Fight Aging! Newsletter, September 25th 2023
In conclusion, this individual patient data meta-analysis of longitudinal cohort studies found that antihypertensive use was associated with decreased dementia risk compared with individuals with untreated hypertension through all ages in late life. Individuals with treated hypertension had no increased risk of dementia compared with healthy controls.
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Results from Human Clinical Trials Do Not Support Metformin as a Longevity Drug
https://www.fightaging.org/archives/2023/09/results-from-human-clinical-trials-do-not-support-metformin-as-a-longevity-drug/
The SENS Research Fou...
Source: Fight Aging! - September 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
This Physical Feature Makes Men More Attractive
The feature is also linked to higher genetic fitness. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - September 21, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Attractiveness Social psychology Source Type: blogs
Addressing the Mental Health Crisis: Why Personalized Digital Solutions Are Essential To Meet Growing Demand
The following is a guest article by Byron Crowe, MD, Chief Medical Officer at Solera
Demand for mental services has never been higher, and an ongoing shortage of psychiatrists and psychologists is preventing millions of Americans from timely access to mental health services. And the timing couldn’t be worse — findings from Solera Health’s recent Mental Health Index, a nationally representative survey of over 3,000 U.S. adults, found that 42% of Americans continue to be bothered by symptoms of anxiety and depression, a staggering figure that remains substantially elevated from pre-pandemic numbers. Moreover, these sym...
Source: EMR and HIPAA - September 21, 2023 Category: Information Technology Authors: Guest Author Tags: Healthcare IT Telemedicine and Remote Monitoring CBT Cognitive Behavioral Therapy Digital CBT Digital Mental Health Tools Dr. Byron Crowe M.D. Healthcare Barriers Personalized Healthcare Solera Solera Network Teletherapy Therapist Source Type: blogs
Many Researchers and Companies Will Aim to Produce Small Molecule Reprogramming Therapies
The typical path for any program in biomedical research and development is to first demonstrate interesting results in animal studies using forms of genetic engineering or gene therapy, and then find small molecules that adjust the same mechanism. Small molecules are never as good as genetic manipulations, the size of the effect is always smaller, usually much smaller, and there are inevitably side-effects. Small molecule development is much easier to conduct, however, more familiar to investors and regulators and program managers, a well-trodden path. Thus while the future of medicine is gene therapy, in search of large e...
Source: Fight Aging! - September 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How Could Digital Technology Make An Impact On Primary Care?
I truly hope that very soon I do not have to make an appointment at the GP when I suspect signs of a disease, but my GP will send me a message that she spotted something irregular in my latest test results and my digital health data, so I’d better visit. Let me show you in detail how primary care should be carried out in the future!
Digital health should become an organic part of primary care in the future
I live a fairly healthy life. I use data to improve my lifestyle and to make better decisions by optimising my sleep pattern, my physical, my cognitive or my emotional abilities; and I had several genetic tests....
Source: The Medical Futurist - September 21, 2023 Category: Information Technology Authors: berci.mesko Tags: Digital Health Research Healthcare Innovation technology wearables GP primary care general practitioner Source Type: blogs
Aging Rate Indicators as Speedometers for Aging Research
Is it possible to measure the pace of aging at any given moment? Are there biomarkers that reveal not the biological age of the individual, but rather how fast that biological age is changing? The field is presently focused on developing measures of biological age, such as the extensive work on epigenetic clocks. Some information about pace of aging might be inferred from whether biological age is higher or lower than chronological age, assuming a biological age measurement that is actually accurate, something that still a topic for contention. But that doesn't say anything about the momentary pace of aging at any given ti...
Source: Fight Aging! - September 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Cells Release Insulin in Response to Music
Researchers at ETH Zurich have developed an insulin delivery system that relies on music as a trigger. The unusual technology is based on calcium ion channels that typically reside in the cell membrane. Such channels are sensitive to mechanical deformation and these researchers discovered that sound waves will activate the channels. When insulin-producing cells are genetically modified to express this channel, they will experience an influx in calcium ions when music is played close by, prompting them to release insulin. The concept could be useful as a treatment for diabetes, whereby such cells, housed in a specialized ca...
