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Cost Analysis of Operating an Anatomic Pathology Laboratory in a Middle-Income Country.
Conclusions: Anatomic pathology is more costly than other hospital laboratories due to the labor-intensive work, but is essential, particularly for cancer diagnoses and treatment. PMID: 29267843 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 18, 2017 Category: Pathology Authors: Cheah PL, Looi LM, Horton S Tags: Am J Clin Pathol Source Type: research

Hemolysis in In-Date RBC Concentrates.
Abstract Objectives: Hemolysis is one of the most prominent changes that occur during the liquid storage of RBCs in additive solution (AS), but most studies have measured hemolysis only on day 42. Methods: Prestorage leukoreduced RBCs in AS-1 and AS-3 were studied, one group on day 42 and a second group between day 0 and day 40. Each product was sampled for direct measurement of supernatant hemoglobin and hematocrit. Results: Ninety day 42 and 218 day 7 to day 39 RBCs showed a mean ± SD supernatant hemoglobin of 75 ± 100 vs 25.5 ± 16 mg/dL respectively (P
Source: American Journal of Clinical Pathology - December 16, 2017 Category: Pathology Authors: Gultawatvichai P, Tavares MF, DiQuattro PJ, Cheves TC, Sweeney JD Tags: Am J Clin Pathol Source Type: research

Low pO2 Contributes to Potential Error in Oxygen Saturation Calculations Using a Point-of-Care Assay.
Conclusions: Our results suggest that the likelihood of discrepant sO2 is 27% among patients with pO2 less than 50 mm Hg. Direct measurement of sO2 by CO-oximetry is strongly suggested in this clinical scenario. PMID: 29228083 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 7, 2017 Category: Pathology Authors: Gunsolus IL, Love SA, Kohl LP, Schmidt M, Apple FS Tags: Am J Clin Pathol Source Type: research

Immunolocalization of CD163+ Tumor-Associated Macrophages and Symmetric Proliferation of Ki-67 as Biomarkers to Differentiate New Different Grades of Laryngeal Dysplasia.
Abstract Objectives: To evaluate CD163+ tumor-associated macrophages (TAMs), Ki-67, and cyclin D1 to differentiate laryngeal dysplasia in the 2017 World Health Organization classification. Methods: Immunohistochemistry for CD163, Ki-67, and cyclin D1 was performed using paraffin-embedded specimens. CD163+ TAMs infiltrating the epithelium were estimated. Ki-67 and cyclin D1 were evaluated in four parts of the epithelium-basal, parabasal, middle third, and upper third layers. Results: In total, 133 specimens were analyzed, including low-grade dysplasia (n = 31), high-grade dysplasia (n = 49), carcinoma in ...
Source: American Journal of Clinical Pathology - December 7, 2017 Category: Pathology Authors: Su C, Jia S, Liu H Tags: Am J Clin Pathol Source Type: research

Prophylactic Preprocedure Platelet Transfusion Is Associated With Increased Risk of Thrombosis and Mortality.
Conclusions: Preprocedure platelet transfusion is associated with an increased risk of thrombosis and 30-day mortality. Whether these findings are due to higher incidences of comorbidities and confounding or to cause and effect is not determinable from these data. This study highlights an association between prophylactic platelet transfusion and thrombosis and poor outcome, including death. PMID: 29228089 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 7, 2017 Category: Pathology Authors: Schmidt AE, Henrichs KF, Kirkley SA, Refaai MA, Blumberg N Tags: Am J Clin Pathol Source Type: research

Epstein-Barr Virus-Positive Extranodal Marginal Zone Lymphoma of Bronchial-Associated Lymphoid Tissue in the Posttransplant Setting: An Immunodeficiency-Related (Posttransplant) Lymphoproliferative Disorder?
Conclusions: We review the literature of ENMZL occurring in immunocompromised patients and present this case for consideration that this specific entity is a PTLD. We believe that additional studies might lend strength to the hypothesis that this particular group of EBV-positive, posttransplant ENMZLs merits classification and management as PTLDs. PMID: 29228090 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 7, 2017 Category: Pathology Authors: Cassidy DP, Vega F, Chapman JR Tags: Am J Clin Pathol Source Type: research

