Photomicrograph-Based Neuropathology Consultation in Tanzania.
CONCLUSIONS: Telepathology offers a promising means of providing diagnostic support, second-opinion consultations, and ongoing training to pathologists practicing in resource-limited countries. Moreover, static digital teleneuropathology is an uncomplicated, cost-effective, and reliable way to achieve these goals. PMID: 32715312 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 27, 2020 Category: Pathology Authors: Zerd F, Moore BE, Malango AE, Hosokawa PW, Lillehei KO, Mchome LL, Ormond DR Tags: Am J Clin Pathol Source Type: research

Specimens Received as a Critical Indicator for Blood Bank Preparedness in the SARS-CoV-2 Era.
PMID: 32710106 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 25, 2020 Category: Pathology Authors: Booth GS, Gehrie EA, Tormey CA, Sanford KW Tags: Am J Clin Pathol Source Type: research

Plasma Cell Myeloma Presenting With Amyloid-Laden Crystal-Negative Histiocytosis.
CONCLUSIONS: We describe a case of crystal-negative histiocytosis associated with PCM. CSH is a rare disorder associated with paraprotein-producing conditions in which immunoglobulins aggregate as intracellular crystals in the lysosomes of organ-specific phagocytic macrophages. Light chain tropism in PCM can also lead to the development of amyloid deposition in organs and, in rare cases, is associated with light chain aggregation as intracellular crystals in macrophages. PMID: 32705137 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 24, 2020 Category: Pathology Authors: Braunstein MJ, Petrova-Drus K, Rosenbaum CA, Jayabalan DS, Rossi AC, Salvatore S, Rech K, Pearse RN, Hassane DC, Postley J, Jhanwar YS, Geyer JT, Niesvizky R Tags: Am J Clin Pathol Source Type: research

Integration of Genomic Medicine in Pathology Resident Training.
CONCLUSIONS: The RISE is a powerful tool for assessing the current state and also trends related to resident training in genomic pathology. The results show progress but also the need for improvement in not only genomic pathology but traditional molecular pathology training as well. PMID: 32696061 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 22, 2020 Category: Pathology Authors: Haspel RL, Genzen JR, Wagner J, Lockwood CM, Fong K, Training Residents in Genomics (TRIG) Working Group Tags: Am J Clin Pathol Source Type: research

An In Silico Exploration of the Factors That Affect the Precision of the Bethesda Assay.
CONCLUSIONS: This in silico model will assist future laboratory efforts in standardizing the quantification of specific coagulation factor inhibitors and improving the precision of the reported results. PMID: 32686817 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 20, 2020 Category: Pathology Authors: Seheult JN, Cardel L, Tange JI, Ashrani A, Nichols WL, Heikal N, Chen D Tags: Am J Clin Pathol Source Type: research

Androgenetic Complete Hydatidiform Moles With p57KIP2-Positive Immunostaining.
CONCLUSIONS: The cause of one of the CHMs was trisomy with an additional maternal chromosome 11. Although rare, the confirmation of p57KIP2-positive androgenetic CHM status is necessary to manage GTN risk. PMID: 32686837 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 20, 2020 Category: Pathology Authors: Usui H, Sato A, Ota M, Ikeda JI, Shozu M Tags: Am J Clin Pathol Source Type: research

Identification of SARS-CoV-2 in a Proficiency Testing Program.
CONCLUSIONS: Overall performance in this SARS-CoV-2 RNA detection challenge was excellent, providing confidence in the results of these new molecular tests and assurance for the clinical and public health decisions based on these test results. PMID: 32687172 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 20, 2020 Category: Pathology Authors: Edson DC, Casey DL, Harmer SE, Downes FP Tags: Am J Clin Pathol Source Type: research

