Immune microenvironment of intimal sarcomas: Adaptive immune resistance with potential therapeutic implications
CONCLUSIONS: These data show that intimal sarcomas have an active tumor microenvironment with an adaptive pattern of PD-L1 expression. Our results suggest that immunotherapy may be an effective treatment option.PMID:37921094 | DOI:10.1093/ajcp/aqad142 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 3, 2023 Category: Pathology Authors: Jacqueline E Birkness-Gartman Dwayne L Thomas Logan L Engle Lysandra Voltaggio Elizabeth D Thompson Source Type: research

Determination of age-dependent bone marrow normocellularity
CONCLUSIONS: The findings revealed a more stable and slower rate of decline in cellularity with age in adults than the widely used linear model of "100% minus the patient age in decades." Normocellularity is better modeled based on age group. In those younger than 20 years of age, normocellularity ranges from 45% to 85% (mean [SD], 65% [20%]), as defined by Friebert et al in 1998. Based on our study finding of a little less than 3% decline per decade of age, the following is our recommendation for normocellularity range: For individuals 20 to 40 years of age, it ranges from 40% to 70% (mean [SD], 55% [15%]); for individual...
Source: American Journal of Clinical Pathology - October 31, 2023 Category: Pathology Authors: Jerry Wong Ryan Jackson Lu Chen Joo Song Raju Pillai Michelle Afkhami Olga Danilova Patricia Aoun Karl K Gaal Young Kim Source Type: research

Determination of age-dependent bone marrow normocellularity
CONCLUSIONS: The findings revealed a more stable and slower rate of decline in cellularity with age in adults than the widely used linear model of "100% minus the patient age in decades." Normocellularity is better modeled based on age group. In those younger than 20 years of age, normocellularity ranges from 45% to 85% (mean [SD], 65% [20%]), as defined by Friebert et al in 1998. Based on our study finding of a little less than 3% decline per decade of age, the following is our recommendation for normocellularity range: For individuals 20 to 40 years of age, it ranges from 40% to 70% (mean [SD], 55% [15%]); for individual...
Source: American Journal of Clinical Pathology - October 31, 2023 Category: Pathology Authors: Jerry Wong Ryan Jackson Lu Chen Joo Song Raju Pillai Michelle Afkhami Olga Danilova Patricia Aoun Karl K Gaal Young Kim Source Type: research

Prognostic role of the log odds of positive lymph nodes in Western patients with resected gastric cancer: A comparison with the 8th edition of the TNM staging system
CONCLUSIONS: For our cohort, the LODDS system showed better prognostic performance than pN stage; it was an independent predictor of OS and DFS, and it provided valuable prognostic information in cases without lymph node metastases. Its prognostic accuracy, however, decreased in cases with fewer than 16 lymph nodes resected.PMID:37901915 | DOI:10.1093/ajcp/aqad119 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 30, 2023 Category: Pathology Authors: Cristina D íaz Del Arco Lourdes Estrada Mu ñoz Andr és Sánchez Pernaute Luis Ortega Medina Soledad Garc ía Gómez de Las Heras Ricardo Garc ía Martínez Mar ía Jesús Fernández Aceñero Source Type: research

Prognostic role of the log odds of positive lymph nodes in Western patients with resected gastric cancer: A comparison with the 8th edition of the TNM staging system
CONCLUSIONS: For our cohort, the LODDS system showed better prognostic performance than pN stage; it was an independent predictor of OS and DFS, and it provided valuable prognostic information in cases without lymph node metastases. Its prognostic accuracy, however, decreased in cases with fewer than 16 lymph nodes resected.PMID:37901915 | DOI:10.1093/ajcp/aqad119 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 30, 2023 Category: Pathology Authors: Cristina D íaz Del Arco Lourdes Estrada Mu ñoz Andr és Sánchez Pernaute Luis Ortega Medina Soledad Garc ía Gómez de Las Heras Ricardo Garc ía Martínez Mar ía Jesús Fernández Aceñero Source Type: research

168 Cases of aneurysmal dermatofibroma and 29 cases of hemosiderotic dermatofibroma: A clinicopathologic study
CONCLUSIONS: Our findings indicate a potential close relationship between ADF and HDF. Contrary to conventional beliefs, we also presented the possibility of ADF progressing into HDFs. Physical trauma may induce ADF, and HDFs may emerge from ADFs in conjunction with venous stasis in the lower extremities.PMID:37897209 | DOI:10.1093/ajcp/aqad136 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 28, 2023 Category: Pathology Authors: Akana Nishimoto Keigo Ito Satoshi Usami Rei Ogawa Satoshi Akaishi Shin-Ichi Ansai Source Type: research

168 Cases of aneurysmal dermatofibroma and 29 cases of hemosiderotic dermatofibroma: A clinicopathologic study
CONCLUSIONS: Our findings indicate a potential close relationship between ADF and HDF. Contrary to conventional beliefs, we also presented the possibility of ADF progressing into HDFs. Physical trauma may induce ADF, and HDFs may emerge from ADFs in conjunction with venous stasis in the lower extremities.PMID:37897209 | DOI:10.1093/ajcp/aqad136 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 28, 2023 Category: Pathology Authors: Akana Nishimoto Keigo Ito Satoshi Usami Rei Ogawa Satoshi Akaishi Shin-Ichi Ansai Source Type: research

