Malpractice Concerns, Defensive Medicine, and the Histopathology Diagnosis of Melanocytic Skin Lesions.
Conclusions: One of four US skin pathologists upgrade MSL diagnosis due to malpractice concerns, and nearly all practice assurance behaviors. Assurance behaviors are associated with rendering a more severe MSL diagnosis. PMID: 30007278 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 10, 2018 Category: Pathology Authors: Titus LJ, Reisch LM, Tosteson ANA, Nelson HD, Frederick PD, Carney PA, Barnhill RL, Elder DE, Weinstock MA, Piepkorn MW, Elmore JG Tags: Am J Clin Pathol Source Type: research

Estimate of the Prevalence of Anti-Gastric Parietal Cell Autoantibodies in Healthy Individuals Is Method Dependent.
Conclusions: A great discrepancy in APCA prevalence detected by different methods in this cohort was apparent. Thus, the results on APCA prevalence in healthy individuals are likely method-dependent. PMID: 30007281 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 10, 2018 Category: Pathology Authors: Bagnasco M, Saverino D, Pupo F, Marchiano M, Alessio MG, Schlumberger W, Antico A, Pesce G, Bizzaro N Tags: Am J Clin Pathol Source Type: research

Spontaneously Ruptured Spleen Samples in Patients With Infectious Mononucleosis: Analysis of Histology and Lymphoid Subpopulations.
Conclusions: IM should be considered a possible diagnosis in any case of splenic rupture whose histology suggests possible aggressive lymphoma. PMID: 30007337 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 10, 2018 Category: Pathology Authors: Siliézar MM, Muñoz CC, Solano-Iturri JD, Ortega-Comunian L, Mollejo M, Montes-Moreno S, Piris MA Tags: Am J Clin Pathol Source Type: research

Survey-Defined and Interview-Elicited Challenges That Faced Ethiopian Government Hospital Laboratories as They Applied ISO 15189 Accreditation Standards in Resource-Constrained Settings in 2017.
Conclusions: The survey and interviews specified nine major challenges for Ethiopian government hospital laboratories that seriously obstruct meeting ISO 15189 demands. PMID: 29992301 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 10, 2018 Category: Pathology Authors: Girma M, Desale A, Hassen F, Sisay A, Tsegaye A Tags: Am J Clin Pathol Source Type: research

Chronic Myeloid Leukemia Following Treatment for Primary Neoplasms or Other Medical Conditions: A Report of 21 Cases and Review of the Literature.
Conclusions: Therapy-related CML has a clinical presentation, pathologic features, and cytogenetic profile akin to de novo CML. Absence of additional significant aberrations seems to suggest a pathogenesis different from therapy-related AML/MDS. Therapy-related CML exhibits a robust therapeutic response to imatinib/derivatives and favorable clinical outcomes similar to de novo CML. PMID: 29992292 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 9, 2018 Category: Pathology Authors: Yang LH, Su P, Luedke C, Lu CM, Louissaint A, McCall CM, Rapisardo S, Vallangeon B, Wang E Tags: Am J Clin Pathol Source Type: research

Interpretation of Endocervical Cells With Gastric-Type Mucin on Pap Smears: A Proposal for a Cytologic Category "Atypical Endocervical Cells With Gastric-Type Mucin".
Conclusions: Yellow mucin is a diagnostic clue for endocervical glandular lesions with gastric differentiation. We recommend describing AEC-GAM on cytologic reports to improve cytologic screening for HPV-negative cervical cancers. PMID: 29982289 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 5, 2018 Category: Pathology Authors: Omori M, Kondo T, Nakazawa K, Tagaya H, Ohgi M, Fukasawa H, Nakazawa T, Hashi A, Hirata S Tags: Am J Clin Pathol Source Type: research

