Interactions between maternal fluoxetine exposure, the maternal gut microbiome and fetal neurodevelopment in mice
In this study, we investigate effects of prenatal SSRI exposure on fetal neurodevelopment and further evaluate potential modulatory influences of the maternal gut microbiome. We demonstrate that maternal treatment with the SSRI fluoxetine induces widespread alterations in the fetal brain transcriptome during midgestation, including increases in the expression of genes relevant to synaptic organization and neuronal signaling and decreases in the expression of genes related to DNA replication and mitosis. Notably, maternal fluoxetine treatment from E7.5 to E14.5 has no overt effects on the composition of the maternal gut mic...
Source: Brain Research - May 12, 2021 Category: Neurology Authors: Helen E Vuong Elena J L Coley Maria Kazantsev Michaela E Cooke Tomiko K Rendon Jorge Paramo Elaine Y Hsiao Source Type: research

Interactions between maternal fluoxetine exposure, the maternal gut microbiome and fetal neurodevelopment in mice
In this study, we investigate effects of prenatal SSRI exposure on fetal neurodevelopment and further evaluate potential modulatory influences of the maternal gut microbiome. We demonstrate that maternal treatment with the SSRI fluoxetine induces widespread alterations in the fetal brain transcriptome during midgestation, including increases in the expression of genes relevant to synaptic organization and neuronal signaling and decreases in the expression of genes related to DNA replication and mitosis. Notably, maternal fluoxetine treatment from E7.5 to E14.5 has no overt effects on the composition of the maternal gut mic...
Source: Behavioural Brain Research - May 12, 2021 Category: Neurology Authors: Helen E Vuong Elena J L Coley Maria Kazantsev Michaela E Cooke Tomiko K Rendon Jorge Paramo Elaine Y Hsiao Source Type: research

[ASAP] 5-HT < sub > 4 < /sub > Receptors Are Not Involved in the Effects of Fluoxetine in the Corticosterone Model of Depression
ACS Chemical NeuroscienceDOI: 10.1021/acschemneuro.1c00158 (Source: ACS Chemical Neuroscience)
Source: ACS Chemical Neuroscience - May 11, 2021 Category: Neuroscience Authors: Josep Amigo, Emilio Garro-Martinez, Rebeca Vidal Casado, Valerie Compan, Fuencisla Pilar-Cue ́llar, Angel Pazos, Alvaro Díaz, and Elena Castro Source Type: research

The role of 5-HT2B-receptors in fluoxetine-mediated modulation of Th17- and Th1-cells in multiple sclerosis
Fluoxetine is a selective serotonin reuptake inhibitor, which also has an immunomodulatory effect. We investigated the effects of fluoxetine and serotonin (5-HT) on the pro-inflammatory Th17- and Th1-cells in 30 patients with relapsing-remitting MS and 20 healthy subjects. Fluoxetine and 5-HT suppressed IL-17, IFN- γ and GM-CSF production by stimulated СD4+ T-cells in both groups. Blockade of 5-HT2B-receptors decreased the inhibitory effect of fluoxetine on cytokine production in MS patients. Finally, 5-HT2B-receptor activation inhibits IL-17, IFN-γ and GM-CSF production in both groups. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - May 11, 2021 Category: Allergy & Immunology Authors: Anastasiya Sviridova, Vladimir Rogovskii, Vladimir Kudrin, Mikhail Pashenkov, Alexey Boyko, Mikhail Melnikov Source Type: research

Magic Shotgun Nature with Scattergun Approach of Curcumin Repurposing in Obsessive-Compulsive disorder: A Novel Metaphysician of Drug Discovery
CNS Neurol Disord Drug Targets. 2021 May 6. doi: 10.2174/1871527320666210506185510. Online ahead of print.ABSTRACTBACKGROUND: Obsessive-compulsive disorder (OCD) is an intricate, debilitating neuropsychiatric disorder. Exclusively Selective serotonin reuptake inhibitors (SSRIs) are effective agents use for the treatment of OCD. However, SSRIs (Selective serotonin reuptake inhibitors) are not a magic pill-they do not respond adequately to everybody. In this consideration, a single drug target (magic bullet) is only a slightly superior option for all patients with a lot of pathognomic signs.OBJECTIVE: The principal aim of th...
Source: CNS and Neurological Disorders Drug Targets - May 10, 2021 Category: Drugs & Pharmacology Authors: Rahul Kumar Mishra Ashutosh Mishra Amresh Gupta Source Type: research