Automated prediction of acute promyelocytic leukemia from flow cytometry data using a graph neural network pipeline
CONCLUSIONS: Our ML pipeline shows robust performance on predicting APL and could be used to screen for APL using MFC data. It also allowed for intuitive interrogation of the model's predictions by clinicians.PMID:37878540 | DOI:10.1093/ajcp/aqad145 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 25, 2023 Category: Pathology Authors: Andrew M Cox Daehwan Kim Rolando Garc ía Franklin S Fuda Olga K Weinberg Weina Chen Source Type: research

Effect of residual platelets in frozen-thawed plasma on results of dilute Russell's viper venom time assay for lupus anticoagulant testing
CONCLUSIONS: Residual platelets in plasma samples result in shortening of DRVVT assay after 1 freeze-thaw cycle. This may result in a false-negative LAC test result.PMID:37878771 | DOI:10.1093/ajcp/aqad138 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 25, 2023 Category: Pathology Authors: Brenda J Nelson Strande Meera Sridharan Rachel R Leger Melissa S Stuart Julie I Tange Serena D Navitska Nahla Heikal Aneel A Ashrani Dong Chen Jansen N Seheult Rajiv K Pruthi Source Type: research

Automated prediction of acute promyelocytic leukemia from flow cytometry data using a graph neural network pipeline
CONCLUSIONS: Our ML pipeline shows robust performance on predicting APL and could be used to screen for APL using MFC data. It also allowed for intuitive interrogation of the model's predictions by clinicians.PMID:37878540 | DOI:10.1093/ajcp/aqad145 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 25, 2023 Category: Pathology Authors: Andrew M Cox Daehwan Kim Rolando Garc ía Franklin S Fuda Olga K Weinberg Weina Chen Source Type: research

Effect of residual platelets in frozen-thawed plasma on results of dilute Russell's viper venom time assay for lupus anticoagulant testing
CONCLUSIONS: Residual platelets in plasma samples result in shortening of DRVVT assay after 1 freeze-thaw cycle. This may result in a false-negative LAC test result.PMID:37878771 | DOI:10.1093/ajcp/aqad138 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 25, 2023 Category: Pathology Authors: Brenda J Nelson Strande Meera Sridharan Rachel R Leger Melissa S Stuart Julie I Tange Serena D Navitska Nahla Heikal Aneel A Ashrani Dong Chen Jansen N Seheult Rajiv K Pruthi Source Type: research

Automated prediction of acute promyelocytic leukemia from flow cytometry data using a graph neural network pipeline
CONCLUSIONS: Our ML pipeline shows robust performance on predicting APL and could be used to screen for APL using MFC data. It also allowed for intuitive interrogation of the model's predictions by clinicians.PMID:37878540 | DOI:10.1093/ajcp/aqad145 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 25, 2023 Category: Pathology Authors: Andrew M Cox Daehwan Kim Rolando Garc ía Franklin S Fuda Olga K Weinberg Weina Chen Source Type: research

Effect of residual platelets in frozen-thawed plasma on results of dilute Russell's viper venom time assay for lupus anticoagulant testing
CONCLUSIONS: Residual platelets in plasma samples result in shortening of DRVVT assay after 1 freeze-thaw cycle. This may result in a false-negative LAC test result.PMID:37878771 | DOI:10.1093/ajcp/aqad138 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 25, 2023 Category: Pathology Authors: Brenda J Nelson Strande Meera Sridharan Rachel R Leger Melissa S Stuart Julie I Tange Serena D Navitska Nahla Heikal Aneel A Ashrani Dong Chen Jansen N Seheult Rajiv K Pruthi Source Type: research

Acute leukemia with cytogenetically cryptic FGFR1 rearrangement and lineage switch during therapy: A case report and literature review
CONCLUSIONS: Ours is the only reported case of FGFR1-rearranged neoplasms with a disease sequence of acute myeloid leukemia transforming to B-cell acute lymphoblastic leukemia and 1 of only 3 reported cases with cytogenetically cryptic FGFR1 rearrangement. Fluorescence in situ hybridization testing for FGFR1 rearrangement should be a standard investigation in leukemia of mixed or switching lineage.PMID:37855739 | DOI:10.1093/ajcp/aqad135 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 19, 2023 Category: Pathology Authors: Sean J McKeague Kacey O'Rourke Stephen Fanning Christopher Joy Duncan Throp Rebecca Adams Yasmin Harvey Tee Beng Keng Source Type: research

Acute leukemia with cytogenetically cryptic FGFR1 rearrangement and lineage switch during therapy: A case report and literature review
CONCLUSIONS: Ours is the only reported case of FGFR1-rearranged neoplasms with a disease sequence of acute myeloid leukemia transforming to B-cell acute lymphoblastic leukemia and 1 of only 3 reported cases with cytogenetically cryptic FGFR1 rearrangement. Fluorescence in situ hybridization testing for FGFR1 rearrangement should be a standard investigation in leukemia of mixed or switching lineage.PMID:37855739 | DOI:10.1093/ajcp/aqad135 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 19, 2023 Category: Pathology Authors: Sean J McKeague Kacey O'Rourke Stephen Fanning Christopher Joy Duncan Throp Rebecca Adams Yasmin Harvey Tee Beng Keng Source Type: research