An Update on Reversal of Atherosclerosis at Repair Biotechnologies

As some of you know, Repair Biotechnologies is the company I co-founded with Bill Cherman back in 2018. We've been working on an approach to reverse atherosclerosis for much of that time, and matters have progressed through the stage of great data in mice to present preparations for a pre-IND meeting with the FDA. While excess cholesterol has long been understood to be important to the development of atherosclerosis, it turns out that circulating cholesterol bound to LDL particles is less important than the amount of localized excess cholesterol in the liver and blood vessel walls. Any localized excess of cholesterol can overwhelm the ability of cells to reduce uptake or store cholesterol in either the cell membrane or in esterified droplets. The resulting free cholesterol inside cells is toxic. The gene therapies developed by the Repair Biotechnologies scientists put in place novel protein machinery that can selectively and safely break down this excess free cholesterol without harming the cholesterol necessary to cell function. This can, for example, protect macrophages from becoming foam cells when exposed to excessive cholesterol. It can also put a halt to dysfunction in liver cells affected by the excess cholesterol present in a fatty liver. Repair Biotechnologies' gene therapy rapidly reverses atherosclerosis in mice Gene therapy company Repair Biotechnologies has revealed promising preclinical results that demonstrate its technology rapidly rever...
Source: Fight Aging! - Category: Research Authors: Tags: Longevity Industry Source Type: blogs