Laboratory Monitoring of Platelet P2Y12 Receptor Inhibitors and Reversal of Antiplatelet Agents: An ACLPS Critical Review.
Conclusions: Current evidence does not support changing antiplatelet therapy based on the results of platelet function monitoring tests. For emergent reversal of P2Y12 inhibitors, test method can affect platelet dosing recommendations, as different methods may give different results. PMID: 30395148 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 3, 2018 Category: Pathology Authors: Senzel L, Ahmed T, Spitzer ED Tags: Am J Clin Pathol Source Type: research

Breast Cancers With Magee Equation Score of Less Than 18, or 18-25 and Mitosis Score of 1, Do Not Require Oncotype DX Testing: A Value Study.
Conclusions: Cases with ME scores less than 18, or 18 to 25 and mitosis score 1, do not require Oncotype DX testing, an estimated saving of US$280,000 per 100 clinical requests. PMID: 30395177 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 2, 2018 Category: Pathology Authors: Bhargava R, Clark BZ, Dabbs DJ Tags: Am J Clin Pathol Source Type: research

Comparison of the Seventh and Eighth Editions of the American Joint Committee on Cancer pT and pN Classifications as Predictors of Survival in Patients With Oral Squamous Cell Carcinoma.
Conclusions: Of the competing AJCC staging criteria, the revised pN classification was the most powerful system to predict OSCC survivals. PMID: 30383186 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 31, 2018 Category: Pathology Authors: Jain D, Dravid C, Singla A, Kumari S, Grover RK Tags: Am J Clin Pathol Source Type: research

Microarray-Based Nucleic Acid Assay and MALDI-TOF MS Analysis for the Detection of Gram-Negative Bacteria in Direct Blood Cultures.
Conclusions: The BC-GN assay exhibited superior performance compared with MALDI-TOF MS for the identification of targeted GNRs in direct BCs, particularly in polymicrobial samples. PMID: 30383194 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 31, 2018 Category: Pathology Authors: Kim SY, Park JS, Hong YJ, Kim TS, Hong K, Song KH, Lee H, Kim ES, Kim HB, Park KU, Song J, Koo SH, Kim EC Tags: Am J Clin Pathol Source Type: research

Reference Values for WBC Differential by Hematoflow Analysis.
Conclusions: These normal values will be helpful in the definition of relevant threshold for the automatic validation of samples analyzed by flow cytometry and the flagging of pathologic samples. PMID: 30383211 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 31, 2018 Category: Pathology Authors: Magierowicz M, Lechevalier N, Freynet N, Pastoret C, Badaoui B, Ly-Sunnaram B, Fest T, Lacombe F, Wagner-Ballon O, Roussel M Tags: Am J Clin Pathol Source Type: research

Anemia Management and Audit Feedback Practices for Reducing Overuse of RBC Transfusion: A Laboratory Medicine Best Practice Systematic Review and Meta-Analysis.
Conclusions: Preoperative anemia management reduces the proportion of patients transfused and units of RBCs transfused. Audit with feedback across cases, physicians, and/or service areas, as part of a continuous quality improvement practice, reduces the proportion of patients and units of RBCs transfused. PMID: 30357323 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 24, 2018 Category: Pathology Authors: Derzon J, Alford A, Clarke N, Gross I, Shander A, Thurer R Tags: Am J Clin Pathol Source Type: research

Portal Cavernoma Cholangiopathy: Histologic Features and Differential Diagnosis.
Conclusions: This case series provides clinicopathologic characteristics of portal cavernoma cholangiopathy. Histologic changes are reminiscent of hepatoportal sclerosis and/or bile duct obstruction. Attention to portal veins can provide helpful diagnostic clues, especially when biopsy samples are obtained from patients with a known portal vein thrombus or cavernoma. PMID: 30357333 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 24, 2018 Category: Pathology Authors: Pittman ME, Kierans AS, Rao D, Yantiss RK, Samstein B, Jessurun J Tags: Am J Clin Pathol Source Type: research

