Genes, Vol. 15, Pages 551: Whole-Genome Resequencing Revealed Selective Signatures for Growth Traits in Hu and Gangba Sheep
This study analyzes the genetic basis for significant differences in sheep phenotypes, identifies candidate genes related to sheep growth traits, lays the foundation for molecular genetic breeding in sheep, and accelerates the genetic improvement in livestock. (Source: Genes)
Source: Genes - April 26, 2024 Category: Genetics & Stem Cells Authors: Peifu Yang Mingyu Shang Jingjing Bao Tianyi Liu Jinke Xiong Jupeng Huang Jinghua Sun Li Zhang Tags: Article Source Type: research
Genes, Vol. 15, Pages 550: Complete Chloroplast Genome Sequence Structure and Phylogenetic Analysis of Kohlrabi (Brassica oleracea var. gongylodes L.)
g Ren
Kohlrabi is an important swollen-stem cabbage variety belonging to the Brassicaceae family. However, few complete chloroplast genome sequences of this genus have been reported. Here, a complete chloroplast genome with a quadripartite cycle of 153,364 bp was obtained. A total of 132 genes were identified, including 87 protein-coding genes, 37 transfer RNA genes and eight ribosomal RNA genes. The base composition analysis showed that the overall GC content was 36.36% of the complete chloroplast genome sequence. Relative synonymous codon usage frequency (RSCU) analysis showed that most codons with values greater tha...
Source: Genes - April 26, 2024 Category: Genetics & Stem Cells Authors: Mengliang Zhao Yanxun Wu Yanjing Ren Tags: Article Source Type: research
Genes, Vol. 15, Pages 552: Novel Genome-Engineered H Alleles Differentially Affect Lateral Inhibition and Cell Dichotomy Processes during Bristle Organ Development
. Nagel
Hairless (H) encodes the major antagonist in the Notch signaling pathway, which governs cellular differentiation of various tissues in Drosophila. By binding to the Notch signal transducer Suppressor of Hairless (Su(H)), H assembles repressor complexes onto Notch target genes. Using genome engineering, three new H alleles, HFA, HLLAAand HWA were generated and a phenotypic series was established by several parameters, reflecting the residual H-Su(H) binding capacity. Occasionally, homozygous HWA flies develop to adulthood. They were compared with the likewise semi-viable HNN allele affecting H-Su(H) nuclear entr...
Source: Genes - April 26, 2024 Category: Genetics & Stem Cells Authors: Tanja C. M önch Thomas K. Smylla Franziska Br ändle Anette Preiss Anja C. Nagel Tags: Article Source Type: research
Genes, Vol. 15, Pages 553: Exploring the Role of Cell-Free Nucleic Acids and Peritoneal Dialysis: A Narrative Review
Conclusions: This review explores the relevance of cf-NAs in PD, demonstrating its promising role for both diagnosis and treatment. Further studies are necessary to implement the use of cf-NAs in PD clinical practice. (Source: Genes)
Source: Genes - April 26, 2024 Category: Genetics & Stem Cells Authors: Niccol ò Morisi Grazia Maria Virz ì Marco Ferrarini Gaetano Alfano Monica Zanella Claudio Ronco Gabriele Donati Tags: Review Source Type: research
Genes, Vol. 15, Pages 554: Exploring the Role of the MUTYH Gene in Breast, Ovarian and Endometrial Cancer
Conclusions: our results fail to demonstrate that germinal monoallelic MUTYH variants increase cancer risk through a LOH (loss of heterozygosity) mechanism in the somatic tissue; however, the absence or partial loss of the MUTYH protein in many tumors suggests its dysregulation regardless of MUTYH genetic status. (Source: Genes)
Source: Genes - April 26, 2024 Category: Genetics & Stem Cells Authors: Carla Lintas Benedetta Canalis Alessia Azzar à Giovanna Sabarese Giuseppe Perrone Fiorella Gurrieri Tags: Article Source Type: research
Genes, Vol. 15, Pages 555: GhCLCc-1, a Chloride Channel Gene from Upland Cotton, Positively Regulates Salt Tolerance by Modulating the Accumulation of Chloride Ions
gbin Ma
Wei Liu
The ionic toxicity induced by salinization has adverse effects on the growth and development of crops. However, researches on ionic toxicity and salt tolerance in plants have focused primarily on cations such as sodium ions (Na+), with very limited studies on chloride ions (Cl−). Here, we cloned the homologous genes of Arabidopsis thaliana AtCLCc, GhCLCc-1A/D, from upland cotton (Gossypium hirsutum), which were significantly induced by NaCl or KCl treatments. Subcellular localization showed that GhCLCc-1A/D were both localized to the tonoplast. Complementation of Arabidopsis...