Magic Shotgun Nature with Scattergun Approach of Curcumin Repurposing in Obsessive-Compulsive disorder: A Novel Metaphysician of Drug Discovery
CNS Neurol Disord Drug Targets. 2021 May 6. doi: 10.2174/1871527320666210506185510. Online ahead of print.ABSTRACTBACKGROUND: Obsessive-compulsive disorder (OCD) is an intricate, debilitating neuropsychiatric disorder. Exclusively Selective serotonin reuptake inhibitors (SSRIs) are effective agents use for the treatment of OCD. However, SSRIs (Selective serotonin reuptake inhibitors) are not a magic pill-they do not respond adequately to everybody. In this consideration, a single drug target (magic bullet) is only a slightly superior option for all patients with a lot of pathognomic signs.OBJECTIVE: The principal aim of th...
Source: CNS and Neurological Disorders Drug Targets - May 10, 2021 Category: Drugs & Pharmacology Authors: Rahul Kumar Mishra Ashutosh Mishra Amresh Gupta Source Type: research

Magic Shotgun Nature with Scattergun Approach of Curcumin Repurposing in Obsessive-Compulsive disorder: A Novel Metaphysician of Drug Discovery
CNS Neurol Disord Drug Targets. 2021 May 6. doi: 10.2174/1871527320666210506185510. Online ahead of print.ABSTRACTBACKGROUND: Obsessive-compulsive disorder (OCD) is an intricate, debilitating neuropsychiatric disorder. Exclusively Selective serotonin reuptake inhibitors (SSRIs) are effective agents use for the treatment of OCD. However, SSRIs (Selective serotonin reuptake inhibitors) are not a magic pill-they do not respond adequately to everybody. In this consideration, a single drug target (magic bullet) is only a slightly superior option for all patients with a lot of pathognomic signs.OBJECTIVE: The principal aim of th...
Source: CNS and Neurological Disorders Drug Targets - May 10, 2021 Category: Drugs & Pharmacology Authors: Rahul Kumar Mishra Ashutosh Mishra Amresh Gupta Source Type: research

Comparative efficacy and acceptability of antidepressants and benzodiazepines for the treatment of panic disorder: A systematic review and network meta-analysis
Asian J Psychiatr. 2021 May 3;60:102664. doi: 10.1016/j.ajp.2021.102664. Online ahead of print.ABSTRACTOBJECTIVE: This systematic review aims to assess the efficacy and acceptability of the different types of antidepressants and benzodiazepines for the treatment of panic disorder (PD) in adult patients.METHODS: PubMed, Web of Science, EMBASE, MEDLINE, the Cochrane Library, and ClinicalTrials.gov were searched for randomized controlled trials (RCTs) published between 1995 and 2020 on the use of antidepressants and benzodiazepines for the treatment of PD. A systematic review and network meta-analysis were performed.RESULTS: ...
Source: Asian Journal of Psychiatry - May 9, 2021 Category: Psychiatry Authors: Yang Du Biao Du Yun Diao Zubin Yin Jin Li Yunfeng Shu Zizhen Zhang Lizhi Chen Source Type: research

Baicalin promotes hippocampal neurogenesis via the Wnt/ β-catenin pathway in a chronic unpredictable mild stress-induced mouse model of depression
In conclusion, these findings suggest that baicalin may promote hippocampal neurogenesis, thereby exerting the antidepressant effect via regulation of the Wnt/β-catenin signaling pathway.PMID:33964281 | DOI:10.1016/j.bcp.2021.114594 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - May 8, 2021 Category: Drugs & Pharmacology Authors: Zhigang Xiao Zhuoqing Cao Jiali Yang Zhixia Jia Yuru Du Guoqiang Sun Ye Lu Lin Pei Source Type: research

Withanone Ameliorates Stress Symptoms in Caenorhabditis Elegans by Acting through Serotonin Receptors
Conclusion WN ameliorated depressive-associated stress symptoms by activating the serotonin system. WN may serve as potential candidate in developing new drugs to treat depression. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - May 6, 2021 Category: Psychiatry Authors: Na ß, Janine Efferth, Thomas Tags: Original Paper Source Type: research

The Role of the Excitation:Inhibition Functional Balance in the mPFC in the Onset of Antidepressants
Neuropharmacology. 2021 May 1:108573. doi: 10.1016/j.neuropharm.2021.108573. Online ahead of print.ABSTRACTCurrently available antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), generally require weeks to months to produce a therapeutic response, but the mechanism of action underlying the delayed onset of antidepressant-like action remains to be elucidated. The balance between excitatory glutamatergic pyramidal neurons and inhibitory γ-aminobutyric acid (GABA) interneurons, i.e., the excitation:inhibition functional (E:I) balance, in ...
Source: Neuropharmacology - May 4, 2021 Category: Drugs & Pharmacology Authors: Yong-Yu Yin Yun-Hui Wang Wen-Gang Liu Jun-Qi Yao Jin Yuan Ze-Han Li Yu-Hua Ran Li-Ming Zhang Yun-Feng Li Source Type: research

