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A Survey of the Prevalence and Impact of Reporting Guideline Endorsement in Pathology Journals.
Abstract Objectives: To determine the prevalence of reporting guideline endorsement in pathology journals and to estimate the impact of guideline endorsement. Methods: We compared the quality of reporting in two sets of studies: (1) studies published in journals that explicitly mentioned a guideline vs studies published in journals that did not and (2) studies that cited a guideline vs studies that did not. The quality of reporting in prognostic biomarker studies was assessed using the REporting recommendations for tumor MARKer prognostic studies (REMARK) guideline. Results: We found that six (10%) of th...
Source: American Journal of Clinical Pathology - October 1, 2017 Category: Pathology Authors: Caron JE, March JK, Cohen MB, Schmidt RL Tags: Am J Clin Pathol Source Type: research

Utility of Reference Change Values for Delta Check Limits.
Conclusions: Comparison of estimated RCVs and real-world patient data revealed the pitfalls of applying RCVs in clinical laboratories. Laboratory managers should be aware of the limitations of RCVs and exercise caution when using them. PMID: 28967949 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2017 Category: Pathology Authors: Ko DH, Park HI, Hyun J, Kim HS, Park MJ, Shin DH Tags: Am J Clin Pathol Source Type: research

Impact of Use of Smaller Volume, Smaller Vacuum Blood Collection Tubes on Hemolysis in Emergency Department Blood Samples.
Abstract Objectives: Hemolyzed blood samples commonly occur in hospital emergency departments (EDs). Our objective was to determine whether replacing standard large-volume/high-vacuum sample tubes with low-volume/low-vacuum tubes would significantly affect ED hemolysis. Methods: This was a prospective intervention of the use of small-volume/vacuum collection tubes. We evaluated all potassium samples in ED patients and associated hemolysis. We used χ2 tests to compare hemolysis incidence prior to and following utilization of small tubes for chemistry collection. Results: There were 35,481 blood sample...
Source: American Journal of Clinical Pathology - October 1, 2017 Category: Pathology Authors: Phelan MP, Reineks EZ, Berriochoa JP, Schold JD, Hustey FM, Chamberlin J, Kovach A Tags: Am J Clin Pathol Source Type: research

Impact of 2013 American Society of Clinical Oncology/College of American Pathologists Guidelines on HER2 Fluorescent In Situ Hybridization Testing in Breast Cancers : Experience From a National Reference Laboratory.
Conclusions: The 2013 ASCO/CAP guidelines lead to a higher number of HER2 FISH positive and equivocal cases. In a reference laboratory setting where an alternative control probe was used to resolve equivocal FISH cases, 31.2% of patients with initial equivocal results became HER2 positive. PMID: 28967951 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2017 Category: Pathology Authors: Gulbahce HE Tags: Am J Clin Pathol Source Type: research

Real-Time Methylation-Specific Polymerase Chain Reaction for MGMT Promoter Methylation Clinical Testing in Glioblastoma: An Alternative Detection Method for a Heterogeneous Process.
Conclusions: The RT-MSP assay that we developed in-house is a robust clinical detection method for the heterogeneous process of MGMT promoter methylation in glioblastoma. PMID: 28967952 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2017 Category: Pathology Authors: Ida CM, Butz ML, Jenkins RB, Sarkaria JN, Kitange GJ, Giannini C, Kipp BR Tags: Am J Clin Pathol Source Type: research

Ensuring the Quality of Point-of-Care Testing in a Large and Decentralized Ambulatory Care Setting.
Conclusions: This decentralization of laboratory testing presents challenges to ensuring quality POC testing. Optimization and analysis of informatics data allow for the identification of POC test utilization trends, areas of improvement for clinical workflows, and increased education on national guidelines. PMID: 28967953 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2017 Category: Pathology Authors: Arboleda VA, Garner OB Tags: Am J Clin Pathol Source Type: research

Deviation Management: Key Management Subsystem Driver of Knowledge-Based Continuous Improvement in the Henry Ford Production System.
Conclusions: Deviation management is a key subsystem of managers' standard work whereby knowledge of nonconformities assists in directing corrective actions and continuous improvements that promote consistent execution and higher levels of performance. PMID: 28967954 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2017 Category: Pathology Authors: Zarbo RJ, Copeland JR, Varney RC Tags: Am J Clin Pathol Source Type: research