Distribution of SARS-CoV-2 PCR Cycle Threshold Values Provide Practical Insight Into Overall and Target-Specific Sensitivity Among Symptomatic Patients.
CONCLUSIONS: Based on the distribution of observed CT values, including the small proportion of specimens with values near the assay LoD, there is a low risk of false-negative RT-PCR results in combined nasopharyngeal-oropharyngeal specimens obtained from symptomatic individuals. PMID: 32687186 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 20, 2020 Category: Pathology Authors: Buchan BW, Hoff JS, Gmehlin CG, Perez A, Faron ML, Munoz-Price LS, Ledeboer NA Tags: Am J Clin Pathol Source Type: research

SARS-CoV-2 Infection-Associated Hemophagocytic Lymphohistiocytosis.
CONCLUSIONS: This is the first report of severe acute respiratory syndrome coronavirus 2-associated HLH. Identification of HLH in a subset of patients with severe COVID-19 will inform clinical trials of therapeutic strategies. PMID: 32681166 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 18, 2020 Category: Pathology Authors: Prilutskiy A, Kritselis M, Shevtsov A, Yambayev I, Vadlamudi C, Zhao Q, Kataria Y, Sarosiek SR, Lerner A, Sloan JM, Quillen K, Burks EJ Tags: Am J Clin Pathol Source Type: research

SARS-CoV-2 Antibody Responses Do Not Predict COVID-19 Disease Severity.
CONCLUSIONS: The studied SARS-CoV-2 IgG assay had 100% specificity and no adverse cross-reactivity. Measures of IgG and IgM antibodies did not predict disease severity in our patient population. PMID: 32666092 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 15, 2020 Category: Pathology Authors: Phipps WS, SoRelle JA, Li QZ, Mahimainathan L, Araj E, Markantonis J, Lacelle C, Balani J, Parikh H, Solow EB, Karp DR, Sarode R, Muthukumar A Tags: Am J Clin Pathol Source Type: research

Unrecognized Hemoglobin Variants in the Donor Blood Supply Are Detectable in the Transfused Population.
CONCLUSIONS: We confirmed that hemoglobin variants are present within the blood supply, and the frequency of hemoglobin variant transfusion is elevated for patients with sickle cell disease given the increased prevalence of hemoglobin variants in the population of matched donors. PMID: 32651584 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 11, 2020 Category: Pathology Authors: Rutherford-Parker NJ, Colby JM, Gehrie EA, Booth GS Tags: Am J Clin Pathol Source Type: research

Malpractice and Patient Safety Concerns.
Abstract OBJECTIVES: "Assurance behaviors," a type of defensive medicine, involve physicians' utilization of additional patient services to avoid adverse legal outcomes. We aim to compare the use of clinical behaviors (such as ordering additional tests, services, and consultations) due to malpractice concerns with the same behaviors due to patient safety concerns. METHODS: A national sample of dermatopathologists (n = 160) completed an online survey. RESULTS: Participants reported using one or more of five clinical behaviors due to concerns about medical malpractice (95%) and patient safety (99...
Source: American Journal of Clinical Pathology - July 11, 2020 Category: Pathology Authors: Reisch LM, Flores MJ, Radick AC, Shucard HL, Kerr KF, Piepkorn MW, Barnhill RL, Elder DE, Knezevich SR, Elmore JG Tags: Am J Clin Pathol Source Type: research

Validation of "Outcome-Based" Pediatric Critical Value Threshold for Plasma Glucose in an Infant and Maternity Hospital Setting.
Validation of "Outcome-Based" Pediatric Critical Value Threshold for Plasma Glucose in an Infant and Maternity Hospital Setting. Am J Clin Pathol. 2020 Jul 11;: Authors: Robbiano C, Aloisio E, Birindelli S, Dolci A, Panteghini M, Markus C, Loh TP PMID: 32651591 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 11, 2020 Category: Pathology Authors: Robbiano C, Aloisio E, Birindelli S, Dolci A, Panteghini M, Markus C, Loh TP Tags: Am J Clin Pathol Source Type: research