The Value of T-Cell Receptor γ (TRG) Clonality Evaluation by Next-Generation Sequencing in Clinical Hematolymphoid Tissues: A Descriptive Study of 41 Cases From a Single Institution.
Conclusions: TRG clonality evaluation by NGS provides greater clinical utility than PCR. PMID: 29982316 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 5, 2018 Category: Pathology Authors: Kansal R, Grody WW, Zhou J, Dong L, Li X Tags: Am J Clin Pathol Source Type: research

Prospective Postimplementation Study of Solana Group A Streptococcal Nucleic Acid Amplification Test vs Conventional Throat Culture.
Conclusions: In summary, this postimplementation study supported high sensitivity and specificity of the GAS NAAT as a backup test for negative rapid GAS antigen tests. PMID: 29982326 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 5, 2018 Category: Pathology Authors: Arbefeville S, Nelson K, Thonen-Kerr E, Ferrieri P Tags: Am J Clin Pathol Source Type: research

Clinical Utility of Classical and Nonclassical Monocyte Percentage in the Diagnosis of Chronic Myelomonocytic Leukemia.
Conclusions: Quantification of monocyte subsets is useful in clinical practice as a diagnostic marker of CMML in blood and bone marrow specimens. The percentage of nonclassical monocytes should be included in analysis of monocyte subsets. PMID: 29982327 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 5, 2018 Category: Pathology Authors: Hudson CA, Burack WR, Leary PC, Bennett JM Tags: Am J Clin Pathol Source Type: research

Platelet Survival in Hematology Patients Assessed by the Corrected Count Increment and Other Formulas.
Conclusions: PI, PPR, and PPI are comparable to CCI for assessing 24-hour platelet survival. PMID: 29982409 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 5, 2018 Category: Pathology Authors: Jaime-Pérez JC, Vázquez-Hernández KE, Jiménez-Castillo RA, Fernández LT, Salazar-Riojas R, Gómez-Almaguer D Tags: Am J Clin Pathol Source Type: research

Bone Marrow as a Source of Cells for Paroxysmal Nocturnal Hemoglobinuria Detection.
Conclusions: PNH clone sizes measured in mature BM leukocytes and in PB are comparable, making BM suitable for PNH assessment. We further demonstrate that commonly used reagents (not FLAER or CD55/CD59) can reliably identify abnormalities of BM neutrophils and monocytes consistent with PNH cells. PMID: 29982419 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 5, 2018 Category: Pathology Authors: Dulau-Florea AE, Young NS, Maric I, Calvo KR, Dunbar CE, Townsley DM, Winkler T, Monreal M, Jiang C, Jordan EK, Braylan RC Tags: Am J Clin Pathol Source Type: research

Correction.
Authors: PMID: 29982436 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 3, 2018 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Clinical Referral Laboratories in Rwanda: The Status of Quality Improvement After 7 Years of the SLMTA Program.
Conclusions: Four of five laboratories are not moving toward accreditation. However, this target is still achievable by energizing responsibilities of stakeholders and monitoring and evaluation. This would be possible because of the ability that laboratories showed in earlier audits, coupled with existing health policy that enables sustainable quality health care in Rwanda. PMID: 29931081 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 19, 2018 Category: Pathology Authors: Rusanganwa V, Gahutu JB, Nzabahimana I, Ngendakabaniga JMV, Hurtig AK, Evander M Tags: Am J Clin Pathol Source Type: research

Comparison of Alere i Strep A Rapid Molecular Assay With Rapid Antigen Testing and Culture in a Pediatric Outpatient Setting.
Conclusions: The Alere test is sufficiently sensitive and specific for definitive GAS testing in a pediatric urgent care setting. This implementation has enabled us to provide definitive patient results at the time of each patient encounter. PMID: 29931106 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 19, 2018 Category: Pathology Authors: Weinzierl EP, Jerris RC, Gonzalez MD, Piccini JA, Rogers BB Tags: Am J Clin Pathol Source Type: research