The Role of the Excitation:Inhibition Functional Balance in the mPFC in the Onset of Antidepressants
Neuropharmacology. 2021 May 1:108573. doi: 10.1016/j.neuropharm.2021.108573. Online ahead of print.ABSTRACTCurrently available antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), generally require weeks to months to produce a therapeutic response, but the mechanism of action underlying the delayed onset of antidepressant-like action remains to be elucidated. The balance between excitatory glutamatergic pyramidal neurons and inhibitory γ-aminobutyric acid (GABA) interneurons, i.e., the excitation:inhibition functional (E:I) balance, in ...
Source: Neuropharmacology - May 4, 2021 Category: Drugs & Pharmacology Authors: Yong-Yu Yin Yun-Hui Wang Wen-Gang Liu Jun-Qi Yao Jin Yuan Ze-Han Li Yu-Hua Ran Li-Ming Zhang Yun-Feng Li Source Type: research

The Role of the Excitation:Inhibition Functional Balance in the mPFC in the Onset of Antidepressants
Neuropharmacology. 2021 May 1:108573. doi: 10.1016/j.neuropharm.2021.108573. Online ahead of print.ABSTRACTCurrently available antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), generally require weeks to months to produce a therapeutic response, but the mechanism of action underlying the delayed onset of antidepressant-like action remains to be elucidated. The balance between excitatory glutamatergic pyramidal neurons and inhibitory γ-aminobutyric acid (GABA) interneurons, i.e., the excitation:inhibition functional (E:I) balance, in ...
Source: Neuropharmacology - May 4, 2021 Category: Drugs & Pharmacology Authors: Yong-Yu Yin Yun-Hui Wang Wen-Gang Liu Jun-Qi Yao Jin Yuan Ze-Han Li Yu-Hua Ran Li-Ming Zhang Yun-Feng Li Source Type: research

The Role of the Excitation:Inhibition Functional Balance in the mPFC in the Onset of Antidepressants
Neuropharmacology. 2021 May 1:108573. doi: 10.1016/j.neuropharm.2021.108573. Online ahead of print.ABSTRACTCurrently available antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), generally require weeks to months to produce a therapeutic response, but the mechanism of action underlying the delayed onset of antidepressant-like action remains to be elucidated. The balance between excitatory glutamatergic pyramidal neurons and inhibitory γ-aminobutyric acid (GABA) interneurons, i.e., the excitation:inhibition functional (E:I) balance, in ...
Source: Neuropharmacology - May 4, 2021 Category: Drugs & Pharmacology Authors: Yong-Yu Yin Yun-Hui Wang Wen-Gang Liu Jun-Qi Yao Jin Yuan Ze-Han Li Yu-Hua Ran Li-Ming Zhang Yun-Feng Li Source Type: research

Physiologically ‐based pharmacokinetic modeling to predict drug interactions of lemborexant with CYP3A inhibitors
AbstractLemborexant, a recently approved dual orexin receptor antagonist for treatment of adults with insomnia, is eliminated primarily by cytochrome P450 (CYP)3A metabolism. The recommended dose of lemborexant is 5  mg once per night, with a maximum recommended dose of 10 mg once daily. A physiologically‐based pharmacokinetic (PBPK) model for lemborexant was developed and applied to integrate data obtained from in vivo drug–drug interaction (DDI) assessments, and to further explore lemborexant interactio n with CYP3A inhibitors and inducers. The model predictions were in good agreement with observed phar...
Source: CPT: Pharmacometrics and Systems Pharmacology - May 1, 2021 Category: Drugs & Pharmacology Authors: Takashi Ueno, Yukiko Miyajima, Ishani Landry, Bojan Lalovic, Edgar Schuck Tags: ARTICLE Source Type: research

False-Positive Urine Drug Screen for Benzodiazepines in a Child Taking Fluoxetine
No abstract available (Source: Pediatric Emergency Care)
Source: Pediatric Emergency Care - May 1, 2021 Category: Emergency Medicine Tags: Letters to the Editors Source Type: research

A Case Report of Clozapine-Associated Stuttering and Amisulpride-Associated Stuttering and Seizure in an Adult on Concurrent Fluoxetine Therapy
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - April 30, 2021 Category: Psychiatry Tags: Letters to the Editors – Case Reports Source Type: research

Fluoxetine incentivizes ventral striatum encoding of reward and punishment
Neuropsychopharmacology, Published online: 29 April 2021; doi:10.1038/s41386-021-01012-7Fluoxetine incentivizes ventral striatum encoding of reward and punishment (Source: Neuropsychopharmacology)
Source: Neuropsychopharmacology - April 29, 2021 Category: Neurology Authors: Vincent D. Costa Bruno B. Averbeck Source Type: research

