A Phase I/II Study of AZD0466 as Monotherapy or in Combination With Anticancer Agents in Advanced Non-Hodgkin Lymphoma
Condition:   Non-Hodgkin Lymphoma Intervention:   Drug: AZD0466 Sponsor:   AstraZeneca Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury
Condition:   TBI (Traumatic Brain Injury) Intervention:   Device: depth electrodes Sponsor:   University of Minnesota Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Gut Microbiota and Metabonomics
Conditions:   Stomach Neoplasms;   Gut Microbiota;   Metabolomics Interventions:   Procedure: Healthy control specimen collection;   Procedure: Non-Borrmann IV patient specimen collection;   Procedure: Borrmann IV patient specimen collection Sponsors:   First Hospital of China Medical University;   Liaoning Cancer Hospital & Institute;   The Second Hospital of Shandong University;   The General Hospital of Fushun Mining Bureau;   The&nbs...
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Immune Therapy in HR-positive/HER2-negative Metastatic Breast Cancer(ENIGMA)
Conditions:   Breast Cancer;   Metastatic Cancer Interventions:   Drug: SHR-1316;   Drug: SHR6390;   Drug: Nab paclitaxel;   Drug: SERD;   Drug: AI Sponsor:   Fudan University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Stepwise for the Treatment of Lateral Incisional Hernias
Conditions:   Incisional Hernia;   Abdominal Wall Defect;   Abdominal Wall Hernia;   Hernia Intervention:   Other: Surgical Technique (lateral retromuscular preperitoneal) Sponsor:   Henares University Hospital Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Local Radiotherapy for Residual Tumor Lesions During the First-line Treatment
Condition:   Non Small Cell Lung Cancer Intervention:   Sponsor:   Hunan Province Tumor Hospital Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Small Bowel Motility in Patients With Systemic Sclerosis
Condition:   System Sclerosis Intervention:   Diagnostic Test: Endoluminal image analysis by capsule endoscopy Sponsor:   Hospital Universitari Vall d'Hebron Research Institute Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Multi Cohort Study of Tazemetostat in Combination With Various Treatments For R/R Hematologic Malignancies
Condition:   Relapsed/Refractory Interventions:   Drug: Tafasitamab;   Drug: Lenalidomide;   Drug: Tazemetostat;   Drug: Acalabrutinib;   Drug: Daratumumab;   Drug: Hyaluronidase-Fihj;   Drug: Pomalidomide 4 MG;   Drug: Dexamethasone 20mg;   Drug: Dexamethasone 40mg Sponsor:   Epizyme, Inc. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Rivet PVS Therapy in Group 2 PH-HFpEF
Conditions:   Heart Failure;   Pulmonary Hypertension Intervention:   Device: Rivet Shunt Sponsor:   NXT Biomedical Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Effect of Progressive Isolated Core Stability Training
Conditions:   CORE STABILITY;   Upper Extremity;   Physical Performance Intervention:   Other: exercise training Sponsor:   Ankara Yildirim Beyaz─▒t University Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Molecular Imaging of Inflammation in Parkinson's Disease Using LPS and TSPO-PET/MR
Conditions:   Neurodegenerative Diseases;   Parkinson Disease Interventions:   Drug: Lipopolysaccharide;   Radiation: PET/MR with [11C]PBR28 Sponsor:   University of Exeter Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

The Role of Transdermal CO2 in MDA Level in Patient Underwent Abdominal Aortic Temporary Cross Clamp
Condition:   Placenta Accreta Intervention:   Drug: D'Oxyva Sponsor:   Universitas Airlangga Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Comparison of the Therapeutic Effects of VR and VR + Metformin in the Treatment of Cesarean Section Scar Defect
Condition:   Defect Interventions:   Drug: Metformin Hydrochloride Sustained-release Tablets;   Procedure: Vaginal repair Sponsor:   Xinhua Hospital, Shanghai Jiao Tong University School of Medicine Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