Optimization of Laboratory Ordering Practices for Complete Blood Count With Differential.
Conclusions: The educational intervention changed the ordering practices of CBC w/diff and CBC tests. This was sustained after the intervention and no negative effects on patient care were noted. Similar interventions may lead to optimization of ordering practices of other laboratory tests. PMID: 30357374 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 24, 2018 Category: Pathology Authors: Shen JZ, Hill BC, Polhill SR, Evans P, Galloway DP, Johnson RB, Reddy VVB, Bosarge PL, Rice-Jennings LA, Lorenz RG Tags: Am J Clin Pathol Source Type: research

Measuring Scientific Impact With the h-Index: A Primer for Pathologists.
Conclusions: Pathologists and clinical laboratory scientists should be familiar with the h-index, as it may be used in decisions about professional advancement. PMID: 30346467 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 20, 2018 Category: Pathology Authors: Schreiber WE, Giustini DM Tags: Am J Clin Pathol Source Type: research

Association of PD-L1, PD-L2, and Immune Response Markers in Matched Renal Clear Cell Carcinoma Primary and Metastatic Tissue Specimens.
Abstract Objectives: Immune checkpoint therapy has been promising in renal cell carcinoma, but no validated clinically relevant biomarkers exist. Metastatic deposits may have discordant biomarker expression. Methods: Fifty matched pairs of primary and metastatic kidney tumors were evaluated via immunohistochemistry for immune checkpoint proteins PD-1, PD-L1, and PD-L2 and the T-cell and macrophage surface markers CD3, FOXP3, and CD163. Semiquantitative scores incorporating prevalence of both tumor and nontumor labeling were compared between metastatic and primary kidney tumor specimens. Results: A large ...
Source: American Journal of Clinical Pathology - October 20, 2018 Category: Pathology Authors: Basu A, Yearley JH, Annamalai L, Pryzbycin C, Rini B Tags: Am J Clin Pathol Source Type: research

IRTA1 and MNDA Expression in Marginal Zone Lymphoma: Utility in Differential Diagnosis and Implications for Classification.
Abstract Objectives: To evaluate the clinical utility of immune receptor translocation-associated protein 1 (IRTA1) and myeloid nuclear differentiation antigen (MNDA) expression in the diagnosis and classification of marginal zone lymphomas (MZLs). Methods: IRTA1 was examined using a novel RNA in situ hybridization assay and MNDA expression determined by immunohistochemistry in 127 small B-cell neoplasms, including 80 cases of MZL. Results: IRTA1 expression was detected in 31 (42%) of 74 MZLs vs one (2%) of 43 other small B-cell neoplasms (P
Source: American Journal of Clinical Pathology - October 20, 2018 Category: Pathology Authors: Wang Z, Cook JR Tags: Am J Clin Pathol Source Type: research

Implementation of Good Clinical Laboratory Practice in an Immunology Basic Research Laboratory: The KEMRI-Wellcome Trust Research Laboratories Experience.
Conclusions: The methodology, suggestions, and comments that arose from our experience in implementing GCLP guidelines can be used by other laboratories to develop a quality system using GCLP guidelines to support medical research conducted to ensure the research data are reliable and can be easily reconstructed in other research settings. PMID: 30339188 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 18, 2018 Category: Pathology Authors: Gumba H, Musyoki J, Mosobo M, Lowe B Tags: Am J Clin Pathol Source Type: research

Evaluation of Peritumoral Fibrosis in Metastatic Colorectal Adenocarcinoma to the Liver Using Digital Image Analysis.
Conclusions: Fibrosis is markedly increased in peritumoral liver. Fibrosis levels returned to baseline by 5 mm from tumor in approximately 75% of cases. Pathologists should be cautious of fibrosis in mass-directed liver biopsies without at least 5 mm of liver tissue distal to the mass. PMID: 30339201 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 18, 2018 Category: Pathology Authors: Waters KM, Cottrell TR, Besharati S, Zhu Q, Anders RA Tags: Am J Clin Pathol Source Type: research