Intraoperative Pathologic Consultation on Hysterectomy Specimens for Endometrial Cancer: An Assessment of the Accuracy of Frozen Sections, "Gross-Only" Evaluations, and Obtaining Random Sections of a Grossly "Normal" Endometrium.
Conclusions: Obtaining random sections in the absence of a gross lesion has no significant benefit, and a negative result is likely to provide inaccurate data to the surgeon. Frozen-section analyses are a generally reliable tool to determine "low-risk" pathologic parameters that were evaluated herein when a gross lesion is present. PMID: 28967955 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2017 Category: Pathology Authors: Desouki MM, Li Z, Hameed O, Fadare O Tags: Am J Clin Pathol Source Type: research

Variability and Error in Cardiac Troponin Testing: An ACLPS Critical Review.
Conclusions: cTn assays are reliable diagnostic tests for acute myocardial infarction, but understanding their limitations is required for appropriate result interpretation. PMID: 28967956 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2017 Category: Pathology Authors: Herman DS, Kavsak PA, Greene DN Tags: Am J Clin Pathol Source Type: research

Creation and Evaluation of a Laboratory Administration Curriculum for Pathology Residents.
Conclusions: The multimodal CLM training described here is an easily adoptable, objective system for teaching CLM. It was well liked by residents and provided an objective measurement of mastery of concepts for faculty. PMID: 28927229 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 11, 2017 Category: Pathology Authors: Guarner J, Hill CE, Amukele T Tags: Am J Clin Pathol Source Type: research

Fibromatosis of the Breast: Diagnostic Accuracy of Core Needle Biopsy.
Conclusions: CNB can be an accurate method of diagnosing fibromatosis, allowing observation for a select group of patients. PMID: 28821190 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Kuba MG, Lester SC, Giess CS, Bertagnolli MM, Wieczorek TJ, Brock JE Tags: Am J Clin Pathol Source Type: research

Impact of Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Features on Adequacy Criteria and Risk of Malignancy of Thyroid Fine-Needle Aspiration.
Conclusions: With NIFTP, reducing the threshold for adequacy from 60 to 10 cells led to nonsignificant decrease in the risk of malignancy of a benign diagnosis (2.4% to 2.3%). Thyroid fine-needle aspirates with 10 to 60 benign cells without atypia or Hürthle cell change should be diagnosed as benign. PMID: 28821191 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Renshaw AA, Gould EW Tags: Am J Clin Pathol Source Type: research

Could the PD-1 Pathway Be a Potential Target for Treating Small Intestinal Adenocarcinoma?
Conclusions: PD-1 and PD-L1 are highly expressed by most small intestinal adenocarcinomas. Blockage of the PD-1 pathway should be evaluated in the treatment of small intestinal adenocarcinomas. PMID: 28821192 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Thota R, Gonzalez RS, Berlin J, Cardin DB, Shi C Tags: Am J Clin Pathol Source Type: research

Therapeutic Plasma Exchange and Its Impact on Drug Levels: An ACLPS Critical Review.
Conclusions: There were several limitations with existing studies, many of which relate to procedural and/or clinical properties of patients undergoing TPE. As such, additional studies are needed before definitive guidelines can be established. There is clear need for development of consensus and additional investigations in this domain. PMID: 28821193 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Cheng CW, Hendrickson JE, Tormey CA, Sidhu D Tags: Am J Clin Pathol Source Type: research

Primary Benign and Malignant Thyroid Neoplasms With Signet Ring Cells: Cytologic, Histologic, and Molecular Features.
Conclusions: Our study demonstrates the range of thyroid tumors with SRCs. While most thyroid tumors with SRCs are benign, primary thyroid SC should also be considered in the differential diagnosis. PMID: 28821194 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Farhat NA, Onenerk AM, Krane JF, Dias-Santagata D, Sadow PM, Faquin WC Tags: Am J Clin Pathol Source Type: research

