Polymorphism of ApoE in Alzheimer's Disease: Genetic Study in Castile and Leon (Spain)
Conditions: Alzheimer Disease Interventions: Diagnostic Test: Kit Buccal swab collection& stabilization de Canvax ®; Other: Cholesterol levels according to ApoE Genotype; Other: Assessing cardiovascular risk factors in all participants Sponsors: Universidad de Le ón; Consejo General de Colegios Oficiales de Enfermería España Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 23, 2024 Category: Research Source Type: clinical trials
Dentatorubral-pallidoluysian Atrophy Natural History and Biomarkers Study
Conditions: Dentatorubral-Pallidoluysian Atrophy Interventions: Other: Positive genetic test for pathological expansion in ATN1 Sponsors: University College, London; University of North Carolina, Chapel Hill; NYU Grossman School of Medicine Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 22, 2024 Category: Research Source Type: clinical trials
Neurological Dry Eye Study Stimulating Both Lacrimal and Vagus Nerves
Conditions: Dry Eye Disease; Dry Eye Interventions: Dietary Supplement: NeuroTears; Dietary Supplement: Placebo Sponsors: Genetic Disease Investigators Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 21, 2024 Category: Research Source Type: clinical trials
An Observational Study Comparing Delandistrogene Moxeparvovec With Standard of Care in Participants With Duchenne Muscular Dystrophy
Conditions: Duchenne Muscular Dystrophy Interventions: Genetic: delandistrogene moxeparvovec; Drug: Standard of Care Sponsors: Sarepta Therapeutics, Inc. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 21, 2024 Category: Research Source Type: clinical trials
Positron Emission Mammography and Liquid Biopsy in Women With High-risk Breast Screenings
Conditions: Breast Cancer Interventions: Genetic: Liquid Biopsy; Device: Positron Emission Mammography (PEM) Sponsors: University Health Network, Toronto Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 20, 2024 Category: Research Source Type: clinical trials
Phenotypic and Genotypic Characterization of Patients With Dysmetabolism in Greenland
Conditions: Diabetes Mellitus, Type 2; Obesity, Morbid; Obstructive Sleep Apnea; MODY; Diabetic Retinopathy; Diabetic Neuropathies Interventions: Genetic: Whole genome sequencing; Diagnostic Test: VAGUS; Diagnostic Test: NightOwl; Device: CPAP Sponsors: Steno Diabetes Center Greenland; Zealand University Hospital; University of Copenhagen Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 19, 2024 Category: Research Source Type: clinical trials
Evaluation of a Genetically Determined Personalized Approach in Prescribing Biologically Active Substances in Patients With Elevated Blood Homocysteine Levels.
Conditions: Hyperhomocysteinemia Interventions: Dietary Supplement: B-TMG supplementation; Dietary Supplement: B-SAM supplementation; Other: B-TMG placebo; Other: B-SAM placebo Sponsors: S.LAB (SOLOWAYS); Center of New Medical Technologies Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 19, 2024 Category: Research Source Type: clinical trials
Decoding Developmental Disorders in Humams
Conditions: Genetic Diseases Interventions: Genetic: Whole genome sequencing and Genome-Epigenome-Phenome Associations Sponsors: Institut National de la Sant é Et de la Recherche Médicale, France; Imagine Institute; Commissariat A L ' energie Atomique Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 15, 2024 Category: Research Source Type: clinical trials
Association of Gene Polymorphism With Susceptibility to T2DM and the Therapeutic Responses to Exenatide in Chinese Patients With T2DM
Conditions: Type 2 Diabetes Mellitus; Susceptibility, Genetic Interventions: Drug: GLP-1 receptor agonist; Drug: responders group and nonresponders group Sponsors: The Affiliated Hospital of Xuzhou Medical University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 13, 2024 Category: Research Source Type: clinical trials
Genome-wide Epistasis for Cardiovascular Severity in Marfan Study
Conditions: Marfan Syndrome; FBN1 Mutation Interventions: Genetic: Saliva collection (screening of all participants); Genetic: Bloodsampling Sponsors: University Hospital, Antwerp; University Hospital, Ghent Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 13, 2024 Category: Research Source Type: clinical trials
An Open-label Study to Investigate ECUR-506 in Male Babies Less Than 9 Months of Age With Neonatal Onset OTC Deficiency (OTC-HOPE)
Conditions: Ornithine Transcarbamylase Deficiency; Ornithine Transcarbamylase Deficiency Disease; Ornithine Carbamoyltransferase Deficiency (Disorder); Urea Cycle Disorders, Inborn Interventions: Genetic: ECUR-506 Sponsors: iECURE, Inc. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 13, 2024 Category: Research Source Type: clinical trials
Surveillance of the Genetic Signature in Circulating Tumor DNA for Guiding Adjuvant Chemotherapy in Urothelial Carcinoma: A Pilot Randomized Controlled Trial
Conditions: Muscle Invasive Bladder Urothelial Carcinoma; Muscle-Invasive Bladder Carcinoma Interventions: Drug: gemcitabine; Drug: Cisplatin Sponsors: Yung NA; Pamela Youde Nethersole Eastern Hospital; Queen Mary Hospital, Hong Kong Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 13, 2024 Category: Research Source Type: clinical trials
Diet-Induced Changes in GEnetic Material
Conditions: Diet, Healthy; Body Weight; Metabolic Disturbance Sponsors: Pennington Biomedical Research Center Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 12, 2024 Category: Research Source Type: clinical trials
Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer
Conditions: Metastatic Solid Cancers; Colorectal Cancer; Breast Cancer; Non-Small Cell Lung Cancer; Gastrointestinal Cancer; Ovarian Cancer; Genitourinary Cancer Interventions: Drug: Aldesleukin; Drug: Fludarabine; Drug: Cyclophosphamide; Biological: KRAS TCR-Transduced PBL; Biological: GRT-C903/GRT-R904 Sponsors: National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 12, 2024 Category: Research Source Type: clinical trials
Genetics of Cardiovascular Disease
Conditions: Atherosclerosis; Coronary Heart Disease; Myocardial Infarction; Atrial Fibrillation Sponsors: Center for Strategic Planning, of the Federal Medical and Biological Agency; National Medical Research Center for Cardiology, Ministry of Health of Russian Federation Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 12, 2024 Category: Research Source Type: clinical trials