Myeloid Neoplasms Following Solid Organ Transplantation: Clinicopathologic Studies of 23 Cases.
Conclusions: Posttransplant MNs have a latency period between that seen in AML/MDS related to alkylators and that associated with topoisomerase II inhibitors. The cytogenetic profile suggests a mutagenic effect on leukemogenesis. The clinical outcome for AML/MDS is dismal, with death occurring at an early phase of treatment. PMID: 29228125 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 7, 2017 Category: Pathology Authors: Wu B, Ingersoll K, Jug R, Yang LH, Luedke C, Lo A, Su P, Liu X, Rehder C, Gong J, Lu CM, Wang E Tags: Am J Clin Pathol Source Type: research

Impact of the Pathologist on Prostate Biopsy Diagnosis and Immunohistochemical Stain Usage Within a Single Institution.
Abstract Objectives: To determine whether pathologists in a tertiary care institution vary in diagnosis and immunohistochemical stain usage in prostate biopsy specimens. Methods: Men who underwent prostate needle biopsies between 2008 and 2013 were included. Results: In total, 1,777 prostate biopsy specimens diagnosed by nine pathologists showed variation in diagnostic reporting (atypical small acinar proliferation, 2.0%-8.0%; high-grade prostatic intraepithelial neoplasia, 2.0%-8.5%; nonneoplastic, 30.2%-48.3%; adenocarcinoma, 46.2%-55.3%; P
Source: American Journal of Clinical Pathology - November 20, 2017 Category: Pathology Authors: Shah MD, Parwani AV, Zynger DL Tags: Am J Clin Pathol Source Type: research

Second Harmonic Generation Reveals Subtle Fibrosis Differences in Adult and Pediatric Nonalcoholic Fatty Liver Disease.
Conclusions: SHG analysis accurately reproduces NASH CRN staging in NAFLD, as well as reveals differences and similarities between adult and pediatric collagen deposition not captured by currently available quantitative methods. PMID: 29165568 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 20, 2017 Category: Pathology Authors: Liu F, Zhao JM, Rao HY, Yu WM, Zhang W, Theise ND, Wee A, Wei L Tags: Am J Clin Pathol Source Type: research

Preferential Usage of Specific Immunoglobulin Heavy Chain Variable Region Genes With Unmutated Profile and Advanced Stage at Presentation Are Common Features in Patients With Chronic Lymphocytic Leukemia From Senegal.
Conclusions: The different IGH repertoire we observed in the Senegalese cohort may reflect the diverse genetic and microenvironmental (ie, polymicrobial stimulation) background. PMID: 29165569 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 20, 2017 Category: Pathology Authors: Amato T, Sall A, Dièye TN, Gozzetti A, Iacono M, Ambrosio MR, Granai M, Somma S, Diop S, Touré AO, May E, Gattiollat CH, Wiels J, Ahmed Y, Raphael M, Leoncini L, Bellan C, Piccaluga PP Tags: Am J Clin Pathol Source Type: research

Impact of Laboratory Charge Display Within the Electronic Health Record Across an Entire Academic Medical Center: Results of a Randomized Controlled Trial.
Conclusions: The impact of charge display depends on context. Charge display is not always effective. PMID: 29165570 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 20, 2017 Category: Pathology Authors: Schmidt RL, Colbert-Getz JM, Milne CK, Vargo DJ, Hussong JW, Hoidal JR, Markewitz BA, Walker BS, Kawamoto K Tags: Am J Clin Pathol Source Type: research