Atypical IgG4+ Plasmacytic Proliferations and Lymphomas: Characterization of 11 Cases.
Conclusions: Monotypic IgG4+ proliferations include lymphomas, plasmacytic neoplasms, and a previously uncharacterized group of proliferations not meeting criteria for conventional hematolymphoid neoplasia. Distinct features included prominent Mott cells and/or monotypic plasma cells within follicles. The proliferations were infrequently associated with IgG4-related disease (IgG4-RD). Our findings raise questions regarding the relationship between clonal IgG4+ proliferations, reactive/inflammatory processes, and IgG4-RD. PMID: 28821195 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Bledsoe JR, Wallace ZS, Deshpande V, Richter JR, Klapman J, Cowan A, Stone JH, Ferry JA Tags: Am J Clin Pathol Source Type: research

Negative Predictive Value and Significance of Benign-Appearing Endometrial Cells in Papanicolaou Tests.
Conclusions: nEMCs in Pap test reports of women 40 years and older are a normal cytology finding in premenopausal women, which may result in unnecessary endometrial biopsies. The NPV associated with this finding for women aged 40 to 49 years exceeded 99%. PMID: 28821196 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Yu J, Onisko A, Austin RM Tags: Am J Clin Pathol Source Type: research

Regional Variability in Percentage of Breast Cancers Reported as Positive for HER2 in California: Implications of Patient Demographics on Laboratory Benchmarks.
Conclusions: These results deepen our understanding of population characteristics' influence on the distribution of HER2-positive breast cancers. Taking these factors into account can be useful when setting laboratory benchmarks and assessing test quality. PMID: 28821197 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Lin CY, Carneal EE, Lichtensztajn DY, Gomez SL, Clarke CA, Jensen KC, Kurian AW, Allison KH Tags: Am J Clin Pathol Source Type: research

CD200 Expression in Neuroendocrine Neoplasms.
Conclusions: CD200 is a relatively sensitive marker of neuroendocrine neoplasms and represents a potential therapeutic target in these difficult-to-treat malignancies. PMID: 28821198 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Love JE, Thompson K, Kilgore MR, Westerhoff M, Murphy CE, Papanicolau-Sengos A, McCormick KA, Shankaran V, Vandeven N, Miller F, Blom A, Nghiem PT, Kussick SJ Tags: Am J Clin Pathol Source Type: research

Keratin 17 Is a Prognostic Biomarker in Endocervical Glandular Neoplasia.
Conclusions: K17 is highly expressed in most cases of both invasive adenocarcinoma and in AIS and is a powerful, negative prognostic marker for patient survival. PMID: 28821199 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Authors: Mockler D, Escobar-Hoyos LF, Akalin A, Romeiser J, Shroyer AL, Shroyer KR Tags: Am J Clin Pathol Source Type: research

Corrections.
Authors: PMID: 28821200 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Corrections.
Authors: PMID: 28821201 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Corrections.
Authors: PMID: 28821202 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2017 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Atypical Histiocytoid Cells in Metastatic Papillary Thyroid Carcinoma An Underrecognized Cytologic Pattern.
Conclusions: AHCs are an often unrecognized metastatic morphologic pattern of cystic PTC, as it does not show diagnostic classic nuclear features of PTC. AHCs are the predominant cytologic finding in approximately 13% of metastatic PTCs to neck LNs. PMID: 28633426 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 15, 2017 Category: Pathology Authors: Canepa M, Elsheikh TM, Sabo DA, Kolosiwsky AM, Reynolds JP Tags: Am J Clin Pathol Source Type: research

Proposed Terminology for Anal Squamous Lesions: Its Application and Interobserver Agreement Among Pathologists in Academic and Community Hospitals.
Abstract Objectives: To analyze interobserver reproducibility and compare practice patterns between academic and community settings of Lower Anogenital Squamous Terminology (LAST). Methods: In total, 132 anal biopsy slides were revised as well as p16 immunostains. Results: LAST was used in 49% of cases (academic center, 68%; satellite hospitals [community practice setting], 32%). After pathology review and consensus interpretation, 23 (17%) case diagnoses were reclassified: eight (34.8%) cases (benign or low-grade squamous intraepithelial lesion [LSIL]) were upgraded to high-grade squamous intraepithelia...
Source: American Journal of Clinical Pathology - June 12, 2017 Category: Pathology Authors: Roma AA, Liu X, Patil DT, Xie H, Allende D Tags: Am J Clin Pathol Source Type: research

