A Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma.
Abstract OBJECTIVES: The aim of this study was to devise reproducible biopsy criteria for distinguishing pulmonary large cell neuroendocrine carcinoma (LCNEC) from non-small cell lung carcinoma (NSCLC). METHODS: Tissue microarrays of LCNEC and NSCLC were generated from resection specimens and used as biopsy surrogates. They were stained for neuroendocrine markers, Ki-67, napsin-A, and p40, and independently analyzed by standardized morphologic criteria by four pathologists. Tumors were scored based on morphology, neuroendocrine marker expression, and Ki-67 proliferative index. RESULTS: The average total ...
Source: American Journal of Clinical Pathology - October 8, 2019 Category: Pathology Authors: Baine MK, Sinard JH, Cai G, Homer RJ Tags: Am J Clin Pathol Source Type: research

ASCP Continues to Choose Wisely.
PMID: 31589749 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 7, 2019 Category: Pathology Authors: Kroft SH, Bertholf RL Tags: Am J Clin Pathol Source Type: research

Detection of Nonhematologic Neoplasms by Routine Flow Cytometry Analysis.
CONCLUSIONS: Our findings highlight the importance of carefully inspecting CD45-negative events to identify non-HNs by routine FC analysis. This can help expedite further downstream immunophenotypic analysis of specimens and triage samples for appropriate genetic and molecular studies. PMID: 31587038 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 6, 2019 Category: Pathology Authors: Annunziata J, Miller ML, Park DC, Vlad G, Bhagat G, Alobeid B Tags: Am J Clin Pathol Source Type: research

Toward Improving Practices for Submission of Diagnostic Tissue Blocks for National Cancer Institute Clinical Trials.
PMID: 31586436 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 5, 2019 Category: Pathology Authors: Mccall SJ Tags: Am J Clin Pathol Source Type: research

Status of Histopathology Services in Ethiopia.
PMID: 31586440 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 5, 2019 Category: Pathology Authors: Okubazgi G, Berhane B, Nigussie M, Tsegaye A, Hassen F Tags: Am J Clin Pathol Source Type: research

Laboratory Blood-Based Testing for Non-Lyme Disease Tick-Borne Infections at a National Reference Laboratory.
CONCLUSIONS: This report provides an important complementary source of data to best understand trends in and spread of NLTBI. PMID: 31584611 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 4, 2019 Category: Pathology Authors: Lee-Lewandrowski E, Chen Z, Branda J, Baron J, Kaufman HW Tags: Am J Clin Pathol Source Type: research

Hashimoto Thyroiditis in Primary Thyroid Non-Hodgkin Lymphoma.
CONCLUSIONS: Overall, 78.9% of patients with PTL have any HT evidence, but only half of these had been clinically followed. The difference in HT prevalence suggests that a subset of DLBCL may not derive from MALT lymphoma. PMID: 31584614 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 4, 2019 Category: Pathology Authors: Travaglino A, Pace M, Varricchio S, Insabato L, Giordano C, Picardi M, Pane F, Staibano S, Mascolo M Tags: Am J Clin Pathol Source Type: research

Diagnosis of Congenital Hepatic Fibrosis in Adulthood.
CONCLUSIONS: While other disease associations and characteristic liver histomorphology are helpful clues to suspect the diagnosis of CHF in adult patients, other differential diagnoses should be excluded clinically and radiologically. This study highlights the importance of a multidisciplinary diagnostic approach by pathologists, radiologists, and hepatologists for the accurate diagnosis of CHF during adulthood. PMID: 31584623 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 4, 2019 Category: Pathology Authors: Alsomali MI, Yearsley MM, Levin DM, Chen W Tags: Am J Clin Pathol Source Type: research

Rapid Diagnosis of Tuberculosis Meningitis by Detecting Mycobacterium tuberculosis Cell-Free DNA in Cerebrospinal Fluid.
In this study, we report a new method for detecting cell-free Mycobacterium tuberculosis DNA (cf-TB) in CSF and evaluate its clinical value for TBM diagnosis. METHODS: Of 68 patients prospectively recruited, 46 were diagnosed as having TBM and 22 as non-TBM. We compared the cf-TB method with CSF smear microscopy, mycobacterial culture, and the Xpert MTB/RIF assay (Xpert) using the consensus case definition for TBM proposed in 2009 as a reference standard. RESULTS: The sensitivity of the cf-TB test was 56.5% (26/46) in patients with TBM, and it was significantly higher than other methods: microscopy (2.2%, 1/46; P
Source: American Journal of Clinical Pathology - October 4, 2019 Category: Pathology Authors: Li X, Du W, Wang Y, Liu Z, Li K, Chen H, Liu R, Ma L, Zhang L, Dong Y, Che N, Gao M Tags: Am J Clin Pathol Source Type: research