Degraded Encoding of Reversal Learning Resulting From Abnormal Grooming-Related LOFC Activity Normalizes After Fluoxetine Treatment in a Model of Compulsive Behavior
Patients with obsessive-compulsive disorder (OCD) display abnormal orbitofrontal cortex (OFC) activity during symptom provocation and reversal learning that is normalized by fluoxetine. However, it is unknown if the same OFC neurons encode both behaviors. Using Sapap3-KO mice to model OCD-relevant behaviors (compulsive grooming; impaired reversal learning), we used in vivo calcium imaging to measure self-grooming and reversal learning-related neural activity in the same lateral OFC (LOFC) neurons before and after fluoxetine. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 27, 2021 Category: Psychiatry Authors: Matthew Geramita, Elizabeth Manning, Sean Piantadosi, Susanne Ahmari Source Type: research

Mother ’s Little Helpers: The Effects of Diazepam and Chronic Fluoxetine on Anxiety Differs in Nulliparous and Primiparous Rats
1 in 5 mothers experience an onset of anxiety after giving birth yet anxiety medications are typically only tested in male or virgin female animals. This is problematic because motherhood changes brain regions on which these drugs act. Therefore, the aim of this study was to examine two common pharmacological treatments of anxiety, a benzodiazepine and a selective serotonin reuptake inhibitor, on animal models of anxiety in females pre- and post-motherhood. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 27, 2021 Category: Psychiatry Authors: Jodie Pestana, Bronwyn Graham Source Type: research

P019  Audit of prostanoid use in severe Raynaud’s and adherence to treatment of digital ulcers in patients with SSc NHSE pathway: commissioning policy cost analysis and alternative therapeutic pathway proposed
Conclusion Epoprostenol is used in our unit for patients with severe RP from a range of conditions. Sildenafil and CCB have been trialled in the majority of our patients prior to escalation. Only a minority of patients have received bosentan according to current guidelines and licensing. Given the reduction in cost, combined with the importance of avoiding hospital admissions with COVID-19, we would suggest that bosentan could be used earlier in the treatment pathway for a broader range of indications. NHSE is revising the SSc commissioning policy.Disclosure A. Young: None.B. Griffiths: None.J. Vila: None. (Source: Rheumatology)
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research

P126  The effectiveness of pharmacological interventions and cognitive behavioural therapy in improving sleep in fibromyalgia: a systematic review
Conclusion The optimal management of sleep disorders in FM is complex and needs to be tailored to the individual patient. We have shown that there are varying degrees of efficacy throughout a range of commonly used drugs in FM. Unfortunately, lack of consistency in outcome measures between studies makes it difficult to draw definitive conclusions pertaining to superiority between these agents. Conversely, CBT interventions appear to show consistent sleep improvement in FM. It is not clear whether this translates to online variations of CBT. We believe that a longitudinal appraisal of sleep as a primar y variable, with...
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research

Fluoxetine tunes the abnormal hippocampal oscillations in association with cognitive impairments in 6-OHDA lesioned rats
Behav Brain Res. 2021 Apr 21:113314. doi: 10.1016/j.bbr.2021.113314. Online ahead of print.ABSTRACTCognitive decline is a common clinical symptom in Parkinson's disease (PD) patients. Fluoxetine (FLU), a selective serotonin reuptake inhibitor, can improve cognitive deficits in demented patients. The present study investigated the effects of FLU on spatial learning and memory cognitions in 6-OHDA lesioned rats. Morris water maze (MWM) test showed that FLU significantly improved spatial cognitive deficits in rats with unilateral 6-OHDA injection at 4 and 7 weeks after 6-OHDA injection. Electrophysiological recordings demonst...
Source: Brain Research - April 24, 2021 Category: Neurology Authors: Weitang Liu Renxing Zhang Hu Feng Hongyan Zhu Source Type: research

Fluoxetine tunes the abnormal hippocampal oscillations in association with cognitive impairments in 6-OHDA lesioned rats
Behav Brain Res. 2021 Apr 21:113314. doi: 10.1016/j.bbr.2021.113314. Online ahead of print.ABSTRACTCognitive decline is a common clinical symptom in Parkinson's disease (PD) patients. Fluoxetine (FLU), a selective serotonin reuptake inhibitor, can improve cognitive deficits in demented patients. The present study investigated the effects of FLU on spatial learning and memory cognitions in 6-OHDA lesioned rats. Morris water maze (MWM) test showed that FLU significantly improved spatial cognitive deficits in rats with unilateral 6-OHDA injection at 4 and 7 weeks after 6-OHDA injection. Electrophysiological recordings demonst...
Source: Behavioural Brain Research - April 24, 2021 Category: Neurology Authors: Weitang Liu Renxing Zhang Hu Feng Hongyan Zhu Source Type: research

Exercise and fluoxetine treatment during adolescence protect against early life stress-induced behavioral abnormalities in adult rats
Publication date: June 2021Source: Pharmacology Biochemistry and Behavior, Volume 205Author(s): Fatemeh Sadat Zolfaghari, Fardad Pirri, Evan Gauvin, Maghsoud Peeri, Shayan Amiri (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - April 19, 2021 Category: Biochemistry Source Type: research