Molecular Diagnosis of Thalassemias and Hemoglobinopathies: An ACLPS Critical Review.
Conclusions: Molecular genetic testing serves an important role in identifying individuals carrying thalassemia traits that can cause adverse outcomes in offspring. Furthermore, prenatal genetic testing can identify fetuses with severe globin phenotypes. PMID: 28605432 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 12, 2017 Category: Pathology Authors: Sabath DE Tags: Am J Clin Pathol Source Type: research

Sociodemographic Correlates of Clinical Laboratory Test Expenditures in a Major Canadian City.
Conclusions: There is variation in testing costs for patients among different sociodemographic variables. PMID: 28605433 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 12, 2017 Category: Pathology Authors: Barber J, Guo M, Nguyen LT, Thomas R, Turin TC, Vaska M, Naugler C, COAPT (Collaboration On Assessing Physician Testing) Tags: Am J Clin Pathol Source Type: research

Comparison of Three Methods for Measuring Workload in Surgical Pathology and Cytopathology.
This study compares three methods for measuring workload. Methods: Surgical pathology and cytopathology workload for 1 representative month at Stanford Health Care was assessed using three different methods: RVUs, Royal College of Pathologists (RCP) point system, and University of Washington-Seattle (UW) slide count method. Results: Pearson linear regression analysis showed a strong positive correlation of RVUs with the RCP (0.93, P  
Source: American Journal of Clinical Pathology - June 5, 2017 Category: Pathology Authors: Cloetingh D, Schmidt RA, Kong CS Tags: Am J Clin Pathol Source Type: research

Flow Cytometric Patterns of CD200 and CD1d Expression Distinguish CD10-Negative, CD5-Negative Mature B-Cell Lymphoproliferative Disorders.
Conclusions: Flow cytometric analysis of CD200 and CD1d, along with CD25, CD103, and CD11c, can aid in the diagnosis of CD10-, CD5- mature B-LPDs. PMID: 28575142 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 1, 2017 Category: Pathology Authors: Mason E, Pozdnyakova O, Li B, Dudley G, Dorfman DM Tags: Am J Clin Pathol Source Type: research

Performance of Calculated and Directly Measured Low-Density Lipoprotein Cholesterol in a Pediatric Population.
Conclusions: The novel equation should be used for accurate measurement of pediatric LDL-C when the concentration is below 100 mg/dL in the presence of elevated triglycerides (150-399 mg/dL). PMID: 28575159 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 1, 2017 Category: Pathology Authors: Roper SM, Cao J, Tam E, Devaraj S Tags: Am J Clin Pathol Source Type: research

The Prevalence and Role of Hemoglobin Variants in Biometric Screening of a Multiethnic Population: One Large Health System's Experience.
Conclusions: This study represents one of the largest epidemiologic investigations into the prevalence of Hb variants in a North American metropolitan, multiethnic workforce and their dependents and reinforces the importance of method selection in populations with Hb variants. PMID: 28575177 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 1, 2017 Category: Pathology Authors: Wilburn CR, Bernard DW, Zieske AW, Andrieni J, Miller T, Wang P Tags: Am J Clin Pathol Source Type: research

Predominance of CD4+ T Cells in T-Cell/Histiocyte-Rich Large B-Cell Lymphoma and Identification of a Subset of Patients With Peripheral B-Cell Lymphopenia.
Conclusions: Overall, our work challenges previous findings that cases of THRLBCL are rich in CD8+ T cells and highlights parallels between THRLBCL and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). Also, an association of THRLBCL with systemic B-cell lymphopenia has not been previously reported but may represent an underrecognized manifestation. PMID: 28575178 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 1, 2017 Category: Pathology Authors: Kunder C, Cascio MJ, Bakke A, Venkataraman G, O'Malley DP, Ohgami RS Tags: Am J Clin Pathol Source Type: research