Prognostic Significance of Stromal and Intraepithelial Tumor-Infiltrating Lymphocytes in Small Intestinal Adenocarcinoma.
CONCLUSIONS: High sTIL density can be used as a prognostic indicator and high iTIL count may provide a basis for the clinical use of targeted immunotherapy in SIAC patients. PMID: 31576398 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 2, 2019 Category: Pathology Authors: Jun SY, Park ES, Lee JJ, Chang HK, Jung ES, Oh YH, Hong SM Tags: Am J Clin Pathol Source Type: research

Prostate Biopsy Processing.
CONCLUSIONS: The BxChip reduced tissue fragmentation and increased efficiency of prostate biopsy diagnosis. It also resulted in overall cost savings and significantly increased tissue length. PMID: 31433833 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 21, 2019 Category: Pathology Authors: Murugan P, Shukla D, Morocho J, Smith D, Sciacca D, Pickard M, Wahlsten M, Gunderson A, Konety B, Khalifa MA, Warlick C Tags: Am J Clin Pathol Source Type: research

Congruence Between 1994 WHO Classification of Endometrial Hyperplasia and Endometrial Intraepithelial Neoplasia System.
CONCLUSIONS: WHO 1994 system is not congruent with the EIN system and cannot be directly translated into a dual classification. PMID: 31433834 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 21, 2019 Category: Pathology Authors: Travaglino A, Raffone A, Saccone G, Mascolo M, Guida M, Mollo A, Insabato L, Zullo F Tags: Am J Clin Pathol Source Type: research

An Uncommon Case of Double-Hit Mantle Cell Lymphoma That Demonstrates a Transformation Process.
CONCLUSIONS: The rearrangement of MYC and a mutation in NOTCH2 probably induced the transformation of MCL cells in this patient. This uncommon double-hit MCL case clearly demonstrates a transformation process. PMID: 31433838 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 21, 2019 Category: Pathology Authors: Zhou J, Hu L, Zuo M, Zhou Y, Li G, Zhang X Tags: Am J Clin Pathol Source Type: research

Peripheral T-Cell Lymphoma Arising in Patients With Chronic Lymphocytic Leukemia.
CONCLUSIONS: Further research is required in this area to establish prognostic and management recommendations. Increasing numbers of cases are being described. Positron emission tomography with computed tomography was not useful in our cohort for diagnosing progression. PMID: 31433844 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 21, 2019 Category: Pathology Authors: Van Der Nest BM, Leslie C, Joske D, Radeski D, White R, Cheah CY Tags: Am J Clin Pathol Source Type: research

Detection of Naegleria fowleri, Acanthamoeba spp, and Balamuthia mandrillaris in Formalin-Fixed, Paraffin-Embedded Tissues by Real-Time Multiplex Polymerase Chain Reaction.
CONCLUSIONS: While sensitivity is limited, FLA-PCR assay may serve as a useful adjunct for detection or confirmation of FLA infections in FFPE tissues. PMID: 31415080 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 15, 2019 Category: Pathology Authors: Norgan AP, Sloan LM, Pritt BS Tags: Am J Clin Pathol Source Type: research

Update on Neuroendocrine Carcinomas of the Larynx.
CONCLUSIONS: Accurate diagnosis and grading of laryngeal neuroendocrine carcinomas is critical for prognostication and therapeutic decision making. The use of an algorithm is instrumental in assuring the exclusion of mimickers. PMID: 31415081 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 15, 2019 Category: Pathology Authors: Strosberg C, Ferlito A, Triantafyllou A, Gnepp DR, Bishop JA, Hellquist H, Strojan P, Willems SM, Stenman G, Rinaldo A, Hernandez-Prera JC Tags: Am J Clin Pathol Source Type: research