A single administration of ascorbic acid rapidly reverses depressive-like behavior and hippocampal synaptic dysfunction induced by corticosterone in mice
This study investigated the ascorbic acid's ability to induce a fast antidepressant-like response and to improve hippocampal synaptic markers in mice subjected to chronic corticosterone (CORT) administration. CORT was administered for 21 days, followed by a single administration of ascorbic acid (1 mg ∕Kg, p.o.), ketamine (1 mg ∕Kg, i.p.) or fluoxetine (10 mg ∕Kg, p.o.) in mice. Depressive-like behavior, hippocampal synaptic proteins immunocontent, dendrite spines density in the dentate gyrus (DG) were analyzed 24 h following treatments. The administration of ascorbic acid or ketamine, but not fluoxetine, counteracte...
Source: Chemico-Biological Interactions - April 19, 2021 Category: Molecular Biology Authors: Daiane B Fraga Anderson Camargo Gislaine Olescowicz Dayane Azevedo Francielle Mina Josiane Budni Patricia S Brocardo Ana L úcia S Rodrigues Source Type: research

Exercise and fluoxetine treatment during adolescence showed protective effects against early life stress-induced behavioral abnormalities in adult rats
Publication date: Available online 15 April 2021Source: Pharmacology Biochemistry and BehaviorAuthor(s): Fatemeh Sadat Zolfaghari, Fardad Pirri, Evan Gauvin, Maghsoud Peeri, Shayan Amiri (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - April 16, 2021 Category: Biochemistry Source Type: research

MicroRNA-34a regulates 5-HT2C expression in Dorsal Raphe and contributes to the anti-depressant-like effect of fluoxetine
In this study, acute and chronic fluoxetine treatment differentially alters the expression of 5-HT2C and microRNA-34a in the dorsal raphe. Moreover, by in vitro luciferase assay, we demonstrated the repressive regulatory activity of microRNA-34a against 5-HT2C mRNA. Specific blockade of this interaction through local infusion of a target site blocker was sufficient to prevent the behavioral effects of chronic fluoxetine. Our results demonstrate a new miR-34a-mediated regulatory mechanism of 5-HT2C expression in the dorsal raphe and implicate it in eliciting the behavioral responses to chronic fluoxetine treatment.PMID:3384...
Source: Neuropharmacology - April 12, 2021 Category: Drugs & Pharmacology Authors: Luisa Lo Iacono Donald Ielpo Chiara Parisi Giulia Napoli Alessandra Accoto Matteo Di Segni Lucy Babicola Sebastian Luca D'Addario Serafina Manila Guzzo Tiziana Pascucci Rossella Ventura Diego Andolina Source Type: research

MicroRNA-34a regulates 5-HT2C expression in Dorsal Raphe and contributes to the anti-depressant-like effect of fluoxetine
In this study, acute and chronic fluoxetine treatment differentially alters the expression of 5-HT2C and microRNA-34a in the dorsal raphe. Moreover, by in vitro luciferase assay, we demonstrated the repressive regulatory activity of microRNA-34a against 5-HT2C mRNA. Specific blockade of this interaction through local infusion of a target site blocker was sufficient to prevent the behavioral effects of chronic fluoxetine. Our results demonstrate a new miR-34a-mediated regulatory mechanism of 5-HT2C expression in the dorsal raphe and implicate it in eliciting the behavioral responses to chronic fluoxetine treatment.PMID:3384...
Source: Neuropharmacology - April 12, 2021 Category: Drugs & Pharmacology Authors: Luisa Lo Iacono Donald Ielpo Chiara Parisi Giulia Napoli Alessandra Accoto Matteo Di Segni Lucy Babicola Sebastian Luca D'Addario Serafina Manila Guzzo Tiziana Pascucci Rossella Ventura Diego Andolina Source Type: research

Xiaoyaosan Alleviates Hippocampal Glutamate-Induced Toxicity in the CUMS Rats via NR2B and PI3K/Akt Signaling Pathway
Conclusion: Xiaoyaosan treatment can exert the antidepressant effect by rescuing hippocampal neurons loss induced by the glutamate-mediated excitotoxicity in CUMS rats. The underlying pathway maybe through NR2B and PI3K/Akt signaling pathways. These results may suggest the potential of Xiaoyaosan in preventing the development of depression. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 12, 2021 Category: Drugs & Pharmacology Source Type: research

