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Gastric Adenocarcinoma of the Fundic Gland Type: Update and Literature Review.
Conclusions: GA-FGs are rare lesions that typically follow a benign course. However, despite features of malignancy in some cases, complete surgical excision, sometimes with endoscopic mucosal resection, seems adequate treatment. PMID: 29648578 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 10, 2018 Category: Pathology Authors: Benedict MA, Lauwers GY, Jain D Tags: Am J Clin Pathol Source Type: research

Obtaining a Correct Diagnosis Rapidly in the United States Is Associated With Many Barriers Not Present in Other Countries.
PMID: 29635278 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 4, 2018 Category: Pathology Authors: Laposata M Tags: Am J Clin Pathol Source Type: research

The Impact of an Electronic Expensive Test Notification.
Conclusions: Although this CDST was passive (ie, could be overridden at the point of order entry) and was associated with a relatively low abandonment rate, it achieved a considerable cost savings each year since each abandoned test saved the institution $1,000 or more. PMID: 29635311 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 4, 2018 Category: Pathology Authors: Riley JD, Stanley G, Wyllie R, Kottke-Marchant K, Procop GW Tags: Am J Clin Pathol Source Type: research

Pulmonary Non-Small Cell Carcinoma With Morphologic Features of Adenocarcinoma or "Non-Small Cell Carcinoma Favor Adenocarcinoma" in Cytologic Specimens Share Similar Clinical and Molecular Genetic Characteristics.
Conclusion: Patients diagnosed with pulmonary ACA, NSCLC favor ACA, or NSCLC-NOS in cytology specimens have similar clinical stage, survival, and molecular alterations. PMID: 29635384 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 4, 2018 Category: Pathology Authors: Hutchings D, Maleki Z, Rodriguez EF Tags: Am J Clin Pathol Source Type: research

Body Fluid Processing Workspace Quality Improvement Initiative in a High-Volume Reference Laboratory.
Conclusions: After the redesign, physical steps taken and time to process body fluids were reduced by an average of 40% and 32%, respectively, demonstrating the utility of quality improvement tools in clinical laboratory settings. PMID: 29618001 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 29, 2018 Category: Pathology Authors: Campbell MR, Milam KK, Fisher KR Tags: Am J Clin Pathol Source Type: research

Diagnostic Utility of Twist1, Ki-67, and E-Cadherin in Diagnosing Molar Gestations and Hydropic Abortions.
Conclusions: Twist1 expression is a highly reliable marker for the diagnosis of CHM, where combined Ki-67 and E-cadherin immunoreactivity can distinguish PHM from nonmolar pregnancies. PMID: 29562309 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 19, 2018 Category: Pathology Authors: Moussa RA, Eesa AN, Abdallah ZF, Abdelmeged A, Mahran A, Bahaa H Tags: Am J Clin Pathol Source Type: research

Increased Rate of ASCUS Diagnosis With Concomitant Request for High-Risk Human Papillomavirus Reflex Testing May Be Due to Cognitive Bias.
Conclusions: HPV-HR reflex testing may introduce bias in cytologic diagnosis, making it more likely that an ASCUS diagnosis is rendered. HPV-HR and ASCUS/SIL ratios were similar between the groups, so cytopathologist performance was not significantly affected. There was no effect of cytopathologists' experience. PMID: 29562239 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 17, 2018 Category: Pathology Authors: Pendse AA, Bauer AE, Dodd L, Scanga L Tags: Am J Clin Pathol Source Type: research

Performance Evaluation and Clinical Associations of Immunoassays That Detect Antibodies to Negatively Charged Phospholipids Other Than Cardiolipin.
Conclusions: Increasing titers of APhL, anti-PS, and anti-PI antibodies could indicate an increased risk of thrombotic and/or obstetric aPL-related manifestations. These assays may be promising biomarkers for particular APS manifestations. PMID: 29547897 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 14, 2018 Category: Pathology Authors: Castanon A, Pierre G, Willis R, Harris EN, Papalardo E, Romay-Penabad Z, Schleh A, Jajoria P, Smikle M, DeCeulaer K, Tebo A, Jaskowski T, Guerra MM, Branch DW, Salmon JE, Petri M, Gonzalez EB Tags: Am J Clin Pathol Source Type: research

