Patients in cancer remission at high risk for severe COVID-19 illness
(University of Pennsylvania School of Medicine) Patients with inactive cancer and not currently undergoing treatments also face a significantly higher risk of severe illness from COVID-19. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 21, 2021 Category: International Medicine & Public Health Source Type: news

Target discovered that halts osteoarthritis-type knee cartilage degeneration
(University of Pennsylvania School of Medicine) In a mouse study, researchers used nanotechnology and previous knowledge of a protein pathway to significantly reduce knee cartilage degeneration and pain (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 15, 2021 Category: International Medicine & Public Health Source Type: news

Flip the script: cardiac rehabilitation is underused, but a simple change could fix that
(University of Pennsylvania School of Medicine) Making doctors opt out from prescribing cardiac rehabilitation instead of opting in increased referrals by roughly 70 percent (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 14, 2021 Category: International Medicine & Public Health Source Type: news

Climate change doesn't spare the smallest
(University of Pennsylvania) With a combined century of experience in the tropics, the University of Pennsylvania's Daniel Janzen and Winnie Hallwachs have seen a striking contraction of insect numbers and diversity. They share new data suggesting that climate change is the culprit and a way to protect the survivors: a bioliteracy program that aims to educate Costa Rican residents about the diversity around them and empower them to conserve it. It's a model they hope catches on and spreads around the globe. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 14, 2021 Category: Biology Source Type: news

Scoring system to redefine how U.S. patients prioritized for liver transplant
(University of Miami Miller School of Medicine) Researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine are collaborating with faculty at the University of Pennsylvania to develop a risk score that more comprehensively prioritizes liver cancer patients for transplantation. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 13, 2021 Category: Cancer & Oncology Source Type: news

Why independent cultures think alike when it comes to categories: It's not in the brain
(University of Pennsylvania) A study from the Network Dynamics Group (NDG) at Penn's Annenberg School for Communication conducted an experiment in which people were asked to categorize unfamiliar shapes. Individuals and small groups created many different unique categorization systems while large groups created systems nearly identical to one another. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 12, 2021 Category: International Medicine & Public Health Source Type: news

Hunters and busybodies: Researchers use Wikipedia to measure different types of curiosity
(University of Pennsylvania) In the past, research on curiosity has mostly tried to quantify it, rather than to understand the different ways it can be expressed. Now, a new study led by researchers at Penn and American University uses Wikipedia browsing as a method for describing curiosity styles. Using a branch of mathematics known as graph theory, their analysis of curiosity opens doors for using it as a tool to improve learning and life satisfaction. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 12, 2021 Category: International Medicine & Public Health Source Type: news

mRNA Technology Gave Us the First COVID-19 Vaccines. It Could Also Upend the Drug Industry
“No!” The doctor snapped. “Look at me!” I had been staring her in the eyes, as she had ordered, but when a doctor on my other side began jabbing me with a needle, I started to turn my head. “Don’t look at it,” the first doctor said. I obeyed. This was in early August in New Orleans, where I had signed up to be a participant in the clinical trial for the Pfizer-BioNTech COVID-19 vaccine. It was a blind study, which meant I was not supposed to know whether I had gotten the placebo or the real vaccine. I asked the doctor if I would really been able to tell by looking at the syringe. &...
Source: TIME: Health - January 11, 2021 Category: Consumer Health News Authors: Walter Isaacson Tags: Uncategorized COVID-19 feature Magazine Source Type: news

mRNA Technology Gave Us the First COVID-19 Vaccines. It Could Also Upend the Drug Industry
“No!” The doctor snapped. “Look at me!” I had been staring her in the eyes, as she had ordered, but when a doctor on my other side began jabbing me with a needle, I started to turn my head. “Don’t look at it,” the first doctor said. I obeyed. This was in early August in New Orleans, where I had signed up to be a participant in the clinical trial for the Pfizer-BioNTech COVID-19 vaccine. It was a blind study, which meant I was not supposed to know whether I had gotten the placebo or the real vaccine. I asked the doctor if I would really been able to tell by looking at the syringe. &...
Source: TIME: Science - January 11, 2021 Category: Science Authors: Walter Isaacson Tags: Uncategorized COVID-19 feature Magazine Source Type: news

