Testing Afatinib as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH - Subprotocol A)
Conditions: Advanced Lymphoma; Advanced Malignant Solid Neoplasm; Refractory Lymphoma; Refractory Malignant Solid Neoplasm; Refractory Multiple Myeloma Interventions: Drug: Afatinib; Procedure: Biopsy; Procedure: Biospecimen Collection; Procedure: Computed Tomography; Procedure: Echocardiography; Procedure: Magnetic Resonance Imaging; Procedure: Radionuclide Imaging Sponsors: National Cancer Institute (NCI) Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 26, 2024 Category: Research Source Type: clinical trials
Testing MLN0128 (TAK-228) as Potentially Targeted Treatment in Cancers With mTOR Genetic Changes (MATCH - Subprotocol L)
Conditions: Advanced Lymphoma; Advanced Malignant Solid Neoplasm; Refractory Lymphoma; Refractory Malignant Solid Neoplasm; Refractory Multiple Myeloma Interventions: Procedure: Biopsy; Procedure: Biospecimen Collection; Procedure: Computed Tomography; Procedure: Magnetic Resonance Imaging; Drug: Sapanisertib Sponsors: National Cancer Institute (NCI) Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 26, 2024 Category: Research Source Type: clinical trials
Adversity and Its Association With the Development and Expression of Rheumatic Diseases
Conditions: RhA - Rheumatoid Arthritis Interventions: Other: Rheumatic diseases Mistreatment Scale (RDMS); Other: Routine assessment of patient index data 3 (RAPID-3); Other: Health Assessment Questionnaire (HAQ); Other: WHOQOL-BREF; Other: Depression, Anxiety and Stress Scale (DASS-21); Other: Brief Resilient Coping Scale; Genetic: Expression of CDKN2A /p16INK4a; Other: Immunophenotype of leukocyte subpopulations; Genetic: Telomere length; Other: Cellular senescence Sponsors: National Institute of Medical Sciences and Nutrition, Salvador Zubiran Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 26, 2024 Category: Research Source Type: clinical trials
Developing & Evaluating Models for Early Predicting Obstetrical Diseases in Pregnant Women by Non-invasive Prenatal Test
Conditions: Pregnant With Complication; Preeclampsia; Preterm Birth; Gestational Diabetes Sponsors: Gene Solutions; Medical Genetics Institute (MGI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 26, 2024 Category: Research Source Type: clinical trials
Gene-Based Therapy Restores Cellular Development and Function in Brain Cells From People With Timothy Syndrome
April 24, 2024 -- In a proof-of-concept study, researchers demonstrated the effectiveness of a potential new therapy for Timothy syndrome, an often life-threatening and rare genetic disorder that affects a wide range of bodily systems, leading to... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - April 24, 2024 Category: Pharmaceuticals Source Type: clinical trials
Engaging Patients in Prenatal Genetic Testing Decisions as a Pathway to Improve Obstetric Outcomes
Conditions: Prenatal Disorder Interventions: Behavioral: Standard Care; Behavioral: Obstetric Prenatal Genetic Testing Engagement Solution (OPUS) AI Chatbot Sponsors: The Cleveland Clinic Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 24, 2024 Category: Research Source Type: clinical trials
Developmental and Epileptic Encephalopathy of Genetic Etiology: Natural History Through Reuse of Clinical Data
Conditions: Developmental and Epileptic Encephalopathy Sponsors: Imagine Institute Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 23, 2024 Category: Research Source Type: clinical trials
Using the EHR to Advance Genomic Medicine Across a Diverse Health System
Conditions: Genetic Predisposition; Paraganglioma; Pheochromocytoma; ALS; Parkinson Disease; Polyneuropathies; Frontotemporal Dementia; Alzheimer Disease; Cardiomyopathy Non-ischemic; Thoracic Aortic Aneurysm Interventions: Behavioral: Behavioral nudge Sponsors: University of Pennsylvania Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 22, 2024 Category: Research Source Type: clinical trials
WiTNNess - TNNT1 Myopathy Natural History Study
Conditions: TNNT1-associated Myopathy; Infantile-onset Nemaline Rod Myopathy; Myopathies, Nemaline; Myopathy; Myopathy, Rod; Myopathy; Hereditary; Amish Nemaline Myopathy; Nemaline Myopathy 5; NEM5; Genetic Muscle Disease; Recessive Hereditary Disorder (Autosomal); ANM Sponsors: Clinic for Special Children Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 19, 2024 Category: Research Source Type: clinical trials
Artificial Intelligence for the Prioritization of Genetic Background in Brugada Syndrome
Conditions: Brugada Syndrome Sponsors: IRCCS San Raffaele Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 19, 2024 Category: Research Source Type: clinical trials
Genetic Diagnosis in Inborn Errors of Metabolism
Conditions: Metabolic Disease; Mitochondrial Diseases; Epilepsy in Children; Epilepsy; LHON; Motor Neuron Disease Interventions: Genetic: IEM-EP Sponsors: Region Stockholm; Karolinska Institutet Enrolling by invitation (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 19, 2024 Category: Research Source Type: clinical trials
Next-Generation alzheImer'S Therapeutics
Conditions: Alzheimer Disease Interventions: Other: genetically encoded engineered proteins Sponsors: Fondazione Policlinico Universitario Agostino Gemelli IRCCS Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 18, 2024 Category: Research Source Type: clinical trials
Single Participant Study of an Experimental ASO Treatment for TUBB4A-related Leukodystrophy
Conditions: Leukodystrophy, Hypomyelinating Interventions: Genetic: Antisense oligonucleotide treatment (ASO) Sponsors: Massachusetts General Hospital; n-Lorem Foundation Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 17, 2024 Category: Research Source Type: clinical trials
Clinical and Genetic Findings in Patients With PRPF31-associated Retinitis Pigmentosa
Conditions: Retinitis Pigmentosa Sponsors: University Hospital Tuebingen Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 16, 2024 Category: Research Source Type: clinical trials
Result of tDCS in ASD Children With Comorbidities Like PANDAS, Rare Genetic Diseases or Autoimmune Disorders
Conditions: Attention; Visual Perceptual Weakness; Social Behavior; Fluency Disorder; EEG With Periodic Abnormalities Interventions: Device: tDCS or Transcranial Direct Current Stimulation; Drug: Risperidone Sponsors: Spanish Foundation for Neurometrics Development; Fundacion para la Salud Materno Infantil Enrolling by invitation (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 16, 2024 Category: Research Source Type: clinical trials
