NIDCR Clinical Research Fellowship Grand Round: The temporomandibular Joint (TMJ)

The temporomandibular joint (TMJ) is the synovial joint of craniofacial complex and is critical for dental occlusion, mastication, and speech. TMJ trauma and diseases, such as osteoarthritis, are debilitating and compromise quality of life. Current TMJ treatments are two-fold, involving either palliative care or invasive total joint replacement surgeries. There are no minimally invasive, regenerative TMJ therapies. We have identified TMJ-specific fibrocartilage stem cells that self-organize and regenerate cartilage, fat and vascularized bone. Here we define heterogeneous populations of TMJ fibrocartilage stem cells and the signals regulating their fate in jaw development and disease. Finally we therapeutically exploit endogenous fibrocartilage stem cells as a potential strategy for TMJ regeneration using a pre-clinal, large animal model. Our studies will contribute towards the development of a non-surgical, minimally invasive stem cell-based therapy for TMJ regeneration. Dr. Embree is currently the Dr. Edwin S. Robinson Assistant Professor of Dental Medicine (Orthodontics) a Columbia College of Dental Medicine. She completed her DMD, PhD, Cell Biology, Medical University of South Carolina and her Residency at Columbia University School of Dentistry. While with NIH she has worked on multiple publications and many more outside of NIH. Dr. Embree conducts cutting edge research in both an academic and clinical setting with the goal of translating basic science into clinical pract...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video

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Conclusion: Female patients had a higher prevalence and severity of TMJ-OA than male patients. The prevalence and severity of TMJ-OA increased with age, with peaks in the fifth and seventh decades of life. PMID: 33005582 [PubMed]
Source: Imaging Science in Dentistry - Category: Dentistry Tags: Imaging Sci Dent Source Type: research
This study aims to review the correlation of FasL and IL-6 expression in temporomandibular internal derangement and osteoarthritis (OA) found by our group in previous “in vivo” human TMJ studies.
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research
Temporomandibular disorders (TMDs) are widely spread within the population, and a subgroup has progressive degenerative changes with progressive cartilage degeneration and subchondral bone remodeling. Ten to 17% of patients have TMJ osteoarthritis (OA).1,2 Mesenchymal stem/progenitor cells (MSPCs) are critical for tissue regeneration. Moreover, CD105 antigen identifies early MSPCs with increased chondrogenic differentiation ability. The aim of this study was to evaluate a mouse temporomandibular joint (TMJ) derived CD105+ MSPC subgroup (mCoSPC) on functionalized biosilica incorporating hydrogel scaffolds, under chondrogeni...
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research
Source: Cranio - Journal of Craniomandibular and Sleep Practice - Category: Sleep Medicine Authors: Source Type: research
ConclusionsUnilateral symptomatic TMD is related to the presence of imaging abnormalities on the contralateral, asymptomatic side, suggesting that the development and progression of joint changes in symptomatic and contralateral asymptomatic TMJs are interrelated.
Source: Oral Radiology - Category: Radiology Source Type: research
The purpose of this study was to elucidate the role of the circadian gene Bmal1 in human cartilage and its crosstalk with the MAPK/ERK signaling pathway in temporomandibular joint osteoarthritis (TMJ-OA). We verified the periodical variation of the circadian gene Bmal1 and then established a modified multiple platform method (MMPM) to induce circadian rhythm disturbance leading to TMJ-OA. IL-6, p-ERK, and Bmal1 mRNA and protein expression levels were assessed by real-time RT-PCR and immunohistochemistry. Chondrocytes were treated with an ERK inhibitor (U0126), siRNA and plasmid targeting Bmal1 under IL-6 simulation; then, ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
To study the effect of autologous platelet-rich plasma (PRP) injected into the upper cavity of the temporomandibular joint (TMJ) on the treatment of temporomandibular joint osteoarthritis (TMJOA).
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research
The aim of this study was to investigate the effects of intra-articular resveratrol injections on cartilage destruction and synovial inflammation in an experimental temporomandibular joint osteoarthritis (TMJ-OA) model.
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research
Abstract The abundance of inflammatory mediators in injured joint indicates innate immune reactions activated during temporomandibular joint osteoarthritis (TMJOA) progression. Toll-like receptor 4 (TLR4) can mediate innate immune reaction. Herein, we aimed to investigate the expression profile and effect of TLR4 in the cartilage and subchondral bone of the discectomy-induced TMJOA mice. The expression of TLR4 and NFκB p65 in the synovium of TMJOA patients was measured by immunohistochemistry, Western blotting and RT-PCR. H&E and Masson staining were utilized to assess the damage of cartilage and subchondral...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
This study sought to investigate associations among progressive temporomandibular joint osteoarthritis (TMJ OA), airway dimensions, and head and neck posture.
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research
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