Solid Tumor Metastases to the Pancreas Diagnosed Using Fine-Needle Aspiration.
Abstract OBJECTIVES: Solid tumor metastases to the pancreas are rare, and only limited literature on the topic is available. In this retrospective study, we reviewed 107 cases of solid tumor metastases to the pancreas diagnosed by fine-needle aspiration (FNA) from 2005 to 2019. METHODS: Information including the patients' clinical histories, radiologic and pathologic findings, treatments, and follow-up were collected. RESULTS: The mean age of the patients was 62.4 years. The mean tumor size was 2.64 cm with even distribution throughout the pancreas (head, neck and body, and tail). The most common primary...
Source: American Journal of Clinical Pathology - July 11, 2020 Category: Pathology Authors: Hou T, Stewart JM, Lee JH, Gan Q Tags: Am J Clin Pathol Source Type: research

Contributions of Liquid-Based (Papanicolaou) Cytology and Human Papillomavirus Testing in Cotesting for Detection of Cervical Cancer and Precancer in the United States.
CONCLUSIONS: Analysis of 9-year cotest results from a national reference laboratory confirms the value of LBC element in cotesting. This supports that LBC/HPV cotesting enhances screening for the identification of CxCa in women 30 years and older, more so than LBC or HPV alone within cotesting. PMID: 32637991 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 8, 2020 Category: Pathology Authors: Kaufman HW, Alagia DP, Chen Z, Onisko A, Austin RM Tags: Am J Clin Pathol Source Type: research

Gastrin Staining in Inflamed Stomach Biopsies Labeled as "Antral" Rarely Detects Atrophic Gastritis.
CONCLUSIONS: Pathologists should be aware of the histologic features of early AMAG and meticulously analyze tissue regardless of specimen labeling. Gastrin immunostain is a supplemental diagnostic tool when encountering inflamed antral-appearing specimens. PMID: 32632455 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 7, 2020 Category: Pathology Authors: Dunn ALJ, Drage MG, Whitney-Miller CL, McMahon LA, Gonzalez RS Tags: Am J Clin Pathol Source Type: research

On the Use of Accuracy in Optimized Delta Check Rules for Detecting Misidentified Specimens in Children.
PMID: 32591795 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 27, 2020 Category: Pathology Authors: Baskin LB, Naugler CT, Tan RZ, Markus C, Choy KW, Doery JCG, Loh TP Tags: Am J Clin Pathol Source Type: research

Scoring of Programmed Death-Ligand 1 Immunohistochemistry on Cytology Cell Block Specimens in Non-Small Cell Lung Carcinoma.
Abstract OBJECTIVES: Recent investigations have shown strong correlations between cytology and surgical non-small cell lung carcinoma (NSCLC) specimens in programmed death-ligand 1 (PD-L1) immunohistochemical (IHC) evaluations. Our study aims to evaluate the reproducibility of PD-L1 IHC scoring in NSCLC cytology cell blocks (CBs) and to assess the impact of CB cellularity, method of sample collection, and observer subspecialty on scoring agreement. METHODS: PD-L1 IHC was performed on 54 NSCLC cytology CBs and was scored independently by seven cytopathologists (three of seven with expertise in pulmonary pathol...
Source: American Journal of Clinical Pathology - June 26, 2020 Category: Pathology Authors: Hernandez A, Brandler TC, Chen F, Zhou F, Xia Y, Zhong J, Moreira AL, Simms A, Sun W, Wei XJ, Simsir A Tags: Am J Clin Pathol Source Type: research

Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytologic Evaluation of Intraductal Papillary Mucinous Neoplasm and Mucinous Cystic Neoplasms of Pancreas.
CONCLUSIONS: A multidisciplinary approach including combined use of cytology and ancillary testing is helpful in establishing a diagnosis of MCL and identifying associated malignancy. PMID: 32589187 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 26, 2020 Category: Pathology Authors: Gilani SM, Adeniran AJ, Cai G Tags: Am J Clin Pathol Source Type: research

Cytoplasmic Expression of CD3 ε Heterodimers by Flow Cytometry Rapidly Distinguishes Between Mature T-Cell and Natural Killer-Cell Neoplasms.
CONCLUSIONS: Uniform cCD3 positivity and homogeneous cCD3 negativity highly suggest T-cell and NK lineage, respectively. When partial cCD3 expression is encountered, additional confirmatory studies should be pursued for the most accurate lineage assignment. PMID: 32589191 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 26, 2020 Category: Pathology Authors: Shi M, Nguyen P, Timm MM, Otteson GE, Horna P, Olteanu H, Jevremovic D Tags: Am J Clin Pathol Source Type: research