Evaluation of Opportunities to Improve Hematopathology Diagnosis for Vietnam Pathologists.
Conclusions: Vietnamese pathologists would benefit from hematopathology training or opportunities to consult with hematopathologists in the United States. Expert hematopathology consultation services are currently unavailable within Vietnam, as postgraduate training for laboratory physicians consists of residency training in anatomic pathology only. Limitations in the quality of histopathology and immunohistochemistry could impose a barrier to success of efforts to improve hematopathology diagnosis. Implementation of a histopathology and immunohistochemistry quality improvement program might overcome this limitation. ...
Source: American Journal of Clinical Pathology - November 11, 2017 Category: Pathology Authors: Dayton V, Nguyen CK, Van TT, Thanh NV, To TV, Hung NP, Dung NN, Milner DA Tags: Am J Clin Pathol Source Type: research

The Apoptotic Crypt Abscess: An Underappreciated Histologic Finding in Gastrointestinal Pathology.
Abstract Objectives: To differentiate apoptotic crypt abscesses (ACAs) from neutrophilic crypt abscesses (NCAs). Methods: Cases with crypt abscesses were classified as containing ACAs, NCAs, or mixed crypt abscesses (MCAs) by H&E staining. Sections were stained with cleaved caspase 3 and myeloperoxidase and recategorized. Results: Fifty-nine cases were reviewed: inflammatory bowel disease (IBD; n = 33), acute cellular rejection (n = 5), graft vs host disease (GVHD; n = 14), cytomegalovirus (n = 5), and drug reaction (n = 2). Concordance was seen in 59%, with most reclassifications resulting from a ch...
Source: American Journal of Clinical Pathology - November 11, 2017 Category: Pathology Authors: Talmon G, Manasek T, Miller R, Muirhead D, Lazenby A Tags: Am J Clin Pathol Source Type: research

Philadelphia Chromosome-like Mixed-Phenotype Acute Leukemia Demonstrating P2RY8-CRLF2 Fusion and JAK1 Mutation.
Conclusions: To our knowledge, this is the first report of Ph-like MPAL, which may represent a new diagnostic entity. We emphasize the need for refinement of diagnostic criteria for MPALs and highlight an opportunity for expansion of inclusion criteria in ongoing clinical trials studying the use of tyrosine kinase inhibitor therapy to include cases of Ph-like MPAL. PMID: 29140408 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 11, 2017 Category: Pathology Authors: Choi SM, Frederiksen JK, Ross CW, Bixby DL, Shao L Tags: Am J Clin Pathol Source Type: research

Gastric Carcinomas With Lymphoid Stroma: Categorization and Comparison With Solid-Type Colonic Carcinomas.
Conclusions: Morphology may help classify gastric carcinomas with lymphoid stroma, although ancillary testing appears more reliable. Lymphoepithelioma-like carcinoma and medullary carcinoma should not be used interchangeably. PMID: 29126141 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 8, 2017 Category: Pathology Authors: Gonzalez RS, Cates JMM, Revetta F, McMahon LA, Washington K Tags: Am J Clin Pathol Source Type: research

CD30 Expression in Monomorphic Posttransplant Lymphoproliferative Disorder, Diffuse Large B-Cell Lymphoma Correlates With Greater Regulatory T-Cell Infiltration.
Conclusions: These findings suggest a pathophysiologic link between CD30 activity and Tregs and may indicate differential expression of CD30 in B-cell lymphomas arising in the setting of immune dysregulation. PMID: 29126177 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 8, 2017 Category: Pathology Authors: Hartley C, Vaughan JW, Jarzembowski J, Kroft SH, Hosking P, Harrington AM, Olteanu H Tags: Am J Clin Pathol Source Type: research

Robbins Basic Pathology.
PMID: 29126182 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 6, 2017 Category: Pathology Authors: Hoda SA, Cheng E Tags: Am J Clin Pathol Source Type: research

Rapid Loss of RNA Detection by In Situ Hybridization in Stored Tissue Blocks and Preservation by Cold Storage of Unstained Slides.
We report marked reductions in signals after 5 years and significant reductions often after 1 year. Furthermore, storing unstained slides cut from recent cases (
Source: American Journal of Clinical Pathology - November 2, 2017 Category: Pathology Authors: Baena-Del Valle JA, Zheng Q, Hicks JL, Fedor H, Trock BJ, Morrissey C, Corey E, Cornish TC, Sfanos KS, De Marzo AM Tags: Am J Clin Pathol Source Type: research