A Phase Ib/IIa Study of CR6086 in Combination With Balstilimab in pMMR-MSS Metastatic Colorectal Cancer Patients
Conditions:   Refractory Metastatic Colorectal Cancer;   Solid Tumor;   Metastatic Microsatellite-stable Colorectal Cancer;   Mismatch Repair Protein Proficient Interventions:   Drug: CR6086;   Biological: AGEN2034 Sponsors:   Rottapharm Biotech;   Agenus Inc. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Trans-Pacific Multicenter Collaborative Study of Minimally Invasive Proximal Versus Total Gastrectomy for Proximal Gastric and Gastroesophageal Junction Cancers
Conditions:   Gastrostomy;   Gastric;   GastroEsophageal Cancer Interventions:   Other: Standard of Care;   Other: Control Group Sponsor:   M.D. Anderson Cancer Center Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

VIGOR: Virtual Genome Center for Infant Health
Conditions:   Genetics Disease;   Genetics/Birth Defects;   Genetic Predisposition to Disease Intervention:   Sponsors:   Boston Children's Hospital;   Boston Medical Center;   Baystate Medical Center;   UMASS Memorial Medical Center;   The Cooper Health System;   National Human Genome Research Institute (NHGRI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Effects of Yi Jin Bang Exercise and Usual Exercise Therapy in Adults With Subacromial Pain Syndrome
Condition:   Subacromial Pain Syndrome Interventions:   Behavioral: 10-week home-based Yi Jin Bang exercise program;   Behavioral: 10-week home-based usual exercise therapy program Sponsor:   Chinese University of Hong Kong Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Assessing the Effect of Nicotine Reduction on ENDS User's Addiction and Exposures
Condition:   Electronic Cigarette Use Interventions:   Behavioral: 5% nicotine;   Behavioral: 3% nicotine;   Behavioral: 0% nicotine Sponsor:   Florida International University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Relationship Between Q-tip Test and Urethral Hypermobility
Condition:   Urodynamic Stress Incontinence Intervention:   Diagnostic Test: Transperineal ultrasound Sponsor:   Kaohsiung Medical University Chung-Ho Memorial Hospital Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

A Study of Intratumoral Administration of Oncolytic Virus Injection (RT-01) in Patients With Advanced Solid Tumors
Condition:   Advanced Solid Tumor Intervention:   Biological: Oncolytic Virus Injection(RT-01) Sponsor:   First Affiliated Hospital Bengbu Medical College Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

A Study of Oncolytic Virus Injection (RT-01) in Patients With Advanced Solid Tumors
Condition:   Advanced Solid Tumor Intervention:   Biological: Oncolytic Virus Injection(RT-01) Sponsor:   First Affiliated Hospital Bengbu Medical College Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Efficacy of Synchronous and Asynchronous Telerehabilitation in COVID-19 Discharges
Conditions:   COVID-19;   Telerehabilitation Interventions:   Other: Synchronous telerehabilitation programme;   Other: Asynchronous telerehabilitation programme Sponsors:   Bitlis Eren University;   Marmara University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Study of the Effects of Itraconazole and Carbamazepine on LY3410738 in Healthy Participants
Condition:   Healthy Interventions:   Drug: LY3410738;   Drug: Itraconazole;   Drug: Carbamazepine Sponsors:   Eli Lilly and Company;   Loxo Oncology, Inc. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Telehealth Exercise Training in Post-COVID Patients
Condition:   COVID-19 Interventions:   Device: Home-based telehealth exercise training program;   Behavioral: Education and self-exercise Sponsor:   Tri-Service General Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Sciatic Nerve Blockade by Subgluteal Access 12.5 ml of 1% Lidocaine: US Guidance Versus US Guidance With Electrical Stimulation of Peripheral Nerves (Influence of the Sciatic Nerve Blockade on the Effectiveness of Small Doses of Local Anesthetic.).
Conditions:   Nerve Block;   Efficiency;   Sciatic Nerve;   Ultrasonography;   Minimum Effective Dose Interventions:   Procedure: Sciatic nerve block under ultrasound control with a electrostimulator peripheral nerves 12.5 ml 1% lidocaine;   Procedure: sciatic nerve blockade under ultrasound control without a peripheral nerve stimulator 12.5 ml 1% lidocaine Sponsor:   Mogilev Regional Clinical Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Pharmacokinetics and Safety of Cefazolin 3gm DUPLEX in Adults
Condition:   Infections Intervention:   Drug: Cefazolin 3gm for Injection USP and Dextrose Injection USP Sponsor:   B. Braun Medical Inc. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