Source: Medgadget - September 19, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Medicine diabetes ETH Zurich Source Type: blogs
Integral Secures $6.9 Million Seed Round Led by Haystack to Maximize Data Privacy and Quality
The General Partnership, Virtue Ventures, Caffeinated Capital, Array Ventures, GreatPoint Ventures, LiveRamp Ventures, Venrex, and Also Capital also Invest to Support the First Privacy Preserving Data Compliance Software Built for Pharma, Life Sciences, and Healthcare Enterprises
Integral, an innovator in safeguarding privacy and maximizing data quality, today announced it raised a $6.9 million seed round to protect sensitive health data and provide automated expert certification software that enables health and life sciences companies access to compliant, rich, de-identified data in hours, rather than months. The seed rou...
Source: EMR and HIPAA - September 19, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Aashay Sanghvi Abhishek Chandra Airbyte Also Capital Amruta Moktali Andrew Arruda Array Ventures Caffeinated Capital Dr. Bradley Malin Flexpa GreatPoint Ventures Haystack Health IT Funding Heal Source Type: blogs
In Search of Immune System Differences in Long-Lived Mammals
What are the mechanisms that allow long-lived mammals to be long-lived? It remains to be seen as to whether it will be cost-effective and of sizable benefit to isolate specific genetic differences that can be used as a basis for therapies in humans, but it isn't a terrible idea to conduct the search. Clearly cancer suppression is an interesting topic, and one it might well be possible to build novel therapies based on the study of whales and elephants. Another good place to start is the operation of the immune system. The age-related decline of immune function is clearly important to the onset and progression of age-relate...
Source: Fight Aging! - September 19, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Chatting Apton Acquisition with PacBio CEO Christian Henry
PacBio CEO Christian Henry chatted with me recently by teleconference on a variety of topics, but the focus was the recent PacBio acquisition of Apton Biosystems for $85M in equity. As a regular reminder, my employer’s CEO reports in a sense to Henry, as he’s on the Board of Directors. A particularly interesting revelation by Henry is that PacBio had its eye on Apton in late 2021, essentially as soon as they completed theOmniome acquisition announced in July 2021 that formed the foundation for their now-released Onso short read instrument. PacBio believed then that the desktop instrument design from Omniome...
Source: Omics! Omics! - September 19, 2023 Category: Bioinformatics Authors: Keith Robison Source Type: blogs
Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Wanted: Division of Genetics and Molecular, Cellular, and Developmental Biology Program Directors
We’re seeking two highly qualified scientists to serve as program directors in the Genetic Mechanisms and Developmental and Cellular Processes Branches of our Division of Genetics and Molecular, Cellular, and Developmental Biology (GMCDB).
GMCDB supports research grants focused on understanding the structure and function of cells and cellular components and the cellular and molecular mechanisms that underlie inheritance, gene expression, and development. All prospective candidates should have expertise in the mechanism and regulation of genetics including basic molecular processes, cellular biology, and/or development...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - September 15, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs
The Open Genes Database of Associations with Aging and Longevity
The Open Genes database provides summaries of the information available on longevity-associated genes, from well-established and well-replicated effects such as that associated with klotho expression, to much less well supported data. Thousands of genes have at least a study or two suggesting an effect on longevity in studies of lower animals, and many of those may turn out to be experimental error. Yet since every fundamental cellular process can be influenced by dozens or hundreds of genes, even though there are comparatively few important processes of aging, one might well expect there be to be thousands of related gene...
Source: Fight Aging! - September 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Damage Done by Non-Standard Scientific Controls
To say that there is a lack of standardization in aging research is understating the matter. Pity the authors of reviews and meta-reviews, as they struggle to compare outcomes of animal studies between completely different, incompatible methodologies. Inconsistency in results is something of a feature even when different research groups attempt replication. The authors of this paper-length complaint focus down on one specific issue, the lack of standarization in the scientific control arm of a life span study, which is enough in and of itself to make comparison and replication challenging.
The search for intervent...
Source: Fight Aging! - September 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Organoids Produce Tooth Enamel Proteins
Researchers at the University of Washington School of Medicine have developed a method to create stem cell-derived organoids that can produce tooth enamel proteins. The breakthrough could pave the way for lab grown enamel that can be used in dental repairs and may even allow for living fillings or completely new living teeth that can be implanted into a patient’s jaw. The researchers studied the genetic activity that occurs during tooth development, and then used this information to steer stem cells into becoming ameloblasts, which are the cell type responsible for enamel creation. Once present in organoids, the cells ca...
Source: Medgadget - September 12, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Dentistry Genetics Materials uwsomwwami Source Type: blogs