Is Standard Histology Sufficient to Detect Cytomegalovirus Reactivation in Inflammatory Bowel Disease?
PMID: 29106458 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 2, 2017 Category: Pathology Authors: Tandon P, McCurdy JD, Smyrk TC Tags: Am J Clin Pathol Source Type: research

Epitope Preservation Methods for Tissue Microarrays: Longitudinal Prospective Study.
Conclusions: For precut slides, there is a time, storage condition, and antibody-dependent loss of immunoreactivity that could compromise analysis of prognostic, predictive, and diagnostic markers. Our findings support previous recommendations and suggest that the best storage conditions are at -20°C, without paraffin coating or vacuum sealing. PMID: 29106459 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 2, 2017 Category: Pathology Authors: Andeen NK, Bowman R, Baullinger T, Brooks JM, Tretiakova MS Tags: Am J Clin Pathol Source Type: research

Correspondence.
PMID: 29106460 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 2, 2017 Category: Pathology Authors: Schaberg KB, Higgins JPT, Kambham N, Sibley RK, Troxell ML Tags: Am J Clin Pathol Source Type: research

Erratum.
Authors: PMID: 29106461 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 2, 2017 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Erratum.
Authors: PMID: 29106462 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 2, 2017 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Correspondence.
PMID: 29106463 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 2, 2017 Category: Pathology Authors: Solomon IH, Hornick JL, Laga AC Tags: Am J Clin Pathol Source Type: research

Undifferentiated Pancreatic Carcinomas Display Enrichment for Frequency and Extent of PD-L1 Expression by Tumor Cells.
Abstract Objectives: Programmed death ligand 1 (PD-L1) expression in pancreatic ductal adenocarcinoma (PDA) has been described, but unselected PDAs have shown limited clinical responsiveness to anti-programmed death 1 (PD-1)/PD-L1 therapy. Methods: We studied 24 cases of undifferentiated pancreatic carcinoma (UPC) using immunohistochemistry for PD-L1 (E1L3N clone), CD3, CD20, CD68, and DNA mismatch repair proteins in this study. Slides were scored for extent of PD-L1 expression on tumor cells and tumor-infiltrating immune cells. Results: PD-L1 expression was more frequent in UPCs than in PDAs (63% vs 15%, P
Source: American Journal of Clinical Pathology - October 23, 2017 Category: Pathology Authors: Lehrke HD, Graham RP, McWilliams RR, Lam-Himlin DM, Smyrk TC, Jenkins S, Dong H, Zhang L Tags: Am J Clin Pathol Source Type: research

Submucosal Invasive Depth Predicts Lymph Node Metastasis and Poor Prognosis in Submucosal Invasive Esophageal Squamous Cell Carcinoma.
Abstract Objectives: Lymph node metastasis (LNM) in submucosal invasive esophageal squamous cell carcinoma (SM-ESCC) is a prognostic factor. The aim of this study was to identify a histopathologic predictor of LNM in SM-ESCC. Methods: In total, 108 patients who underwent an esophagectomy and lymph node dissection without preoperative therapy and who were pathologically diagnosed with SM-ESCC were enrolled in this study. Relationships between several clinicopathologic factors and LNM were examined. Results: A multivariate analysis revealed that a tumor size of 35 mm or more (P = .0025), submucosal invasiv...
Source: American Journal of Clinical Pathology - October 20, 2017 Category: Pathology Authors: Kadota T, Yano T, Fujita T, Daiko H, Fujii S Tags: Am J Clin Pathol Source Type: research

Evaluation of a Reflex Testing Algorithm for Suspected Heparin-Induced Thrombocytopenia.
Conclusions: The IgG-specific HIT immunoassay OD correlates with the likelihood of a positive SRA but does not achieve high specificity. The reflex testing algorithm allows for definitive classification of patients, and the cost of such a reflex testing program may be offset by decreased utilization of DTIs. PMID: 29059268 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 20, 2017 Category: Pathology Authors: Vanderbilt CM, McFarland C, Lind SE Tags: Am J Clin Pathol Source Type: research

