Study surveys molecular landscape of endometrial cancer
(NYU Langone Health / NYU School of Medicine) The most comprehensive molecular study of endometrial cancer to date has further defined the contributions of key genes and proteins to the disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2020 Category: Cancer & Oncology Source Type: news

New, detailed molecular roadmap boosts fight against endometrial cancer
(DOE/Pacific Northwest National Laboratory) Scientists have taken an unprecedented look at the proteins involved in endometrial cancer, commonly known as uterine cancer. The study offers insights about how physicians might be able to better identify which patients will need aggressive treatment and which won't, and offers clues about why a common cancer treatment is not effective with some patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2020 Category: Cancer & Oncology Source Type: news

Utah researchers discover key protein in endometrial cancer growth
(Huntsman Cancer Institute) New research, published today in the journal Cancer Research, outlines findings scientists hope will advance our understanding of endometrial cancer and lead to more effective treatments. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 11, 2020 Category: Cancer & Oncology Source Type: news

Testosterone Has Different Effect in Men and Women
In women, testosterone may increase the risk for type 2 diabetes, while in men it lowers that risk. But high levels of testosterone increase the risk for breast and endometrial cancer in women and prostate cancer in men, the researchers reported. (Source: WebMD Health)
Source: WebMD Health - February 10, 2020 Category: Consumer Health News Source Type: news

LY3023414 Demonstrates Manageable Safety Profile in Patients with Endometrial Cancer
The dual PI3K/mTOR inhibitor LY3023414 also displayed moderate single-agent activity in this study of patients with heavily pretreated advanced endometrial cancer. (Source: CancerNetwork)
Source: CancerNetwork - January 26, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

The Big Number: Why your risks for 7 types of cancer could be reduced with physical activity
Research shows several exercises can be effective against these cancers: breast, colon, endometrial, kidney, liver, multiple myeloma and non-Hodgkin lymphoma. (Source: Washington Post: To Your Health)
Source: Washington Post: To Your Health - January 12, 2020 Category: Consumer Health News Authors: Linda Searing Source Type: news

The Prognosis of Stage IA Mixed Endometrial Carcinoma The Prognosis of Stage IA Mixed Endometrial Carcinoma
A study determines that the serous subtype may be associated with a poor prognosisin in uterine cancer.American Journal of Clinical Pathology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 31, 2019 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news

Study Identifies Factors of Microbiome Composition in Endometrial Cancer
A research team from the Mayo clinic verified the known risk factors for endometrial cancer, while identifying a possible microbiome signature associated with the disease. (Source: CancerNetwork)
Source: CancerNetwork - December 27, 2019 Category: Cancer & Oncology Authors: Kevin Wright Source Type: news

Exercise may reduce risk for cancer by as much as 25 percent
People who engaged in physical activity as recommended by the NIH were able to reduce their risk for colon and breast cancers, as well as endometrial cancer, kidney cancer, myeloma, liver cancer and non-Hodgkin lymphoma. (Source: Health News - UPI.com)
Source: Health News - UPI.com - December 26, 2019 Category: Consumer Health News Source Type: news

Model predicts metastases in endometrial cancer patients
Using ultrasound in combination with endometrial biopsy results and clinical...Read more on AuntMinnie.comRelated Reading: MRI helps predict outcomes of endometriosis surgery PET/CT makes case for directing cervical cancer treatment Contrast ultrasound identifies early cervical cancer (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - December 24, 2019 Category: Radiology Source Type: news

Mayo Clinic researchers look at post menopause as key factor in endometrial cancer
(Mayo Clinic) Endometrial cancer is the most common gynecological malignancy in the US and the fourth most common cancer among women. In addition, endometrial cancer incidence rates are on the rise in the western world, suggesting that alterations in environmental factors such as diet, lifestyle, and the vaginal microbiome may be important drivers in its cause. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 16, 2019 Category: Cancer & Oncology Source Type: news

Mayo Clinic researchers look at post menopause as key factor in endometrial cancer
ROCHESTER, Minn. -- Endometrial cancer is the most common gynecological malignancy in the U.S. and the fourth most common cancer among women. In addition, endometrial cancer incidence rates are on the rise in the western world, suggesting that alterations in environmental factors such as diet, lifestyle, and the vaginal microbiome may be important drivers in [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - December 16, 2019 Category: Databases & Libraries Source Type: news

