Existing Geroprotective Drugs May Not Interact Well with Exercise
The big disadvantage of the geroprotective approach to aging, which is essentially to undertake the long-term use of supplements and small molecule drugs to alter metabolism in ways that slow aging over years and decades, is that distinct supplements and small molecules and adjustments tend to combine in unexpected ways. Short of testing every combination in laboratory species, something that Brian Kennedy's team has been working on, one can never know the outcome of combining a treatment. Based on presentations and interviews given by Kennedy in the last few years, the result of combining two geroprotectors that individua...
Source: Fight Aging! - December 21, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Profiling the Development of Gene Therapies at Rejuvenate Bio
Here find a high-level look at the work of Rejuvenate Bio, a gene therapy company aiming to manipulating aging metabolism into a better shape. They have chosen to focus on the strategy of altering tissues to generate signal molecules known to be influential in the progression of aging. This is perhaps the easiest way forward for any gene therapy platform. Gene therapies are clearly the future, but at present it is somewhere between hard, expensive, and impossible to specifically target a gene therapy to most organs or cell types or tissues. If one can use one of the few established approaches, such as delivery of a gene th...
Source: Fight Aging! - December 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reviewing the Contributions of Circadian Rhythm Dysfunction and Dysbiosis to Blood-Brain Barrier Leakage
The blood-brain barrier is a layer of specialized cells wrapping blood vessels that pass through the brain. Only certain molecules and cells are admitted. The metabolism of the brain is thus isolated from that of the rest of the body. In particular, the immune system of the brain is quite different from that of the rest of the body. Unfortunately, this isolation is a vulnerability when, like all biological systems, the blood-brain barrier begins to break down and leak. The leakage of inappropriate molecules and cells into the brain provokes inflammation and dysfunction, and this is likely a contributing factor in the devel...
Source: Fight Aging! - December 18, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Intermittent Fisetin Supplementation Improves Vascular Function in Old Mice
Given that the Interventions Testing Program found that fisetin supplementation did not extend life in mice, it is interesting to see that other researchers are still demonstrating that this intervention clears senescent cells and, as a direct consequence, improves function in older mice. Fisetin is something of a puzzle in this respect, and the Mayo Clinic needs to hurry up and publish useful data from their ongoing phase 2 human trials of fisetin supplementation.
Cellular senescence and the senescence-associated secretory phenotype (SASP) contribute to age-related arterial dysfunction, in part, by promoting oxid...
Source: Fight Aging! - December 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Bonus Features – December 17, 2023 – 97% of hospitals now capable of enabling electronic access to patient records, 70% of hospitals face hidden business continuity challenge, plus 31 more stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News
In a blog post, ONC highlighted trends in patient access to electronic health information. Nearly all (97%) hospitals and roughly almost two-thirds (65%) of physician practices are now capable of enabling patient access. Th...
Source: EMR and HIPAA - December 17, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Aaniie American Organization for Nursing Leadership Andor Health Arcadia Healthcare Solutions Avalon Healthcare Solutions AVIA Biofourmis Brett Zelkind Bryan Olson Carallel CAST Software CLEAR CodaMetrix CommonWel Source Type: blogs
Fight Aging! Newsletter, December 18th 2023
In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team.
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Aged Transplant Organs Cause Harm to Younger Recipients
https://www.fightaging.org/archives/2023/12/aged-transplant-organs-cause-harm-to-younger-recipients/
Old tissues are dysfunctional in ways that young tissues are not. This has always been known in the context of organ transplants, but absent me...
Source: Fight Aging! - December 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Looking for Evidence of Antagonistic Pleiotropy in Human Data
The dominant view of the evolution of aging is that it emerges from what is known as antagonistic pleiotropy, a term used to describe a mechanism that is initially helpful but later harmful. Mutations that help early life reproductive fitness will be selected even if they cause later harm, as a greater chance of earlier reproduction tends to win out over a greater chance of sustained reproduction over time. Natural selection thus tends to produce biological systems that invest little in long-term maintenance and sustainability. Aging is the result.
In 1957, evolutionary biologist George Williams proposed that gene...
Source: Fight Aging! - December 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How gene editing and immunotherapy are changing lives
When I started medical school thirty years ago, and learned about the discovery of streptomycin, I wondered what it must have been like for the doctors who first used it to cure the “white death.” How satisfying it must have been to tell a previously hopeless patient, “We can cure you.” What brought this to
Read more…
How gene editing and immunotherapy are changing lives originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 14, 2023 Category: General Medicine Authors: L. Joseph Parker, MD Tags: Meds Genetics Source Type: blogs
From Xenobots to Anthrobots
By KIM BELLARD
There were many things I could have written bout this week – e.g., in A.I., in quantum computing, even “transparent wood” — but when I saw some news about biological robots, I knew I had my topic.