Measurement Bias of Gross Pathologic Compared With Radiologic Tumor Size of Resected Lung Adenocarcinomas: Implications for the T-Stage Revisions in the Eighth Edition of the American Joint Committee on Cancer Staging Manual.
Conclusions: Compared to radiologic measurements, gross pathologic measurements cluster around whole- and half-cm values. This measurement bias could lead to incorrect pathologic tumor staging and influence clinical treatment plans. PMID: 28575179 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 1, 2017 Category: Pathology Authors: Anderson KR, Heidinger BH, Chen Y, Bankier AA, VanderLaan PA Tags: Am J Clin Pathol Source Type: research

Performance Evaluation of Serum Free Light Chain Analysis: Nephelometry vs Turbidimetry, Monoclonal vs Polyclonal Reagents.
Conclusions: FLC analysis requires continuous awareness of analytical limitations. Monitoring of disease response requires FLC analysis on the same platform using the same reagents. PMID: 28575180 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 1, 2017 Category: Pathology Authors: Messiaen AS, De Sloovere MMW, Claus PE, Vercammen M, Van Hoovels L, Heylen O, Debrabandere J, Vanpoucke H, De Smet D Tags: Am J Clin Pathol Source Type: research

Comprehensive Platelet Phenotypic Laboratory Testing and Bleeding History Scoring for Diagnosis of Suspected Hereditary Platelet Disorders: A Single-Institution Experience.
Abstract Objectives: Patients with hereditary/congenital platelet disorders (HPDs) have a broad range of clinical manifestations and laboratory phenotypes. We assessed the performance characteristics of the International Society on Thrombosis and Haemostasis bleeding assessment tool (ISTH-BAT) and clinically validated platelet laboratory tests for diagnosis of HPDs. Methods: The records of 61 patients with suspected HPDs were reviewed and ISTH-BAT scores calculated. Results: Nineteen (31%) patients had thrombocytopenia, and 46 (75%) had positive ISTH-BAT scores. Thirteen and 17 patients had prolonged PFA...
Source: American Journal of Clinical Pathology - June 1, 2017 Category: Pathology Authors: Perez Botero J, Warad DM, He R, Uhl CB, Tian S, Otteson GE, Barness RL, Olson MC, Gossman SC, Charlesworth JE, Nichols WL, Pruthi RK, Chen D Tags: Am J Clin Pathol Source Type: research

The Effects of Indirect- and Direct-Acting Anticoagulants on Lupus Anticoagulant Assays: A Large, Retrospective Study at a Coagulation Reference Laboratory.
Abstract Objectives: To investigate the effects of indirect- and direct-acting anticoagulants on the interpretation of lupus anticoagulant (LAC) assays. Methods: A retrospective database review was performed to identify all LAC panels from November 2012 to November 2015. The positivity rates for three LAC tests were compared among various anticoagulant medications. Results: This analysis included 7,721 LAC panels. Direct oral anticoagulants, warfarin, and unfractionated heparin (UFH) were associated with higher LAC positivity rates compared with patients not receiving documented anticoagulation (83% for ...
Source: American Journal of Clinical Pathology - May 19, 2017 Category: Pathology Authors: Seheult JN, Meyer MP, Bontempo FA, Chibisov I Tags: Am J Clin Pathol Source Type: research

Multicenter Evaluation of the Bruker MALDI Biotyper CA System for the Identification of Clinically Important Bacteria and Yeasts.
Conclusions: The Bruker MALDI Biotyper CA System accurately identifies most clinically important bacteria and yeasts and has optional processing methods to improve isolate characterization. PMID: 28505220 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 13, 2017 Category: Pathology Authors: Wilson DA, Young S, Timm K, Novak-Weekley S, Marlowe EM, Madisen N, Lillie JL, Ledeboer NA, Smith R, Hyke J, Griego-Fullbright C, Jim P, Granato PA, Faron ML, Cumpio J, Buchan BW, Procop GW Tags: Am J Clin Pathol Source Type: research