Patients with Endometrial Cancer Pose High Risk of Dying from Cardiovascular Disease
Patients with endometrial cancer pose a very high risk of dying from cardiovascular diseases in the year after diagnosis, suggesting the necessity of early involvement of cardiologists for these patients. (Source: CancerNetwork)
Source: CancerNetwork - December 2, 2019 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Early Chemo Does Not Improve Survival in Endometrial Cancer
Endometrial cancer survival correlates with total number of chemotherapy cycles – but not whether they are started earlier than radiation, according to the results of a new study. (Source: CancerNetwork)
Source: CancerNetwork - November 1, 2019 Category: Cancer & Oncology Authors: Seth Augenstein Source Type: news

Role of COX7RP in Endometrial, Breast Cancer Growth
COX7RP contributes to endometrial and breast cancer growth. (Source: CancerNetwork)
Source: CancerNetwork - October 4, 2019 Category: Cancer & Oncology Authors: Leanne Marcello, MS Source Type: news

Analysis of Cervical Mutations Aids Endometrial Cancer Diagnosis
Diagnosis of endometrial carcinoma made easier by analysis of mutations in cervix or endometrial tissue. (Source: CancerNetwork)
Source: CancerNetwork - October 2, 2019 Category: Cancer & Oncology Authors: Leanne Marcello, MS Source Type: news

Can Recurrent Ovarian Cancer Patients Avoid Chemotherapy?
The AVANOVA2 trial enrolled a total of 97 patients with high-grade serous or endometrioid platinum-sensitive recurrent ovarian cancer. (Source: CancerNetwork)
Source: CancerNetwork - September 20, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Project Orbis Enables First International Approval in U.S., Canada, Australia
The first-of-its-kind collaboration led to the approval of a combination therapy for patients with endometrial cancer. (Source: CancerNetwork)
Source: CancerNetwork - September 19, 2019 Category: Cancer & Oncology Authors: Seth Augenstein Source Type: news

US, Canada, Australia Approve Endometrial Cancer Combo US, Canada, Australia Approve Endometrial Cancer Combo
Regulatory agencies in three countries, including the United States, all approved lenvatinib in combination with pembrolizumab for the treatment of patients with advanced endometrial carcinoma.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 17, 2019 Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news

FDA takes first action under new international collaboration with Australia and Canada designed to provide a framework for concurrent review of cancer therapies, approving treatment for patients with endometrial carcinoma
Project Orbis provides a framework for concurrent submission and review of oncology drugs among its international partners. Under this project, the FDA, Australia and Canada collaboratively reviewed applications for two oncology drugs, allowing for simultaneous decisions in all three countries. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - September 17, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news

ASTRO: Cervical cancer deaths rise as women's centers close
CHICAGO - Women in states where family planning clinics have closed received...Read more on AuntMinnie.comRelated Reading: ASTRO: Is hormone therapy after prostate surgery needed? 3D printing customizes brachytherapy for cervical cancer Contrast ultrasound identifies early cervical cancer FDG-PET/CT targets metastases in cervical, endometrial cancer Volumetric MR images boost cervical cancer treatment planning (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - September 17, 2019 Category: Radiology Source Type: news

Pembrolizumab Plus Lenvatinib Approved for Endometrial Cancer
The combination was simulataneously approved in Australia and Canada and was the first such action under a new international collaboration. (Source: CancerNetwork)
Source: CancerNetwork - September 17, 2019 Category: Cancer & Oncology Authors: Erin Kayata Source Type: news

FDA Approves Keytruda (pembrolizumab) plus Lenvima (lenvatinib) Combination Treatment for Patients with Certain Types of Endometrial Carcinoma
KENILWORTH, N.J.,& WOODCLIFF LAKE, N.J.-- September 17, 2019 -- (BUSINESS WIRE)--Merck (NYSE: MRK), known as MSD outside the United States and Canada, and Eisai today announced that the U.S. Food and Drug Administration (FDA) approved the... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - September 17, 2019 Category: Drugs & Pharmacology Source Type: news

