Potential Role of Inflammasome NLRP3 And IL-1B Gene Expression in COVID-19 Patients: Impact of Ferretin and D -Dimer.
Conditions: Inflammasome NLRP3 And IL-1B Gene Expression in COVID-19 Patients Interventions: Genetic: Quantitative Real Time Polymerase chain reaction (qRT-PCR); Diagnostic Test: ELISA and colorimeter Sponsors: Assiut University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 12, 2023 Category: Research Source Type: clinical trials
Traumatic Events in Childhood, Attachment, Pain Perception, Epigenetic Marks, Quality of Life and Resilience.
Conditions: Chronic Pain; Adverse Childhood Experiences; Attachment Styles; Chronic Stress; Resilience, Psychological; Quality of Life; Epigenesis, Genetic Interventions: Genetic: Biological samples Sponsors: University of Lorraine Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 11, 2023 Category: Research Source Type: clinical trials
Genomic Study of Cutis Tricolor
Conditions: Pigmentary; Dermatosis Interventions: Biological: Blood sample; Biological: Cutaneous biopsy; Genetic: High troughput sequencing of human ' s exome Sponsors: University Hospital, Montpellier; IntegraGen SA Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 9, 2023 Category: Research Source Type: clinical trials
Structural Chromosome Rearrangements and Brain Disorders
Conditions: Rare Diseases; Genetic Disease; Chromosome Abnormality Sponsors: Karolinska Institutet; Karolinska University Hospital Enrolling by invitation (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 9, 2023 Category: Research Source Type: clinical trials
Personalized Oncology Promoting Equity for Black Lives
Conditions: Hereditary Cancer; Genetic Testing Interventions: Behavioral: Relational agent (RA) / Chatbot; Behavioral: Enhanced Usual Care (EUC) Sponsors: Rutgers, The State University of New Jersey; Georgetown University; National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 9, 2023 Category: Research Source Type: clinical trials
Clinical and Genetic Investigation of the Association Between Primary Aldosteronism and Thyroid Cancer
Conditions: Thyroid Cancer, Papillary; Primary Aldosteronism Interventions: Diagnostic Test: Secreening test for primary aldosteronism and Confirmatory Testing Sponsors: Instituto do Cancer do Estado de S ão Paulo; Fundação de Amparo à Pesquisa do Estado de São Paulo Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 5, 2023 Category: Research Source Type: clinical trials
A Study to Assess Efficacy and Safety of Oral Tazemetostat in Adult Participants With Relapsed/Refractory Follicular Lymphoma That Does Not Have an " EZH2 Gain-of-function " Genetic Mutation
Conditions: Follicular Lymphoma; Refractory Follicular Lymphoma Interventions: Drug: Tazverik (Tazemetostat) Sponsors: Epizyme, Inc.; Ipsen Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 5, 2023 Category: Research Source Type: clinical trials
Exploring Cancer-Associated Thromboembolism Prognosis Biomarkers and Polymorphisms
Conditions: Cancer; Solid Tumor; Thromboembolism; Cardiovascular Diseases; Immune System Diseases; Inflammatory Diseases; Colon Cancer; Breast Cancer; Prostate Cancer; Hepatocellular Carcinoma; Lung Cancer; Chemotherapy; Immunotherapy Interventions: Drug: Palbociclib; Drug: Rivaroxaban; Genetic: SNP Sponsors: Lebanese University; Haykel Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 4, 2023 Category: Research Source Type: clinical trials
Phase I/II Randomized Trial of Cord Blood-derived NK Cells Genetically Engineered With NY-ESO-1 TCR/IL-15 Cell Receptor for Relapsed/Refractory Multiple Myeloma
Conditions: Myeloma Interventions: Drug: Fludarabine phosphate; Drug: Cyclophosphamide; Drug: NY-ESO-1 TCR/IL-15 NK Sponsors: M.D. Anderson Cancer Center Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 4, 2023 Category: Research Source Type: clinical trials
A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)
Conditions: Frontotemporal Dementia; FTD; FTD-GRN; Dementia, Frontotemporal Interventions: Procedure: Intrathalamic AAV.PGRN administration; Genetic: Intrathalamic AVB-101 Sponsors: AviadoBio Ltd Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 3, 2023 Category: Research Source Type: clinical trials
AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy
Conditions: Mesial Temporal Lobe Epilepsy Interventions: Genetic: AAV9-hSyn1-miGRIK2 Sponsors: uniQure France SAS Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 3, 2023 Category: Research Source Type: clinical trials
Leber Congenital Amaurosis Inherited Blindness of Gene Therapy Trial (LIGHT)
Conditions: Leber Congenital Amaurosis Interventions: Genetic: HG004 Sponsors: HuidaGene Therapeutics Co., Ltd.; Xinhua Hospital, Shanghai Jiao Tong University School of Medicine Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 3, 2023 Category: Research Source Type: clinical trials
Hispanic Patient Engagement in Colorectal Cancer Genomics, COPECC Study
Conditions: Colorectal Carcinoma Interventions: Procedure: Archive Sample Retrieval; Procedure: Biospecimen Collection; Other: Electronic Health Record Review; Other: Genetic Testing; Other: Questionnaire Administration Sponsors: University of Southern California; National Cancer Institute (NCI) Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 3, 2023 Category: Research Source Type: clinical trials
The antidepressant effect of intermittent theta burst stimulation (iTBS): study protocol for a randomized double-blind sham-controlled trial
DiscussionThe aims of the present trial are to investigate the antidepressive effect of a 10-session iTBS protocol on moderately depressed outpatients and to explore the factors that can explain the reduction in depressive symptoms after iTBS but also a poorer response to the treatment. In separate, but related work packages, the trial will assess how clinical, cognitive, brain imaging and genetic measures at baseline relate to the variability in the antidepressive effects of iTBS.Trial registrationClinicalTrials.gov NCT05516095. Retrospectively registered on August 25, 2022. (Source: Trials)
Source: Trials - October 2, 2023 Category: Research Source Type: clinical trials
Role of NFKBIA and PTPN22 Genes Polymorphism in Acute Rejection Susceptibility After Living Donor Liver Transplantation in Egyptian Patients.
Conditions: Liver Transplant Rejection Interventions: Genetic: gene polymorphism Sponsors: Helwan University Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 29, 2023 Category: Research Source Type: clinical trials