Review of Current Advances in Serologic Testing for COVID-19.
CONCLUSIONS: The use of serologic testing, in conjunction with reverse transcription polymerase chain reaction testing, was demonstrated to significantly increase the sensitivity of detection of patients infected with SARS-CoV-2. There was conflicting evidence regarding whether antibody titers correlated with clinical severity. However, preliminary investigations indicated some immunoassays may be a surrogate for the prediction of neutralizing antibody titers and the selection of recovered patients for convalescent serum donation. PMID: 32583852 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 25, 2020 Category: Pathology Authors: Espejo AP, Akgun Y, Al Mana AF, Tjendra Y, Millan NC, Gomez-Fernandez C, Cray C Tags: Am J Clin Pathol Source Type: research

Transfusion Service Response to the COVID-19 Pandemic.
PMID: 32584950 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 25, 2020 Category: Pathology Authors: Gehrie E, Tormey CA, Sanford KW Tags: Am J Clin Pathol Source Type: research

Antibody Testing for COVID-19.
PMID: 32577723 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 24, 2020 Category: Pathology Authors: Grenache DG, Sever C, Mathur G, Mathur S Tags: Am J Clin Pathol Source Type: research

Interobserver Variability in Ductal Carcinoma In Situ of the Breast.
CONCLUSIONS: Reproducible histopathologic assessment is a prerequisite for robust risk stratification and adequate clinical decision-making. Two-tier histopathologic assessment might enhance the quality of care. PMID: 32566938 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 22, 2020 Category: Pathology Authors: Van Bockstal MR, Berlière M, Duhoux FP, Galant C Tags: Am J Clin Pathol Source Type: research

Data-Driven Development of an Institutional "Gross-Only" Policy for the Examination of Select Surgical Pathology Specimens.
CONCLUSIONS: Establishing a gross-only policy should be guided by established recommendations but institutionally individualized and data driven. It was reasonable for us to establish a gross-only policy for most evaluated specimens, while excluding bariatric stomach specimens in which microscopic pathology could be missed, given the lack of H pylori screening at our institution. PMID: 32561904 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 20, 2020 Category: Pathology Authors: Arispe Angulo KR, Farooq A, Samra H, Weldemichael W, Anderson J, Jorns JM Tags: Am J Clin Pathol Source Type: research

Voxelotor Treatment Interferes With Quantitative and Qualitative Hemoglobin Variant Analysis in Multiple Sickle Cell Disease Genotypes.
CONCLUSIONS: Technical limitations in quantifying HbS percentage may preclude the use of HPLC or CZE for monitoring patients treated with voxelotor. Furthermore, it is unclear whether HbS-voxelotor complexes are clinically equivalent to HbS. Consensus guidelines for reporting hemoglobin variant percentages for patients taking voxelotor are needed, as these values are necessary for determining the number of RBC units to exchange in acute situations. PMID: 32561909 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 20, 2020 Category: Pathology Authors: Rutherford-Parker NJ, Campbell ST, Colby JM, Shajani-Yi Z Tags: Am J Clin Pathol Source Type: research

Steatohepatitis-Like Changes in Hepatocellular Adenoma.
CONCLUSIONS: Approximately 15% of HCAs in our series demonstrated steatohepatitic changes. Lack of such morphology in β-catenin-mutated subtype suggests reassurance in this morphologic variant of HCA. PMID: 32561910 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 20, 2020 Category: Pathology Authors: Liu Y, Zen Y, Yeh MM Tags: Am J Clin Pathol Source Type: research