Diagnostic Performance of Ultrasound-Guided Fine-Needle Aspiration of Nonpalpable Breast Lesions in a Multidisciplinary Setting: The Institut Curie's Experience.
ijanienko J Abstract Objectives: To assess the diagnostic performance of ultrasound-guided fine-needle aspiration (USFNA) in nonpalpable breast lesions (NPBLs) in a multidisciplinary setting. Methods: In total, 2,601 NPBLs underwent USFNA by a radiologist-pathologist team. Gold-standard diagnosis was based on surgery, core-needle biopsy, or 1-year imaging follow-up. USFNA's diagnostic performance was analyzed in different clinical and imaging subgroups. Results: USFNA's sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were, respectively, 92.6% (95% confidence...
Source: American Journal of Clinical Pathology - May 13, 2017 Category: Pathology Authors: Farras Roca JA, Tardivon A, Thibault F, El Khoury C, Alran S, Fourchotte V, Marck V, Alépée B, Sigal B, de Rycke Y, Rouzier R, Klijanienko J Tags: Am J Clin Pathol Source Type: research

Can p40 (Polyclonal) Replace p63 (Clone 4A4) in the Cytologic Diagnosis of Pulmonary Non-Small Cell Carcinoma?
Conclusions: Polyclonal p40 yields a level of false positivity in ACAs similar to p63, which is highest in effusions and is not limited to lung origin. PMID: 28498881 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 12, 2017 Category: Pathology Authors: Alexander M, Chiaffarano J, Zhou F, Cangiarella J, Yee-Chang M, Simsir A Tags: Am J Clin Pathol Source Type: research

A Limited Immunohistochemical Panel Can Subtype Hepatocellular Adenomas for Routine Practice.
Conclusions: Inflammatory and β-catenin-activated adenomas were readily identified by immunostaining patterns. These findings reinforce the necessity of immunohistochemistry in classifying adenomas, as assessing morphology alone often provided inaccurate subclassification. β-Catenin-activated and inflammatory adenomas can be accurately diagnosed using only a limited panel of widely available immunostains. PMID: 28472207 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 3, 2017 Category: Pathology Authors: Larson BK, Guindi M Tags: Am J Clin Pathol Source Type: research

Determination of VH Family Usage in B-Cell Malignancies via the BIOMED-2 IGH PCR Clonality Assay.
Conclusions: We have developed an algorithm that can correctly assign V H family usage when all three BIOMED-2 framework reactions produced clonal products. Given the wide adoption of BIOMED-2 assay, the algorithm can facilitate collection of IGH V H usage data without additional cost to the laboratories. PMID: 28472420 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 3, 2017 Category: Pathology Authors: McDonald TJ, Kuo L, Kuo FC Tags: Am J Clin Pathol Source Type: research

Diagnostic Testing Approaches for Activated Protein C Resistance and Factor V Leiden: A Comparison of Institutional and National Provider Practices.
Conclusions: The cost-optimized algorithmic approach reduces health care costs. PMID: 28472350 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 2, 2017 Category: Pathology Authors: Perez Botero J, Majerus JA, Strege AK, Johnson RD, Chen D, Pruthi RK Tags: Am J Clin Pathol Source Type: research

Using the Modified Magee Equation to Identify Patients Unlikely to Benefit From the 21-Gene Recurrence Score Assay (Oncotype DX Assay).
This study aimed to compare a modified Magee equation with Oncotype DX (Genomic Health, Redwood City, CA) recurrence score (RS) and identify patients who are unlikely to benefit from Oncotype DX. Methods: Magee equation RS was calculated in 438 cases and correlated with Oncotype DX RS. Results: The Pearson correlation coefficient ( r ) for the Magee equation and Oncotype DX RS was 0.6645 ( P  
Source: American Journal of Clinical Pathology - April 25, 2017 Category: Pathology Authors: Hou Y, Tozbikian G, Zynger DL, Li Z Tags: Am J Clin Pathol Source Type: research

Comparison of the Mutational Profiles of Primary Myelofibrosis, Polycythemia Vera, and Essential Thrombocytosis.
Conclusions: PMF, PV, and ET show different mutational profiles, which may be helpful in resolving the differential diagnosis between MPNs. Due to the relatively small number of cases and variable testing over time, larger controlled studies are necessary to confirm the findings. PMID: 28419183 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 15, 2017 Category: Pathology Authors: Song J, Hussaini M, Zhang H, Shao H, Qin D, Zhang X, Ma Z, Hussnain Naqvi SM, Zhang L, Moscinski LC Tags: Am J Clin Pathol Source Type: research