A Randomized Controlled Trial to Assess the Impact of Upfront Point-of-Care Testing on Emergency Department Treatment Time.
Conclusions: The full benefit of POC testing can be realized if it is implemented prior to doctor evaluation, as part of a standardized procedure in the ED. This allows for a more rapid availability of investigation results subsequently leading to decreased treatment times. PMID: 29931184 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 19, 2018 Category: Pathology Authors: Goldstein L, Wells M, Vincent-Lambert C Tags: Am J Clin Pathol Source Type: research

Interference of Therapeutic Monoclonal Antibodies With Routine Serum Protein Electrophoresis and Immunofixation in Patients With Myeloma: Frequency and Duration of Detection of Daratumumab and Elotuzumab.
Conclusions: When distinguishable from M-protein, t-mAbs are detectable in 93% of treated patients as soon as 7 days after the initial dose and are consistently observed throughout induction therapy, warranting increased monitoring and careful interpretation of SPE/IF. PMID: 29901687 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 13, 2018 Category: Pathology Authors: Tang F, Malek E, Math S, Schmotzer CL, Beck RC Tags: Am J Clin Pathol Source Type: research

HITTING the Diagnosis: Testing for Heparin-Induced Thrombocytopenia in Cancer Patients.
Conclusions: HIT can be ruled out in cancer patients (negative predictive value and sensitivity = 100%) with low pretest probability, defined by 4Ts scores of 2 or less, significantly reducing the need for laboratory testing in this patient population. PMID: 29901688 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 13, 2018 Category: Pathology Authors: Fenelus M, Peerschke EIB Tags: Am J Clin Pathol Source Type: research

The Future of Pathology and Laboratory Medicine-Again.
PMID: 29901689 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 13, 2018 Category: Pathology Authors: Wilson ML Tags: Am J Clin Pathol Source Type: research

A Case Series of Five Patients With Pure or Mixed Gestational Epithelioid Trophoblastic Tumors and a Literature Review on Mixed Tumors.
Conclusions: ETT is indolent. Recurrence can happen, but the risk factors are not clear. When patients with GTN fail to respond to chemotherapy, the possibility of mixed GTN should be considered. PMID: 29897391 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 11, 2018 Category: Pathology Authors: Tse KY, Chiu KWH, Chan KKL, Chu MMY, Ngu SF, Cheung ANY, Ngan HYS, Ip PPC Tags: Am J Clin Pathol Source Type: research

Modified Plasma-Thrombin Method of Cell Block Preparation for Fine-Needle Aspiration Biopsies in Resource-Limited Settings.
Conclusions: The modified plasma-thrombin method is a reliable cell block preparation method that can be easily applied in resource-limited settings. PMID: 29893770 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 9, 2018 Category: Pathology Authors: Aisagbonhi O, Birungi A, Atwine R, Behayo P, Ayebaziwe B, Roberts D, Tambouret R Tags: Am J Clin Pathol Source Type: research

Establishment and Utilization of a Transfusion Recipient Registry in Korea: Estimating the Frequencies of Specific Antigen-Negative Blood Units.
Conclusions: The distribution of unexpected antibodies and frequencies of specific antigen-negative blood units were investigated using data from the Korean national registry. The results provide useful data to predict the number of blood units to be tested to obtain compatible blood units. PMID: 29893771 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 9, 2018 Category: Pathology Authors: Shin DW, Kim H, Chung Y, Kim JN, Hong YJ, Park KU, Han KS Tags: Am J Clin Pathol Source Type: research

Metastatic Involvement of the Prostatic Anterior Fat Pad: Implications for the Pathologist.
Conclusions: Pathologic evaluation of the PAFP may be useful even in patients with low probability of recurrence because it may change staging by detecting metastatic involvement of small PAFP lymph nodes. PMID: 29893778 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 8, 2018 Category: Pathology Authors: Lopez-Hisijos N, Genco I, Gorbonos A, Pambuccian SE, Barkan GA Tags: Am J Clin Pathol Source Type: research