Identification of HER2 Immunohistochemistry-Negative, FISH-Amplified Breast Cancers and Their Response to Anti-HER2 Neoadjuvant Chemotherapy.
Conclusions: A small percentage of patients (1.5%) showed discordant HER2 IHC and ISH results (IHC-/ISH+) and would have lost the opportunity for potentially beneficial anti-HER2-targeted therapy if only HER2 IHC testing had been used. PMID: 30339245 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 18, 2018 Category: Pathology Authors: Gibbons-Fideler IS, Nitta H, Murillo A, Tozbikian G, Banks P, Parwani AV, Li Z Tags: Am J Clin Pathol Source Type: research

Lymphoepithelioma-Like Carcinoma of the Uterine Cervix: A Pathologic Study of Eight Cases With Emphasis on the Association With Human Papillomavirus.
Conclusions: This study shows that cervical LELCs are associated with HPV and not EBV. PMID: 30321260 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 15, 2018 Category: Pathology Authors: Pinto A, Huang M, Nadji M Tags: Am J Clin Pathol Source Type: research

Sensitivity of Cerebrospinal Fluid Cytology for the Diagnosis of Cryptococcal Infections: A 21-Year Single-Institution Retrospective Review.
Conclusions: When culture is used as a gold standard, CSF cytology is 100% specific and 39% sensitive, with a positive predictive value of 100% and a negative predictive value of 99.8%. PMID: 30321269 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 15, 2018 Category: Pathology Authors: McHugh KE, Gersey M, Rhoads DD, Procop GW, Zhang Y, Booth CN, Sturgis CD Tags: Am J Clin Pathol Source Type: research

Performance Evaluation and Measurement Uncertainty Determination of the New Version of the Abbott ARCHITECT 25-OH Vitamin D 5P02 Assay.
Conclusions: The restandardized ARCHITECT assay has acceptable performance in a clinical setting. However, there is still a need for further standardization of total vitamin D measurement among the automated immunoassays. PMID: 30307462 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 10, 2018 Category: Pathology Authors: Lim YK, Park AJ, Kweon OJ, Choi JH Tags: Am J Clin Pathol Source Type: research

Diagnostic Accuracy of β-d-Glucan (Fungitell) Testing Among Patients With Hematologic Malignancies or Solid Organ Tumors: A Systematic Review and Meta-Analysis.
Conclusions: The overall sensitivity and specificity of Fungitell as a diagnostic test for IFI is moderate, and there is substantial heterogeneity between studies. Limiting studies to only low-bias risk reduced heterogeneity but also lowered the overall specificity estimate. PMID: 30307463 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 10, 2018 Category: Pathology Authors: White SK, Walker BS, Hanson KE, Schmidt RL Tags: Am J Clin Pathol Source Type: research

Bone Marrow Biopsy Needle Type Affects Core Biopsy Specimen Length and Quality and Aspirate Hemodilution.
Conclusions: Bone marrow biopsy needle type affects the length of evaluable marrow and quality of core and aspirate specimens. PMID: 30307478 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 10, 2018 Category: Pathology Authors: Brestoff JR, Toland A, Afaneh K, Qavi AJ, Press B, Westervelt P, Kreisel F, Hassan A Tags: Am J Clin Pathol Source Type: research

False-Positive Light Chain Clonal Restriction by Flow Cytometry in Patients Treated With Alemtuzumab: Potential Pitfalls for the Misdiagnosis of B-Cell Neoplasms.
Conclusions: Alemtuzumab can produce direct interference during flow cytometry analysis, resulting in false-positive evidence of light chain clonality. Clinicians and laboratorians should be cognizant of this risk to avoid misdiagnosis of B-cell neoplasms. PMID: 30307483 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 10, 2018 Category: Pathology Authors: Chen PP, Tormey CA, Eisenbarth SC, Torres R, Richardson SS, Rinder HM, Smith BR, Siddon AJ Tags: Am J Clin Pathol Source Type: research

Establishing Pediatric and Adult RBC Reference Intervals With NHANES Data Using Piecewise Regression.
Conclusions: The reference intervals provided here, based on a large, nationally representative healthy population, contribute to the ongoing transition to precision medicine. PMID: 30285066 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 4, 2018 Category: Pathology Authors: Fulgoni VL, Agarwal S, Kellogg MD, Lieberman HR Tags: Am J Clin Pathol Source Type: research