Women Who Use IUDs May Be At Lower Risk For Ovarian Cancer, Study Finds
BOSTON (CBS) – Nearly 14,000 American women will die from ovarian cancer this year, but a new study from the UCHealth University of Colorado Hospital finds that women who use IUDs may be at lower risk. The symptoms of ovarian cancer can be mild or vague and there is no reliable screening test, so the diagnosis often isn’t made until it’s pretty advanced. But a new study of thousands of women around the world found that women who use intrauterine devices, or IUDs, for contraception may be 15-32% less likely to develop ovarian cancer. It’s not clear for how long they need to use one or why they may be...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - September 11, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health Syndicated CBSN Boston Syndicated Local Dr. Mallika Marshall HealthWatch IUD Source Type: news

Mayo Clinic Minute: 3 things women should know about gynecologic cancer
Cancer of a woman's reproductive organs is referred to as "gynecologic cancer." Dr. Amanika Kumar, a Mayo Clinic OB-GYN, says there are many forms of gynecologic cancer: endometrial or uterine, ovarian, vulvar, cervical, and vaginal. Watch: The Mayo Clinic Minute https://youtu.be/G6371uKfois Journalists: Broadcast-quality video pkg (0:58) is in the downloads at the end of the post. [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - September 9, 2019 Category: Databases & Libraries Source Type: news

Is Precision Therapy an Option for Advanced Endometrial Carcinoma?
Researchers identified a highly recurrent, disease-specific PP2A PPP2R1A mutation as a driver of endometrial carcinoma and as a target for new drugs. (Source: CancerNetwork)
Source: CancerNetwork - September 5, 2019 Category: Cancer & Oncology Authors: Naveed Saleh, MD, MS Source Type: news

Adjuvant Chemoradiotherapy May Boost Endometrial-Cancer Survival Adjuvant Chemoradiotherapy May Boost Endometrial-Cancer Survival
Combined adjuvant chemotherapy and radiotherapy appear significantly more effective than pelvic radiotherapy alone for women with high-risk endometrial cancer, according to a post hoc analysis of the PORTEC-3 trial.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 14, 2019 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Obesity 'raises cancer risk by TWICE as much as previously thought', study warns
Scientists at the International Agency for Research on Cancer in Lyon, France, found the risk was underestimated for bowel, kidney, pancreatic, endometrial and ovarian cancers. (Source: the Mail online | Health)
Source: the Mail online | Health - August 9, 2019 Category: Consumer Health News Source Type: news

Two Genes Conspire in Endometriosis and Cancer to Help Cells Migrate
The genes promote the migration of endothelial cells outside of the uterus, a characteristic of both endometriosis and endometrial cancers, a study of mice and human tissue finds. (Source: The Scientist)
Source: The Scientist - August 9, 2019 Category: Science Tags: News & Opinion Source Type: news

Podcast: Use of computer or robotic technology to assist surgeons in performing gynaecological surgery
In conclusion, low-certainty evidence for hysterectomy and sacrocolpopexy operations suggests that complication rates for robot-assisted surgery might be similar to those for conventional laparoscopic surgery. Things are more uncertain for gynaecological cancer, where we found no comparative evidence on cancer recurrence or survival after the surgery. As robot-assisted surgery depends on the skill and experience of the surgeon and is expensive, evaluating its effectiveness and safety continues to present a challenge; but this needs to be met if we are to have reliable evidence on its potential benefits and harms.Read the C...
Source: Cochrane News and Events - August 9, 2019 Category: Information Technology Authors: Lydia Parsonson Source Type: news

Guardant Brings Home Strong Results as Liquid Biopsy Space Heats Up
Guardant Health is one of the biggest names in liquid biopsy and after Monday its presence in the space can only increase. The Redwood City, CA-based company revealed results of a study conducted by it along with researchers from The University of Texas MD Anderson Cancer Center, the Samsung Medical Center, and other institutions. Results show the Guardant360 assay can accurately detect microsatellite instability status (MSI) as accurately as tissue biopsy. The company said this is the largest comparison of MSI testing to traditional tissue methods across multiple solid tumor types. Findings were reported in Cl...
Source: MDDI - August 5, 2019 Category: Medical Devices Authors: Omar Ford Tags: IVD Source Type: news