A Single Institutional Experience With the Paris System for Reporting Urinary Cytology: Correlation of Cytology and Histology in 194 Cases.
Conclusions: TPS improves the overall performance of urinary tract cytology by standardizing the criteria and terminology. PMID: 29878037 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 6, 2018 Category: Pathology Authors: Zare S, Mirsadraei L, Reisian N, Liao X, Roma A, Shabaik A, Hasteh F Tags: Am J Clin Pathol Source Type: research

Decreased Hemolysis and Improved Platelet Function in Blood Components Washed With Plasma-Lyte A Compared to 0.9% Sodium Chloride.
Abstract Objectives: Washing cellular blood products is accepted to ameliorate repeated severe allergic reactions but is associated with RBC hemolysis and suboptimal platelet function. We compared in vitro hemolysis and platelet function in blood components after washing with Plasma-Lyte A (PL-A) vs normal saline (NS). Methods: RBC (n = 14) were washed/resuspended in NS or PL-A. Free hemoglobin and heme were determined at 0, 24, 48, and 72 hours. Platelet concentrates (PCs; n = 21) were washed with NS or PL-A and resuspended in same washing solution (n = 13) or ABO-identical plasma (n = 8). Platelet aggregati...
Source: American Journal of Clinical Pathology - June 6, 2018 Category: Pathology Authors: Refaai MA, Conley GW, Henrichs KF, McRae H, Schmidt AE, Phipps RP, Spinelli SL, Masel D, Cholette JM, Pietropaoli A, Eaton MP, Blumberg N Tags: Am J Clin Pathol Source Type: research

Detection of BRAF V600E Mutations With Next-Generation Sequencing in Infarcted Thyroid Carcinomas After Fine-Needle Aspiration.
Conclusions: We demonstrate detection of hallmark BRAF V600E mutations by NGS within infarcted tissue of thyroid carcinomas after FNA. This suggests a potential ancillary method of characterizing infarcted thyroid carcinomas whose altered histology may be nondiagnostic. PMID: 29868707 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 2, 2018 Category: Pathology Authors: Kouba E, Ford A, Brown CG, Yeh C, Siegal GP, Manne U, Eltoum IE Tags: Am J Clin Pathol Source Type: research

Defining Lymphoplasmacytic Lymphoma: Does MYD88L265P Define a Pathologically Distinct Entity Among Patients With an IgM Paraprotein and Bone Marrow-Based Low-Grade B-Cell Lymphomas With Plasmacytic Differentiation?
Conclusions: Our data support a clinicopathologic approach to LPL diagnosis and recognition that it may manifest with varying morphologies, phenotypes, and molecular features. PMID: 29868855 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 2, 2018 Category: Pathology Authors: Fang H, Kapoor P, Gonsalves WI, Frederick LA, Viswanatha D, Howard MT, He R, Morice WG, McPhail ED, Greipp PT, Ansell SM, Kyle RA, Gertz MA, Paludo J, Abeykoon J, King RL Tags: Am J Clin Pathol Source Type: research

Correction.
Authors: PMID: 29860273 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 31, 2018 Category: Pathology Tags: Am J Clin Pathol Source Type: research

Quality Control Practices for Chemistry and Immunochemistry in a Cohort of 21 Large Academic Medical Centers.
Conclusions: This variation in practice indicates an opportunity exists to establish an evidence-based approach to QC that can be generalized across institutions. PMID: 29850771 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 29, 2018 Category: Pathology Authors: Rosenbaum MW, Flood JG, Melanson SEF, Baumann NA, Marzinke MA, Rai AJ, Hayden J, Wu AHB, Ladror M, Lifshitz MS, Scott MG, Peck-Palmer OM, Bowen R, Babic N, Sobhani K, Giacherio D, Bocsi GT, Herman DS, Wang P, Toffaletti J, Handel E, Kelly KA, Albeiroti S, Tags: Am J Clin Pathol Source Type: research