CD4-Negative Variant of Cutaneous Blastic Plasmacytoid Dendritic Cell Neoplasm With a Novel PBRM1 Mutation in an 11-Year-Old Girl.
Conclusions: CD4- variant of BPDCN may be mistaken for myeloid sarcoma or extramedullary lymphoblastic leukemia/lymphoma because of their overlapping morphologic and immunophenotypic features; thus, a careful clinicopathologic evaluation is essential to reach the correct diagnosis. PBRM1 mutation seems to be a driver event in this case. Our study underscores the importance of alterations in chromatin remodeling in the pathogenesis of BPDCN. PMID: 28419186 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 15, 2017 Category: Pathology Authors: Yigit N, Suarez LF, Roth LG, Orazi A, Tam W Tags: Am J Clin Pathol Source Type: research

A New Automated Technology for Cerebrospinal Fluid Cell Counts: Comparison of Accuracy and Clinical Impact of GloCyte, Sysmex XN, and Manual Methods.
Conclusions: Replacing manual WBC counts by GloCyte or Sysmex XN WBC counts would improve consistency of results without compromising diagnostic accuracy. PMID: 28419185 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 13, 2017 Category: Pathology Authors: Sandhaus LM, Dillman CA, Hinkle WP, MacKenzie JM, Hong G Tags: Am J Clin Pathol Source Type: research

Systematic Evaluation of Endothelin 1 Measurement Relative to Traditional and Modern Biomarkers for Clinical Assessment and Prognosis in Patients With Chronic Systolic Heart Failure: Serial Measurement and Multimarker Testing.
Conclusions: ET-1 may be a unique predictor of HF prognosis, complementing other biomarkers in a multimarker profile. Serial measurement of ET-1 may provide additional prognostic information. PMID: 28398455 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 7, 2017 Category: Pathology Authors: Gaggin HK, Truong QA, Gandhi PU, Motiwala SR, Belcher AM, Weiner RB, Baggish AL, Januzzi JL Tags: Am J Clin Pathol Source Type: research

Epigenetic Regulation of CD133 in Gastrointestinal Stromal Tumors.
Conclusions: Our results strongly suggest epigenetic regulation of CD133 expression by promoter methylation in GISTs. Pending further validation studies, high abundance of the protein can serve as a marker for malignant GISTs. PMID: 28398518 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 7, 2017 Category: Pathology Authors: Geddert H, Braun A, Kayser C, Dimmler A, Faller G, Agaimy A, Haller F, Moskalev EA Tags: Am J Clin Pathol Source Type: research

Bile Cast Nephropathy in Cirrhotic Patients: Effects of Chronic Hyperbilirubinemia.
Conclusions: To our knowledge, this is the largest study of BCN in human subjects and a first report describing the association of BCN with HCV-related cirrhosis. We demonstrated that in the face of protracted chronic hyperbilirubinemia, bile casts are formed at much lower bilirubin levels than previously thought. Furthermore, we proposed an algorithm to assist in better identification of bile casts. PMID: 28398539 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 7, 2017 Category: Pathology Authors: Foshat M, Ruff HM, Fischer WG, Beach RE, Fowler MR, Ju H, Aronson JF, Afrouzian M Tags: Am J Clin Pathol Source Type: research

Breast Tumor Resembling Tall Cell Variant of Papillary Thyroid Carcinoma: A Solid Papillary Neoplasm With Characteristic Immunohistochemical Profile and Few Recurrent Mutations.
Conclusions: BTRPTC is a slow-growing neoplastic lesion that needs to be distinguished from other papillary lesions for optimizing therapy. PMID: 28375433 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 1, 2017 Category: Pathology Authors: Bhargava R, Florea AV, Pelmus M, Jones MW, Bonaventura M, Wald A, Nikiforova M Tags: Am J Clin Pathol Source Type: research