Unexpectedly High Prevalence of Cystoisospora belli Infection in Acalculous Gallbladders of Immunocompetent Patients.
Conclusions: C belli resides in a latent state in the gallbladder and may be best considered a commensal organism. PMID: 30285068 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 4, 2018 Category: Pathology Authors: Noor M, Katzman PJ, Huber AR, Findeis-Hosey JJ, Whitney-Miller C, Gonzalez RS, Zhou Z, N'kodia HD, Skonick K, Abell RL, Saubermann LJ, Lamps LW, Drage MG Tags: Am J Clin Pathol Source Type: research

HLA-Mediated Platelet Refractoriness: An ACLPS Critical Review.
Conclusions: Following confirmation and review of HLA antibody testing, platelets are ordered based upon the PRA% and approach employed, HLA-matched platelets, antigen restricted platelets, or cross-matched platelets. The platelets are transfused and a posttransfusion increment count is monitored to determine transfusion success. PMID: 30285067 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 3, 2018 Category: Pathology Authors: Schmidt AE, Refaai MA, Coppage M Tags: Am J Clin Pathol Source Type: research

The American Society for Clinical Pathology's 2017 Wage Survey of Medical Laboratories in the United States.
Conclusions: Survey results encourage laboratory professionals to be actively engaged in advocating for the profession in the workforce and educational training programs. Awareness of the career opportunities and value of the profession is needed to strengthen the future of the field. PMID: 30272142 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2018 Category: Pathology Authors: Garcia E, Kundu I, Fong K Tags: Am J Clin Pathol Source Type: research

Correction.
Authors: PMID: 30277508 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2018 Category: Pathology Tags: Am J Clin Pathol Source Type: research

The Impact of Renal Tissue Procurement at Bedside on Specimen Adequacy and Best Practices.
Abstract Objectives: Renal biopsy is the gold standard for the diagnosis of both native and allograft renal diseases. We studied the impact of tissue procurement at bedside (TPB) omission on the adequacy of renal biopsies. Methods: We compared 120 renal biopsies collected during 2015 using TPB with 111 renal biopsies collected during 2016 when TPB was discontinued. Adequacy criteria were applied as follows: by light microscopy, 10 glomeruli and two arteries for allograft biopsies and seven glomeruli for native biopsies. At least one glomerulus was considered adequate for immunofluorescence and electron micros...
Source: American Journal of Clinical Pathology - September 28, 2018 Category: Pathology Authors: Wooldridge JT, Davis A, Fischer WG, Khalil MF, Zhang M, Afrouzian M Tags: Am J Clin Pathol Source Type: research

Establishing a Long-Term Model for Analysis and Improvement of Underfilled Blood Culture Volumes.
Conclusions: Partnering with a specific unit and providing monthly volume reports with educational sessions has a direct positive correlation on increasing ABCFVs. Increasing ABCFVs has the potential to decrease false-negative blood cultures, time to detection of positive blood cultures, and time to appropriate and specific antimicrobial therapy, as well as improve patient outcomes in high-acuity patient care units. PMID: 30260386 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2018 Category: Pathology Authors: Zaleski M, Erdman P, Adams J, Michael A, Rudy A, Boesch R, Allison L, Mailander P, Hess W, Myers D, Craft D Tags: Am J Clin Pathol Source Type: research

Comparison Study of BD Onclarity HPV With digene HC2 High-Risk HPV DNA Test and Roche Cobas 4800 HPV for Detecting High-Risk Human Papillomavirus in Japan.
Conclusion: The results showed that the clinical performance of Onclarity was equivalent to HC2 and Cobas. PMID: 30260388 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 26, 2018 Category: Pathology Authors: Nakamura M, Nakade K, Orisaka S, Iwadare J, Mizumoto Y, Fujiwara H Tags: Am J Clin Pathol Source Type: research

Thymomas With a Prominent Alveolar Growth Pattern: A Clinicopathologic and Immunohistochemical Study of 12 Cases.
Conclusions: The cases herein described highlight the spectrum of growth patterns that thymomas may show and also highlight the importance to keep thymomas in the differential diagnosis of tumor with prominent alveolar-like growth pattern. PMID: 30247496 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 22, 2018 Category: Pathology Authors: Kalhor N, Moran CA Tags: Am J Clin Pathol Source Type: research

