NIH Director's Seminar: Of humans and mice: Fundamental mechanisms of tissue-specific antifungal immunity

NIH Director's Seminar Series Over the past few decades, fungal infections have emerged as major causes of morbidity and mortality in immunosuppressed patients despite the administration of antifungal therapy. This talk will highlight recent advances in our understanding of the cellular and molecular basis of protective host immunity against mucosal and invasive fungal infections. These insights have been gained via enrollment at the NIH Clinical Center of large cohorts of patients with inherited and acquired susceptibility to fungal disease and via corroborating immunological research in clinically relevant mouse models of fungal infections. Better knowledge of the genetic and immune defects that underlie the development of human fungal disease may help develop improved vaccine- and immune-based strategies in vulnerable patients.Air date: 6/7/2019 11:00:00 AM
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