[Editors' Choice] Tamoxifen as an immunotherapy
Antiestrogen drugs may treat some estrogen receptor-negative tumors by limiting the proliferation and activity of suppressive immune cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 15, 2017 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news
GPs 'failing to prescribe tamoxifen to prevent breast cancer'
Conclusion
This large survey shows around half of GPs surveyed were unaware of the benefits of tamoxifen: namely, that the drug can reduce the risk of breast cancer in women with a family history of the condition. Only around a quarter of GPs surveyed were aware of the current UK guidelines.
Researchers found GPs were more likely to feel comfortable carrying on a prescription initiated by hospital doctors, rather than being the one to take the decision to prescribe.
This is perhaps unsurprising given that the drug is still not licensed for the primary prevention of cancer. NICE currently recommends prescribers need to ta...
Source: NHS News Feed - February 14, 2017 Category: Consumer Health News Tags: Cancer Medication Medical practice Source Type: news
Ignorant GPs deny patients drugs that ward off cancer
Two major UK studies have shown many GPs are unaware that prescribing certain patients daily pills - such as tamoxifen and aspirin - can slash their odds of developing certain tumours. (Source: the Mail online | Health)
Source: the Mail online | Health - February 14, 2017 Category: Consumer Health News Source Type: news
Work needed to boost GPs ’ knowledge of cancer drug
Only a quarter of GPs aware of NICE guideline on tamoxifen Related items fromOnMedica Tamoxifen linked to reduced contralateral breast cancer risk One in six breast cancer patients have symptom other than a lump Big data advances breast cancer research by ‘decades’ (Source: OnMedica Latest News)
Source: OnMedica Latest News - February 13, 2017 Category: UK Health Source Type: news
Secondary care support can boost GP use of breast cancer prevention drug
Researchers have called for a joint primary and secondary care pathway to encourage prescribing of tamoxifen as a preventative treatment for women at increased risk of breast cancer. (Source: GP Online News)
Source: GP Online News - February 13, 2017 Category: Primary Care Tags: 12 Care of People with Cancer and Palliative Care Source Type: news
Older women less likely to be offered breast reconstruction after mastectomy
Guidelines state that surgeons should discuss breast reconstruction with all suitable patients Related items fromOnMedica Tamoxifen linked to reduced contralateral breast cancer risk Big data advances breast cancer research by ‘decades’ Breast conservation beats mastectomy for some patients Schoolboy youngest in UK to undergo mastectomy Study finds overuse of double mastectomy (Source: OnMedica Latest News)
Source: OnMedica Latest News - February 8, 2017 Category: UK Health Source Type: news
Black Women Face Devastating Losses If Obamacare Is Repealed
Bianca Adams worked part-time jobs as a spa professional, sometimes juggling two or three at a time, for years. But none of them offered her insurance, which meant that the 47-year-old with diabetes often went to the emergency room for care.
“I was one of those people that had to go to the emergency when my blood sugar got too high and I needed fluids,” Adams told The Huffington Post. “There was really no one managing my health at that point.”
When her Medicaid coverage through the Affordable Care Act began in 2014, Adams, who has been disabled with severe knee problems for 25 years, under...
Source: Healthy Living - The Huffington Post - February 4, 2017 Category: Consumer Health News Source Type: news
How Soy Can Both Prevent Breast Cancer And Fuel Its Spread
To eat soy or not: That’s the question many U.S. women have been asking. Tofu, miso paste and other soybean-based foods are high-quality sources of protein that are low in calories and saturated fat. And studies have shown that they can help prevent cancer.
Yet many doctors recommend that women who have, or are at risk of developing, a common form of breast cancer called estrogen-receptor-positive breast cancer avoid eating soybean-based foods because they contain compounds called isoflavones. Some studies suggest that isoflavones can mimic the hormone estrogen and encourage tumor growth.
Now, in an animal study, res...
Source: Healthy Living - The Huffington Post - February 3, 2017 Category: Consumer Health News Source Type: news
How Soy Can Both Prevent Breast Cancer And Fuel Its Spread
To eat soy or not: That’s the question many U.S. women have been asking. Tofu, miso paste and other soybean-based foods are high-quality sources of protein that are low in calories and saturated fat. And studies have shown that they can help prevent cancer.
Yet many doctors recommend that women who have, or are at risk of developing, a common form of breast cancer called estrogen-receptor-positive breast cancer avoid eating soybean-based foods because they contain compounds called isoflavones. Some studies suggest that isoflavones can mimic the hormone estrogen and encourage tumor growth.
Now, in an animal study, res...
Source: Science - The Huffington Post - February 3, 2017 Category: Science Source Type: news
Many Breast Cancer Survivors Don't Get Life-Extending Therapy
THURSDAY, Feb. 2, 2017 -- Hormonal therapies such as tamoxifen, or a class of drugs called aromatase inhibitors, can reduce the likelihood that women diagnosed with certain breast cancers will experience a recurrence of their disease.
However, a... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 2, 2017 Category: Journals (General) Source Type: news
Initiating tamoxifen in secondary care increases GP prescribing
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - January 31, 2017 Category: Drugs & Pharmacology Source Type: news
New insights into why breast cancer drugs fail for some women
Conclusion
This laboratory study aimed to investigate the mechanism behind how some oestrogen receptor-positive breast cancer tumours develop resistance to the hormone drugs tamoxifen and aromatase inhibitors.
This resistance effectively makes these drugs powerless, causing the cancer to return.
The researchers seemed to find at least part of the answer as to why resistance to aromatase inhibitors can develop.
In some cases, they found treatment triggered the amplification of the CYP19A1 gene, which increased the production of aromatase, essentially allowing the cells to keep making their own oestrogen.
But this doesn't...
Source: NHS News Feed - January 24, 2017 Category: Consumer Health News Tags: Cancer Medication Genetics/stem cells Source Type: news
Menopause Symptoms Can Predict Tamoxifen Adherence for Breast Cancer Prevention
This video examines findings from the International Breast Cancer Intervention Study (IBIS-1), which found that patients with menopause symptoms were less likely to continue long-term tamoxifen therapy. (Source: CancerNetwork)
Source: CancerNetwork - January 14, 2017 Category: Cancer & Oncology Authors: Samuel Smith, PhD Tags: Videos Breast Cancer Source Type: news
Aromatase inhibitors for breast cancer: Advantages over tamoxifen in early-stage disease
Patients survive longer, recurrences occur later, and certain side effects occur less often. Overall, the evidence for late-stage disease is much poorer. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 29, 2016 Category: Science Source Type: news
Aromatase inhibitors for breast cancer: Advantages over tamoxifen in early-stage disease
(Institute for Quality and Efficiency in Health Care) Patients survive longer, recurrences occur later, and certain side effects occur less often. Overall, the evidence for late-stage disease is much poorer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 29, 2016 Category: Global & Universal Source Type: news
