Rozlytrek, Roche ’s first tumour-agnostic therapy, approved in Europe for people with NTRK fusion-positive solid tumours and for people with ROS1-positive advanced non-small cell lung cancer
             Basel, 03 August 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the European Commission has granted conditional marketing authorisation for Rozlytrek®(entrectinib) for the treatment of adult and paediatric patients 12 years of age and older with solid tumours expressing a neurotrophic tyrosine receptor kinase (NTRK) gene fusion, who have a disease that is locally advanced, metastatic or where surgical resection is likely to result in severe morbidity, and who have not received a prior NTRK inhibitor, who have no satisfactory t...
Source: Roche Investor Update - August 3, 2020 Category: Pharmaceuticals Source Type: news

Rozlytrek, Roche ’s first tumour-agnostic therapy, approved in Europe for people with NTRK fusion-positive solid tumours and for people with ROS1-positive advanced non-small cell lung cancer
             Basel, 03 August 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the European Commission has granted conditional marketing authorisation for Rozlytrek®(entrectinib) for the treatment of adult and paediatric patients 12 years of age and older with solid tumours expressing a neurotrophic tyrosine receptor kinase (NTRK) gene fusion, who have a disease that is locally advanced, metastatic or where surgical resection is likely to result in severe morbidity, and who have not received a prior NTRK inhibitor, who have no satisfactory t...
Source: Roche Media News - August 3, 2020 Category: Pharmaceuticals Source Type: news

AI spots cervical cancer lymph node metastasis on MRI
An artificial intelligence (AI) algorithm was able to preoperatively identify...Read more on AuntMinnie.comRelated Reading: Textural analysis improves breast MRI's accuracy ASTRO releases first cervical cancer guidelines Model predicts metastases in endometrial cancer patients Caution urged for breast MRI evaluation of lymph nodes AI may predict lymph node metastasis in gastric cancer (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - July 24, 2020 Category: Radiology Source Type: news

Yale Cancer Center study validates combination therapy for aggressive endometrial cancer
(Yale University) Yale Cancer Center (YCC) scientists have found that combining the targeted drug trastuzumab with chemotherapy significantly improves survival rates for women with a rare, aggressive form of endometrial cancer. These results may help to change the standard of care worldwide for the disease. The findings are published today in the journal Clinical Cancer Research. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 29, 2020 Category: Cancer & Oncology Source Type: news

FDA Approves Keytruda for Certain Mesothelioma Patients
Patients with pleural mesothelioma cancer may have another treatment option after the U.S. Food and Drug Administration approved the use of pembrolizumab for certain metastatic tumors this week. Pembrolizumab, often known by the brand name Keytruda, is a well-known immunotherapy drug already being used with mixed success for several cancers. This latest FDA approval is for the treatment of adult and pediatric cancers with unresectable disease and high mutational burden that have progressed following prior treatment and have no alternative treatment options. A number of mesothelioma patients already are being treated with p...
Source: Asbestos and Mesothelioma News - June 17, 2020 Category: Environmental Health Authors: Fran Mannino Source Type: news

New, Non-Invasive Blood Test Could Assist in Early Detection of Endometrial Cancer
Researchers from a study published in Cancers discovered a new method of detecting endometrial cancer in women via a simple, non-invasive blood test. (Source: CancerNetwork)
Source: CancerNetwork - May 26, 2020 Category: Cancer & Oncology Authors: Matthew Fowler Source Type: news

WHRY funds studies on stroke, endometrial cancer, and addiction to opioids
Women ’s Health Research at Yale is expanding its work to “address the enduring and pressing medical conditions that continue to affect women’s lives.” (Source: Yale Science and Health News)
Source: Yale Science and Health News - May 21, 2020 Category: Universities & Medical Training Source Type: news

Weight Loss Intervention Fails in Endometrial Cancer Survivors Weight Loss Intervention Fails in Endometrial Cancer Survivors
Almost half of obese endometrial cancer survivors in a recent study gained weight during 12 months of follow-up, whether or not they participated in a behavioral weight loss intervention.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 8, 2020 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Philadelphia biopharm company partners with Chinese firm to advance cancer therapy
Context Therapeutics, a Philadelphia biopharmaceutical company focused on hormone-driven cancers, is teaming up with a Chinese biotech firm to advance the development of Context's lead new drug candidate. That experimental therapy, called onapristone ER, is being evaluated in mid-stage clinical testing in patients with certain types of ovarian and endometrial cancers. Context plans to conduct mid-stage clinical testing of onapristone ER in patients with breast cancer later this year. Financial… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - March 23, 2020 Category: Biotechnology Authors: John George Source Type: news