Effect of Diabetes Mellitus on Sickle Hemoglobin Quantitation in Sickle Cell Trait.
Conclusions: Glycosylation can interfere with HbS% measurement by HPLC. Susceptible specimens should be identified and preferentially analyzed via CE. PMID: 29850781 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 29, 2018 Category: Pathology Authors: Li SH, Harro D, Alfsen J, Bolterman J, Ketha H, Schroeder LF, Giacherio DA, Keren DF Tags: Am J Clin Pathol Source Type: research

Overexpression of Golgi Phosphoprotein 2 Is Associated With Poor Prognosis in Oral Squamous Cell Carcinoma.
Conclusions: These findings suggest GOLPH2 is a potential marker for estimating the patient's prognosis and may be a target for molecular-targeted therapy against OSCC. PMID: 29788173 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 16, 2018 Category: Pathology Authors: Li H, Yang LL, Xiao Y, Deng WW, Chen L, Wu L, Zhang WF, Sun ZJ Tags: Am J Clin Pathol Source Type: research

Recurrent Cytogenetic Abnormalities in Intravascular Large B-Cell Lymphoma.
Conclusions: Recurrent cytogenetic abnormalities involving chromosomes 1, 6q, and 18 are present in greater than 50% of ILBCL. PMID: 29767679 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 14, 2018 Category: Pathology Authors: Klairmont MM, Cheng J, Martin MG, Gradowski JF Tags: Am J Clin Pathol Source Type: research

Is a 500-Cell Count Necessary for Bone Marrow Differentials?: A Proposed Analytical Method for Validating a Lower Cutoff.
Conclusions: Performing differential counts on 300 cells would produce clinically and statistically similar results to 500 cells. Reducing the cell number counted has potential cost/labor reductions without affecting quality of care. PMID: 29757362 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 10, 2018 Category: Pathology Authors: Abdulrahman AA, Patel KH, Yang T, Koch DD, Sivers SM, Smith GH, Jaye DL Tags: Am J Clin Pathol Source Type: research

Clinical Significance of Complex Glandular Patterns in Lung Adenocarcinoma: Clinicopathologic and Molecular Study in a Large Series of Cases.
Abstract Objectives: To explore whether complex glandular patterns (CGPs) have a potential role in the clinical management of patients with lung adenocarcinoma. Methods: We included 356 patients with lung adenocarcinoma with available clinicopathologic information, gene mutations, and clinical outcomes for analysis. Results: We identified 54 (15.2%) CGP-predominant cases. The CGPs were associated with ALK rearrangement and HER2 mutation. Survival analysis showed that the clinical outcome of CGP-predominant patients was worse than that for acinar-predominant patients (overall survival [OS], 66.4 vs 90.3 months, P
Source: American Journal of Clinical Pathology - May 9, 2018 Category: Pathology Authors: Kuang M, Shen X, Yuan C, Hu H, Zhang Y, Pan Y, Cheng C, Zheng D, Cheng L, Zhao Y, Tao X, Li Y, Chen H, Sun Y Tags: Am J Clin Pathol Source Type: research

Contemporary Evaluation of Breast Lymph Nodes in Anatomic Pathology.
Conclusions: It is not necessary for pathologists to search for all small metastases to predict non-SLN involvement, regional recurrence, or death due to disease. Processing should be designed with the goal of detecting macrometastases. Multiple levels, routine immunohistochemistry, and molecular testing are not recommended. PMID: 29746624 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 9, 2018 Category: Pathology Authors: Harrison BT, Brock JE Tags: Am J Clin Pathol Source Type: research

Detection of Albumin Expression by RNA In Situ Hybridization Is a Sensitive and Specific Method for Identification of Hepatocellular Carcinomas and Intrahepatic Cholangiocarcinomas.
Conclusions: RNAscope for albumin is highly sensitive and specific for identifying HCCs and is highly specific and moderately sensitive for detection of ICCs; however, rare carcinomas (non-HCC, non-ICC, and those with no hepatoid histomorphology) can also have aberrant expression of albumin. PMID: 29746696 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - May 9, 2018 Category: Pathology Authors: Lin F, Shi J, Wang HL, Ma XJ, Monroe R, Luo Y, Chen Z, Liu H Tags: Am J Clin Pathol Source Type: research