A Clinical Trial to Evaluate the Safety and Efficacy of IBS in Patients With Coronary Artery Disease
Condition:   Coronary Artery Disease Intervention:   Device: Sirolimus-Eluting Iron Bioresorbable Coronary Scaffold System Sponsor:   Biotyx Medical (Shenzhen) Co., Ltd. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Telehealth Exercise Intervention to Improve Cardiovascular Health in Lymphoma Survivors, TECHS Trial
Conditions:   Hodgkin Lymphoma;   Non-Hodgkin Lymphoma Interventions:   Other: Exercise Intervention;   Other: Questionnaire Administration;   Other: Telemedicine Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Delayed Antibiotic Therapy in Non-severe Ventilator Acquired Pneumonia (VAP)
Conditions:   Ventilator Associated Pneumonia;   Critical Care;   Antibiotic Therapy Interventions:   Other: Restrictive antibiotic strategy;   Other: Aggressive antibiotic strategy Sponsor:   Nantes University Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Does Biological Sex Influence the Cardiac Output Response to Sprint Interval Exercise Training in Humans?
Condition:   Exercise Intervention:   Other: Sprint interval exercise training Sponsor:   McMaster University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Prospera Test Evaluation in Cardiac Transplant (ProTECT)
Condition:   Heart Transplant Rejection Intervention:   Sponsor:   Natera, Inc. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Stress and Coping, Resilience, and Compassion Fatigue of Front-line Nurses During COVID-19 Pandemic
Conditions:   COVID-19 Pandemic;   Stressor, Psychological;   Mental Health Issue Intervention:   Other: This is a cross-sectional research design. Sponsors:   National Taiwan University;   National Taiwan University Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Trial of Auricular Vagus Nerve Stimulation in Painful Covid Long
Condition:   COVID-19 Intervention:   Device: Tens Eco Plus Sponsors:   Assistance Publique - Hôpitaux de Paris;   Schwa medico (device lending) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

COVID-19 Pandemic and Migraine Disorder, Tension Headache and Epilepsy
Condition:   COVID-19 Intervention:   Other: Non Sponsor:   Aswan University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Efficacy of Mesalazine Combined With Biologics in the Treatment of Moderate to Severe Ulcerative Colitis
Conditions:   Ulcerative Colitis;   Efficacy, Self;   Biologics;   Mesalazine Interventions:   Drug: Infliximab;   Drug: Vedolizumab;   Drug: Mesalazine Sponsor:   Sixth Affiliated Hospital, Sun Yat-sen University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

In-person Randomized Control Trial of the Incidence of Postoperative Hypoesthesia Among Bilateral Sagittal Split Osteotomy Patients Treated With Ultrasonic vs. Reciprocating Saw Instrumentation
Condition:   Postoperative Hypoesthesia Among Bilateral Sagittal Split Osteotomy Patients Interventions:   Device: Sonopet ultrasonic saw;   Device: Reciprocating saw Sponsor:   University of California, San Francisco Enrolling by invitation (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