Ribociclib-Letrozole Regimen Tested in Ovarian, Endometrial Cancer
Researchers examined the results of ribociclib and letrozole as a treatment for patients with  estrogen receptor-positive ovarian cancer and endometrial cancer. (Source: CancerNetwork)
Source: CancerNetwork - July 23, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Many of the deadliest cancers receive the least amount of research funding
(Northwestern University) Many of the deadliest or most common cancers get the least amount of nonprofit research funding, reports a new Northwestern Medicine study. 'Embarrassing' or stigmatized cancers, like lung and liver, are underfunded. Colon, endometrial, liver and bile duct, cervical, ovarian, pancreatic and lung cancers were all poorly funded compared to how common they are and how many deaths they cause, the study found. In contrast, breast cancer, leukemia, lymphoma and pediatric cancers were all well-funded, respective to their impact on society. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 18, 2019 Category: Cancer & Oncology Source Type: news

Endometrial Safety of Vaginal Estrogens in Menopausal Women Endometrial Safety of Vaginal Estrogens in Menopausal Women
Does treatment of vulvar and vaginal atrophy with unopposed vaginal estrogens increase the risk for endometrial hyperplasia or cancer in menopausal women?Menopause (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 16, 2019 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Journal Article Source Type: news

Endometrial cancer clinical trial aims to pave the way for practice-changing therapy
(University of Colorado Anschutz Medical Campus) The University of Colorado Cancer Center is leading the way in the development of a new endometrial cancer clinical trial that may lead to practice-changing therapies. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 11, 2019 Category: International Medicine & Public Health Source Type: news

The Case for Tumor and Germline Testing in Endometrial Cancer Patients
A new study reinforces the need for universal mismatch repair protein immunohistochemistry screening of tumors from endometrial cancer patients, as well as germline genetic testing in accordance with guidelines. (Source: CancerNetwork)
Source: CancerNetwork - June 27, 2019 Category: Cancer & Oncology Authors: Christina Bennett, MS Source Type: news

Breaking New Ground in the Treatment of Advanced Endometrial Cancer
Dr. Makker summarizes the standard of care for the treatment of advanced endometrial cancer, with a look forward to the multitude of clinical trials evaluating novel therapy combinations that are currently enrolling patients or underway. (Source: CancerNetwork)
Source: CancerNetwork - June 19, 2019 Category: Cancer & Oncology Authors: Vicky Makker, MD Source Type: news

Molecular analysis could improve the early detection and prevention of endometrial cancer
(IDIBELL-Bellvitge Biomedical Research Institute) Researchers from IDIBELL and ICO lead the proposal to evaluate genomic analyzes in cervical cytologies to improve the detection of cancer of the uterine cavity. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 17, 2019 Category: Cancer & Oncology Source Type: news

Carboplatin & paclitaxel chemotherapy alone should remain standard treatment for endometrial cancer
(NRG Oncology) The New England Journal of Medicine recently published the primary endpoint of the NRG Oncology clinical trial NRG-GOG 0258, which showed that carboplatin and paclitaxel chemotherapy preceded by radiotherapy with concurrent cisplatin, or combined modality therapy, did not significantly increase recurrence-free survival for women with stage 3-4A endometrial cancer when compared to chemotherapy with carboplatin and paclitaxel alone. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 13, 2019 Category: International Medicine & Public Health Source Type: news

Chemo Alone in Advanced Endometrial Cancer? Chemo Alone in Advanced Endometrial Cancer?
Chemotherapy plus radiation was not associated with longer relapse-free survival than chemotherapy alone in patients with advanced endometrial carcinoma.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - June 13, 2019 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Chemoradiation Does Not Up Survival in Endometrial Cancer
WEDNESDAY, June 12, 2019 -- For patients with stage III or IVA endometrial cancer, chemotherapy plus radiation is not associated with improved relapse-free survival versus chemotherapy alone, according to a study published in the June 13 issue of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 12, 2019 Category: Pharmaceuticals Source Type: news