The news comes from researchers at Tufts University and Harvard’s Wyss Institute. Their paper appeared in Advanced Science, introducing “a spheroid-shaped multicellular biological robot (biobot) platform” that they fondly dubbed “Anthrobots.” Importantly, the Anthrobots are made from human cells.
Let’s back up. In 2020, senior researcher Michael Levin, Ph.D., who holds positions at ...
Source: The Health Care Blog - December 13, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Biological Robots Kim Bellard Source Type: blogs
Reviewing What is Known of Hair Aging
The aging of hair is a priority for many, but in the grand scheme of things we might perhaps want to suffer that loss in preference to the decline of other bodily systems more essential to life. If that choice in priority of research and development is offered, at least. In fact, while a sizable and vocal industry focuses on the little that can be done today to satisfy the demand for an end to the aging of hair, research and development does occur, but not to the degree one might imagine, and is moving very slowly. The age-related disruption of hair growth and coloration processes is complex and incompletely understood. Ev...
Source: Fight Aging! - December 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The NIA Interventions Testing Program Shows that Fisetin Does Not Extend Life in Mice
The latest results from the NIA Interventions Testing Program (ITP) were recently published. The ITP conducts the most rigorous of animal life span studies, frequently demonstrating that earlier promising results were incorrect. The most interesting outcome from this batch of different interventions is that fisetin, demonstrated to clear senescent cells in mice and improve health measures, did not extend life. In contrast, dasatinib and quercetin, the most well-studied senolytic, has been shown by other groups to extend life in mice, by 36% in one study. This is puzzling!
We might theorize that either fisetin at th...
Source: Fight Aging! - December 12, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Collagen, wrinkles, and ageing skin
Collagen is a protein that plays a crucial role in maintaining the structure, firmness, and elasticity of the skin. As we age, several changes occur in the collagen of our skin, contributing to the visible signs of ageing, such as the appearance of wrinkles.
Here are some key aspects of how collagen changes with age:
Decreased Production: The synthesis of collagen decreases with age, leading to a reduction in the overall amount of collagen in the skin. This reduced production is influenced by both genetic and environmental factors, such as sun exposure and lifestyle choices, like smoking and alcohol consumption. a balanced...
Source: David Bradley Sciencebase - Songs, Snaps, Science - December 12, 2023 Category: Science Authors: David Bradley Tags: Health and Medicine Source Type: blogs
What Is the Immune System?
A computer-generated image of the rotavirus, a virus that commonly causes illness in children through inflammation of the stomach and intestines. Credit: Bridget Carragher, The Scripps Research Institute, La Jolla, California.
What do antibodies, mucus, and stomach acid have in common? They’re all parts of the immune system!
The immune system is a trained army of cells, tissues, and organs that work together to block, detect, and eliminate harmful insults to your body. It can protect you from invaders like bacteria, viruses, fungi, and parasites.
Innate and Adaptive
The immune system is often thought of as two...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 11, 2023 Category: Research Authors: Chrissa Chverchko Tags: Cells Common questions Immunology Miniseries Infectious Diseases Microbes Source Type: blogs
Aranscia Acquires YouScript from Invitae
Aranscia, a global provider of diagnostics software, services, and testing solutions, and Invitae Corporation, a leading medical genetics company, today announced that Aranscia has acquired select assets of the YouScript personalized medication management platform from Invitae Corporation in an all-cash transaction. YouScript is a widely recognized leader in providing actionable, real-time medication risk and pharmacogenomics (PGx) insights that enable healthcare providers and organizations to build, deliver, and scale comprehensive personalized medication management programs. YouScript’s foundational peer-reviewed resea...
Source: EMR and HIPAA - December 11, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT 2bPrecise AccessDX Laboratory Aranscia Health IT Acquisitions Healthcare M&A Invitae Corporation Joe Spinelli Kristine Ashcraft SinguLab YouScript Source Type: blogs
Cellular Stress Signaling in the Development of Ventricular Fibrillation
Researchers here report on a mechanism by which increased cellular stress in heart tissue can disrupt the regulation of the heartbeat, thus leading to arrhythmia and potentially fibrillation. The accumulated molecular damage of aging, of course, provides increased contributions to cell stress, whether from inflammatory signaling, mitochondrial dysfunction, increased presence of molecular waste, or other causes. When researchers characterize more of the ways in which regulatory pathways in cells can produce maladaptive reactions to this damage, they tend to then search for means to alter the response, rather than means to r...
Source: Fight Aging! - December 11, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