Philadelphia biopharm company partners with Chinese firm to advance cancer therapy
Context Therapeutics, a Philadelphia biopharmaceutical company focused on hormone-driven cancers, is teaming up with a Chinese biotech firm to advance the development of Context's lead new drug candidate. That experimental therapy, called onapristone ER, is being evaluated in mid-stage clinical testing in patients with certain types of ovarian and endometrial cancers. Context plans to conduct mid-stage clinical testing of onapristone ER in patients with breast cancer later this year. Financial… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - March 23, 2020 Category: Pharmaceuticals Authors: John George Source Type: news

Combined therapy may improve clinical responses for endometrial, colorectal and gastric tumors
(University of Texas M. D. Anderson Cancer Center) Combined therapy may improve clinical responses for endometrial, colorectal and gastric tumors. Enzyme inhibitor with anti-PD1 checkpoint blockade boosted efficacy over either treatment alone. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 27, 2020 Category: Cancer & Oncology Source Type: news

Risk factors for endometrial cancer identified
A study published in theJournal of Medical Genetics identifies risk factors for endometrial cancer that could help develop targeted screening and prevention strategies.Science Codex (Source: Society for Endocrinology)
Source: Society for Endocrinology - February 19, 2020 Category: Endocrinology Source Type: news

Twenty four genetic variants linked to heightened womb cancer risk
(BMJ) Twenty four common variations in genes coding for cell growth and death, the processing of oestrogen, and gene control factors may be linked to a heightened risk of developing womb (endometrial) cancer, indicates the most comprehensive review of the published evidence so far in the Journal of Medical Genetics. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 17, 2020 Category: International Medicine & Public Health Source Type: news

Study identifies risk factors for endometrial cancer
(University of Manchester) An analysis of 149 scientific studies has identified 24 genetic variants which predispose women to endometrial cancer. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 17, 2020 Category: Biology Source Type: news

Study surveys molecular landscape of endometrial cancer
(NYU Langone Health / NYU School of Medicine) The most comprehensive molecular study of endometrial cancer to date has further defined the contributions of key genes and proteins to the disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2020 Category: Cancer & Oncology Source Type: news

New, detailed molecular roadmap boosts fight against endometrial cancer
(DOE/Pacific Northwest National Laboratory) Scientists have taken an unprecedented look at the proteins involved in endometrial cancer, commonly known as uterine cancer. The study offers insights about how physicians might be able to better identify which patients will need aggressive treatment and which won't, and offers clues about why a common cancer treatment is not effective with some patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2020 Category: Cancer & Oncology Source Type: news

Utah researchers discover key protein in endometrial cancer growth
(Huntsman Cancer Institute) New research, published today in the journal Cancer Research, outlines findings scientists hope will advance our understanding of endometrial cancer and lead to more effective treatments. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 11, 2020 Category: Cancer & Oncology Source Type: news

Testosterone Has Different Effect in Men and Women
In women, testosterone may increase the risk for type 2 diabetes, while in men it lowers that risk. But high levels of testosterone increase the risk for breast and endometrial cancer in women and prostate cancer in men, the researchers reported. (Source: WebMD Health)
Source: WebMD Health - February 10, 2020 Category: Consumer Health News Source Type: news

LY3023414 Demonstrates Manageable Safety Profile in Patients with Endometrial Cancer
The dual PI3K/mTOR inhibitor LY3023414 also displayed moderate single-agent activity in this study of patients with heavily pretreated advanced endometrial cancer. (Source: CancerNetwork)
Source: CancerNetwork - January 26, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

The Big Number: Why your risks for 7 types of cancer could be reduced with physical activity
Research shows several exercises can be effective against these cancers: breast, colon, endometrial, kidney, liver, multiple myeloma and non-Hodgkin lymphoma. (Source: Washington Post: To Your Health)
Source: Washington Post: To Your Health - January 12, 2020 Category: Consumer Health News Authors: Linda Searing Source Type: news

The Prognosis of Stage IA Mixed Endometrial Carcinoma The Prognosis of Stage IA Mixed Endometrial Carcinoma
A study determines that the serous subtype may be associated with a poor prognosisin in uterine cancer.American Journal of Clinical Pathology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 31, 2019 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news

Study Identifies Factors of Microbiome Composition in Endometrial Cancer
A research team from the Mayo clinic verified the known risk factors for endometrial cancer, while identifying a possible microbiome signature associated with the disease. (Source: CancerNetwork)
Source: CancerNetwork - December 27, 2019 Category: Cancer & Oncology Authors: Kevin Wright Source Type: news