Youth with family history of suicide attempts have worse neurocognitive functioning
(Children's Hospital of Philadelphia) Children and adolescents with a family history of suicide attempts have lower executive functioning, shorter attention spans, and poorer language reasoning than those without a family history, according to a new study by researchers from the Lifespan Brain Institute (LiBI) of Children's Hospital of Philadelphia (CHOP) and the University of Pennsylvania. The study is the largest to date to examine the neurocognitive functioning of youth who have a biological relative who made a suicide attempt. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 11, 2021 Category: International Medicine & Public Health Source Type: news

New statistical method exponentially increases ability to discover genetic insights
(University of Pennsylvania School of Medicine) A test of the Sum-Share statistical method with only summary-level data found 1,734 genetic variations associated with cardiovascular-related conditions when just one had previously been likely. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 8, 2021 Category: Biology Source Type: news

Delivering the news with humor makes young adults more likely to remember and share
(University of Pennsylvania) Could the merging of humor and news actually help inform the public? New research from the Annenberg School at the University of Pennsylvania and the School of Communication at Ohio State University found that young people were more likely to remember information about politics and government policy when it was conveyed in a humorous rather than non-humorous manner. They were also more willing to share the information online. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 7, 2021 Category: International Medicine & Public Health Source Type: news

How medical schools can transform curriculums to undo racial biases
(University of Pennsylvania School of Medicine) Medical school curriculums may misuse race and play a role in perpetuating physician bias, a team led by Penn Medicine researchers found in an analysis of curriculum from the preclinical phase of medical education. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 7, 2021 Category: International Medicine & Public Health Source Type: news

Significant disparities in telemedicine use, especially among older and POC patients
(University of Pennsylvania School of Medicine) Older people as well as minorities, non-English speakers and those with lower incomes face inequities in accessing telemedicine care (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 29, 2020 Category: International Medicine & Public Health Source Type: news

How the Pandemic Is Imperiling a Working-Class College
The coronavirus has hurt Indiana University of Pennsylvania, but its financial problems were planted years ago. (Source: Reuters: Health)
Source: Reuters: Health - December 28, 2020 Category: Consumer Health News Source Type: news

Gut cells sound the alarm when parasites invade
(University of Pennsylvania) When the parasite Cryptosporidium enters the body, it's cells in the intestines that first recognize the invader, triggering an early immune response, according to a new study led by a team from the University of Pennsylvania. A leading cause of diarrheal disease in young children globally, the parasite generates an inflammatory response beginning in the intestines that exacerbates the effects of malnutrition. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 28, 2020 Category: International Medicine & Public Health Source Type: news

Will coronavirus vaccines work against new variant? University of Pennsylvania doctor weighs in
The new variant or mutation to the coronavirus reported in the United Kingdom is prompting new questions, like will the vaccine still work? (Source: Reuters: Health)
Source: Reuters: Health - December 23, 2020 Category: Consumer Health News Source Type: news

High rates of COVID-19 in a community reduces survival rates among hospitalized patients
A new study, from the University of Pennsylvania, found that hospitals located in counties in states like New York, New Jersey and Connecticut saw worse survival rates early on in the pandemic. (Source: the Mail online | Health)
Source: the Mail online | Health - December 22, 2020 Category: Consumer Health News Source Type: news

Concerns over infecting others matter more for vaccination in sparsely populated areas
(Annenberg Public Policy Center of the University of Pennsylvania) Concerns over infecting others play a greater role in people's willingness to be vaccinated in sparsely populated areas than in dense urban ones, according to new research. The findings have implications for public health communications regarding the COVID-19 and flu vaccines and others, and could help in reducing the rural-urban disparity in vaccination. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - December 21, 2020 Category: International Medicine & Public Health Source Type: news

Improving hospital nurse staffing is associated with fewer deaths from sepsis
(University of Pennsylvania School of Nursing) According to a new study published in American Journal of Infection Control, improving nurse staffing as proposed in pending legislation in New York state would likely save lives of sepsis patients and save money by reducing the length of hospital stays. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 17, 2020 Category: International Medicine & Public Health Source Type: news

