Brain cells glow in dark with bioluminescent sensor
Three hippocampal neurons glowing with bioluminescent light produced by a new genetically engineered sensor. A team of Vanderbilt University scientists have genetically modified luciferase, the enzyme that produces bioluminescence, so that it acts as an optical sensor that records activity in ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - March 1, 2017 Category: Science Source Type: video
Genetics and immunology of alopecia areata
NIH Director ’ s Wednesday Afternoon Lecture Series
For the past 20 years, Dr. Christiano's research has focused on understanding the molecular processes that lead to inherited skin and hair disorders in humans. Her research career began with the discovery of genetic mutations associated with epidermolysis bullosa, a skin disease that causes severe blistering. Dr. Christiano's recent work has focused on the investigation of the underlying genetic causes of and identification of potential therapies for alopecia areata, an autoimmune form of hair loss.For more information go tohttps://oir.nih.gov/walsAir date: 3/1/2017 3...
Source: Videocast - All Events - February 27, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Return of Genetic Results in the All Of Us Research Program (Day 1)
All Of Us Research ProgramAir date: 3/6/2017 8:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 21, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Return of Genetic Results in the All Of Us Research Program (Day 2)
All Of Us Research ProgramAir date: 3/7/2017 8:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 21, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
CANCELLED - Exploring the behavioral responses to danger one millisecond at a time
The NIH Neuroscience Seminar scheduled for today, February 13, has been cancelled. Our speaker, Clifford Woolf, was unable to fly out of Boston due to a large snow storm. An attempt will be made to reschedule.
NIH Neuroscience Series Seminar
Neuronal plasticity, its mechanistic basis, how it contributes to the normal and abnormal functions of the nervous system, and how it can be a target for therapy comprise the major focus of Dr. Woolf ’ s investigations. Specifically, he studies neural plasticity in relation to pain, regeneration, neurodegenerative disorders and developmental neurobiology.
Dr. Woolf has spearheaded d...
Source: Videocast - All Events - February 13, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
The microbiota as instructor and arbiter of immune responses in health and disease
NIH Director's Wednesday Afternoon Lecture Series
Dr. Littman ’ s laboratory applies molecular and genetics tools to study how T lymphocytes develop and participate in inflammation and how HIV interacts with the host innate immune system. Dr. Littman isolated the genes for the CD4 and CD8 co-receptors and determined how their expression is regulated and their signaling influences selection of helper and cytotoxic cells. His group discovered that the nuclear receptor ROR t regulates differentiation of Th17 cells and lymphoid tissue inducer cells and that it can be targeted for autoimmune disease therapy. He and his co...
Source: Videocast - All Events - February 6, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
The future of genetic codes and BRAIN codes
Marshall W. Nirenberg LectureFor more information go tohttps://oir.nih.gov/wals/2016-2017Air date: 2/8/2017 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 2, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Curing HIV infection: going beyond N=1
Immunology Interest Group Seminar Series
The latent reservoir for HIV is a major barrier to curing HIV
infection. This talk will discuss recent studies of the mechanism by
which the reservoir arises, the mechanism by which it is maintained, and
approaches for measuring the reservoir in patients participating in HIV
cure trials.
Dr. Robert F. Siliciano is a Professor of Medicine and Molecular Biology and Genetics at the Johns Hopkins University School of Medicine and a member of the Howard Hughes Medical Institute. In 1995, his laboratory provided the first demonstration that latently infected memory CD4+ T cells were p...
Source: Videocast - All Events - January 26, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Magic in the Web of It: How a Rare Disorder is Untangling the Mysteries of Parkinson Disease
NHGRI Director Seminar Series
Dr. Ellen Sidransky,Sr. Investigator at the Medical Genetics Branch will be giving a seminar on: The “ Magic in the Web of It ” : How a Rare Disorder is Untangling the Mysteries of Parkinson Disease. There will be one patient for interview.Air date: 1/26/2017 2:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 25, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Demystifying Medicine 2017: Genetic Disease Testing: Current Status and Future Prospects
The Demystifying Medicine Lecture Series is designed to help bridge the gap between advances in biology and their applications to major human diseases. Each lecture will feature a presentation on a major disease, including current research and advancements on treatments.For more information go tohttps://demystifyingmedicine.od.nih.govAir date: 3/14/2017 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 23, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Human pluripotent stem cells in understanding genetic cardiovascular disease and effects of drugs
NIH Director ’ s Wednesday Afternoon Lecture Series
There's a growing interest in how the derivation of many different cell types from human pluripotent stem cells-embryonic stem cells (HESCs) and induced pluripotent stem cells (hiPS cells)-could be used for potential cell therapy and as a platform for drug discovery and toxicity. In particular, new methods of introducing specific disease mutations into human pluripotent stem cells and/or reprogramming them to derive hiPS cells, allow the creation of disease models " in a dish " so scientists can study ways to treat diseases or slow them down. To move the field forward, ...
Source: Videocast - All Events - January 23, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Leptin and the neural circuit regulation food intake and glucose metabolism
NIH Director ’ s Wednesday Afternoon Lecture Series
Jeffrey Friedman studies the molecular mechanisms that regulate food intake and body weight. Genetic studies in mice led to the identification of leptin, a hormone made by fat tissue, that plays a key role in regulating weight. Current studies explore the mechanisms by which leptin controls feeding behavior and body weight. Studies to identify other key regulators are also under way.For more information go tohttps://oir.nih.gov/walsAir date: 1/11/2017 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - December 23, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Modeling Zika virus in mice: What have we learned so far?
Immunology Interest Group Seminar Series
The recent spread of Zika virus (ZIKV) and its association with increased rates of Guillain Barre and other neurological disorders as well as congenital defects that include microcephaly has created an urgent need to develop animal models to examine the pathogenesis of the disease and explore the efficacy of potential therapeutics and vaccines. Recently developed infection models for ZIKV utilize mice defective in interferon responses. This talk will describe a new model of peripheral ZIKV infection using immunocompetent neonatal C57BL/6 mice and compare its clinical progression, vi...
Source: Videocast - All Events - December 1, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Digging for genes that contribute to behavioral evolution
NIH Director's Wednesday Afternoon Lecture Series
Dr. Hoekstra is an evolutionary geneticist who studies the molecular basis of adaptation in wild deer mice. Her work spans the fields of evolution, behavior, morphology, genetics, genomics, development, and neurobiology. Her first major work focused on the genetic basis of cryptic coloration in wild mice, but more recently her lab has extended this work to study the genetic and neural basis of natural behaviors.
Understanding which genes affect behavior, and how the resultant proteins work in the brain, remains a major challenge in biology. To address this goal, Dr. Hoekstr...
Source: Videocast - All Events - November 28, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Roles of regulatory RNAs & RNA-binding proteins in (re)programming patterns of gene expression
NIH Director's Seminar Series
The Integrative Immunobiology Section is interested in understanding how gene expression programs are orchestrated in our cells, particularly stem cells. Specifically, the laboratory studies how these systems are controlled by non-coding RNAs and RNA-binding proteins. Our major goal is to discover novel molecular circuits that control cell fates in the hematopoietic and immune systems, since perturbations in their genetic regulatory networks underlie many diseases. To address these fundamental issues, we employ an integrative systems biology approach to reverse engineer the molecular logic of ...
Source: Videocast - All Events - November 14, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