Offering Aspartate Aminotransferase as a Reflex Test: An Easy but Effective Way to Improve Appropriateness of Laboratory Requests.
PMID: 29547948 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 14, 2018 Category: Pathology Authors: Birindelli S, Pasqualetti S, Panteghini M Tags: Am J Clin Pathol Source Type: research

Multinodular Goiter Progression Toward Malignancy in a Case of DICER1 Syndrome: Histologic and Molecular Alterations.
Conclusions: The findings obtained from this single case support the assumption that DICER1 syndrome-related WDTC NOS may develop on a background of MNG, via a stepwise process, involving DICER1 somatic mutations and additional molecular events, distinct from the classic pathways of papillary/follicular carcinoma. PMID: 29538609 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 10, 2018 Category: Pathology Authors: Gullo I, Batista R, Rodrigues-Pereira P, Soares P, Barroca H, do Bom-Sucesso M, Sobrinho-Simões M Tags: Am J Clin Pathol Source Type: research

Upregulation of miR-125b, miR-181d, and miR-221 Predicts Poor Prognosis in MGMT Promoter-Unmethylated Glioblastoma Patients.
Conclusions: miR 125b-5p, miR 181d-3p, and miR 221-3p are useful in predicting poor prognosis in patients with MGMT-unmethylated glioblastomas. PMID: 29538610 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 10, 2018 Category: Pathology Authors: Chen YY, Ho HL, Lin SC, Ho TD, Hsu CY Tags: Am J Clin Pathol Source Type: research

Acinar-Predominant Pattern Correlates With Poorer Prognosis in Invasive Mucinous Adenocarcinoma of the Lung.
Conclusions: Lepidic-predominant and acinar-predominant IMA are two different subtypes of IMA. Acinar-predominant IMA is associated with lymph node metastasis and a poorer prognosis. PMID: 29538611 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 10, 2018 Category: Pathology Authors: Lin G, Li H, Kuang J, Tang K, Guo Y, Han A, Xie C Tags: Am J Clin Pathol Source Type: research

Preparing for a Computational Pathology Future Through Informaticians and a Computational Technologist Workforce.
PMID: 29538613 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 10, 2018 Category: Pathology Authors: Sirintrapun Md SJ Tags: Am J Clin Pathol Source Type: research

Limited Utility of Fluorescence In Situ Hybridization for Recurrent Abnormalities in Acute Myeloid Leukemia at Diagnosis and Follow-up.
Conclusions: Clinically significant discordance between karyotype and AML FISH is uncommon. Consequently, FISH testing can safely be omitted from most of these samples. Focused FISH testing is more useful at follow-up, for minimal residual disease detection. PMID: 29538617 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 10, 2018 Category: Pathology Authors: Wheeler FC, Kim AS, Mosse CA, Shaver AC, Yenamandra A, Seegmiller AC Tags: Am J Clin Pathol Source Type: research

The American Society for Clinical Pathology's 2016-2017 Vacancy Survey of Medical Laboratories in the United States.
Conclusions: Focus on the qualifications and certification status of laboratory professionals would be crucial factors in addressing the needs of the laboratory workforce. The field needs to intensify its efforts on recruiting the next generation of laboratory personnel. PMID: 29522068 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 7, 2018 Category: Pathology Authors: Garcia E, Kundu I, Ali A, Soles R Tags: Am J Clin Pathol Source Type: research

Loss of Full-Length GATA1 Expression in Megakaryocytes Is a Sensitive and Specific Immunohistochemical Marker for the Diagnosis of Myeloid Proliferative Disorder Related to Down Syndrome.
Conclusions: The lack of GATA1f expression is a sensitive and specific immunohistochemical marker for MPD-DS. PMID: 29481579 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 22, 2018 Category: Pathology Authors: Lee WY, Weinberg OK, Evans AG, Pinkus GS Tags: Am J Clin Pathol Source Type: research