Strengthening Quality of Tuberculosis Laboratories Toward Accreditation in Viet Nam.
CONCLUSIONS: The program led to improved quality systems. Sites should be monitored to ensure sustainability of improvements and country capacity expanded for national scaleup. PMID: 31415083 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 15, 2019 Category: Pathology Authors: Gumma V, Bennett DL, Nguyen Thi Phong L, Duong Ngoc C, Bond KB, Nguyen Thi Hoang Y, Erni D, Nguyen Van N, Nguyen Van H, Albert H Tags: Am J Clin Pathol Source Type: research

Accelerated Tissue Processing With Minimal Formalin Fixation Time for 9-Gauge Vacuum-Assisted Breast Biopsy Specimens.
CONCLUSIONS: Nine-gauge VAB specimens can be processed within 4 hours. Slides are suitable for all routine pathologic stains. This enables a same-day diagnosis. PMID: 31415692 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 15, 2019 Category: Pathology Authors: Bulte JP, Halilovic A, Burgers LJM, Diepenbroek CJM, de la Roij RAK, Mann RM, van der Leest M, van Cleef PHJ, Strobbe LJA, de Wilt JHW, Bult P Tags: Am J Clin Pathol Source Type: research

Grading Pancreatic Neuroendocrine Tumors by Ki-67 Index Evaluated on Fine-Needle Aspiration Cell Block Material.
CONCLUSIONS: Grade 2 PanNETs can be significantly undergraded when Ki-67 index is evaluated on cell block material. In cases with 1,000 or more cells, the hot spot counting method has better correlation with surgical specimens. PMID: 31415691 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 11, 2019 Category: Pathology Authors: Abi-Raad R, Lavik JP, Barbieri AL, Zhang X, Adeniran AJ, Cai G Tags: Am J Clin Pathol Source Type: research

Improving Outcomes.
CONCLUSIONS: Most studies describing pathology educational interventions are not of strong experimental design. Consumers of educational research should be cognizant of these potential weaknesses in educational studies. PMID: 31390654 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 8, 2019 Category: Pathology Authors: McBrien S, Bailey Z, Ryder J, Scholer P, Talmon G Tags: Am J Clin Pathol Source Type: research

The Authors' Reply.
, Lamps LW PMID: 31367766 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 1, 2019 Category: Pathology Authors: Authors' Reply. Tags: Am J Clin Pathol Source Type: research

Genetic Testing in the Diagnosis and Biology of Acute Leukemia.
CONCLUSIONS: Our understanding of the molecular genetics of acute leukemias continues to grow rapidly. Awareness of the potential complexity of genetic architecture and environment is critical and emphasizes the importance of integrating clinical information with morphologic, immunophenotypic, and molecular genetic evaluation. PMID: 31367767 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 1, 2019 Category: Pathology Authors: Harris MH, Czuchlewski DR, Arber DA, Czader M Tags: Am J Clin Pathol Source Type: research

Limited Tissue Biopsies and Hematolymphoid Neoplasms.
CONCLUSIONS: FNA/CNB is practical in evaluating most hematolymphoid lesions, with high efficacy in recurrent disease and some primary neoplasms with homogeneous/ aggressive histology, or characteristic immunophenotype. PMID: 31365922 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 1, 2019 Category: Pathology Authors: Ingersoll KF, Zhao Y, Harrison GP, Li Y, Yang LH, Wang E Tags: Am J Clin Pathol Source Type: research

Comparison of the cobas Human Immunodeficiency Virus 1 (HIV-1) Test Using the cobas 4800 System With COBAS AmpliPrep/COBAS TaqMan HIV-1 Test and Abbott RealTime HIV-1 Assay and Performance Evaluation of cobas HIV-1.
CONCLUSIONS: The cobas HIV-1 test showed good performance, and its results correlated well with those of other two tests. PMID: 31365738 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 31, 2019 Category: Pathology Authors: Shin KH, Lee HJ, Lee JH, Chang CL, Kim HH Tags: Am J Clin Pathol Source Type: research

Development of a Nonradioactive Platelet Serotonin Uptake and Release Assay by Micro-Liquid Chromatography Tandem Mass Spectrometry Using Minimal Blood Volume.
CONCLUSIONS: Quantification of d45-HT by micro-LC-MS/MS assay offers a highly sensitive, nonradioactive methodology for quantitating platelet serotonin uptake and dense granule secretion, requiring only small volumes of patient blood. PMID: 31365739 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 31, 2019 Category: Pathology Authors: Chan SL, Yi X, Wysocki E, Bridgman R, Gutierrez J, Mikrut K, Leung EK, Yeo KJ, Miller JL Tags: Am J Clin Pathol Source Type: research