Juvenile Granulosa Cell Tumors of the Ovary.
CONCLUSIONS: JGCT is a rare neoplasm with a wide morphologic spectrum and is easily confused with other tumors. Familiarity with the characteristics, rare atypical appearances, and immunohistochemical results may aid in obtaining a correct diagnosis. PMID: 32561911 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 20, 2020 Category: Pathology Authors: Ye Y, Lv C, Xu S, Chen Y, Qian R, Wang P, Wang S Tags: Am J Clin Pathol Source Type: research

CALIPER Hematology Reference Standards (I).
Abstract OBJECTIVES: Accurate hematologic test interpretation based on normative reference standards is critical to ensure appropriate clinical decision making. However, healthy pediatric reference data for most hematology parameters are lacking. To address this gap, this study establishes age- and sex-specific hematologic reference standards in the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) cohort of healthy children and adolescents. METHODS: Fresh whole blood samples collected from a total of 566 healthy children and adolescents (birth to
Source: American Journal of Clinical Pathology - June 20, 2020 Category: Pathology Authors: Tahmasebi H, Higgins V, Bohn MK, Hall A, Adeli K Tags: Am J Clin Pathol Source Type: research

Histologic Findings of Uterine Niches.
CONCLUSIONS: As more prospective studies of uterine niche development and treatment will be conducted, a detailed pathologic report with the criteria proposed herein can be designed. PMID: 32561918 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 20, 2020 Category: Pathology Authors: Karpathiou G, Chauleur C, Dridi M, Baillard P, Corsini T, Dumollard JM, Peoc'h M Tags: Am J Clin Pathol Source Type: research

Effects of Implementing the Dual Papanicolaou Test Interpretation of ASC-H and LSIL Following Bethesda 2014.
CONCLUSIONS: Considering the similar risks of CIN 2+ and CIN 3+ for ASCHL and ASC-H, having a separate category of ASCHL for reporting cervical cytology appears to be redundant. PMID: 32556080 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 18, 2020 Category: Pathology Authors: Goyal A, Patel AP, Dilcher TL, Alperstein SA Tags: Am J Clin Pathol Source Type: research

Engrailed Homeobox 1 and Cytokeratin 19 Are Independent Diagnostic Markers of Eccrine Porocarcinoma and Distinguish It From Squamous Cell Carcinoma.
CONCLUSIONS: A combination of En1 and CK19 expression can improve the accuracy of histologic diagnosis of EPC. PMID: 32556098 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 18, 2020 Category: Pathology Authors: Miura K, Akashi T, Namiki T, Hishima T, Bae Y, Sakurai U, Murano K, Shiraishi J, Warabi M, Tanizawa T, Tanaka M, Bhunchet E, Kumagai J, Ayabe S, Sekiya T, Ando N, Shintaku H, Kinowaki Y, Tomii S, Kirimura S, Kayamori K, Yamamoto K, Ito T, Eishi Y Tags: Am J Clin Pathol Source Type: research

The Importance of Tumor Length in Needle Biopsies of the Prostate.
CONCLUSIONS: The composite variable cx uses preoperative information that may allow the sorting of patients into low, intermediate, and high risk for adverse outcomes after prostatectomy. PMID: 32556114 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 18, 2020 Category: Pathology Authors: Vollmer RT Tags: Am J Clin Pathol Source Type: research

Frontline Workers in the Backrooms of COVID-19.
CONCLUSIONS: Forensic pathology is important to successfully navigating emerging diseases like the COVID-19 pandemic. Direct conversations with families are common in forensic pathology and serve as a model for patient- and family-centered care. PMID: 32556078 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 17, 2020 Category: Pathology Authors: Myers JL, Mulder L Tags: Am J Clin Pathol Source Type: research

Placental Pathology in COVID-19.
PMID: 32533690 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 13, 2020 Category: Pathology Authors: Baergen RN, Heller DS, Goldstein JA Tags: Am J Clin Pathol Source Type: research

A Reappraisal of Superficial Pleomorphic Liposarcoma.
CONCLUSIONS: Careful integration of histologic and genetic features may improve classification of lipomatous neoplasms with atypia, allowing reclassification of some superficial PL as ASPLT. PMID: 32525520 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 11, 2020 Category: Pathology Authors: Berg SH, Massoud CM, Jackson-Cook C, Boikos SA, Smith SC, Mochel MC Tags: Am J Clin Pathol Source Type: research