Prognostic Significance of Modified Residual Disease in Breast and Nodes (mRDBN) Algorithm After Neoadjuvant Chemotherapy for Breast Cancer.
Abstract Objectives: We hypothesized that prognostic accuracy of the residual disease in breast and lymph nodes (RDBN) method, which is calculated using residual tumor size, nodal involvement, and tumor grade, may be improved by incorporating residual tumor cellularity. Methods: Cases included 614 patients who underwent neoadjuvant therapy for breast cancer. Tumor size was adjusted for residual cellularity of invasive carcinoma and used to calculate modified RDBN (mRDBN) and compared with unmodified gross tumor size (gRDBN). Results: RDBN could be calculated in 428 cases. Relative risks of recurrence and...
Source: American Journal of Clinical Pathology - February 22, 2018 Category: Pathology Authors: Clark BZ, Farrugia DJ, Landmann A, Diego EJ, Dabbs DJ, Puhalla SL, Jankowitz RC, Brufsky AM, Ahrendt GM, McAuliffe PF, Bhargava R Tags: Am J Clin Pathol Source Type: research

Derivation of Outcome-Based Pediatric Critical Values.
Abstract Objectives: There is currently a lack of an outcomes-based definition of critical values for the pediatric population. This has contributed to a highly heterogeneous critical value reporting practice between laboratories. Methods: Anonymized results were extracted from a laboratory information system for 10 biochemistry tests. The probability of high-dependency/intensive care unit admission (as a proxy for adverse outcomes) for each individual laboratory concentration was calculated and adjusted to fit using a polynomial function to model the probability trend. The laboratory value that intersected t...
Source: American Journal of Clinical Pathology - February 21, 2018 Category: Pathology Authors: Du H, Markus C, Metz M, Feng M, Loh TP Tags: Am J Clin Pathol Source Type: research

Uncommon Human Telomerase Reverse Transcriptase Promoter Mutations Are Associated With Poor Survival in Ovarian Clear Cell Carcinoma.
Abstract Objectives: The present study assessed whether human telomerase reverse transcriptase (TERT) promoter mutations mediate the increased mortality risk observed in patients with ovarian clear cell carcinoma (CCC) and characterized the pathologic features of TERT promoter mutation-associated ovarian CCC. Methods: The TERT promoter region in genomic DNA extracted from paraffin-embedded ovarian CCC specimens (n = 93) was bidirectionally sequenced. Results: A total of 24 TERT promoter mutations were identified among the analyzed CCC cases, of which 11 were known "hotspot" mutations whose freq...
Source: American Journal of Clinical Pathology - February 21, 2018 Category: Pathology Authors: Nishikimi K, Nakagawa K, Tate S, Matsuoka A, Iwamoto M, Kiyokawa T, Shozu M Tags: Am J Clin Pathol Source Type: research

Delay to Formalin Fixation (Cold Ischemia Time) Effect on Breast Cancer Molecules.
Conclusions: The vast majority of the studies agree that DFF has negative effect on breast biomarkers. PMID: 29471352 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 19, 2018 Category: Pathology Authors: Khoury T Tags: Am J Clin Pathol Source Type: research

Improving Anatomic Pathology in Sub-Saharan Africa to Support Cancer Care.
Conclusions: Both CBT and a blended approach are effective methods for training pathologists in pathologic cancer staging. Both are superior to traditional lectures alone. PMID: 29471457 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 19, 2018 Category: Pathology Authors: Wilson ML, Ayers S, Berney D, Eslan A, Guarner J, Lester S, Masia R, Moloo Z, Mutuku A, Roberts D, Stall J, Sayed S Tags: Am J Clin Pathol Source Type: research

Influence of Prior Knowledge of Human Papillomavirus Status on the Performance of Cytology Screening.
Conclusions: Our data indicate that cytology interpreted with prior knowledge of the HPV status provides higher sensitivity for CIN 2+ lesions while marginally reducing the overall specificity compared with HPV status blinded cytology. PMID: 29471316 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 17, 2018 Category: Pathology Authors: Martins TR, Longatto-Filho A, Cohen D, Viscondi JYK, Fuza LM, Cury L, Villa LL, Levi JE, Eluf-Neto J Tags: Am J Clin Pathol Source Type: research