Performance of the cobas HPV Test for the Triage of Atypical Squamous Cells of Undetermined Significance Cytology in Cervical Specimens Collected in SurePath.
Conclusions: Performance of cobas HPV for ASC-US triage in pretreated SurePath specimens meets criteria for validation. Preliminary data indicate reliable performance of HPV testing in a highly vaccinated population. PMID: 29045515 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 13, 2017 Category: Pathology Authors: Tewari D, Novak-Weekley S, Hong C, Aslam S, Behrens CM Tags: Am J Clin Pathol Source Type: research

A Survey of the Prevalence and Impact of Reporting Guideline Endorsement in Pathology Journals.
Abstract Objectives: To determine the prevalence of reporting guideline endorsement in pathology journals and to estimate the impact of guideline endorsement. Methods: We compared the quality of reporting in two sets of studies: (1) studies published in journals that explicitly mentioned a guideline vs studies published in journals that did not and (2) studies that cited a guideline vs studies that did not. The quality of reporting in prognostic biomarker studies was assessed using the REporting recommendations for tumor MARKer prognostic studies (REMARK) guideline. Results: We found that six (10%) of th...
Source: American Journal of Clinical Pathology - October 1, 2017 Category: Pathology Authors: Caron JE, March JK, Cohen MB, Schmidt RL Tags: Am J Clin Pathol Source Type: research

Utility of Reference Change Values for Delta Check Limits.
Conclusions: Comparison of estimated RCVs and real-world patient data revealed the pitfalls of applying RCVs in clinical laboratories. Laboratory managers should be aware of the limitations of RCVs and exercise caution when using them. PMID: 28967949 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2017 Category: Pathology Authors: Ko DH, Park HI, Hyun J, Kim HS, Park MJ, Shin DH Tags: Am J Clin Pathol Source Type: research

Impact of Use of Smaller Volume, Smaller Vacuum Blood Collection Tubes on Hemolysis in Emergency Department Blood Samples.
Abstract Objectives: Hemolyzed blood samples commonly occur in hospital emergency departments (EDs). Our objective was to determine whether replacing standard large-volume/high-vacuum sample tubes with low-volume/low-vacuum tubes would significantly affect ED hemolysis. Methods: This was a prospective intervention of the use of small-volume/vacuum collection tubes. We evaluated all potassium samples in ED patients and associated hemolysis. We used χ2 tests to compare hemolysis incidence prior to and following utilization of small tubes for chemistry collection. Results: There were 35,481 blood sample...
Source: American Journal of Clinical Pathology - October 1, 2017 Category: Pathology Authors: Phelan MP, Reineks EZ, Berriochoa JP, Schold JD, Hustey FM, Chamberlin J, Kovach A Tags: Am J Clin Pathol Source Type: research

Impact of 2013 American Society of Clinical Oncology/College of American Pathologists Guidelines on HER2 Fluorescent In Situ Hybridization Testing in Breast Cancers : Experience From a National Reference Laboratory.
Conclusions: The 2013 ASCO/CAP guidelines lead to a higher number of HER2 FISH positive and equivocal cases. In a reference laboratory setting where an alternative control probe was used to resolve equivocal FISH cases, 31.2% of patients with initial equivocal results became HER2 positive. PMID: 28967951 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2017 Category: Pathology Authors: Gulbahce HE Tags: Am J Clin Pathol Source Type: research

Real-Time Methylation-Specific Polymerase Chain Reaction for MGMT Promoter Methylation Clinical Testing in Glioblastoma: An Alternative Detection Method for a Heterogeneous Process.
Conclusions: The RT-MSP assay that we developed in-house is a robust clinical detection method for the heterogeneous process of MGMT promoter methylation in glioblastoma. PMID: 28967952 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2017 Category: Pathology Authors: Ida CM, Butz ML, Jenkins RB, Sarkaria JN, Kitange GJ, Giannini C, Kipp BR Tags: Am J Clin Pathol Source Type: research

