Cell and genome organization in mitosis, development, and homeostasis
NIH Director ’ s Wednesday Afternoon Lecture Series
I began my research career studying how microtubules regulate various cellular processes, especially microtubule assembly, mitotic spindle assembly, and chromosome segregation. As a PhD student in Dr. Berl Oakley ’ s lab, my study of g-tubulin has inspired me to use biochemical approaches to investigate the mechanism of microtubule nucleation as a postdoctoral fellow in Drs. Bruce Alberts and Tim Mitchison ’ s labs at UCSF. This has led to the discovery of the g-tubulin ring complex (gTuRC) and the demonstration of its microtubule-nucleating activity from purified t...
Source: Videocast - All Events - June 12, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
1) Hematopoietic Stem Cell Transplantation: Evolution in Understanding, Revolution in Therapy and 2) Minimizing the Scourge of Graft-Versus-Host Disease with Post-Transplantation Cyclophosphamide
For more information go tohttps://www.cc.nih.gov/about/news.htmlAir date: 5/23/2018 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - April 24, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Uncovering Unknown Unknowns of Gene Regulation
NIH Director's Seminar Series
Identification of genes and processes associated with specific biological phenotypes is a fundamental step toward understanding the molecular basis of development and pathogenesis. This seminar will discuss the use of integrative systems biology approaches to uncover unknown unknowns of gene regulation. Dr. Raja Jothi will discuss data-driven efforts toward identification and characterization of genes with previously unknown roles in embryonic stem cell biology and findings on an unanticipated role for intragenic enhancers in attenuating their host gene expression.Air date: 4/13/2018 12:00:00 ...
Source: Videocast - All Events - March 26, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Inflammation and hematopoietic stem cell regulation
NIH Director ’ s Wednesday Afternoon Lecture Series
Blood-forming hematopoietic stem cells (HSC) usually remain quiescent until activated to respond to hematopoietic demands. Quiescence is an actively enforced state that is regulated by important bone marrow (BM) niche signals, which prevent entry into the cell cycle and suppress oxidative metabolism. In fact, HSC activation is as much a metabolic remodeling with oxidative phosphorylation (OXPHOS) activation, as a direct triggering of the cell-cycle machinery. It is now becoming clear that the most glycolytic and quiescent HSCs perform the best in transplantation experim...
Source: Videocast - All Events - February 20, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Hematopoietic stem cells in stress, disease, and aging
NIH Director ’ s Wednesday Afternoon Lecture Series
Dr. Passagu é 's research investigates the biology of blood-forming hematopoietic stem cells in normal and deregulated contexts such as development of hematological malignancies and physiological aging.For more information go tohttps://oir.nih.gov/wals/2017-2018Air date: 2/21/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 5, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
2018 Demystifying Medicine: Use of induced pluripotent stem cells (iPSC) for regenerative medicine
The Demystifying Medicine Lecture Series is designed to help bridge the gap between advances in biology and their applications to major human diseases. The lectures include presentations of patients, pathology, diagnosis, and therapy in the context of major diseases and current research. All clinicians, trainees including fellows, medical students, Ph.D. students, and other healthcare and research professionals are welcome to attend.For more information go tohttps://demystifyingmedicine.od.nih.govAir date: 4/10/2018 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 15, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Norman P. Salzman Memorial Award and Symposium in Virology 2017
The Foundation for the National Institutes of Health (FNIH) and the NIH Virology Interest Group announce the Nineteenth Annual Norman P. Salzman Memorial Symposium and Award in Virology. The Award will be presented to an outstanding Postdoctoral Fellow, Research Fellow, or Clinical Fellow working in the field of virology within the intramural NIH, CBER, or Leidos community. The Award honors Dr. Salzman's 40-year career in virology research and his accomplishments in mentoring of young scientists. The Symposium program highlights current research of eminent extramural and intramural virologists.
Michel Nussenzweig, M.D., Ph...
Source: Videocast - All Events - October 27, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Stem Cell Aging
GeroScience Interest Group
The Trans-NIH GeroScience Interest Group (GSIG), cordially invites you to its fall seminar, featuring Dr. Sean Morrison. Dr. Morrison is the Director of the Children ’ s Medical Center Research Institute at UT Southwestern and is the Mary McDermott Cook Chair in Pediatric Genetics as well as an Investigator of the Howard Hughes Medical Institute. The Morrison laboratory studies the cellular and molecular mechanisms that regulate the function of stem cells and cancer cells in the nervous and hematopoietic systems. The laboratory is particularly interested in the mechanisms that regulate stem cel...