Impact of Interventions to Change CBC and Differential Ordering Patterns in the Emergency Department.
Abstract Objectives: A CBC with leukocyte differential (CBC-DIFF) is a frequently ordered emergency department (ED) test. The DIFF component often does not add to clinical decision making. Our objective was to evaluate the impact of a performance improvement project on CBC ordering. Methods: ED orders for CBC-DIFF were identified through the laboratory information system. Two interventions were evaluated: an educational intervention regarding CBC-DIFF uses and a reprioritization of ED CBC-DIFF and CBC in the electronic medical record (EMR) orders. Pearson χ2 tests were used to assess for differences in th...
Source: American Journal of Clinical Pathology - September 22, 2018 Category: Pathology Authors: Phelan MP, Nakashima MO, Good DM, Hustey FM, Procop GW Tags: Am J Clin Pathol Source Type: research

Development, Implementation, and Evaluation of a Fourth-Year Medical School Elective Course in Blood Banking and Transfusion Medicine.
Conclusions: A short course for medical students that allowed repetition of concepts using several teaching modalities improved their knowledge in transfusion medicine. PMID: 30239572 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 18, 2018 Category: Pathology Authors: Sullivan HC, Stowell SR, Meyer EK, Duncan AD, Guarner J Tags: Am J Clin Pathol Source Type: research

Analysis and Comparison of Tissue-Marking Dye Detection via Light Microscopy, Telemicroscopy, and Virtual Microscopy.
Conclusions: TMD identification via telepathology showed loss of sensitivity/specificity vs LM and highlighted the need for caution when interpreting TMDs with digital technologies and the need for validation protocols. PMID: 30239594 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 17, 2018 Category: Pathology Authors: Hon JD, Chen W, Minerowicz C, Thomas S, Barnard N, Gilbert N, Fyfe B Tags: Am J Clin Pathol Source Type: research

Quality and Quantity in Kidney Cancer Surgery: The Role of Nonneoplastic Kidney and Kidney Volumetrics in Predicting Postoperative Renal Function.
Conclusions: Quantitative analysis of the nephrectomized kidney in conjunction with patient age can accurately predict renal function at 2 years. PMID: 30212840 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 13, 2018 Category: Pathology Authors: Pruthi DK, Oomah S, Lu V, Ting T, Knickle C, Liss MA, Gibson IW, Kirkpatrick IDC, McGregor TB Tags: Am J Clin Pathol Source Type: research

A Proposal for Separation of Nuclear Atypia and Architectural Atypia in Bethesda Category III (AUS/FLUS) Based on Differing Rates of Thyroid Malignancy.
This study investigates whether the two types of atypia have different rates of malignancy (ROMs). Methods: Cytologic and histologic diagnoses of resected thyroid nodules were recorded. ROM was calculated for all Bethesda categories and for 3N and 3A subcategories. Possible noninvasive follicular thyroid neoplasms with papillary-like nuclear features were reviewed and removed from malignancies, and ROM was recalculated. Results: A total of 1,396 nodules were included. ROM of 3N (33.3%-26.0%) was higher than 3A (7.7%-5.0%) (P
Source: American Journal of Clinical Pathology - September 13, 2018 Category: Pathology Authors: Johnson DN, Cavallo AB, Uraizee I, Tanager K, Lastra RR, Antic T, Cipriani NA Tags: Am J Clin Pathol Source Type: research

Herpes Simplex Virus-1 qPCR in the Diagnosis of Lower Respiratory Tract Infections in Organ Transplant Recipients and Critically Ill Patients.
Abstract Objectives: To determine a quantitative herpes simplex virus (HSV) DNA threshold in lower respiratory tract specimens that correlates with positive viral culture and clinical outcomes. Methods: Bronchoalveolar lavage and bronchial wash samples from 53 HSV culture-positive and 61 culture-negative matched controls were tested using HSV-1 and HSV-2 quantitative polymerase chain reaction (qPCR). Results: Median viral culture turnaround time was 21.8 days and 9.9 days for culture-negative and culture-positive specimens, respectively. Using an HSV-1 viral load threshold of 1.62 × 103 copies/mL, ...
Source: American Journal of Clinical Pathology - September 13, 2018 Category: Pathology Authors: Stram MN, Suciu CN, Seheult JN, McCullough MA, Kader M, Wells A, William Pasculle A, Rinaldo CR, Ismail N Tags: Am J Clin Pathol Source Type: research