Exercise may reduce risk for cancer by as much as 25 percent
People who engaged in physical activity as recommended by the NIH were able to reduce their risk for colon and breast cancers, as well as endometrial cancer, kidney cancer, myeloma, liver cancer and non-Hodgkin lymphoma. (Source: Health News - UPI.com)
Source: Health News - UPI.com - December 26, 2019 Category: Consumer Health News Source Type: news

Model predicts metastases in endometrial cancer patients
Using ultrasound in combination with endometrial biopsy results and clinical...Read more on AuntMinnie.comRelated Reading: MRI helps predict outcomes of endometriosis surgery PET/CT makes case for directing cervical cancer treatment Contrast ultrasound identifies early cervical cancer (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - December 24, 2019 Category: Radiology Source Type: news

Mayo Clinic researchers look at post menopause as key factor in endometrial cancer
(Mayo Clinic) Endometrial cancer is the most common gynecological malignancy in the US and the fourth most common cancer among women. In addition, endometrial cancer incidence rates are on the rise in the western world, suggesting that alterations in environmental factors such as diet, lifestyle, and the vaginal microbiome may be important drivers in its cause. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 16, 2019 Category: Cancer & Oncology Source Type: news

Mayo Clinic researchers look at post menopause as key factor in endometrial cancer
ROCHESTER, Minn. -- Endometrial cancer is the most common gynecological malignancy in the U.S. and the fourth most common cancer among women. In addition, endometrial cancer incidence rates are on the rise in the western world, suggesting that alterations in environmental factors such as diet, lifestyle, and the vaginal microbiome may be important drivers in [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - December 16, 2019 Category: Databases & Libraries Source Type: news

Patients with Endometrial Cancer Pose High Risk of Dying from Cardiovascular Disease
Patients with endometrial cancer pose a very high risk of dying from cardiovascular diseases in the year after diagnosis, suggesting the necessity of early involvement of cardiologists for these patients. (Source: CancerNetwork)
Source: CancerNetwork - December 2, 2019 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Early Chemo Does Not Improve Survival in Endometrial Cancer
Endometrial cancer survival correlates with total number of chemotherapy cycles – but not whether they are started earlier than radiation, according to the results of a new study. (Source: CancerNetwork)
Source: CancerNetwork - November 1, 2019 Category: Cancer & Oncology Authors: Seth Augenstein Source Type: news

Role of COX7RP in Endometrial, Breast Cancer Growth
COX7RP contributes to endometrial and breast cancer growth. (Source: CancerNetwork)
Source: CancerNetwork - October 4, 2019 Category: Cancer & Oncology Authors: Leanne Marcello, MS Source Type: news

Analysis of Cervical Mutations Aids Endometrial Cancer Diagnosis
Diagnosis of endometrial carcinoma made easier by analysis of mutations in cervix or endometrial tissue. (Source: CancerNetwork)
Source: CancerNetwork - October 2, 2019 Category: Cancer & Oncology Authors: Leanne Marcello, MS Source Type: news

Can Recurrent Ovarian Cancer Patients Avoid Chemotherapy?
The AVANOVA2 trial enrolled a total of 97 patients with high-grade serous or endometrioid platinum-sensitive recurrent ovarian cancer. (Source: CancerNetwork)
Source: CancerNetwork - September 20, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Project Orbis Enables First International Approval in U.S., Canada, Australia
The first-of-its-kind collaboration led to the approval of a combination therapy for patients with endometrial cancer. (Source: CancerNetwork)
Source: CancerNetwork - September 19, 2019 Category: Cancer & Oncology Authors: Seth Augenstein Source Type: news

US, Canada, Australia Approve Endometrial Cancer Combo US, Canada, Australia Approve Endometrial Cancer Combo
Regulatory agencies in three countries, including the United States, all approved lenvatinib in combination with pembrolizumab for the treatment of patients with advanced endometrial carcinoma.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 17, 2019 Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news

FDA takes first action under new international collaboration with Australia and Canada designed to provide a framework for concurrent review of cancer therapies, approving treatment for patients with endometrial carcinoma
Project Orbis provides a framework for concurrent submission and review of oncology drugs among its international partners. Under this project, the FDA, Australia and Canada collaboratively reviewed applications for two oncology drugs, allowing for simultaneous decisions in all three countries. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - September 17, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news

ASTRO: Cervical cancer deaths rise as women's centers close
CHICAGO - Women in states where family planning clinics have closed received...Read more on AuntMinnie.comRelated Reading: ASTRO: Is hormone therapy after prostate surgery needed? 3D printing customizes brachytherapy for cervical cancer Contrast ultrasound identifies early cervical cancer FDG-PET/CT targets metastases in cervical, endometrial cancer Volumetric MR images boost cervical cancer treatment planning (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - September 17, 2019 Category: Radiology Source Type: news