Metastatic Basal Cell Carcinoma.
CONCLUSIONS: This study illustrates multiple distinct morphologic patterns in metastatic BCC and highlights the utility of ancillary molecular testing for accurate diagnosis. PMID: 31355851 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 29, 2019 Category: Pathology Authors: Laga AC, Schaefer IM, Sholl LM, French CA, Hanna J Tags: Am J Clin Pathol Source Type: research

Repeat Biomarker Status in Breast Resection Specimens With Controlled Cold Ischemic Time.
CONCLUSIONS: When CIT is optimized, a meaningful change in biomarker expression is infrequent. This study supports that when specimens are appropriately triaged, CIT of 4 hours or less may be acceptable. PMID: 31338514 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 24, 2019 Category: Pathology Authors: East EG, Roberts E, Zhao L, Jorns JM Tags: Am J Clin Pathol Source Type: research

Harmonization of Training, Training Requirements, Board Certification, and Practice of Hematopathology.
CONCLUSIONS: These results highlight how varied the practice of HP is and can provide guidance to HP PDs, those responsible for assessing HP programs, and the American Board of Pathology. PMID: 31338515 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 24, 2019 Category: Pathology Authors: Swerdlow SH, Monaghan SA, Douglas AR, Johnson K, Johnson RL Tags: Am J Clin Pathol Source Type: research

Does Provider Specialty Matter?
CONCLUSIONS: This study provides a framework for using a cross-sectional analytical approach to assess test utilization patterns and evaluate components of laboratory testing menus. PMID: 31332424 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 23, 2019 Category: Pathology Authors: Stubblefield JM, Lasley MV, Virant FS, Dickerson JA Tags: Am J Clin Pathol Source Type: research

Clinical and Histopathologic Predictors of Disaccharidase Deficiency in Duodenal Biopsy Specimens.
CONCLUSIONS: Utilization could be reduced by only testing cases with normal duodenal histopathology and ongoing clinical suspicion for DS deficiency after reviewing pathology. In cases with suspected celiac disease and/or mucosal injury, DS deficiency is common and likely secondary, limiting test utility. PMID: 31332425 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 23, 2019 Category: Pathology Authors: Reed RC, Pacheco MC Tags: Am J Clin Pathol Source Type: research

Selective vs Complete Sampling in Hysterectomy Specimens Performed for Atypical Hyperplasia.
CONCLUSIONS: Selective sampling is a feasible method to save time and resources while maintaining diagnostic accuracy. PMID: 31332427 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 23, 2019 Category: Pathology Authors: Bryant BH, Doughty E, Kalof AN Tags: Am J Clin Pathol Source Type: research

Printculture of Surgical Pathology and Autopsy Specimens.
CONCLUSIONS: Printculture allows the identification of microorganisms from routinely frozen tissues and provides a bridge between microbiology and histomorphology through the identification of associated histologic features of infection. This technique can be successfully integrated into autopsy and surgical pathology workup of potentially infected tissues. PMID: 31334549 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 23, 2019 Category: Pathology Authors: McMullen PD, Tesic V, Pytel P Tags: Am J Clin Pathol Source Type: research

The Prognosis of Stage IA Mixed Endometrial Carcinoma.
CONCLUSIONS: Patients with endometrial cancer of mixed subtypes had inferior survival outcomes. PMID: 31318970 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 19, 2019 Category: Pathology Authors: Li W, Li L, Wu M, Lang J, Bi Y Tags: Am J Clin Pathol Source Type: research

Comparison of Two Commercial Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) Systems for Identification of Nontuberculous Mycobacteria.
CONCLUSIONS: Both systems identified most NTM isolates to the group/complex level, and many to the highest taxonomic level. Performance was comparable. PMID: 31314059 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 17, 2019 Category: Pathology Authors: Brown-Elliott BA, Fritsche TR, Olson BJ, Vasireddy S, Vasireddy R, Iakhiaeva E, Alame D, Wallace RJ, Branda JA Tags: Am J Clin Pathol Source Type: research