An Audit of Repeat Testing at an Academic Medical Center: Consistency of Order Patterns With Recommendations and Potential Cost Savings.
Abstract Objectives: To evaluate the prevalence of potentially unnecessary repeat testing (PURT) and the associated economic burden for an inpatient population at a large academic medical facility. Methods: We evaluated all inpatient test orders during 2016 for PURT by comparing the intertest times to published recommendations. Potential cost savings were estimated using the Centers for Medicare & Medicaid Services maximum allowable reimbursement rate. We evaluated result positivity as a determinant of PURT through logistic regression. Results: Of the evaluated 4,242 repeated target tests, 1,849 (44%...
Source: American Journal of Clinical Pathology - April 30, 2018 Category: Pathology Authors: Hueth KD, Jackson BR, Schmidt RL Tags: Am J Clin Pathol Source Type: research

The Five Es of Efficient Engagement: Attaining Esprit de Corps.
PMID: 29718091 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 28, 2018 Category: Pathology Authors: Prayson RA, Rowe JJ Tags: Am J Clin Pathol Source Type: research

Variability of High-Sensitivity Troponin T Concentrations in Emergency Settings: Impact for the Diagnosis of Myocardial Infarction.
Conclusions: An absolute delta of 16 ng/L has good specificity in the emergency setting. This threshold is valid for any sex, age, and sampling interval between 3 and 24 hours and is higher than published limits found in healthy outpatients. PMID: 29718099 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 28, 2018 Category: Pathology Authors: Douville P, Thériault S Tags: Am J Clin Pathol Source Type: research

Gastric Adenocarcinoma of the Fundic Gland Type: Update and Literature Review.
Conclusions: GA-FGs are rare lesions that typically follow a benign course. However, despite features of malignancy in some cases, complete surgical excision, sometimes with endoscopic mucosal resection, seems adequate treatment. PMID: 29648578 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 10, 2018 Category: Pathology Authors: Benedict MA, Lauwers GY, Jain D Tags: Am J Clin Pathol Source Type: research

Obtaining a Correct Diagnosis Rapidly in the United States Is Associated With Many Barriers Not Present in Other Countries.
PMID: 29635278 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 4, 2018 Category: Pathology Authors: Laposata M Tags: Am J Clin Pathol Source Type: research

The Impact of an Electronic Expensive Test Notification.
Conclusions: Although this CDST was passive (ie, could be overridden at the point of order entry) and was associated with a relatively low abandonment rate, it achieved a considerable cost savings each year since each abandoned test saved the institution $1,000 or more. PMID: 29635311 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 4, 2018 Category: Pathology Authors: Riley JD, Stanley G, Wyllie R, Kottke-Marchant K, Procop GW Tags: Am J Clin Pathol Source Type: research

Pulmonary Non-Small Cell Carcinoma With Morphologic Features of Adenocarcinoma or "Non-Small Cell Carcinoma Favor Adenocarcinoma" in Cytologic Specimens Share Similar Clinical and Molecular Genetic Characteristics.
Conclusion: Patients diagnosed with pulmonary ACA, NSCLC favor ACA, or NSCLC-NOS in cytology specimens have similar clinical stage, survival, and molecular alterations. PMID: 29635384 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 4, 2018 Category: Pathology Authors: Hutchings D, Maleki Z, Rodriguez EF Tags: Am J Clin Pathol Source Type: research

Body Fluid Processing Workspace Quality Improvement Initiative in a High-Volume Reference Laboratory.
Conclusions: After the redesign, physical steps taken and time to process body fluids were reduced by an average of 40% and 32%, respectively, demonstrating the utility of quality improvement tools in clinical laboratory settings. PMID: 29618001 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 29, 2018 Category: Pathology Authors: Campbell MR, Milam KK, Fisher KR Tags: Am J Clin Pathol Source Type: research

