Using Biophysical Protein Models to Map Genetic Variation to Phenotypes (Image 2)
The central scientific hypothesis of the research project "Using biophysical protein models to map genetic variation to phenotypes" by the University of Idaho is that biophysical models of proteins provide an efficient framework for predicting how amino acid changes (left side) -- alone, in ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - December 13, 2017 Category: Science Source Type: video
Using Biophysical Protein Models to Map Genetic Variation to Phenotypes (Image 1)
A research project by the University of Idaho looks at how changes in amino acids lead to changes in the characteristics of living organisms. The project focuses on protein biophysical models and uses a diverse set of experimental systems, molecular and mathematical modeling. In this figure, the ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - December 13, 2017 Category: Science Source Type: video
Simulation shows HIV capsid interacting with its environment
The genetic material of the HIV virus is encased in multiple structures that hide it from the host immune system. The capsid, in blue, protects the virus after it enters a cell and shuttles it to the nucleus, where it completes the process of infection.
More about this image
A ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - December 7, 2017 Category: Science Source Type: video
Scientists fight cancers resistance by re-programming chromatin
Scientists have developed an effective new strategy for treating cancer, which has wiped out the disease to near completion in cellular cultures in the laboratory. The treatment works by controlling chromatin, a group of macromolecules -- including DNA, RNA and proteins -- that houses genetic ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - November 29, 2017 Category: Science Source Type: video
Unraveling the complexities of tryptase form and function in humans
Immunonology IG Seminar
Dr. Jonathan Lyons received his undergraduate education from Pomona College, and a Doctorate of Medicine from the University of Southern California in 2007. Dr. Lyons completed residency training in Internal Medicine at the University of California, San Diego, in 2010, remaining an additional year as a Chief Medical Resident. He concluded his formal medical training as a clinical fellow in Allergy and Immunology at NIAID in 2014. Following completion of fellowship, Jonathan was selected for the NIAID Transition Program in Clinical Research, and he is currently an Assistant Clinical Investigator in t...
Source: Videocast - All Events - November 14, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Towards the assembly of a synthetic bacterial cell
NIH Director's Seminar Series
Bacterial spores, amongst the hardiest organisms on earth, are dormant cell types produced by certain species to protect the cell ’ s genetic material from harsh environmental conditions. Spores of Bacillus subtilis are encased in a thick protein shell, the “ coat ” , which participates in conferring the amazing resistance properties of spores. Using a combination of classical genetics and biochemistry, buttressed by cytological, biophysical, and computational techniques, we are studying spore coat assembly to understand how cells build and localize large static biological structures. We...
Source: Videocast - All Events - November 9, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Loss of Type I Interferon Negative Regulation – Lessons from Human Genetics
Immunonology IG Seminar
Dr. Dusan Bogunovic is an Assistant Professor in the Department of Microbiology, Department of Pediatrics at Mindich Child Health and Development Institute at the Icahn School of Medicine at Mount Sinai in New York. He obtained his PhD in Immunology at NYU Medical School where he studied innate immune signaling in dendritic cells as a function of their ability to mount an adaptive immune response against melanoma. That work has inspired two clinical trials. He did his postdoctoral fellowship at The Rockefeller University with Jean-Laurent Casanova where he studied how host genetics contribute to inf...
Source: Videocast - All Events - November 2, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Stem Cell Aging
GeroScience Interest Group
The Trans-NIH GeroScience Interest Group (GSIG), cordially invites you to its fall seminar, featuring Dr. Sean Morrison. Dr. Morrison is the Director of the Children ’ s Medical Center Research Institute at UT Southwestern and is the Mary McDermott Cook Chair in Pediatric Genetics as well as an Investigator of the Howard Hughes Medical Institute. The Morrison laboratory studies the cellular and molecular mechanisms that regulate the function of stem cells and cancer cells in the nervous and hematopoietic systems. The laboratory is particularly interested in the mechanisms that regulate stem cel...
Source: Videocast - All Events - October 26, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Translational fidelity and neurodegeneration
NIH Director's Wednesday Afternoon Lecture Series
The goal of the Ackerman laboratory is to define the molecular pathways necessary to maintain homeostasis in both developing and aging mammalian neurons. To do this they utilize forward genetics to identify mutations that are associated with loss of neurons in the aging mouse brain. To further dissect pathways underlying homeostatic disruption and disease, they also use forward genetics to identify genetic variants that enhance or suppress neural phenotypes. Their approach allows the identification, without a priori assumptions, of molecules critical for neuron homeostasis ...
Source: Videocast - All Events - October 26, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
From human genetics to therapeutic hypothesis for nervous system disorders: pain and Alzheimer ’ s disease
NIH Director's Wednesday Afternoon Lecture Series
Dr. Sheng is Vice-President, Neuroscience, and responsible for directing neuroscience research and drug discovery efforts at Genentech. An expert on synapse biology, Dr. Sheng is now focused on the genetic underpinnings and pathogenic mechanisms of neurodegenerative disease, including Alzheimer ’ s, Parkinson ’ s, fronto-temporal dementia. In this translational context, recent research activities of the Sheng lab have centered on the molecular and cellular mechanisms of synapse loss, regulation of mitophagy, microglial involvement in neurodegeneration, and functions of ...
Source: Videocast - All Events - October 26, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Principles of Epigenetics and Chromatin in Development and Human Disease
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Ali Shilatifard, Professor and Chairman of the Department of Biochemistry and Molecular Genetics of the Northwestern University Feinberg School of Medicine, is a world renown biochemist and molecular biologist. He is a respected expert in the field of transcription and epigenetics, specifically as it relates to cancer biology. He has an immense interest in understanding the intricate molecular mechanisms of the regulation of gene expression, the mechanisms that activate or suppress a particular gene ’ s traits. As a Jane Coffin Childs postdoctoral fellow, Dr. Sh...
Source: Videocast - All Events - October 23, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
How Telomeres Solve the End-Protection Problem
NCI Center for Cancer Research Eminent Lecture Series
Dr. de Lange's lab studies telomeres, protective elements at the ends of chromosomes critical for the stability and maintenance of the genetic information. Deficiency in telomere function can cause genomic alterations found in cancer, and the gradual loss of telomeres contributes to aging of human cells. Dr. de Lange seeks to understand how telomere protection is established and what happens when telomere function is lost during the early stages of tumor formation.
Dr. de Lange ’ s group is working to determine the mechanism by which each shelterin protein inhibits i...
Source: Videocast - All Events - September 11, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
CC Grand Rounds: Contemporary Clinical Medicine: Great Teachers: Discovering New Genetic Syndromes at the NIH Clinical Research Center: Carney-Stratakis Syndrome, 3PAS, iMAD, X-LAG and Others
For more information go tohttp://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 9/20/2017 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - August 28, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Optogenetics -- revolutionary new research technique (Image 2)
Optogenetics is a revolutionary new research technique that enables scientists to use light to precisely control the activity of neurons in the brain. In optogenetics, light-sensitive ion channels and pumps, known as microbial opsins, are genetically targeted to specific cells, so that upon light ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - July 28, 2017 Category: Science Source Type: video
Research in the Luo Lab, Stanford University (Image 1)
Cerebellar Purkinje cells (four large cell bodies, with elaborate dendrites above them) and granule cells (below the Purkinje cells) that are labeled by a genetic mosaic method called MADM, a method used to reveal the relationships between lineage, birth timing and wiring properties in flies. ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - June 21, 2017 Category: Science Source Type: video