Resolution of HCV-Autoimmune Hepatitis Overlap Syndrome With Antiviral TreatmentA Paired Liver Biopsy Study.
CONCLUSIONS: Histologic improvements in inflammation and fibrosis are noted in most HCV-AIH patients after DAA treatment, suggesting that the autoimmune component of the HCV-AIH overlap syndrome is merely a secondary phenomenon of viral infection. PMID: 31310654 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 16, 2019 Category: Pathology Authors: Putra J, Schiano TD, Fiel MI Tags: Am J Clin Pathol Source Type: research

Clinical Referral Laboratory Personnel's Perception of Challenges and Strategies for Sustaining the Laboratory Quality Management System.
CONCLUSIONS: The coordination, follow-up, and assessments of LQMS, in conjunction with training of laboratory workforce, would establish an institutional culture of continuous quality improvement (CQI) towards accreditation and sustainment of quality health care. To achieve CQI culture, routine gap checking and planning for improvement using a system approach is required. PMID: 31304959 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 15, 2019 Category: Pathology Authors: Rusanganwa V, Gahutu JB, Evander M, Hurtig AK Tags: Am J Clin Pathol Source Type: research

Premalignant Clonal Hematopoietic Proliferations.
CONCLUSIONS: Current diagnostic criteria for the diagnoses of premalignant clonal hematopoietic proliferations are reviewed and discussed in the context of the cases presented at the workshop. PMID: 31305863 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 15, 2019 Category: Pathology Authors: Nardi V, Kuo FC, Hasserjian RP Tags: Am J Clin Pathol Source Type: research

Bone Marrow Findings in Patients With Acute Promyelocytic Leukemia Treated With Arsenic Trioxide.
CONCLUSIONS: Bone marrow biopsies from patients treated with ATO have unusual but characteristic features. Despite variability in marrow findings, clinical outcomes were uniformly favorable. PMID: 31305869 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 15, 2019 Category: Pathology Authors: Miller KP, Venkataraman G, Gocke CD, Batista DA, Borowitz MJ, Burns KH, Pratz K, Duffield AS Tags: Am J Clin Pathol Source Type: research

Tumor-Infiltrating Lymphocyte Volume Is a Better Predictor of Disease-Free Survival Than Stromal Tumor-Infiltrating Lymphocytes in Invasive Breast Carcinoma.
CONCLUSIONS: Tumor-stroma ratio needs to be considered in estimation of tumor immunity, and TILV adds more predictive power to TILs. PMID: 31305879 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 15, 2019 Category: Pathology Authors: Vaziri Fard E, Ali Y, Wang XI, Saluja K, H Covinsky M, Wang L, Zhang S Tags: Am J Clin Pathol Source Type: research

Assessment of The Bethesda System for Reporting Thyroid Cytopathology.
CONCLUSIONS: Appropriate ROM for thyroid FNA can be achieved through application of TBSRTC terminology with minimal use of atypical category. PMID: 31305880 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 15, 2019 Category: Pathology Authors: Sauter JL, Lehrke H, Zhang X, Al Badri OT, Rodriguez-Gutierrez R, Delivanis DA, Singh Ospina N, Donegan D, Hamidi O, Iñiguez-Ariza N, Sharma A, Kittah NEN, Tamhane SU, Hurtado Andrade MD, Kotwal A, Jenkins SM, Spears G, Rivera M, Dean DS, Henry MR Tags: Am J Clin Pathol Source Type: research

Laboratory Evaluation of Antiphospholipid Syndrome.
CONCLUSIONS: Noncriteria tests can contribute to diagnosis and stratification of APS but do not improve diagnostic yield. Optimal strategies for implementation require prospective investigation. PMID: 31305881 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 15, 2019 Category: Pathology Authors: Heikal N, Martins TB, White SK, Willis R, Ware Branch D, Schmidt RL, Tebo AE Tags: Am J Clin Pathol Source Type: research

Study on Diagnostic Values of Astrocyte Elevated Gene 1 (AEG-1) and Glypican 3 (GPC-3) in Hepatocellular Carcinoma.
CONCLUSIONS: AEG-1 or GPC-3 alone seemed not an ideal marker for HCC. The combination of AEG-1 and GPC-3 might improve early diagnosis of HCC. PMID: 31305883 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 15, 2019 Category: Pathology Authors: Cao W, Sharma M, Imam R, Yu J Tags: Am J Clin Pathol Source Type: research