What's to Be Done About Laboratory Quality? Process Indicators, Laboratory Stewardship, the Outcomes Problem, Risk Assessment, and Economic Value: Responding to Contemporary Global Challenges.
Conclusions: Clinical laboratories should converge on fewer (7-14) rather than more (21-35) process monitors; monitors should cover all steps of the testing process under laboratory control and include especially high-risk specimen-quality QIs. Clinical laboratory stewardship, the combination of education interventions among clinician test orderers and report consumers with revision of test order formats and result reporting schemes, improves test ordering, but improving result reception is more difficult. Risk calculation reorders the importance of quality monitors by balancing three probabilities: defect frequency, weigh...
Source: American Journal of Clinical Pathology - February 17, 2018 Category: Pathology Authors: Meier FA, Badrick TC, Sikaris KA Tags: Am J Clin Pathol Source Type: research

Effectiveness of Practices to Support Appropriate Laboratory Test Utilization: A Laboratory Medicine Best Practices Systematic Review and Meta-Analysis.
Conclusion: Practice recommendations are made for CPOE (specifically, modifications to existing CPOE), reflex testing, and combined practices. No recommendation for or against could be made for CDSS/CDST, education, feedback, test review, and LTU. Findings from this review serve to inform guidance for future studies. PMID: 29471324 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 17, 2018 Category: Pathology Authors: Rubinstein M, Hirsch R, Bandyopadhyay K, Madison B, Taylor T, Ranne A, Linville M, Donaldson K, Lacbawan F, Cornish N Tags: Am J Clin Pathol Source Type: research

Dual Stain With SATB2 and CK20/Villin Is Useful to Distinguish Colorectal Carcinomas From Other Tumors.
Conclusions: SATB2 dual stain shows the greatest potential clinical utility in identifying CRC and is superior to CDX2 dual stain. More important, SATB2 dual stain could be helpful for specimens with limited tissues or those having a nonclassic staining pattern. PMID: 29471325 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 17, 2018 Category: Pathology Authors: Li Z, Rock JB, Roth R, Lehman A, Marsh WL, Suarez A, Frankel WL Tags: Am J Clin Pathol Source Type: research

Quality Improvement After Multiple Fatal Transfusion-Transmitted Bacterial Infections.
Conclusion: While rare, TTBI is a prominent cause of morbidity and mortality from contaminated platelets. The approach to CAPA presented here may lower the risk of future transfusion-transmitted infections but must be weighed against potential added costs. PMID: 29462235 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 15, 2018 Category: Pathology Authors: Corean J, Al-Tigar R, Pysher T, Blaylock R, Metcalf RA Tags: Am J Clin Pathol Source Type: research

Histoplasma Urinary Antigen Testing Obviates the Need for Coincident Serum Antigen Testing.
Conclusions: These findings support using a single antigen detection test, rather than both UAg and SAg, as an initial screen for suspected histoplasmosis. This aligns with the current practice of most physicians. PMID: 29462251 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 15, 2018 Category: Pathology Authors: Libert D, Procop GW, Ansari MQ Tags: Am J Clin Pathol Source Type: research

Daily Biopsy Diagnosis in Surgical Pathology: Concordance Between Light Microscopy and Whole-Slide Imaging in Real-Life Conditions.
Conclusions: Our study confirms the feasibility and accuracy of WSI diagnosis, even for cases having multiple samples and requiring special staining techniques, such as immunohistochemistry and in situ hybridization. PMID: 29452345 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 14, 2018 Category: Pathology Authors: Villa I, Mathieu MC, Bosq J, Auperin A, Pomerol JF, Lacroix-Triki M, Scoazec JY, Dartigues P Tags: Am J Clin Pathol Source Type: research

Serum Prostate-Specific Antigen (PSA) Concentration, PSA Mass, and Obesity: A Mathematical Analysis.
Conclusions: At a time when obesity is prevalent, expressing analytes in units of total mass may make them relate more closely to disease status and prognosis. PMID: 29425257 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 7, 2018 Category: Pathology Authors: Vollmer RT Tags: Am J Clin Pathol Source Type: research

