Clinical Center Grand Rounds: How Nucleic Acid Structure and Chromatin Environment Influence Gene Transcription
How Nucleic Acid Structure and Chromatin Environment Influence Gene Transcription
Jason Watts, MD, PhD
Earl Stadtman Investigator
Epigenetics& Stem Cell Biology Laboratory
Transcriptional Responses in Disease Group
National Institute of Environmental Health Sciences, NIEHSFor more information go tohttps://clinicalcenter.nih.gov/about/news/grcurrent.htmlAir date: 2/22/2023 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 2, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Matrix Viscoelasticity and Cancer
Changes in matrix stiffness is increasingly appreciated as a key variable in cancer research, but most current work ignores that tissues are viscoelastic, with time-dependent mechanical behavior. Using biomaterials that allow independent control over key variables, we find that the rate of matrix stress relaxation has dramatic effects on stem cell fate, and impacts multiple cell types in the tumor microenvironment, including cancer cells, monocytes, and T cells. Inspired by the importance of viscoelasticity to extracellular matrix, new medical adhesives are being synthesized from energy dissipative hydrogel networks.For mo...
Source: Videocast - All Events - January 17, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Lineage tracking in rhesus macaques: new insights into natural killer cells and tissue-resident myeloid cells.
Dr. Dunbar ’ s research focuses on understanding the process of hematopoiesis in vivo, as well as on optimizing and improving the safety of gene transfer into primary hematopoietic cells for therapeutic purposes. Her goals are synergistic: insight into the control of hematopoiesis is required to successfully manipulate and genetically modify hematopoietic cells; conversely, genetic marking of hematopoietic stem and progenitor cells has provided novel insights into lineage relationships, stem cell dynamics, and stem cell numbers in vivo that are applicable to gene therapy, stem cell transplantation, and other clinical int...
Source: Videocast - All Events - January 9, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH-FDA Immunology Interest Group Seminar
All immune system cells develop from a common hematopoietic stem cell (HSC) whose differentiation pathway is controlled in part by the activation and repression of lineage specific gene programs. Our laboratory is interested in understanding how these transcriptional programs are wired and how alterations in these pathways lead to disease such as autoimmunity, asthma and acute leukemia. ID2 and ID3 control the development and effector fate of innate lymphoid cells including NK cells, ILCs and NKT cells. Our laboratory has focused on understanding how ID protein expression is regulated in innate lymphoid cells and how the t...
Source: Videocast - All Events - December 12, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Allogeneic Hematopoietic Stem Cell Transplant For GATA2 Deficiency: The Past Is Prologue To The Future; Mycobacteria, Monocytopenia And Myelodysplasia Come Together at GATA2
Allogeneic Hematopoietic Stem Cell Transplant For GATA2 Deficiency: “ The Past Is Prologue To The Future
Mycobacteria, Monocytopenia And Myelodysplasia Come Together at GATA2For more information go tohttps://clinicalcenter.nih.gov/about/news/grcurrent.htmlAir date: 6/22/2022 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - May 19, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Assay Guidance Workshop for High-Throughput Screening and Lead Discovery - Day 1
The NCATS Assay Guidance Manual (AGM) is hosting a two-day workshop that will cover a broad range of critical concepts underlying assay development and implementation for high-throughput screening and lead discovery projects. This workshop is designed to disseminate critical information about the implementation of robust assay methods and is particularly relevant for researchers developing molecular probes or clinical candidates. Many of the workshop instructors have 20 to 30 years of experience in the field of drug discovery and will share information not readily found in a classroom or published material outside of the A...
Source: Videocast - All Events - April 25, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Assay Guidance Workshop for High-Throughput Screening and Lead Discovery - Day 2
The NCATS Assay Guidance Manual (AGM) is hosting a two-day workshop that will cover a broad range of critical concepts underlying assay development and implementation for high-throughput screening and lead discovery projects. This workshop is designed to disseminate critical information about the implementation of robust assay methods and is particularly relevant for researchers developing molecular probes or clinical candidates. Many of the workshop instructors have 20 to 30 years of experience in the field of drug discovery and will share information not readily found in a classroom or published material outside of the A...
Source: Videocast - All Events - April 25, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Organoids to Model Human Disease
Stem cells are the foundation of all mammalian life. They come in two flavors. Embryonic stem cells are briefly present in the early human or mouse embryo, a few days after fertilization. These stem cells can be grown indefinitely in the lab and have the potential to build each and every tissue in our body. ES cells hold great promise in the field of regenerative medicine. Adult stem cells. Every organ in our body harbors its own dedicated stem cells. These adult stem cells replace tissue that is lost due to wear and tear, trauma and disease. Adult stem cells can only produce the tissue in which they reside. The adult stem...