Restrictive Transfusion Strategy and Clinical Decision Support Practices for Reducing RBC Transfusion Overuse.
CONCLUSIONS: Based on these procedures, adherence to an institutional restrictive transfusion strategy and use of CPOE/CDS tools for hemoglobin alerts or reminders of the institution's restrictive transfusion policies are effective in reducing RBC transfusion overuse. PMID: 31305890 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 15, 2019 Category: Pathology Authors: H Derzon J, Clarke N, Alford A, Gross I, Shander A, Thurer R Tags: Am J Clin Pathol Source Type: research

Migration of Talc From the Perineum to Multiple Pelvic Organ Sites.
CONCLUSIONS: Our report adds new insights into the biologic potential of talc and suggests additional anatomic sites that should be closely examined for talc by oncologic surgical pathologists in the setting of perineal talc use. PMID: 31305893 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 15, 2019 Category: Pathology Authors: McDonald SA, Fan Y, Welch WR, Cramer DW, Godleski JJ Tags: Am J Clin Pathol Source Type: research

Use of Autofluorescence to Intraoperatively Diagnose Visceral Pleural Invasion From Frozen Sections in Patients With Lung Adenocarcinoma 2 cm or Less.
CONCLUSIONS: Using autofluorescence in frozen sections appears to be an accurate method for diagnosing VPI, which is helpful for surgical decision making. PMID: 31305894 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 15, 2019 Category: Pathology Authors: Xie H, Su H, Chen D, Xie D, Dai C, Ren Y, She Y, Xu L, Zhao S, Wu C, Jiang G, Chen C Tags: Am J Clin Pathol Source Type: research

Expression Pattern of Aquaporin 1 and Aquaporin 3 in Melanocytic and Nonmelanocytic Skin Tumors.
CONCLUSIONS: To our knowledge, this work represents the first demonstration of AQP1/AQP3 expression in human melanocytic skin tumors. More studies are needed to understand the underlying molecular mechanisms of expression of both AQPs in melanocytic tumors and their potential as molecular therapeutic targets. PMID: 31305898 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 15, 2019 Category: Pathology Authors: Osorio G, Zulueta-Dorado T, González-Rodríguez P, Bernabéu-Wittel J, Conejo-Mir J, Ramírez-Lorca R, Echevarría M Tags: Am J Clin Pathol Source Type: research

CD161 Is Expressed in a Subset of T-Cell Prolymphocytic Leukemia Cases and Is Useful for Disease Follow-up.
CONCLUSIONS: These novel results suggest that CD161 is often aberrantly expressed in a defined subset of T-PLL positive for CD8. We are showing the utility of this immunophenotype in diagnosis and follow-up. PMID: 31305900 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 15, 2019 Category: Pathology Authors: Gilles SR, Yohe SL, Linden MA, Dolan M, Hirsch B, Grzywacz B Tags: Am J Clin Pathol Source Type: research

Germline Predisposition to Hematolymphoid Neoplasia.
CONCLUSIONS: The majority of the submitted neoplasms occurring in patients with germline predisposition were myeloid neoplasms with germline mutations in GATA2 and RUNX1. The presence of a germline predisposition mutation is not sufficient for a diagnosis of a neoplasm until the appearance of standard diagnostic features of a hematolymphoid malignancy manifest: in general, the diagnostic criteria for neoplasms associated with germline predisposition disorders are the same as those for sporadic cases. PMID: 31309983 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 12, 2019 Category: Pathology Authors: Weinberg OK, Kuo F, Calvo KR Tags: Am J Clin Pathol Source Type: research

Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma.
CONCLUSIONS: While TLLGNPPA displays a morphological resemblance to papillary thyroid carcinoma (PTC), it is vital to differentiate nasopharyngeal metastasis from PTC for appropriate treatment. PMID: 31287861 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 9, 2019 Category: Pathology Authors: Huang F, Xiang X, Hong B, Min J, Li J Tags: Am J Clin Pathol Source Type: research

Molecular Genetics in the Diagnosis and Biology of Lymphoid Neoplasms.
CONCLUSIONS: Application of emerging technical advances has revealed the complexity of genetic events in lymphomagenesis, progression, and acquired resistance to therapies. They also contribute to enhanced understanding of the biology of indolent vs aggressive behavior, clonal evolution, tumor progression, and transcriptional reprogramming associated with transdifferentiation events that may occur subsequent to therapy. PMID: 31278738 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 6, 2019 Category: Pathology Authors: Lim MS, Bailey NG, King RL, Piris M Tags: Am J Clin Pathol Source Type: research