Comparison of Tissue Molecular Biomarker Testing Turnaround Times and Concordance Between Standard of Care and the Biocartis Idylla Platform in Patients With Colorectal Cancer.
CONCLUSIONS: The described cartridge-based system offers rapid and reliable testing of clinically actionable mutation in colorectal cancer specimens directly from formalin-fixed, paraffin-embedded tissue sections. Its simplicity and ease of use compared with other molecular techniques make it suitable for routine clinical laboratory testing. PMID: 32525522 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 11, 2020 Category: Pathology Authors: Tsongalis GJ, Al Turkmani MR, Suriawinata M, Babcock MJ, Mitchell K, Ding Y, Scicchitano L, Tira A, Buckingham L, Atkinson S, Lax A, Aisner DL, Davies KD, Wood HN, O'Neill SS, Levine EA, Sequeira J, Harada S, DeFrank G, Paluri R, Tan BA, Colabella H, Snea Tags: Am J Clin Pathol Source Type: research

Real-Time Intraoperative Consultation Reporting in the Electronic Health Record.
CONCLUSIONS: Real-time reporting of IOC results to the EHR reliably transmits results immediately to clinical teams. This strategy reduces but does not eliminate postanalytic interpretive errors by clinical teams. PMID: 32525523 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 11, 2020 Category: Pathology Authors: Klein ME, Rudolf JW, Tarbunova M, Jorden T, Clark SR, Khalifa MA Tags: Am J Clin Pathol Source Type: research

Contemporary Classification and Diagnostic Evaluation of Hypereosinophilia.
CONCLUSIONS: A good knowledge of recent advances in HE is necessary to ensure prompt and accurate diagnosis, as well as to help optimize patient care. PMID: 32525541 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 11, 2020 Category: Pathology Authors: Mattis DM, Wang SA, Lu CM Tags: Am J Clin Pathol Source Type: research

CALIPER Hematology Reference Standards (II).
CONCLUSIONS: This study establishes a robust pediatric hematology reference database that will assist in more accurate test result interpretation. Our data clearly demonstrate significant variation in hematologic parameter concentrations in children and adolescents, necessitating the use of pediatric-specific reference standards. PMID: 32525543 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 11, 2020 Category: Pathology Authors: Higgins V, Tahmasebi H, Bohn MK, Hall A, Adeli K Tags: Am J Clin Pathol Source Type: research

Suspicious for Malignancy Diagnoses on Pleural Effusion Cytology.
CONCLUSIONS: Samples with low cellularity, scant cell blocks, and inconclusive immunostains may contribute to a suspicious category diagnosis in pleural effusions. PMID: 32525969 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 11, 2020 Category: Pathology Authors: Rodriguez EF, Pastorello RG, Morris P, Saieg M, Chowsilpa S, Maleki Z Tags: Am J Clin Pathol Source Type: research

Linking Statistics With Testing Policy to Manage COVID-19 in the Community.
CONCLUSIONS: While the contributions of diagnostic testing for SARS-CoV-2 have received considerable attention, concerns abound regarding the availability of sufficient testing capacity to meet demand. Different testing goals require different numbers of tests and different testing strategies; testing strategies for national or local disease surveillance, including monitoring of prevalence, receive less attention. Our clinical laboratory and diagnostic infrastructure are capable of incorporating required volumes for many local, regional, and national public health surveillance studies into their current and projected testi...
Source: American Journal of Clinical Pathology - June 10, 2020 Category: Pathology Authors: Hilborne LH, Wagner Z, Cabreros I, Brook RH Tags: Am J Clin Pathol Source Type: research

Cohort PCR Testing: A Strategic Method for Rapid SARS-CoV-2 Screening.
PMID: 32472673 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 30, 2020 Category: Pathology Authors: Yeo WS, Ng QX, Tan KY Tags: Am J Clin Pathol Source Type: research