A Real-world Study of Donafenib Combined With TACE-based Treatment in Patients With Unresectable HCC
Conditions:   Hepatocellular Carcinoma;   Donafenib Intervention:   Drug: Donafenib combined with TACE Sponsor:   Shanghai Zhongshan Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Exercise Fatigue Parameters and Endothelial Function in Pediatric Patients With a History of COVID-19 Infection or MIS-C
Conditions:   COVID-19;   MIS-C Associated With COVID-19 Interventions:   Device: Cardiopulmonary exercise test (CPET);   Device: Peripheral Arterial Tonography (PAT) using the EndoPAT™ device;   Diagnostic Test: Endothelin Sponsors:   Rambam Health Care Campus;   The Baruch Padeh Medical Center, Poriya Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Detection Dogs as a Help in the Detection of COVID-19
Condition:   Olfaction Intervention:   Behavioral: collection of odour samples Sponsor:   Hôpital Universitaire Sahloul Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Study of F-652 in Subjects With Corona Virus Disease 2019 (COVID-19) Pneumonia
Condition:   COVID-19 Pneumonia Interventions:   Biological: F-652;   Biological: Placebo Sponsor:   EVIVE Biotechnology Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

The Role of Imaging in the Diagnosis of Acute Appendicitis During the COVID-19 Pandemic
Condition:   Appendicitis Intervention:   Diagnostic Test: Pre-operative imaging Sponsor:   University College London Hospitals Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Oral Health in Covid-19 Survivors
Conditions:   COVID-19;   Periodontitis Intervention:   Sponsor:   University of Belgrade Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Association of Circulating ACE2 Levels With COVID-19
Condition:   Level of ACE2 in COVID 19 Patients Intervention:   Diagnostic Test: ACE serum levels Sponsor:   Jordan University Hospital Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Application of Celiac Plexus Block in Postoperative Analgesia of Upper Abdominal Surgery
Conditions:   Pain, Postoperative;   Nerve Block Interventions:   Procedure: Celiac plexus block;   Drug: Ropivacaine Sponsors:   Second Affiliated Hospital, School of Medicine, Zhejiang University;   Health Commission of Zhejiang Province, China Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Expanding Fertility Care to Poor and Low Resourced Settings Study
Conditions:   Healthy;   Male Infertility;   Infertility, Male;   Fertility Disorders Intervention:   Diagnostic Test: Mail-in semen analysis kit Sponsor:   University of California, San Francisco Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Phase II Immunogenicity Study of AVX/COVID-12 (Patria) Vaccine in Subjects With Prior SARS-CoV-2 Immunity Evidence
Condition:   SARS CoV 2 Infection Interventions:   Biological: Recombinant NDV Vectored Vaccine for SARS-CoV-2;   Biological: Placebo Sponsors:   Laboratorio Avi-Mex, S.A. de C.V.;   National Council of Science and Technology, Mexico;   Instituto Nacional de Enfermedades Respiratorias Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Non-inferiority Trial on Monoclonal Antibodies in COVID-19
Condition:   COVID-19 Interventions:   Drug: Bamlanivimab Etesevimab;   Drug: Sotrovimab;   Drug: Casirivimab-Imdevimab Sponsors:   Azienda Ospedaliera Universitaria Integrata Verona;   Agenzia Italiana del Farmaco;   Azienda Sanitaria-Universitaria Integrata di Udine Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Investigating Central Neurophysiologic Correlates of Non-Motor Symptoms of Parkinson's Disease
Conditions:   Parkinson Disease;   Autonomic Dysfunction;   Depression Intervention:   Device: transcranial magnetic stimulation Sponsor:   University of North Carolina, Chapel Hill Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

Human Milk Oligosaccharides (HMOs) for Irritable Bowel Syndrome (IBS)
Conditions:   Irritable Bowel Syndrome;   IBS - Irritable Bowel Syndrome Interventions:   Dietary Supplement: Human Milk Oligosaccharide Mix;   Other: Placebo Sponsor:   DSM Nutritional Products, Inc. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials

The Effect of Plate Size on Food Consumption and Satiety
Conditions:   Satiety;   Food Consumption Interventions:   Behavioral: Food consumption using plates with a diameter of 23 cm.;   Behavioral: Washout period;   Behavioral: Food consumption using plates with a diameter of 31 cm. Sponsor:   Eastern Mediterranean University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2022 Category: Research Source Type: clinical trials