Using the EPIDEM Model of Quality Improvement to Increase Value of BCR-ABL1 Tests.
Conclusions: Our molecular pathology laboratory successfully used the EPIDEM model of quality improvement to improve the ordering of BCR-ABL1 tests and promote better patient care by focusing on educational efforts and modification of laboratory workflow. PMID: 30212872 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 13, 2018 Category: Pathology Authors: Yin F, Zheng W, Lucas MD, Allen RA, Zhou Y Tags: Am J Clin Pathol Source Type: research

NK-Cell Enteropathy and Similar Indolent Lymphoproliferative Disorders: A Case Series With Literature Review.
Conclusions: These cases support the indolent nature of NKCE and similar LPDs, and they indicate that involvement outside the alimentary canal may occur. PMID: 30212873 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 13, 2018 Category: Pathology Authors: Xia D, Morgan EA, Berger D, Pinkus GS, Ferry JA, Zukerberg LR Tags: Am J Clin Pathol Source Type: research

Benefits and Pitfalls of Point-of-Care Coagulation Testing for Anticoagulation Management: An ACLPS Critical Review.
Conclusions: POC coagulation testing for anticoagulation monitoring offers advantages in particular situations. Clear policies and protocols must be developed to guide proper use of POC versus central laboratory hemostasis testing. PMID: 30215666 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 11, 2018 Category: Pathology Authors: Wool GD Tags: Am J Clin Pathol Source Type: research

Detection of Cervical Neoplasia by Human Papillomavirus Testing in an Atypical Squamous Cells-Undetermined Significance Population: Results of the Becton Dickinson Onclarity Trial.
Conclusions: Onclarity is clinically validated for ASC-US triage. Through risk stratification, genotyping could help identify women at highest risk for CIN 3+. PMID: 30189049 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 5, 2018 Category: Pathology Authors: Wright TC, Stoler MH, Parvu V, Yanson K, Eckert K, Kodsi S, Cooper CK Tags: Am J Clin Pathol Source Type: research

Therapeutic Monoclonal Antibodies and the Value of the Free Light Chain Assay in Myeloma.
PMID: 30184092 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 3, 2018 Category: Pathology Authors: Jialal I, Pahwa R, Beck RC, Schmotzer CL Tags: Am J Clin Pathol Source Type: research

Reference Intervals: Comparison of Calculation Methods and Evaluation of Procedures for Merging Reference Measurements From Two US Medical Centers.
Conclusions: Parametric methods are recommended when inappropriate values cannot be excluded. The nonparametric procedures may generate wider RIs. Data sets larger than 200 are recommended for robust estimates. Caution should be exercised when merging intrainstitutional data. PMID: 30169553 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 30, 2018 Category: Pathology Authors: Klee GG, Ichihara K, Ozarda Y, Baumann NA, Straseski J, Bryant SC, Wood-Wentz CM Tags: Am J Clin Pathol Source Type: research

Using Machine Learning-Based Multianalyte Delta Checks to Detect Wrong Blood in Tube Errors.
Conclusions: Machine learning-based multianalyte delta checks may offer a practical strategy to identify WBIT errors prior to test reporting and improve patient safety. PMID: 30169595 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 30, 2018 Category: Pathology Authors: Rosenbaum MW, Baron JM Tags: Am J Clin Pathol Source Type: research

Identification of Clinically Relevant Mycobacterial Species After Extended Incubation Times in the BACTEC MGIT System.
Conclusions: These data provide strong evidence reaffirming that clinically meaningful results are frequently detected after extended incubation times by broth-only methods, including several MTB isolates. PMID: 30169764 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 30, 2018 Category: Pathology Authors: Rea B, Maisel JR, Glaser L, Alby K Tags: Am J Clin Pathol Source Type: research