Repeating Critical Hematology and Coagulation Values Wastes Resources, Lengthens Turnaround Time, and Delays Clinical Action.
Conclusions: Repeating critical hematology and coagulation results was found to be an unnecessary process that wasted laboratory resources and lengthened turnaround time, delaying clinical intervention. PMID: 29425259 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 7, 2018 Category: Pathology Authors: Sun SP, Garcia J, Hayden JA Tags: Am J Clin Pathol Source Type: research

Systematic Review of Non-ASCP Choosing Wisely Recommendations Relevant to Pathology and Laboratory Medicine.
Conclusions: Most of the highest priority, most relevant recommendations among those surveyed concerned utilization of blood products and transfusion management. PMID: 29425260 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 7, 2018 Category: Pathology Authors: Waibel E, Garcia E, Kelly M, Soles R, Hilborne L Tags: Am J Clin Pathol Source Type: research

Lyme Disease Testing in a High-Incidence State: Clinician Knowledge and Patterns.
Conclusions: Additional education and modifications to LD test ordering and reporting systems would likely reduce errors and improve patient care. PMID: 29425271 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 7, 2018 Category: Pathology Authors: Conant JL, Powers J, Sharp G, Mead PS, Nelson CA Tags: Am J Clin Pathol Source Type: research

Giant Cell Tumor of Bone in Patients 55 Years and Older: A Study of 34 Patients.
Conclusions: GCTs in patients 55 years or older share pathologic characteristics with those arising in younger adults. Fibrosis and reactive bone are common, potentially leading to diagnostic confusion in this population. No histologic features correlate with adverse outcome. PMID: 29425276 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 7, 2018 Category: Pathology Authors: Broehm CJ, Inwards CY, Al-Ibraheemi A, Wenger DE, Jenkins SM, Jin L, Oliveira AM, Zreik RT, Carter JM, Boland JM, Fritchie KJ Tags: Am J Clin Pathol Source Type: research

Abdominopelvic and Retroperitoneal Low-Grade Fibromyxoid Sarcoma: A Clinicopathologic Study of 13 Cases.
Conclusion: LGFMS arising in these central locations exhibits similar clinicopathologic features to its counterpart in the extremities. LGFMS at these sites may show limited immunoreactivity for DOG1 and actin. PMID: 29385413 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 29, 2018 Category: Pathology Authors: Ud Din N, Ahmad Z, Zreik R, Horvai A, Folpe AL, Fritchie K Tags: Am J Clin Pathol Source Type: research

Newly Emerging Drugs of Abuse and Their Detection Methods: An ACLPS Critical Review.
Conclusions: Liquid chromatography-tandem mass spectrometry and liquid chromatography-high-resolution mass spectrometry offer improved detection capability of new drugs with simplified sample preparation, making it the new standard. PMID: 29385414 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 29, 2018 Category: Pathology Authors: Liu L, Wheeler SE, Venkataramanan R, Rymer JA, Pizon AF, Lynch MJ, Tamama K Tags: Am J Clin Pathol Source Type: research

Reflecting on the Autopsy in the Training of New Residents.
PMID: 29385415 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 29, 2018 Category: Pathology Authors: Prayson RA Tags: Am J Clin Pathol Source Type: research

Overexpression of Forkhead Box O3a and Its Association With Aggressive Phenotypes and Poor Prognosis in Human Hepatocellular Carcinoma.
Abstract Objectives: Recent research has demonstrated that forkhead box O3a (FoxO3a) may function as an oncogenic transcription factor. We sought to validate the clinicopathologic significance of FoxO3a expression in hepatocellular carcinoma (HCC). Methods: Western blotting and immunohistochemistry were used to determine FoxO3a expression. In vitro cell proliferation and migration assays were performed in a HepG2 cell line. Results: FoxO3a was overexpressed in 121 (64.71%) cases of HCC. FoxO3a overexpression was associated with aggressive phenotypes of HCC, such as histologic grade (P
Source: American Journal of Clinical Pathology - January 21, 2018 Category: Pathology Authors: Ahn H, Kim H, Abdul R, Kim Y, Sim J, Choi D, Paik SS, Shin SJ, Kim DH, Jang K Tags: Am J Clin Pathol Source Type: research