Source: Genes - April 26, 2024 Category: Genetics & Stem Cells Authors: Wenhao Li Siqi Gao Yinghao Zhao Yuchen Wu Xiaona Li Jianing Li Wei Zhu Zongbin Ma Wei Liu Tags: Article Source Type: research
Genes, Vol. 15, Pages 549: A Bidirectional Non-Coding RNA Promoter Mediates Long-Range Gene Expression Regulation
illas-Targa
Recent evidence suggests that human gene promoters display gene expression regulatory mechanisms beyond the typical single gene local transcription modulation. In mammalian genomes, genes with an associated bidirectional promoter are abundant; bidirectional promoter architecture serves as a regulatory hub for a gene pair expression. However, it has been suggested that its contribution to transcriptional regulation might exceed local transcription initiation modulation. Despite their abundance, the functional consequences of bidirectional promoter architecture remain largely unexplored. This work studies the...
Source: Genes - April 25, 2024 Category: Genetics & Stem Cells Authors: Carlos Alberto Peralta-Alvarez Hober Nelson N úñez-Martínez Ángel Josué Cerecedo-Castillo Augusto C ésar Poot-Hernández Gustavo Tapia-Urz úa Sylvia Garza-Manero Georgina Guerrero F élix Recillas-Targa Tags: Article Source Type: research
Genes, Vol. 15, Pages 538: Colorectal Cancer: Genetic Underpinning and Molecular Therapeutics for Precision Medicine
ill
Colorectal cancer (CRC) accounts for about 10% of all cancer cases and 9% of cancer-related deaths globally. In the United States alone, CRC represents approximately 12.6% of all cancer cases, with a mortality rate of about 8%. CRC is now the first leading cause of cancer death in men younger than age 50 and second in women younger than age 50. This review delves into the genetic landscape of CRC, highlighting key mutations and their implications in disease progression and treatment. We provide an overview of the current and emerging therapeutic strategies tailored to individual genomic profiles. (Source: Genes)
Source: Genes - April 25, 2024 Category: Genetics & Stem Cells Authors: Gideon T. Dosunmu Ardaman Shergill Tags: Review Source Type: research
Genes, Vol. 15, Pages 539: Oxidative Stress Biomarkers in Male Infertility: Established Methodologies and Future Perspectives
Lucia Rocco
Male fertility can be affected by oxidative stress (OS), which occurs when an imbalance between the production of reactive oxygen species (ROS) and the body’s ability to neutralize them arises. OS can damage cells and influence sperm production. High levels of lipid peroxidation have been linked to reduced sperm motility and decreased fertilization ability. This literature review discusses the most commonly used biomarkers to measure sperm damage caused by ROS, such as the high level of OS in seminal plasma as an indicator of imbalance in antioxidant activity. The investigated biomarkers inclu...
Source: Genes - April 25, 2024 Category: Genetics & Stem Cells Authors: Filomena Mottola Ilaria Palmieri Maria Carannante Angela Barretta Shubhadeep Roychoudhury Lucia Rocco Tags: Review Source Type: research
Genes, Vol. 15, Pages 541: The Satellite DNA PcH-Sat, Isolated and Characterized in the Limpet Patella caerulea (Mollusca, Gastropoda), Suggests the Origin from a Nin-SINE Transposable Element
In this study, we isolated and characterized a sat-DNA, here named PcH-sat, in the limpet Patella caerulea using the restriction enzyme method, particularly HaeIII. Monomeric units of PcH-sat are 179 bp long, AT-rich (58.7%), and with an identity among monomers ranging from 91.6 to 99.8%. Southern blot showed that PcH-sat is conserved in P. depressa and P. ulyssiponensis, while a smeared signal of hybridization was present in the other three investigated limpets (P. ferruginea, P. rustica and P. vulgata). Dot blot showed that PcH-sat represents about 10% of the genome of P. caerulea, 5% of that of P. depressa, and 0.3% of ...
Source: Genes - April 25, 2024 Category: Genetics & Stem Cells Authors: Agnese Petraccioli Nicola Maio Rosa Carotenuto Gaetano Odierna Fabio Maria Guarino Tags: Article Source Type: research
Genes, Vol. 15, Pages 540: Characterization of the Apoptotic and Antimicrobial Activities of Two Initiator Caspases of Sea Cucumber Apostichopus japonicus
Li Sun
Caspase (CASP) is a protease family that plays a vital role in apoptosis, development, and immune response. Herein, we reported the identification and characterization of two CASPs, AjCASPX1 and AjCASPX2, from the sea cucumber Apostichopus japonicus, an important aquaculture species. AjCASPX1/2 share similar domain organizations with the vertebrate initiator caspases CASP2/9, including the CARD domain and the p20/p10 subunits with conserved functional motifs. However, compared with human CASP2/9, AjCASPX1/2 possess unique structural features in the linker region between p20 and p10. AjCASPX1, but not AjCASPX2, ...