Penn vision researchers honored by End Blindness 2020
(University of Pennsylvania) The Outstanding Achievement Prize highlights the contributions of the School of Veterinary Medicine's Gustavo D. Aguirre and the Perelman School of Medicine's Jean Bennett and Albert M. Maguire toward a gene therapy for a form of blindness. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 15, 2020 Category: International Medicine & Public Health Source Type: news

Behavioral strategies to promote a national COVID-19 vaccine program
(University of Pennsylvania School of Nursing) National efforts to develop a coronavirus disease 2019 (COVID-19) vaccine at 'warp speed' will likely yield a safe and effective vaccine by early 2021. However, this important milestone is only the first step in an equally important challenge: getting a majority of the U.S. public vaccinated. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - December 14, 2020 Category: Infectious Diseases Source Type: news

Fewer than 2 percent of OB-GYN doctors can prescribe life-saving opioid treatment
(University of Pennsylvania School of Medicine) Examining country-wide data, the researchers hoped to gauge how many obstetrician-gynecologists have their waiver to prescribe buprenorphine (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - December 11, 2020 Category: International Medicine & Public Health Source Type: news

CRISPR-edited CAR T cells enhance fight against blood cancers
(University of Pennsylvania School of Medicine) Knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells' ability to eliminate blood cancers. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 7, 2020 Category: Cancer & Oncology Source Type: news

Study finds no change in preterm birth or stillbirth in Philadelphia during pandemic
(Children's Hospital of Philadelphia) Despite early reports suggesting a decline in preterm births during the COVID-19 pandemic period, an analysis by researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania has found no change in preterm births or stillbirths at two Philadelphia hospitals in the first four months of the pandemic. The findings, published today in JAMA, resulted from the examination of an ongoing, racially-diverse pregnancy cohort that assesses both spontaneous and medically-indicated preterm birth. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - December 7, 2020 Category: Infectious Diseases Source Type: news

329 people injured by firearms in US each day, but for every death, 2 survive
(University of Pennsylvania School of Medicine) Researchers examine trends in fatal and nonfatal firearm injuries to inform prevention strategies, finding that twice as many people who are shot survive than die. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 7, 2020 Category: International Medicine & Public Health Source Type: news

Dynamic plants
(University of Pennsylvania) Led by University of Pennsylvania prof Brian Gregory and postdoc Xiang Yu, researchers have uncovered one way plants respond to hormonal cues. A similar process is likely at play in mammals. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 7, 2020 Category: International Medicine & Public Health Source Type: news

Novel anti-craving mechanism discovered to treat cocaine relapse
(University of Pennsylvania School of Nursing) Cocaine continues to be one of the most commonly abused illicit drugs in the United States. Pre-clinical literature suggests that targeting glucagon-like peptide-1 receptors (GLP-1Rs) in the brain may represent a novel approach to treating cocaine use disorder. Specifically, GLP-1R agonists, which are FDA-approved for treating diabetes and obesity, have been shown to reduce voluntary drug taking and seeking in preclinical models of cocaine used disorder. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 7, 2020 Category: International Medicine & Public Health Source Type: news

Updated Results from the Phase 1 Study of the BCMAxCD3 Bispecific Teclistamab Show Preliminary Efficacy in Patients with Heavily Pretreated Relapsed or Refractory Multiple Myeloma
This study evaluated the ability of teclistamab to induce cytotoxicity and T-cell activation.About TeclistamabTeclistamab is an investigational bispecific antibody targeting both BCMA and CD3. BCMA, B-cell maturation antigen, is expressed at high levels on multiple myeloma cells.[3],[4],[5],[6],[7] Teclistamab redirects CD3-positive T-cells to BCMA-expressing myeloma cells to induce cytotoxicity of the targeted cells.5,6 Results from preclinical studies demonstrate that teclistamab kills myeloma cell lines and bone marrow-derived myeloma cells from heavily pretreated patients.6 Teclistamab is currently being evaluated in a...
Source: Johnson and Johnson - December 5, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

ASH: Off-the-shelf immune drug shows promise in aggressive multiple myeloma
(University of Pennsylvania School of Medicine) A subcutaneous injection of the immune-boosting drug teclistamab was found to be safe and elicit responses in a majority of patients with relapsed or refractory multiple myeloma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 5, 2020 Category: Cancer & Oncology Source Type: news

