NIDCR Clinical Research Fellowship Grand Round: The temporomandibular Joint (TMJ)

The temporomandibular joint (TMJ) is the synovial joint of craniofacial complex and is critical for dental occlusion, mastication, and speech. TMJ trauma and diseases, such as osteoarthritis, are debilitating and compromise quality of life. Current TMJ treatments are two-fold, involving either palliative care or invasive total joint replacement surgeries. There are no minimally invasive, regenerative TMJ therapies. We have identified TMJ-specific fibrocartilage stem cells that self-organize and regenerate cartilage, fat and vascularized bone. Here we define heterogeneous populations of TMJ fibrocartilage stem cells and the signals regulating their fate in jaw development and disease. Finally we therapeutically exploit endogenous fibrocartilage stem cells as a potential strategy for TMJ regeneration using a pre-clinal, large animal model. Our studies will contribute towards the development of a non-surgical, minimally invasive stem cell-based therapy for TMJ regeneration. Dr. Embree is currently the Dr. Edwin S. Robinson Assistant Professor of Dental Medicine (Orthodontics) a Columbia College of Dental Medicine. She completed her DMD, PhD, Cell Biology, Medical University of South Carolina and her Residency at Columbia University School of Dentistry. While with NIH she has worked on multiple publications and many more outside of NIH. Dr. Embree conducts cutting edge research in both an academic and clinical setting with the goal of translating basic science into clinical pract...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video

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AbstractOsteoarthritis (OA) is a debilitating disease. A number of treatments like conservative approach, minimally invasive procedures and surgical therapy have proved to be beneficial. However, there is no consensus regarding the use of a single modality of treatment. Our current study evaluates the role of intra articular injection iPRF along with arthrocentesis for the management of temporomandibular joint osteoarthritis (TMJ-OA). A total of 130 patients were selected and divided into two groups, Group A (arthrocentesis only group) and Group B (arthrocentesis +i-PRF). Patients were evaluated for pain scores and maximal...
Source: Oral Surgery - Category: ENT & OMF Authors: Tags: ORIGINAL ARTICLE Source Type: research
In this study, we investigate harnessing fibrocartilage stem cell (FCSC) capacities by regulating tumor necrosis factor α (TNF-α) signaling for cartilage repair in temporomandibular joint osteoarthritis (TMJOA). Stem cell specifics for FCSCs were characterized in the presence of TNF-α. Etanercept as a TNF-α inhibitor and BAY 11-7082 as an Nf-κB inhibitor were used to study TNF-α regulation of FCSCs. Lineage tracing was performed in Gli1-CreERT+;Tmfl/fl mice when etanercept (1 mg/kg, every 3 d) or isometric vehicle was subcutaneously injected to trace specific changes in FCSCs. Surgically...
Source: Cell Research - Category: Cytology Authors: Source Type: research
To observe and analyze the interaction between excessive mechanical stress (MS) and decreased sex hormones on Temporomandibular Joint Osteoarthritis (TMJ-OA), and to discover TMJ-OA disease susceptibility genes by molecular biological analysis to elucidate part of the mechanism of TMJ-OA onset.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research
CONCLUSIONS: While the HCA increased in the presence of TMJ OA, no relationship was found between HCA and three different condylar positions.PMID:34355786 | DOI:10.5603/FM.a2021.0075
Source: Folia Morphologica - Category: Anatomy Authors: Source Type: research
To assess the level of evidence for genetic, biologic, and functional predictive and predisposing factors for end-stage temporomandibular joint arthritis within published literature.
Source: The British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Tags: Review Source Type: research
Biomed Res Int. 2021 Jul 9;2021:9978651. doi: 10.1155/2021/9978651. eCollection 2021.ABSTRACTTemporomandibular joint osteoarthritis (TMJOA) is characterized by chronic inflammatory degradation of mandibular condylar cartilage (MCC). Studies have found a positive correlation between inflammation and cyclooxygenase- (COX-) 2 in OA pathology. NF-κB is a crucial transcription factor of inflammatory and immune responses in the cause of TMJOA pathology. Resveratrol (RES) plays a critical role in antioxidation and anti-inflammation. But, studies on the effects of RES on TMJOA are very limited. So, the purpose of this study ...
Source: Biomed Res - Category: Research Authors: Source Type: research
In terms of diagnostic and therapeutic management, clinicians should adequately address the frequent aspects of temporomandibular joint (TMJ) osteoarthritis (OA) associated with disk displacement. Condylar ero...
Source: BMC Oral Health - Category: Dentistry Authors: Tags: Research Source Type: research
In conclusion, in our prospective community-based study, aging-related biomarkers were associated with measures of subclinical atherosclerosis cross-sectionally and with all-cause mortality prospectively, supporting the concept that these biomarkers may reflect the aging process in community-dwelling adults. The Role of Aging Macrophages in Skin Inflammation https://www.fightaging.org/archives/2021/06/the-role-of-aging-macrophages-in-skin-inflammation/ The immune system is complex and ages in complex ways, pressed by the lifetime burden of infection and rising levels of molecular damage that trigger many...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Senescent cell accumulation appears to be a major player in the pathology of most of the joint-related issues that occur in older individuals. Senescent cells secrete signals that provoke a state of chronic inflammation, alter nearby cell behavior, and disrupt tissue structure and maintenance. Clearance of these cells reverses numerous age-related conditions and measures of aging in mice. Hence the advent of senolytic therapies that selectively destroy senescent cells is a much anticipated development in medicine. Indeed, the first such therapies are pre-existing drugs, such as the dasatinib and quercetin combination, are ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
To explore the suppressing impact of low phosphorus intake on osteoarthritic temporomandibular joint and the possible mechanisms of nuclear acid injury in the insulted chondrocytes.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research
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