Source: Genes - April 25, 2024 Category: Genetics & Stem Cells Authors: Hanshuo Zhu Zihao Yuan Hang Xu Li Sun Tags: Article Source Type: research
Genes, Vol. 15, Pages 543: Downregulation of Histone H3.3 Induces p53-Dependent Cellular Senescence in Human Diploid Fibroblasts
etoshi Tahara
Cellular senescence is an irreversible growth arrest that acts as a barrier to cancer initiation and progression. Histone alteration is one of the major events during replicative senescence. However, little is known about the function of H3.3 in cellular senescence. Here we found that the downregulation of H3.3 induced growth suppression with senescence-like phenotypes such as senescence-associated heterochromatin foci (SAHF) and β-galactosidase (SA-β-gal) activity. Furthermore, H3.3 depletion induced senescence-like phenotypes with the p53/p21-depedent pathway. In addition, we i...
Source: Genes - April 25, 2024 Category: Genetics & Stem Cells Authors: Yuki Yamamoto Ryou-u Takahashi Masaki Kinehara Kimiyoshi Yano Tatsuya Kuramoto Akira Shimamoto Hidetoshi Tahara Tags: Article Source Type: research
Genes, Vol. 15, Pages 542: Comparative Analysis of Virulence and Molecular Diversity of Puccinia striiformis f. sp. tritici Isolates Collected in 2016 and 2023 in the Western Region of China
This study aimed to evaluate the virulence and molecular diversity of 84 old Pst isolates, in comparison to 59 newer ones. By using 19 Chinese wheat differentials, we identified 98 pathotypes, showing virulence complexity ranging from 0 to 16. Associations between 23 Yr gene pairs showed linkage disequilibrium and have the potential for gene pyramiding. The new Pst isolates had a higher number of polymorphic alleles (1.97), while the older isolates had a slightly higher number of effective alleles, Shannon’s information, and diversity. The Gansu Pst population had the highest diversity (uh = 0.35), while the ...
Source: Genes - April 25, 2024 Category: Genetics & Stem Cells Authors: Tesfay Gebrekirstos Gebremariam Fengtao Wang Ruiming Lin Hongjie Li Tags: Article Source Type: research
Genes, Vol. 15, Pages 544: Complete Chloroplast Genome of Alternanthera sessilis and Comparative Analysis with Its Congeneric Invasive Weed Alternanthera philoxeroides
In this study, we sequenced and assembled the complete chloroplast genome of A. sessilis using high-throughput sequencing. The A. sessilis chloroplast genome is 151,935 base pairs long, comprising two inverted repeat regions, a large single copy region, and a small single copy region. This chloroplast genome contains 128 genes, including 8 rRNA-coding genes, 37 tRNA-coding genes, 4 pseudogenes, and 83 protein-coding genes. When compared to the chloroplast genome of the invasive weed A. philoxeroides and other Amaranthaceae species, we observed significant variations in the ccsA, ycf1, and ycf2 regions in the A. sessilis ch...
Source: Genes - April 25, 2024 Category: Genetics & Stem Cells Authors: Yuanxin Wang Xueying Zhao Qianhui Chen Jun Yang Jun Hu Dong Jia Ruiyan Ma Tags: Article Source Type: research
Genes, Vol. 15, Pages 545: Integrated Analysis of Transcriptome and Metabolome Reveals Differential Responses to Alternaria brassicicola Infection in Cabbage (Brassica & nbsp;oleracea var. capitata)
Genes, Vol. 15, Pages 545: Integrated Analysis of Transcriptome and Metabolome Reveals Differential Responses to Alternaria brassicicola Infection in Cabbage (Brassica oleracea var. capitata)
Genes doi: 10.3390/genes15050545
Authors:
Jinzhou Lei
Wei Zhang
Fangwei Yu
Meng Ni
Zhigang Liu
Cheng Wang
Jianbin Li
Jianghua Song
Shenyun Wang
Black spot, caused by Alternaria brassicicola (Ab), poses a serious threat to crucifer production, and knowledge of how plants respond to Ab infection is essential for black spot management. In the current study, combined transcriptomic and metabolic analysis w...
Source: Genes - April 25, 2024 Category: Genetics & Stem Cells Authors: Jinzhou Lei Wei Zhang Fangwei Yu Meng Ni Zhigang Liu Cheng Wang Jianbin Li Jianghua Song Shenyun Wang Tags: Article Source Type: research