Clinical Evaluation and Utilization of Multiple Molecular In Vitro Diagnostic Assays for the Detection of SARS-CoV-2.
CONCLUSIONS: Based on these evaluations, a multiplatform testing approach is proposed, depending on patient population and assay sensitivity, to address testing needs during a public health emergency. PMID: 32462195 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 28, 2020 Category: Pathology Authors: Cradic K, Lockhart M, Ozbolt P, Fatica L, Landon L, Lieber M, Yang D, Swickard J, Wongchaowart N, Fuhrman S, Antonara S Tags: Am J Clin Pathol Source Type: research

How I Diagnose.
PMID: 32458973 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 27, 2020 Category: Pathology Authors: Siddon AJ, Czader M Tags: Am J Clin Pathol Source Type: research

How I Diagnose Low-Grade Myelodysplastic Syndromes.
CONCLUSIONS: The role of pathologists in integrating data from multiple sources in the diagnosis of low-grade MDS is evolving and becoming increasingly complex; in this challenging diagnostic setting, it is important to feel comfortable with uncertainty and maintain a conservative approach. PMID: 32458977 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 27, 2020 Category: Pathology Authors: Siddon AJ, Hasserjian RP Tags: Am J Clin Pathol Source Type: research

Four-Year Experience of Digital Slide Telepathology for Intraoperative Frozen Section Consultations in a Two-Site French Academic Department of Pathology.
CONCLUSIONS: Developing IOC with digital slides is a challenge but is necessary to optimize medical time in the current context of pathologist shortage and budget restrictions. PMID: 32459303 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 27, 2020 Category: Pathology Authors: Laurent-Bellue A, Poullier E, Pomerol JF, Adnet E, Redon MJ, Posseme K, Trassard O, Cherqui D, Zarca K, Guettier C Tags: Am J Clin Pathol Source Type: research

Predominant Stroma-Rich Feature in Hyaline Vascular Variant of Castleman Disease Is Associated With Paraneoplastic Pemphigus.
Abstract OBJECTIVES: We aimed to describe the clinical and histopathologic features of Castleman disease (CD), particularly emphasizing its associations with paraneoplastic pemphigus (PNP) and prognosis. METHODS: We retrospectively enrolled 123 CD patients at our center. Clinical, pathologic, and laboratory data were reviewed. RESULTS: Fifty percent of the patients had PNP. Compared with those without PNP, patients with PNP-associated CD had more hyaline vascular (HV) variants (83.9% vs 57.4%), fewer mixed cellular variants (16.1% vs 24.6%), and no plasmacytic variants (0% vs 18.0%). Thirty-eight of 87 p...
Source: American Journal of Clinical Pathology - May 27, 2020 Category: Pathology Authors: Wang L, Nong L, Li F, Wang X, Wang R, Chen X, Tu P, Dong Y, Li T, Zhu X, Wang M Tags: Am J Clin Pathol Source Type: research

The Uterine Plexiform Lesions Revisited.
CONCLUSIONS: Plexiform lesions represent a diverse pathology varying from epithelioid leiomyomas to epithelioid smooth muscle metaplasia of endometrial type of stroma. PMID: 32459343 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 27, 2020 Category: Pathology Authors: Karpathiou G, Papoudou-Bai A, Clemenson A, Chauleur C, Peoc'h M Tags: Am J Clin Pathol Source Type: research

Molecular Detection of SARS-CoV-2 Infection in FFPE Samples and Histopathologic Findings in Fatal SARS-CoV-2 Cases.
CONCLUSIONS: SARS-CoV-2 testing and viral sequencing can be performed from FFPE tissue. Detection and sequencing of SARS-CoV-2 in combination with morphological findings from postmortem tissue examination can aid in gaining a better understanding of the virus's pathophysiologic effects on human health. PMID: 32451533 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 26, 2020 Category: Pathology Authors: Sekulic M, Harper H, Nezami BG, Shen DL, Sekulic SP, Koeth AT, Harding CV, Gilmore H, Sadri N Tags: Am J Clin Pathol Source Type: research