Radiation plus chemotherapy doesn't improve endometrial cancer recurrence-free survival
(Northwestern University) The standard of care for women with stage III/IVA endometrial cancer following surgery has been chemotherapy and radiation to prevent recurrence. But in a surprising new finding, radiation combined with chemotherapy did not increase recurrence-free survival in these women, reports a National Cancer Institute-sponsored study. Chemotherapy alone should now be the standard of care for stage III uterine cancer, the lead author said. This is the first study comparing the combined regimen to chemotherapy alone. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 12, 2019 Category: Cancer & Oncology Source Type: news

Dr. Yoland Catherine Antill on Results of the PHAEDRA Trial
Cancer Network spoke with Yoland Catherine Antill, MD, of Cabrini Health, about the phase II PHAEDRA trial, which tested the activity of durvalumab in advanced endometrial cancer according to mismatch repair status. (Source: CancerNetwork)
Source: CancerNetwork - June 11, 2019 Category: Cancer & Oncology Authors: Yoland Catherine Antill, MD Source Type: news

Cochrane January-March 2019: highlights from Q1
' Cochrane exists so that healthcare decisions get better. ’ That is the first sentence of our Strategy to 2020 that aims to put Cochrane evidence at the heart of health decision-making all over the world. Here ’s a look back at some key highlights of our work in the first quarter of 2019, from January to March.Cochrane began preparations for its annual flagship event,Cochrane ’s Colloquium in Santiago, Chile 22-25 October, 2019. During this time, many Cochrane contributors submitted abstracts as part of the scientific programme, this year ‘embracing diversity’. We also opened the ca...
Source: Cochrane News and Events - May 7, 2019 Category: Information Technology Authors: Lydia Parsonson Source Type: news

Study reveals amyloid clumps of a truncated p53 structure related to endometrial cancer
(Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem (INBEB)) Brazilian scientists have discovered that a truncated variant of the tumor suppressor protein p53 is present as amyloid aggregates in endometrial cancer cells. Published in the Journal of Biological Chemistry, the study points to new perspectives for treating tumors in which p53 variants are important components of these clusters, given that alterations in the p53 protein are associated with more aggressive versions of these tumors, with a high mortality rate. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 3, 2019 Category: Cancer & Oncology Source Type: news

Loss of a DNA repair system creates a unique vulnerability in many cancer types
(Broad Institute of MIT and Harvard) Cancer cells adapt to potentially fatal mutations and other molecular malfunctions by adjusting one or more other genes' activity, in the process becoming dependent on those genes for their survival and growth. The resulting genetic dependencies may provide targets for developing new precision-guided drugs or other cancer treatment strategies.Reporting in Nature, researchers describe one such vulnerability shared by a large subset of colon, gastric, endometrial, and ovarian cancer cell lines. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 10, 2019 Category: Cancer & Oncology Source Type: news

Taxane + Platinum Feasible for Adjuvant Tx in Endometrial Cancer
Tolerability, survival similar to that for doxorubicin + cisplatin for postoperative adjuvant chemotherapy (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - March 27, 2019 Category: Cancer & Oncology Tags: Gynecology, Oncology, Pharmacy, Journal, Source Type: news

Weight Loss Still a Challenge in Endometrial Cancer Setting Weight Loss Still a Challenge in Endometrial Cancer Setting
A more militarist approach to weight loss may help women with endometrial cancer shed pounds and improve their prognosis.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - March 27, 2019 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Taxane & #43; Platinum Feasible for Adjuvant Tx in Endometrial Cancer
WEDNESDAY, March 27, 2019 -- Taxane plus platinum regimens may be a reasonable alternative to doxorubicin plus cisplatin as postoperative adjuvant chemotherapy for endometrial cancer that carries a high risk for progression, according to a study... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 27, 2019 Category: Pharmaceuticals Source Type: news

Two Surgeries at Once: Endometrial Cancer & Stress Incontinence Two Surgeries at Once: Endometrial Cancer & Stress Incontinence
Women who require surgery for endometrial cancer enjoy a better quality of life if concomitant stress urinary incontinence is surgically repaired at the same time.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - March 26, 2019 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news