Comparison of Three Different TTF-1 Clones in Resected Primary Lung Cancer and Epithelial Pulmonary Metastases.
Conclusions: TTF-1 expression in lung cancer and pulmonary metastases differs between clones, with 8G7G3/1 being more specific but less sensitive compared with SPT24 and SP141. PMID: 30169783 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 30, 2018 Category: Pathology Authors: Vidarsdottir H, Tran L, Nodin B, Jirström K, Planck M, Mattsson JSM, Botling J, Micke P, Jönsson P, Brunnström H Tags: Am J Clin Pathol Source Type: research

Evaluation of Ethanol Interference on Routine Biochemical Tests.
Conclusions: We conclude that ethanol may cause interference in the measurement of some biochemical tests, whereas the most prominent effect was observed for LDH and ALT. PMID: 30169725 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 29, 2018 Category: Pathology Authors: Gümüs A Tags: Am J Clin Pathol Source Type: research

Clinical Utility of CINtec PLUS Triage in Equivocal Cervical Cytology and Human Papillomavirus Primary Screening.
Conclusions: These findings highlight the potential of CINtec PLUS to improve management pathways in HPV-positive women. CINtec PLUS cytology represents a sensitive and efficient triage in HPV-positive women. The clinical performance of the dual-stain was most notable in women younger than 25 years and could potentially improve management pathways. PMID: 30169728 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 29, 2018 Category: Pathology Authors: McMenamin M, McKenna M, McDowell A Tags: Am J Clin Pathol Source Type: research

The Evolution of the Clinical Pathologist.
PMID: 30165557 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 24, 2018 Category: Pathology Authors: Kroft SH Tags: Am J Clin Pathol Source Type: research

Enhanced Detection of Cervical Cancer and Precancer Through Use of Imaged Liquid-Based Cytology in Routine Cytology and HPV Cotesting.
Conclusions: LBC enhanced cotesting detection of CxCa and CIN3/AIS to a greater extent than previously reported with conventional Pap smear and HPV cotesting. PMID: 30137189 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 20, 2018 Category: Pathology Authors: Austin RM, Onisko A, Zhao C Tags: Am J Clin Pathol Source Type: research

Pathologic T Descriptor of Nonmucinous Lung Adenocarcinomas Now Based on Invasive Tumor Size: How Should Pathologists Measure Invasion?
Abstract Objectives: The eighth edition of the American Joint Committee on Cancer staging manual now stratifies nonmucinous lung adenocarcinomas (nmLACAs) by the size of the invasive component only. This is determined by direct gross or microscopic measurement; however, a calculated invasive size based on the percentage of invasive growth patterns has been proposed as an alternative option. Methods: To compare radiologic with different pathologic assessments of invasive tumor size, we retrospectively reviewed a cohort of resected nmLACAs with a part-solid appearance on computed tomography (CT) scan (n = 112)....
Source: American Journal of Clinical Pathology - August 4, 2018 Category: Pathology Authors: Anderson KR, Onken A, Heidinger BH, Chen Y, Bankier AA, VanderLaan PA Tags: Am J Clin Pathol Source Type: research

Magee Equation Recurrence Score Is Associated With Distal Metastatic Risk in Male Breast Carcinomas: Experience From Two Institutions.
Abstract Objectives: To conduct a clinicopathologic study of male breast carcinoma with Magee equation recurrence score (RS). Methods: Seventy-four cases of male invasive breast cancers (MBCs) were studied, including 63 hormone receptor (HR)-positive, 10 human epidermal growth factor receptor 2-positive, and one triple-negative breast cancers. Results: Among 63 HR-positive MBC patients, nine patients developed distal metastasis. Statistical analysis demonstrated distal metastasis was significantly associated with positive lymph node, high Nottingham grade, and increased Magee equation RS. All HR-positive...
Source: American Journal of Clinical Pathology - August 4, 2018 Category: Pathology Authors: Hou Y, Moosavi HS, Wei L, Parwani AV, Li XB, Li Z Tags: Am J Clin Pathol Source Type: research