NIDCR's Winter 2020 E-Newsletter
Having trouble viewing this email? View it as a Web page. NIDCR's Winter 2020 E-Newsletter In this issue: NIDCR News Funding Opportunities NIH/HHS News Funding Notices Science Advances Subscribe to NICDR News Grantee News   NIDCR News NIDCR Welcomes New Director Rena D’Souza Rena N. D’Souza, DDS, MS, PhD, was sworn in as the director of NIDCR by NIH Director Francis S. Collins, MD, PhD, on October 13. Prior to joining NIH, Dr. D’Souza was the assistant vice president for academic affairs and education for health s...
Source: NIDCR Science News - December 4, 2020 Category: Dentistry Source Type: news

Basser Center for BRCA awards 2020 Basser Global Prize to Sheba Medical Center doctor
(University of Pennsylvania School of Medicine) The Basser Center for BRCA at the Abramson Cancer Center of the University of Pennsylvania, the world's first comprehensive center aimed at advancing research, treatment, and prevention of BRCA-related cancers, is pleased to announce Bella Kaufman, MD, of the Sheba Medical Center in Tel-Hashomer, Israel, as the recipient of the eighth annual Basser Global Prize. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 4, 2020 Category: International Medicine & Public Health Source Type: news

In a holiday season unlike any other, avoid unfounded claims about suicide
(Annenberg Public Policy Center of the University of Pennsylvania) The holiday season usually has the lowest monthly suicide rates. And while the COVID-19 pandemic has increased risk factors associated with suicide, the media and the public should be careful this holiday season not to make unfounded claims about suicide trends. Last year, during the holidays and before the pandemic, about half of the newspaper stories that connected the holidays and suicide perpetuated the holiday-suicide myth. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 1, 2020 Category: International Medicine & Public Health Source Type: news

Increasing HPV vaccine uptake in adolescents
(University of Pennsylvania School of Nursing) More than 90 percent of human papillomavirus (HPV)-related cancers could be prevented by widespread uptake of the HPV vaccine. Yet, vaccine use in the United States falls short of public health goals. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 1, 2020 Category: Cancer & Oncology Source Type: news

Diabetes, High Blood Pressure Raise Odds of COVID Harming Brain
MONDAY, Nov. 30, 2020 -- COVID-19 patients with high blood pressure or diabetes may be more likely to develop critical neurological complications, including bleeding in the brain and stroke, according to an ongoing study. University of Pennsylvania... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 30, 2020 Category: General Medicine Source Type: news

Penn researchers unlock the door to tumor microenvironment for CAR T cells
(University of Pennsylvania School of Medicine) Combining chimeric antigen receptor (CAR) T cell therapy with a PAK4 inhibitor drug allowed the engineered cells to punch their way through and attack solid tumors, leading to significantly enhanced survival in mice. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 30, 2020 Category: Cancer & Oncology Source Type: news

Minorities value, perceive, and experience professionalism differently than their peers
(University of Pennsylvania School of Medicine) Marginalized groups of people value professionalism more -- and are more likely to leave a job at an institution due to issues of professionalism -- compared to their white, male counterparts, according to a Penn Medicine study of staff, faculty, and students who were affiliated with a large, academic health system in 2015 and 2017. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 24, 2020 Category: International Medicine & Public Health Source Type: news

Closing the racial disparity gap in survival after in-hospital cardiac arrest
(University of Pennsylvania School of Nursing) In-hospital cardiac arrests (IHCA) represent catastrophic and often terminal events. Despite investments to improve the quality of resuscitation efforts, fewer than 25% of all patients that experience cardiac arrests in hospitals survive to discharge, and survival varies significantly across hospitals and by race. Until now, few have been able to specify reasons for the between-hospital differences. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 24, 2020 Category: International Medicine & Public Health Source Type: news

Home health care improves COVID-19 outcomes
(University of Pennsylvania School of Nursing) Survivors of COVID-19 are a vulnerable population who often have health ramifications from their illness and hospital stay. Upon returning home from acute care, large proportions of survivors experience functional dependencies, pain, dyspnea, and exhaustion. Until now, no data has been available on the outcomes of COVID-19 patients discharged home after hospitalization and their recovery needs. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 23, 2020 Category: Infectious Diseases Source Type: news

