Genes, Vol. 15, Pages 554: Exploring the Role of the MUTYH Gene in Breast, Ovarian and Endometrial Cancer

Conclusions: our results fail to demonstrate that germinal monoallelic MUTYH variants increase cancer risk through a LOH (loss of heterozygosity) mechanism in the somatic tissue; however, the absence or partial loss of the MUTYH protein in many tumors suggests its dysregulation regardless of MUTYH genetic status.
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research