Source: Videocast - All Events - November 26, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
NEI AGI Seminar: Human iPSC-derived 3D retinal tissue for stem cell-based therapies for retinal degenerative diseases
Dr. Canto-Soler completed her Ph.D. in Biomedical Sciences at Austral University in Argentina and a postdoctoral fellowship at the Wilmer Eye Institute, Johns Hopkins University. She joined the Wilmer faculty as a research associate in 2006 and was promoted to assistant professor in 2008. In July 2017 she joined the Department of Ophthalmology at the University of Colorado School of Medicine as the Doni Solich Family Chair in Ocular Stem Cell Research and the Director of CellSight – the Ocular Stem Cell and Regeneration Research Program. Over the years she has received several national and international awards including ...
Source: Videocast - All Events - November 10, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
NEI AGI Seminar
The National Eye Institute (NEI) invites you to “ Human iPSC-derived 3D retinal tissue for stem cell-based therapies for retinal degenerative diseases ” by Dr. Valeria Canto-Soler, as part of the Audacious Goals Initiative (AGI) Seminar Series in Neuroregeneration.For more information go tohttps://www.nei.nih.gov/about/goals-and-accomplishments/nei-research-initiatives/audacious-goals-initiative/events-and-reports/agi-seminar-human-ipsc-derived-3d-retinal-tissueAir date: 11/19/2021 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 7, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Engineering Human Tissues for Medical Impact
The newly established Biomedical Engineering Scientific Interest Group (BMESIG) is launching a seminar series, to start on Tuesday, Oct. 12 at 1 p.m. with a lecture by Dr. Gordana Vunjak-Novakovic, director of the Laboratory for Stem Cells and Tissue Engineering at Columbia University.
The inaugural speaker Vunjak-Novakovic has pioneered the use of stem cell engineering to grow tissue. Working primarily in the field of temporomandibular joint (TMJ) disorders, Vunjak-Novakovic ’ s lab has successfully grown bone grafts that match a patient ’ s original jawbone for facial reconstruction surgery to repair injuries, disea...
Source: Videocast - All Events - October 4, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Blood Stem Cell Clonality and the Niche
Speaker Leonard Zon, M.D., is HHMI Investigator; Grousbeck Professor of Pediatric Medicine, Harvard Medical School; Director, Stem Cell Program at Boston Children's Hospital. The Zon laboratory aims to dissect how assaults to the hematopoietic system cause severe diseases such as leukemias, lymphomas, and anemias. They investigate hematopoietic development and disease using chemical screens, genetic screens, and analysis of novel transgenic lines in zebrafish.For more information go tohttps://oir.nih.gov/walsAir date: 11/17/2021 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 8, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Women Leaders in Academic Research - Building New Roads: The Importance of Tenacity, Resilience, and Mentorship
Women Leaders in Academic Research
Invited monthly lecture series highlighting& honoring women leaders in academic research. The honorary lecture series was established as a small effort to help counter the under-representation of women in academic research& the impact of gender disparity& implicit bias on role modeling and mentoring. Monthly topics are open-ended& are geared towards highlighting successful female or other under-represented academic leaders, as role models for trainees.
Innovation and advancement are critical to Radiology, but the culture and structure of our field and training are rarely conducive to the ...
Source: Videocast - All Events - April 14, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Understanding and Modeling Aging
This is the rescheduled annual Florence Mahoney Lecture on Aging. Speaker Anne Brunet, Ph.D., Stanford University, is interested in the molecular mechanisms of aging and longevity, with a particular emphasis on the nervous system. Her lab is interested in identifying pathways involved in delaying aging in response to external stimuli such as availability of nutrients and mates. She also seeks to understand the mechanisms that influence the rejuvenation of old stem cells. Her lab has pioneered the naturally short-lived African killifish as a new model to explore the regulation of aging and age-related diseases.For more info...
Source: Videocast - All Events - February 10, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
NIDCR Clinical Research Fellowship Grand Round: Stem Cells in Jaw Growth and Disease
NIDCR Clinical Research Fellowship Grand Round
The temporomandibular joint (TMJ) is the synovial joint of craniofacial complex and is critical for dental occlusion, mastication, and speech. TMJ trauma and diseases, such as osteoarthritis, are debilitating and compromise quality of life. Current TMJ treatments are two-fold, involving either palliative care or invasive total joint replacement surgeries. There are no minimally invasive, regenerative TMJ therapies. We have identified TMJ-specific fibrocartilage stem cells that self-organize and regenerate cartilage, fat and vascularized bone. Here we define heterogeneous popul...
Source: Videocast - All Events - November 6, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