Cell cycle abnormality is a cellular phenotype in OCD
In this study, we therefore aimed to explore cell cycle in OCD. To the best of our knowledge, this is the first study to investigate these effects in OCD. We also evaluated the effect of in vitro fluoxetine, commonly used serotonin reuptake inhibitor (SRI) in OCD patients, on cell cycle regulation. The effects of both disease (OCD) and treatment (SRI) were assessed using lymphoblastoid cell lines (LCLs), derived from OCD patients and healthy controls, as a model system. LCLs were treated with 10μM of fluoxetine for 24 h, and the percentage of cells in each phase of the cell cycle was determined by flow cytometry. We obs...
Source: Asian Journal of Psychiatry - April 9, 2021 Category: Psychiatry Authors: Pravallika Manjappa Srinivas Balachander Safoora Naaz Ravi Kumar Nadella Tulika Shukla Pradip Paul Meera Purushottam Y C Janardhan Reddy Sanjeev Jain Biju Viswanath Reeteka Sud Source Type: research

< em > In vitro < /em > and < em > in  vivo < /em > evaluation of taste-masked orodispersible tablets of fluoxetine hydrochloride for the treatment of depression
CONCLUSION: The results obtained showed a promising potential of the prepared FLX ODTs for treating depression effectively.PMID:33826435 | DOI:10.1080/03639045.2021.1908336 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 7, 2021 Category: Drugs & Pharmacology Authors: Maha A Marzouk Dina A Osman Omnia S Mohamed Source Type: research

Putative Anti-Immobility Action of Acute Insulin Is Attributable to an Increase in Locomotor Activity in Healthy Wistar Rats
Conclusion: These results indicate that insulin does not produce a true antidepressant action in healthy rats. The purported antidepressant effects that were observed were instead attributable to an increase in locomotor activity only in the 1-day regimen.Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - April 7, 2021 Category: Psychiatry & Psychology Source Type: research

Chiral Transplacental Pharmacokinetics of Fexofenadine: Impact of P-Glycoprotein Inhibitor Fluoxetine Using the Human Placental Perfusion Model
ConclusionsOur study showed a low extent, slow rate of non-enantioselective placental transfer of fexofenadine enantiomers, indicating a limited fetal fexofenadine exposure mediated by placental P-gp and/or OATP2B1. The fluoxetine interaction did not affect the non-enantioselective transplacental transfer of fexofenadine. The ex vivo placental perfusion model accurately predictsin vivo placental transfer of fexofenadine enantiomers with remarkably similar values (~0.17), and thus estimates the limited fetal exposure. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 6, 2021 Category: Drugs & Pharmacology Source Type: research

Involvement of dorsal raphe nucleus serotonergic systems in social approach-avoidance behaviour and in the response to fluoxetine treatment in peri-adolescent female BALB/c mice
In this study, we examined the involvement of the DR serotonergic systems in social behaviour and in response to SSRI treatment, using peri-adolescent female BALB/c mice. Mice were exposed to the SSRI fluoxetine either chronically (18 mg/kg/day, in drinking water, for 12 days) or acutely (18 mg/kg, i.p.), or to vehicle control condition (0.9% saline, i.p.), prior to being exposed to the three-chambered sociability test. Activation of serotonergic neurons across subregions of the DR were subsequently measured, using dual-label immunohistochemistry for TPH2 and c-Fos. Acute fluoxetine administration increased generalised and...
Source: Behavioural Brain Research - April 3, 2021 Category: Neurology Authors: Jennyfer M Payet Kira-Elise Wilson Adrian M Russo Anthony Angiolino William Kavanagh-Ryan Stephen Kent Christopher A Lowry Matthew W Hale Source Type: research

Involvement of dorsal raphe nucleus serotonergic systems in social approach-avoidance behaviour and in the response to fluoxetine treatment in peri-adolescent female BALB/c mice
In this study, we examined the involvement of the DR serotonergic systems in social behaviour and in response to SSRI treatment, using peri-adolescent female BALB/c mice. Mice were exposed to the SSRI fluoxetine either chronically (18 mg/kg/day, in drinking water, for 12 days) or acutely (18 mg/kg, i.p.), or to vehicle control condition (0.9% saline, i.p.), prior to being exposed to the three-chambered sociability test. Activation of serotonergic neurons across subregions of the DR were subsequently measured, using dual-label immunohistochemistry for TPH2 and c-Fos. Acute fluoxetine administration increased generalised and...
Source: Brain Research - April 3, 2021 Category: Neurology Authors: Jennyfer M Payet Kira-Elise Wilson Adrian M Russo Anthony Angiolino William Kavanagh-Ryan Stephen Kent Christopher A Lowry Matthew W Hale Source Type: research

Agomelatine Softens Depressive-Like Behavior through the Regulation of Autophagy and Apoptosis
In this study, we sought to evaluate the antidepressant effects of AGO on the chronic restraint stress (CRS) mouse model and preliminarily investigate its effects on the gut microbial metabolites. The CRS model mice were established in 28 days with AGO (60 mg/kg/day, by oral) or fluoxetine (15 mg/kg/day, by oral) administration. The number of behavioral tests was conducted to evaluate the effect of AGO on depression-like behavior alleviation. Meanwhile, the expression of the BDNF/TrkB/pERK signaling pathway, apoptosis, autophagy, and inflammatory protein markers were assessed using western blot and immunofluorescence. Our ...
Source: Biomed Res - April 1, 2021 Category: Research Authors: Fengpei Chen Shijia Chen Jie Liu Nashwa Amin Weidong Jin Marong Fang Source Type: research

