discontinuation)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - February 23, 2018 Category: Drugs & Pharmacology Source Type: news

These Antidepressants Are Most Effective, Study Says
Millions of people take antidepressants for depression. But there’s long been debate over just how effective the medications actually are. On Wednesday, a large new study provides evidence that antidepressants are more effective than placebo at treating acute depression in adults. The study, published in the journal The Lancet, looked at the published data from 522 randomized controlled trials testing 21 different types of antidepressants. The study authors also reached out to pharmaceutical companies and study authors for additional unpublished study data. All told, the data collection included 116,477 men and women...
Source: TIME: Health - February 22, 2018 Category: Consumer Health News Authors: Alexandra Sifferlin Tags: Uncategorized healthytime Mental Health/Psychology Source Type: news

Exploring the History & Treatment of PTSD: An Interview with Dr. Paula P. Schnurr
As we celebrate Veterans Day (and Remembrance Day in Canada) and honoring military veterans, many of us think back to World War I but also many other wars throughout history. I recalled the 1980s, when Iran was engaged in an almost decade-long war with Iraq, and millions were killed or injured on both sides. In the West, the older generations may recall World War II and the Vietnam War, while the younger ones remember the more recent wars in Iraq and Afghanistan. We think of the millions who have fought, who have come back with injuries, and those who died serving their countries. But the numbers we rarely think about: How...
Source: Psych Central - November 11, 2017 Category: Psychiatry Authors: Arash Emamzadeh Tags: Interview Medications PTSD Trauma Treatment Combat Trauma Posttraumatic Stress Disorder PSTD Traumatic Experiences veterans Veterans day Source Type: news

Abrogated Freud-1/CC2D1A repression of 5-HT1A autoreceptors induces fluoxetine-resistant anxiety/depression-like behavior - Vahid-Ansari F, Daigle M, Manzini MC, Tanaka KF, Hen R, Geddes SD, B éïque JC, James J, Merali Z, Albert PR.
Freud-1/CC2D1A represses the gene transcription of serotonin-1A (5-HT1A) autoreceptors, which negatively regulate 5-HT tone. To test the role of Freud-1 in vivo, we generated mice with adulthood conditional knockout of Freud-1 in 5-HT neurons (cF1ko). In c... (Source: SafetyLit)
Source: SafetyLit - November 8, 2017 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Olanzapine and Fluoxetine (Symbyax) Capsules (New - Discontinuation)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - September 25, 2017 Category: Drugs & Pharmacology Source Type: news

Antidepressant Plus CBT May Ease Hypochondria Antidepressant Plus CBT May Ease Hypochondria
Fluoxetine may help ease hypochondriasis, and adding cognitive-behavioral therapy (CBT) provides a small incremental benefit, new research shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 12, 2017 Category: Consumer Health News Tags: Psychiatry News Source Type: news

5 things parents should know about eating disorders
Dr. Sara Forman, director of Boston Children’s Hospital’s Outpatient Eating Disorders Program and Dr. Tracy Richmond, director of the PREP weight management program in Adolescent Medicine, share five things parents should know about eating disorders. Kids don’t have to be really thin to have an eating disorder. Not everyone with an eating disorder looks like he or she has an eating disorder. The condition is often hidden in secret habits or obsessions. For example, binge eating and bulimia — or binging and purging &mdash...
Source: Thrive, Children's Hospital Boston - July 7, 2017 Category: Pediatrics Authors: Erin Horan Tags: Mental Health Teen Health anorexia anorexia nervosa bulimia Dr. Sara Forman Dr. Tracy Richmond eating disorder Source Type: news

Analysis examines safety of antidepressant use during pregnancy
Use of fluoxetine -- the most commonly prescribed antidepressant -- during pregnancy is linked with a slightly increased risk of malformations in infants, according to a recent analysis. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 17, 2017 Category: Science Source Type: news