Source: Videocast - All Events - October 26, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
The development and Function of Regulatory T cells
Immunology Interest Group Seminar Series
Dr. Chen ’ s research focuses on elucidating mechanisms of T-cell immunity and tolerance and manipulating T-cell immunity versus tolerance in animal models to understand the pathogenesis of and develop immunotherapy for autoimmunity, cancer and infectious diseases. Among his many scientific contributions to biomedical research, Dr. Chen is the first to discover that TGF-beta induces Foxp3 gene in naive CD4+ T cells and converts them into regulatory T cells (iTregs, pTregs). The paper describing this finding has been cited for more than 4000 times. He has also demonstrated that TGF...
Source: Videocast - All Events - September 25, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Workshop on Translational Challenges of Induced Pluripotent Stem Cells
The discovery of induced pluripotent stem cells (iPSCs) more than a decade ago has transformed stem cell biology and biomedical research in such fields as disease modeling, drug discovery, predictive toxicology and regenerative medicine applications. To bring iPSC-based therapies more efficiently to patients, it is pivotal to continue addressing the key knowledge gaps and roadblocks in a coordinated multidisciplinary fashion. This workshop will focus on defining the collaborative opportunities, challenges and best practices in translational iPSC research. Topics of interest are quality control standards for pluripotency, s...
Source: Videocast - All Events - September 14, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Hematopoietic Stem Cells Aging – Mechanisms, Consequences and Interventions
The Trans-NIH GeroScience Interest Group (GSIG), cordially invites you to its summer seminar, featuring Dr. Emmanuelle Passegu é . Dr. Passegue is a Professor in the Department of Genetics and Development at the Columbia University Medical Center and Director of the Columbia Stem Cell Initiative (CSCI) in New York. She is widely recognized for her expertise on hematopoietic stem cell (HSC) biology. Her research over the past 10-years has focused on understanding the cellular and molecular processes controlling HSC activity during homeostasis, and addressing how these regulations are changed in myeloid malignancies and phy...
Source: Videocast - All Events - June 20, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
CC Grand Rounds: Eltrombopag in Aplastic Anemia: Making Blood Stem Cells Great Again
For more information go tohttp://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 6/21/2017 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - May 16, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Production, characterization, and application of stem cell-derived photoreceptors
NEI AGI Seminar in Neuroregenerative Medicine
3-D organoids are the next big thing in disease modeling, drug screening, and tissue sourcing for transplantation. These miniature organs can be grown from patient-derived stem cells, providing a theoretically unlimited supply.
David Gamm, M.D., Ph.D., will summarize efforts to develop retinal organoids derived from human pluripotent stem cells. The retina is the light-sensitive tissue in the back of the eye that sends visual signals to the brain. The most common blinding conditions in the U.S. affect the retina, including age-related macular degeneration, diabetic retinopathy,...
Source: Videocast - All Events - May 15, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
The Hedgehog Pathway and the Race against Tumor Resistance
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Oro is a Professor of Dermatology, Associate Director of the Center for Definitive and Curative Medicine, a member of the Institute for Stem Cell Biology and Regenerative Medicine and the Stanford Cancer Institute at Stanford University, and the Cancer Biology and Stem Cell graduate student programs. He trained in the medical scientist program at the Salk Institute under Ron Evans lab, working on functions of novel orphan nuclear receptors in model systems. During Dermatology residency/fellowship in Matthew Scott ’ s lab at Stanford, he helped solidify the link ...
Source: Videocast - All Events - May 1, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Strategies for Neuroprotection and Myelin Repair
NIH Neuroscience Series Seminar
Our ability to move, think, perceive, is dependent on a timely transmission of information among specialized cells called neurons. This information is sent via a series of electrical impulses that travel along specialized structures called " axons " , whose ability to conduct signal is dependent on the presence of " myelin " . Myelin is a fatty substance composed of lipids and proteins that is an integral component of a cell called " oligodendrocyte " . Oligodendrocytes are the myelin-forming cells of the CNS and are essential for brain function. Oligodendrocytes originate from neural stem c...
Source: Videocast - All Events - March 31, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