Ensuring the Quality of Point-of-Care Testing in a Large and Decentralized Ambulatory Care Setting.
Conclusions: This decentralization of laboratory testing presents challenges to ensuring quality POC testing. Optimization and analysis of informatics data allow for the identification of POC test utilization trends, areas of improvement for clinical workflows, and increased education on national guidelines. PMID: 28967953 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2017 Category: Pathology Authors: Arboleda VA, Garner OB Tags: Am J Clin Pathol Source Type: research

Deviation Management: Key Management Subsystem Driver of Knowledge-Based Continuous Improvement in the Henry Ford Production System.
Conclusions: Deviation management is a key subsystem of managers' standard work whereby knowledge of nonconformities assists in directing corrective actions and continuous improvements that promote consistent execution and higher levels of performance. PMID: 28967954 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2017 Category: Pathology Authors: Zarbo RJ, Copeland JR, Varney RC Tags: Am J Clin Pathol Source Type: research

Intraoperative Pathologic Consultation on Hysterectomy Specimens for Endometrial Cancer: An Assessment of the Accuracy of Frozen Sections, "Gross-Only" Evaluations, and Obtaining Random Sections of a Grossly "Normal" Endometrium.
Conclusions: Obtaining random sections in the absence of a gross lesion has no significant benefit, and a negative result is likely to provide inaccurate data to the surgeon. Frozen-section analyses are a generally reliable tool to determine "low-risk" pathologic parameters that were evaluated herein when a gross lesion is present. PMID: 28967955 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2017 Category: Pathology Authors: Desouki MM, Li Z, Hameed O, Fadare O Tags: Am J Clin Pathol Source Type: research

Variability and Error in Cardiac Troponin Testing: An ACLPS Critical Review.
Conclusions: cTn assays are reliable diagnostic tests for acute myocardial infarction, but understanding their limitations is required for appropriate result interpretation. PMID: 28967956 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2017 Category: Pathology Authors: Herman DS, Kavsak PA, Greene DN Tags: Am J Clin Pathol Source Type: research

Creation and Evaluation of a Laboratory Administration Curriculum for Pathology Residents.
Conclusions: The multimodal CLM training described here is an easily adoptable, objective system for teaching CLM. It was well liked by residents and provided an objective measurement of mastery of concepts for faculty. PMID: 28927229 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 11, 2017 Category: Pathology Authors: Guarner J, Hill CE, Amukele T Tags: Am J Clin Pathol Source Type: research

Fibromatosis of the Breast: Diagnostic Accuracy of Core Needle Biopsy.
Conclusions: CNB can be an accurate method of diagnosing fibromatosis, allowing observation for a select group of patients. PMID: 28821190 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Kuba MG, Lester SC, Giess CS, Bertagnolli MM, Wieczorek TJ, Brock JE Tags: Am J Clin Pathol Source Type: research

Impact of Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Features on Adequacy Criteria and Risk of Malignancy of Thyroid Fine-Needle Aspiration.
Conclusions: With NIFTP, reducing the threshold for adequacy from 60 to 10 cells led to nonsignificant decrease in the risk of malignancy of a benign diagnosis (2.4% to 2.3%). Thyroid fine-needle aspirates with 10 to 60 benign cells without atypia or Hürthle cell change should be diagnosed as benign. PMID: 28821191 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Renshaw AA, Gould EW Tags: Am J Clin Pathol Source Type: research

Could the PD-1 Pathway Be a Potential Target for Treating Small Intestinal Adenocarcinoma?
Conclusions: PD-1 and PD-L1 are highly expressed by most small intestinal adenocarcinomas. Blockage of the PD-1 pathway should be evaluated in the treatment of small intestinal adenocarcinomas. PMID: 28821192 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Thota R, Gonzalez RS, Berlin J, Cardin DB, Shi C Tags: Am J Clin Pathol Source Type: research