Alteration of predatory behaviour and growth in juvenile cuttlefish by fluoxetine and venlafaxine
Chemosphere. 2021 Mar 17;277:130169. doi: 10.1016/j.chemosphere.2021.130169. Online ahead of print.ABSTRACTAntidepressants in coastal waters may affect ontogeny of predatory behaviour in cuttlefish, which may, as a result, affect growth of newly-hatched cuttlefish. We investigated the effects of two of the most prescribed antidepressants, fluoxetine (FLX) and venlafaxine (VEN) in environmentally realistic concentrations on the predatory behaviour of hatchlings of Sepia officinalis. Newly-hatched cuttlefish were exposed from 1 h (i.e., day 1) to 5 days after hatching to either FLX alone (5 ng·L-1) or combined with VE...
Source: Chemosphere - April 1, 2021 Category: Chemistry Authors: Apolline Chabenat Flavie Bidel Thomas Knigge C écile Bellanger Source Type: research

Alteration of predatory behaviour and growth in juvenile cuttlefish by fluoxetine and venlafaxine
Chemosphere. 2021 Mar 17;277:130169. doi: 10.1016/j.chemosphere.2021.130169. Online ahead of print.ABSTRACTAntidepressants in coastal waters may affect ontogeny of predatory behaviour in cuttlefish, which may, as a result, affect growth of newly-hatched cuttlefish. We investigated the effects of two of the most prescribed antidepressants, fluoxetine (FLX) and venlafaxine (VEN) in environmentally realistic concentrations on the predatory behaviour of hatchlings of Sepia officinalis. Newly-hatched cuttlefish were exposed from 1 h (i.e., day 1) to 5 days after hatching to either FLX alone (5 ng·L-1) or combined with VE...
Source: Chemosphere - April 1, 2021 Category: Chemistry Authors: Apolline Chabenat Flavie Bidel Thomas Knigge C écile Bellanger Source Type: research

Agomelatine Softens Depressive-Like Behavior through the Regulation of Autophagy and Apoptosis
In this study, we sought to evaluate the antidepressant effects of AGO on the chronic restraint stress (CRS) mouse model and preliminarily investigate its effects on the gut microbial metabolites. The CRS model mice were established in 28 days with AGO (60 mg/kg/day, by oral) or fluoxetine (15 mg/kg/day, by oral) administration. The number of behavioral tests was conducted to evaluate the effect of AGO on depression-like behavior alleviation. Meanwhile, the expression of the BDNF/TrkB/pERK signaling pathway, apoptosis, autophagy, and inflammatory protein markers were assessed using western blot and immunofluorescence. Our ...
Source: Biomed Res - April 1, 2021 Category: Research Authors: Fengpei Chen Shijia Chen Jie Liu Nashwa Amin Weidong Jin Marong Fang Source Type: research

Alteration of predatory behaviour and growth in juvenile cuttlefish by fluoxetine and venlafaxine
Chemosphere. 2021 Mar 17;277:130169. doi: 10.1016/j.chemosphere.2021.130169. Online ahead of print.ABSTRACTAntidepressants in coastal waters may affect ontogeny of predatory behaviour in cuttlefish, which may, as a result, affect growth of newly-hatched cuttlefish. We investigated the effects of two of the most prescribed antidepressants, fluoxetine (FLX) and venlafaxine (VEN) in environmentally realistic concentrations on the predatory behaviour of hatchlings of Sepia officinalis. Newly-hatched cuttlefish were exposed from 1 h (i.e., day 1) to 5 days after hatching to either FLX alone (5 ng·L-1) or combined with VE...
Source: Chemosphere - April 1, 2021 Category: Chemistry Authors: Apolline Chabenat Flavie Bidel Thomas Knigge C écile Bellanger Source Type: research

Alteration of predatory behaviour and growth in juvenile cuttlefish by fluoxetine and venlafaxine
Chemosphere. 2021 Mar 17;277:130169. doi: 10.1016/j.chemosphere.2021.130169. Online ahead of print.ABSTRACTAntidepressants in coastal waters may affect ontogeny of predatory behaviour in cuttlefish, which may, as a result, affect growth of newly-hatched cuttlefish. We investigated the effects of two of the most prescribed antidepressants, fluoxetine (FLX) and venlafaxine (VEN) in environmentally realistic concentrations on the predatory behaviour of hatchlings of Sepia officinalis. Newly-hatched cuttlefish were exposed from 1 h (i.e., day 1) to 5 days after hatching to either FLX alone (5 ng·L-1) or combined with VE...
Source: Chemosphere - April 1, 2021 Category: Chemistry Authors: Apolline Chabenat Flavie Bidel Thomas Knigge C écile Bellanger Source Type: research