T-Cell Large Granular Lymphocytic Leukemia and Coexisting B-Cell Lymphomas: A Study From the Bone Marrow Pathology Group.
Conclusion: To our knowledge, this is the first multicenter study looking at the spectrum and incidence of BCLs in patients with T-LGL leukemia and highlights its association with large BCLs (3% of T-LGL leukemias). PMID: 29365010 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 20, 2018 Category: Pathology Authors: Goyal T, Thakral B, Wang SA, Bueso-Ramos CE, Shi M, Jevremovic D, Morice WG, Zhang QY, George TI, Foucar KK, Bhattacharyya S, Bagg A, Rogers HJ, Bodo J, Durkin L, Hsi ED Tags: Am J Clin Pathol Source Type: research

Comparison of a Medical-Grade Monitor vs Commercial Off-the-Shelf Display for Mitotic Figure Enumeration and Small Object (Helicobacter pylori) Detection.
Conclusions: These findings are consistent with previous studies demonstrating that color calibration has limited impact on diagnostic accuracy and suggest that noncalibrated displays could be considered for fine assessment tasks. PMID: 29365023 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 20, 2018 Category: Pathology Authors: Norgan AP, Suman VJ, Brown CL, Flotte TJ, Mounajjed T Tags: Am J Clin Pathol Source Type: research

Practical Diagnostic Approach to the Presence of Hyphae in Neuropathology Specimens With Three Illustrative Cases.
Conclusions: Categorizing hyphae into the three groups described allows pathologists to provide information that is useful for infectious disease treatment with an inclusive differential diagnosis of diverse fungal genera that share the same morphological features. PMID: 29365030 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 20, 2018 Category: Pathology Authors: Chavez JA, Brat DJ, Hunter SB, Velazquez Vega J, Guarner J Tags: Am J Clin Pathol Source Type: research

Precision of CAPILLARYS 2 for the Detection of Hemoglobin Variants Based on Their Migration Positions.
Conclusion: In summary, the CE migration position is a reproducible value and can be used as an aid in the identification of Hb variants. PMID: 29365076 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 20, 2018 Category: Pathology Authors: Riou J, Szuberski J, Godart C, Wajcman H, Oliveira JL, Hoyer JD, Bardakdjian-Michau J Tags: Am J Clin Pathol Source Type: research

Algorithm to Manage Inconclusive RBC Antibodies by Reflex Manual Testing.
Conclusions: RBC reference workflow using SPRCA and manual tube methods for AS and ABID decreases "inconclusive" ABID without adverse events. PMID: 29272886 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 20, 2017 Category: Pathology Authors: O'Brien JJ, Cooke RK, Ebrahim-Nejad AA, Hunt JM, Fontaine MJ Tags: Am J Clin Pathol Source Type: research

The 11q-Gain/Loss Aberration Occurs Recurrently in MYC-Negative Burkitt-like Lymphoma With 11q Aberration, as Well as MYC-Positive Burkitt Lymphoma and MYC-Positive High-Grade B-Cell Lymphoma, NOS.
Conclusions: The 11q-gain/loss is not specific for BLL, 11q, but occurs recurrently in MYC-positive BL and MYC-positive HGBL. PMID: 29272887 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 20, 2017 Category: Pathology Authors: Grygalewicz B, Woroniecka R, Rymkiewicz G, Rygier J, Borkowska K, Kotyl A, Blachnio K, Bystydzienski Z, Nowakowska B, Pienkowska-Grela B Tags: Am J Clin Pathol Source Type: research

Overexpression of SOX11 and TFE3 in Solid-Pseudopapillary Neoplasms of the Pancreas.
Conclusions: Both SOX11 and TFE3 were overexpressed in SPNs and may be involved in the pathogenesis. Clinically, SOX11 and TFE3 can be potentially used as diagnostic markers in distinguishing indeterminate SPNs from their histologic mimickers. PMID: 29272888 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 20, 2017 Category: Pathology Authors: Harrison G, Hemmerich A, Guy C, Perkinson K, Fleming D, McCall S, Cardona D, Zhang X Tags: Am J Clin Pathol Source Type: research