COVID-19 patients survive in-hospital cardiac arrest at pre-pandemic rates
(University of Pennsylvania School of Medicine) Resuscitation and survival rates of hospitalized COVID-19 patients who've had cardiac arrest are much higher than earlier reports of near-zero; variation at the individual hospital level may have affected overall numbers (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 20, 2020 Category: International Medicine & Public Health Source Type: news

Potential cellular target for eliminating bone breakdown in osteoporosis found
(University of Pennsylvania School of Medicine) By disabling a function of a set of cells in mice, researchers appear to have halted the process that breaks down bone, a potential boon for osteoporosis treatment (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 20, 2020 Category: International Medicine & Public Health Source Type: news

Covid-19 patients with high blood pressure or diabetes at risk of fatal brain complications
University of Pennsylvania doctors looked at patients with life-threatening brain problems. Half had diabetes, while seven in 10 had high blood pressure. (Source: the Mail online | Health)
Source: the Mail online | Health - November 18, 2020 Category: Consumer Health News Source Type: news

Controversy continues over '13 Reasons Why' and adolescent suicide
(Annenberg Public Policy Center of the University of Pennsylvania) A new pair of commentaries in PLOS ONE debate a reanalysis of data concerning adolescent suicide and the Netflix series " 13 Reasons Why. " Although a 2019 study found a contagion effect among boys, an Annenberg Public Policy Center reanalysis concluded that, to the contrary, the series had no clear effect. The author of the reanalysis stands by his work. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 18, 2020 Category: International Medicine & Public Health Source Type: news

Just hours of training triples doctor confidence in use of handheld ultrasound devices
(University of Pennsylvania School of Medicine) Filling a training gap, a Penn Medicine doctor created a geriatric medicine-centered course for point-of-care-ultrasound (POCUS) devices that doubled doctor confidence. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 17, 2020 Category: International Medicine & Public Health Source Type: news

Two anti-inflammatory compounds shown to be capable of accelerating recovery from COVID-19
(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) Monoclonal antibody tested by researchers at University of S ã o Paulo and experimental drug given to patients in Italy by University of Pennsylvania research group promoted rapid improvement of respiratory function in patients hospitalized in severe condition. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 13, 2020 Category: Infectious Diseases Source Type: news

Parasitic worms offer 'the missing link' on the dual nature of a key immune regulator
(University of Pennsylvania) By studying two models of parasite infection, the University of Pennsylvania's De'Broski Herbert and colleagues filled in crucial gaps about the activity of the signaling molecule IL-33 that is critical to asthma, allergies, and other diseases. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 13, 2020 Category: International Medicine & Public Health Source Type: news

Penn Nursing Dean Antonia Villarruel to receive 2020 Globy Award
(University of Pennsylvania School of Nursing) The Global Philadelphia Association uses the award to recognize international significant achievements of Philadelphia leaders in medicine and business entrepreneurship. Penn Nursing Dean Antonia Villarruel is one of five recipients to be honored this year during the virtual 2020 Globy Awards celebration on December 14, 2020. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 13, 2020 Category: International Medicine & Public Health Source Type: news

From 84 days to 5 hours: Telemedicine reduces dermatology consult time
(University of Pennsylvania School of Medicine) Allowing primary care doctors to take photos and send them to dermatologists improved access to specialty care. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 11, 2020 Category: International Medicine & Public Health Source Type: news

Diagnostic imaging may increase risk of testicular cancer
(University of Pennsylvania School of Medicine) Early and repeated exposures to diagnostic imaging, such as X-rays and CT scans, may increase the risk of testicular cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 11, 2020 Category: Cancer & Oncology Source Type: news

Penn researchers present findings on cardiac risks for cancer patients
(University of Pennsylvania School of Medicine) Physician-researchers from the Perelman School of Medicine at the University of Pennsylvania will present findings about cardiac care for cancer patients and survivors at the American Heart Association's Scientific Sessions 2020. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 10, 2020 Category: International Medicine & Public Health Source Type: news