Peculiarities of Heart Rate Variability Changes in Random-Bred Male Rats during Transition into Anesthetic Sleep under Stimulation of Central Neurotransmitter Systems
General anesthesia with Nembutal (40 mg/kg) dramatically decreased the power of all waves of HRV spectrum in rats, especially in LF and VLF frequency bands, but the HR and respiration rate were little changed. At this, individual spectral peaks in HF range were observed at the same frequencies (1.3-1.5 Hz), which are characteristic of the wakeful state. Preliminary stimulation of noradrenergic system with maprotiline (10 mg/kg) increased the power of HF waves and elevated the respiratory rate in narcotized rats in comparison with the control values, although it did not shift the spectral peak at 1.5 Hz in frequency axis. P...
Source: Bulletin of Experimental Biology and Medicine - April 1, 2021 Category: Biology Source Type: research

Selecting antidepressants according to a drug-by-environment interaction: a comparison of fluoxetine and minocycline effects in mice living either in enriched or stressful conditions
Behav Brain Res. 2021 Mar 25:113256. doi: 10.1016/j.bbr.2021.113256. Online ahead of print.ABSTRACTSelective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for major depressive disorder. It has been recently proposed that these drugs, by enhancing neural plasticity, amplify the influences of the living conditions on mood. Consequently, SSRI outcome depends on the quality of the environment, improving symptomatology mainly in individuals living in favorable conditions. In adverse conditions, drugs with a different mechanism of action might have higher efficacy. The antibiotic minocycline, with neuroprote...
Source: Behavioural Brain Research - March 29, 2021 Category: Neurology Authors: Silvia Poggini Gloria Matte Bon Maria Teresa Golia Naomi Ciano Albanese Aurelia Viglione Anna Poleggi Cristina Limatola Laura Maggi Igor Branchi Source Type: research

Selecting antidepressants according to a drug-by-environment interaction: a comparison of fluoxetine and minocycline effects in mice living either in enriched or stressful conditions
Behav Brain Res. 2021 Mar 25:113256. doi: 10.1016/j.bbr.2021.113256. Online ahead of print.ABSTRACTSelective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for major depressive disorder. It has been recently proposed that these drugs, by enhancing neural plasticity, amplify the influences of the living conditions on mood. Consequently, SSRI outcome depends on the quality of the environment, improving symptomatology mainly in individuals living in favorable conditions. In adverse conditions, drugs with a different mechanism of action might have higher efficacy. The antibiotic minocycline, with neuroprote...
Source: Brain Research - March 29, 2021 Category: Neurology Authors: Silvia Poggini Gloria Matte Bon Maria Teresa Golia Naomi Ciano Albanese Aurelia Viglione Anna Poleggi Cristina Limatola Laura Maggi Igor Branchi Source Type: research

Selecting antidepressants according to a drug-by-environment interaction: a comparison of fluoxetine and minocycline effects in mice living either in enriched or stressful conditions
Behav Brain Res. 2021 Mar 25:113256. doi: 10.1016/j.bbr.2021.113256. Online ahead of print.ABSTRACTSelective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for major depressive disorder. It has been recently proposed that these drugs, by enhancing neural plasticity, amplify the influences of the living conditions on mood. Consequently, SSRI outcome depends on the quality of the environment, improving symptomatology mainly in individuals living in favorable conditions. In adverse conditions, drugs with a different mechanism of action might have higher efficacy. The antibiotic minocycline, with neuroprote...
Source: Brain Research - March 29, 2021 Category: Neurology Authors: Silvia Poggini Gloria Matte Bon Maria Teresa Golia Naomi Ciano Albanese Aurelia Viglione Anna Poleggi Cristina Limatola Laura Maggi Igor Branchi Source Type: research

Selecting antidepressants according to a drug-by-environment interaction: a comparison of fluoxetine and minocycline effects in mice living either in enriched or stressful conditions
Behav Brain Res. 2021 Mar 25:113256. doi: 10.1016/j.bbr.2021.113256. Online ahead of print.ABSTRACTSelective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for major depressive disorder. It has been recently proposed that these drugs, by enhancing neural plasticity, amplify the influences of the living conditions on mood. Consequently, SSRI outcome depends on the quality of the environment, improving symptomatology mainly in individuals living in favorable conditions. In adverse conditions, drugs with a different mechanism of action might have higher efficacy. The antibiotic minocycline, with neuroprote...
Source: Behavioural Brain Research - March 29, 2021 Category: Neurology Authors: Silvia Poggini Gloria Matte Bon Maria Teresa Golia Naomi Ciano Albanese Aurelia Viglione Anna Poleggi Cristina Limatola Laura Maggi Igor Branchi Source Type: research