Diagnostic Utility of Twist1, Ki-67, and E-Cadherin in Diagnosing Molar Gestations and Hydropic Abortions.
Conclusions: Twist1 expression is a highly reliable marker for the diagnosis of CHM, where combined Ki-67 and E-cadherin immunoreactivity can distinguish PHM from nonmolar pregnancies. PMID: 29562309 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 19, 2018 Category: Pathology Authors: Moussa RA, Eesa AN, Abdallah ZF, Abdelmeged A, Mahran A, Bahaa H Tags: Am J Clin Pathol Source Type: research

Increased Rate of ASCUS Diagnosis With Concomitant Request for High-Risk Human Papillomavirus Reflex Testing May Be Due to Cognitive Bias.
Conclusions: HPV-HR reflex testing may introduce bias in cytologic diagnosis, making it more likely that an ASCUS diagnosis is rendered. HPV-HR and ASCUS/SIL ratios were similar between the groups, so cytopathologist performance was not significantly affected. There was no effect of cytopathologists' experience. PMID: 29562239 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 17, 2018 Category: Pathology Authors: Pendse AA, Bauer AE, Dodd L, Scanga L Tags: Am J Clin Pathol Source Type: research

Performance Evaluation and Clinical Associations of Immunoassays That Detect Antibodies to Negatively Charged Phospholipids Other Than Cardiolipin.
Conclusions: Increasing titers of APhL, anti-PS, and anti-PI antibodies could indicate an increased risk of thrombotic and/or obstetric aPL-related manifestations. These assays may be promising biomarkers for particular APS manifestations. PMID: 29547897 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 14, 2018 Category: Pathology Authors: Castanon A, Pierre G, Willis R, Harris EN, Papalardo E, Romay-Penabad Z, Schleh A, Jajoria P, Smikle M, DeCeulaer K, Tebo A, Jaskowski T, Guerra MM, Branch DW, Salmon JE, Petri M, Gonzalez EB Tags: Am J Clin Pathol Source Type: research

Offering Aspartate Aminotransferase as a Reflex Test: An Easy but Effective Way to Improve Appropriateness of Laboratory Requests.
PMID: 29547948 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 14, 2018 Category: Pathology Authors: Birindelli S, Pasqualetti S, Panteghini M Tags: Am J Clin Pathol Source Type: research

Multinodular Goiter Progression Toward Malignancy in a Case of DICER1 Syndrome: Histologic and Molecular Alterations.
Conclusions: The findings obtained from this single case support the assumption that DICER1 syndrome-related WDTC NOS may develop on a background of MNG, via a stepwise process, involving DICER1 somatic mutations and additional molecular events, distinct from the classic pathways of papillary/follicular carcinoma. PMID: 29538609 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 10, 2018 Category: Pathology Authors: Gullo I, Batista R, Rodrigues-Pereira P, Soares P, Barroca H, do Bom-Sucesso M, Sobrinho-Simões M Tags: Am J Clin Pathol Source Type: research

Upregulation of miR-125b, miR-181d, and miR-221 Predicts Poor Prognosis in MGMT Promoter-Unmethylated Glioblastoma Patients.
Conclusions: miR 125b-5p, miR 181d-3p, and miR 221-3p are useful in predicting poor prognosis in patients with MGMT-unmethylated glioblastomas. PMID: 29538610 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 10, 2018 Category: Pathology Authors: Chen YY, Ho HL, Lin SC, Ho TD, Hsu CY Tags: Am J Clin Pathol Source Type: research

Acinar-Predominant Pattern Correlates With Poorer Prognosis in Invasive Mucinous Adenocarcinoma of the Lung.
Conclusions: Lepidic-predominant and acinar-predominant IMA are two different subtypes of IMA. Acinar-predominant IMA is associated with lymph node metastasis and a poorer prognosis. PMID: 29538611 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 10, 2018 Category: Pathology Authors: Lin G, Li H, Kuang J, Tang K, Guo Y, Han A, Xie C Tags: Am J Clin Pathol Source Type: research