Assessment of the Measurement Error in Cyclosporine Levels Drawn Between Peripheral and Central Sources.
Conclusion: Despite potential for preanalytical error due to adsorption, cyclosporine infusion and monitoring via CVCs produce results similar to monitoring via peripheral blood draws. PMID: 29272889 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 20, 2017 Category: Pathology Authors: Shih AW, Crowther MA, Jamula E, El-Sharkawy R, Brown M, Paterson G, Lui M, Don-Wauchope AC Tags: Am J Clin Pathol Source Type: research

Impact of the Reclassification of "Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma" to "Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features" on the Bethesda System for Reporting Thyroid Cytopathology: A Large Academic Institution's Experience.
Conclusions: Decreased ROM was seen in most BSRTC categories, most significantly in AUS/FLUS, FN/SFN, and SFM categories. PMID: 29272354 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 19, 2017 Category: Pathology Authors: Lau RP, Paulsen JD, Brandler TC, Liu CZ, Simsir A, Zhou F Tags: Am J Clin Pathol Source Type: research

Cost Analysis of Operating an Anatomic Pathology Laboratory in a Middle-Income Country.
Conclusions: Anatomic pathology is more costly than other hospital laboratories due to the labor-intensive work, but is essential, particularly for cancer diagnoses and treatment. PMID: 29267843 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 18, 2017 Category: Pathology Authors: Cheah PL, Looi LM, Horton S Tags: Am J Clin Pathol Source Type: research

Hemolysis in In-Date RBC Concentrates.
Abstract Objectives: Hemolysis is one of the most prominent changes that occur during the liquid storage of RBCs in additive solution (AS), but most studies have measured hemolysis only on day 42. Methods: Prestorage leukoreduced RBCs in AS-1 and AS-3 were studied, one group on day 42 and a second group between day 0 and day 40. Each product was sampled for direct measurement of supernatant hemoglobin and hematocrit. Results: Ninety day 42 and 218 day 7 to day 39 RBCs showed a mean ± SD supernatant hemoglobin of 75 ± 100 vs 25.5 ± 16 mg/dL respectively (P
Source: American Journal of Clinical Pathology - December 16, 2017 Category: Pathology Authors: Gultawatvichai P, Tavares MF, DiQuattro PJ, Cheves TC, Sweeney JD Tags: Am J Clin Pathol Source Type: research

Low pO2 Contributes to Potential Error in Oxygen Saturation Calculations Using a Point-of-Care Assay.
Conclusions: Our results suggest that the likelihood of discrepant sO2 is 27% among patients with pO2 less than 50 mm Hg. Direct measurement of sO2 by CO-oximetry is strongly suggested in this clinical scenario. PMID: 29228083 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 7, 2017 Category: Pathology Authors: Gunsolus IL, Love SA, Kohl LP, Schmidt M, Apple FS Tags: Am J Clin Pathol Source Type: research

Immunolocalization of CD163+ Tumor-Associated Macrophages and Symmetric Proliferation of Ki-67 as Biomarkers to Differentiate New Different Grades of Laryngeal Dysplasia.
Abstract Objectives: To evaluate CD163+ tumor-associated macrophages (TAMs), Ki-67, and cyclin D1 to differentiate laryngeal dysplasia in the 2017 World Health Organization classification. Methods: Immunohistochemistry for CD163, Ki-67, and cyclin D1 was performed using paraffin-embedded specimens. CD163+ TAMs infiltrating the epithelium were estimated. Ki-67 and cyclin D1 were evaluated in four parts of the epithelium-basal, parabasal, middle third, and upper third layers. Results: In total, 133 specimens were analyzed, including low-grade dysplasia (n = 31), high-grade dysplasia (n = 49), carcinoma in ...
Source: American Journal of Clinical Pathology - December 7, 2017 Category: Pathology Authors: Su C, Jia S, Liu H Tags: Am J Clin Pathol Source Type: research