Therapeutic Plasma Exchange and Its Impact on Drug Levels: An ACLPS Critical Review.
Conclusions: There were several limitations with existing studies, many of which relate to procedural and/or clinical properties of patients undergoing TPE. As such, additional studies are needed before definitive guidelines can be established. There is clear need for development of consensus and additional investigations in this domain. PMID: 28821193 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Cheng CW, Hendrickson JE, Tormey CA, Sidhu D Tags: Am J Clin Pathol Source Type: research

Primary Benign and Malignant Thyroid Neoplasms With Signet Ring Cells: Cytologic, Histologic, and Molecular Features.
Conclusions: Our study demonstrates the range of thyroid tumors with SRCs. While most thyroid tumors with SRCs are benign, primary thyroid SC should also be considered in the differential diagnosis. PMID: 28821194 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Farhat NA, Onenerk AM, Krane JF, Dias-Santagata D, Sadow PM, Faquin WC Tags: Am J Clin Pathol Source Type: research

Atypical IgG4+ Plasmacytic Proliferations and Lymphomas: Characterization of 11 Cases.
Conclusions: Monotypic IgG4+ proliferations include lymphomas, plasmacytic neoplasms, and a previously uncharacterized group of proliferations not meeting criteria for conventional hematolymphoid neoplasia. Distinct features included prominent Mott cells and/or monotypic plasma cells within follicles. The proliferations were infrequently associated with IgG4-related disease (IgG4-RD). Our findings raise questions regarding the relationship between clonal IgG4+ proliferations, reactive/inflammatory processes, and IgG4-RD. PMID: 28821195 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Bledsoe JR, Wallace ZS, Deshpande V, Richter JR, Klapman J, Cowan A, Stone JH, Ferry JA Tags: Am J Clin Pathol Source Type: research

Negative Predictive Value and Significance of Benign-Appearing Endometrial Cells in Papanicolaou Tests.
Conclusions: nEMCs in Pap test reports of women 40 years and older are a normal cytology finding in premenopausal women, which may result in unnecessary endometrial biopsies. The NPV associated with this finding for women aged 40 to 49 years exceeded 99%. PMID: 28821196 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Yu J, Onisko A, Austin RM Tags: Am J Clin Pathol Source Type: research

Regional Variability in Percentage of Breast Cancers Reported as Positive for HER2 in California: Implications of Patient Demographics on Laboratory Benchmarks.
Conclusions: These results deepen our understanding of population characteristics' influence on the distribution of HER2-positive breast cancers. Taking these factors into account can be useful when setting laboratory benchmarks and assessing test quality. PMID: 28821197 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Lin CY, Carneal EE, Lichtensztajn DY, Gomez SL, Clarke CA, Jensen KC, Kurian AW, Allison KH Tags: Am J Clin Pathol Source Type: research

CD200 Expression in Neuroendocrine Neoplasms.
Conclusions: CD200 is a relatively sensitive marker of neuroendocrine neoplasms and represents a potential therapeutic target in these difficult-to-treat malignancies. PMID: 28821198 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Love JE, Thompson K, Kilgore MR, Westerhoff M, Murphy CE, Papanicolau-Sengos A, McCormick KA, Shankaran V, Vandeven N, Miller F, Blom A, Nghiem PT, Kussick SJ Tags: Am J Clin Pathol Source Type: research

Keratin 17 Is a Prognostic Biomarker in Endocervical Glandular Neoplasia.
Conclusions: K17 is highly expressed in most cases of both invasive adenocarcinoma and in AIS and is a powerful, negative prognostic marker for patient survival. PMID: 28821199 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Mockler D, Escobar-Hoyos LF, Akalin A, Romeiser J, Shroyer AL, Shroyer KR Tags: Am J Clin Pathol Source Type: research

Corrections.
Authors: PMID: 28821200 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Corrections.
Authors: PMID: 28821201 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Tags: Am J Clin Pathol Source Type: research