Forcing Tumor Progression

NCI’s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians.Dr. Valerie Weaver is the Director of the Center for Bioengineering and Tissue Regeneration in the Surgery Department. She also jointly oversees the UCSF Brain Tumor Microenvironment Program and co-directs the Bay Area Physical Sciences and Oncology Program. During Dr. Weaver’s tenure at LBNL she was awarded a California Breast Cancer Research Grant and received a Distinguished LBNL Scientist award for her seminal observations demonstrating how integrin-dependent tissue phenotype represses tumor genotype and how tissue architecture and a three dimensional extracellular matrix modulate tumor cell growth and survival and treatment response. After joining the faculty of the Institute for Medicine and Engineering at the University of Pennsylvania, Dr. Weaver pioneered studies that identified the critical role of mechanical force in breast tissue homeostasis and malignancy for which she was awarded a Department of Defense Breast Cancer Scholar award (2005). In 2006 Dr. Weaver relocated her group to the Surgery Department at UCSF in San Francisco where she definitively demonstrated, for the first time in 2009, the critical role for tissue tension in tumor progression in vivo. Since arriving at UCSF Dr. Weaver has expanded her research profile to include studies ad...
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