Pembrolizumab Plus Lenvatinib Approved for Endometrial Cancer
The combination was simulataneously approved in Australia and Canada and was the first such action under a new international collaboration. (Source: CancerNetwork)
Source: CancerNetwork - September 17, 2019 Category: Cancer & Oncology Authors: Erin Kayata Source Type: news

FDA Approves Keytruda (pembrolizumab) plus Lenvima (lenvatinib) Combination Treatment for Patients with Certain Types of Endometrial Carcinoma
KENILWORTH, N.J.,& WOODCLIFF LAKE, N.J.-- September 17, 2019 -- (BUSINESS WIRE)--Merck (NYSE: MRK), known as MSD outside the United States and Canada, and Eisai today announced that the U.S. Food and Drug Administration (FDA) approved the... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - September 17, 2019 Category: Drugs & Pharmacology Source Type: news

Women Who Use IUDs May Be At Lower Risk For Ovarian Cancer, Study Finds
BOSTON (CBS) – Nearly 14,000 American women will die from ovarian cancer this year, but a new study from the UCHealth University of Colorado Hospital finds that women who use IUDs may be at lower risk. The symptoms of ovarian cancer can be mild or vague and there is no reliable screening test, so the diagnosis often isn’t made until it’s pretty advanced. But a new study of thousands of women around the world found that women who use intrauterine devices, or IUDs, for contraception may be 15-32% less likely to develop ovarian cancer. It’s not clear for how long they need to use one or why they may be...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - September 11, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health Syndicated CBSN Boston Syndicated Local Dr. Mallika Marshall HealthWatch IUD Source Type: news

Mayo Clinic Minute: 3 things women should know about gynecologic cancer
Cancer of a woman's reproductive organs is referred to as "gynecologic cancer." Dr. Amanika Kumar, a Mayo Clinic OB-GYN, says there are many forms of gynecologic cancer: endometrial or uterine, ovarian, vulvar, cervical, and vaginal. Watch: The Mayo Clinic Minute https://youtu.be/G6371uKfois Journalists: Broadcast-quality video pkg (0:58) is in the downloads at the end of the post. [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - September 9, 2019 Category: Databases & Libraries Source Type: news

Is Precision Therapy an Option for Advanced Endometrial Carcinoma?
Researchers identified a highly recurrent, disease-specific PP2A PPP2R1A mutation as a driver of endometrial carcinoma and as a target for new drugs. (Source: CancerNetwork)
Source: CancerNetwork - September 5, 2019 Category: Cancer & Oncology Authors: Naveed Saleh, MD, MS Source Type: news

Adjuvant Chemoradiotherapy May Boost Endometrial-Cancer Survival Adjuvant Chemoradiotherapy May Boost Endometrial-Cancer Survival
Combined adjuvant chemotherapy and radiotherapy appear significantly more effective than pelvic radiotherapy alone for women with high-risk endometrial cancer, according to a post hoc analysis of the PORTEC-3 trial.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 14, 2019 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Obesity 'raises cancer risk by TWICE as much as previously thought', study warns
Scientists at the International Agency for Research on Cancer in Lyon, France, found the risk was underestimated for bowel, kidney, pancreatic, endometrial and ovarian cancers. (Source: the Mail online | Health)
Source: the Mail online | Health - August 9, 2019 Category: Consumer Health News Source Type: news

Two Genes Conspire in Endometriosis and Cancer to Help Cells Migrate
The genes promote the migration of endothelial cells outside of the uterus, a characteristic of both endometriosis and endometrial cancers, a study of mice and human tissue finds. (Source: The Scientist)
Source: The Scientist - August 9, 2019 Category: Science Tags: News & Opinion Source Type: news

Podcast: Use of computer or robotic technology to assist surgeons in performing gynaecological surgery
In conclusion, low-certainty evidence for hysterectomy and sacrocolpopexy operations suggests that complication rates for robot-assisted surgery might be similar to those for conventional laparoscopic surgery. Things are more uncertain for gynaecological cancer, where we found no comparative evidence on cancer recurrence or survival after the surgery. As robot-assisted surgery depends on the skill and experience of the surgeon and is expensive, evaluating its effectiveness and safety continues to present a challenge; but this needs to be met if we are to have reliable evidence on its potential benefits and harms.Read the C...
Source: Cochrane News and Events - August 9, 2019 Category: Information Technology Authors: Lydia Parsonson Source Type: news

Guardant Brings Home Strong Results as Liquid Biopsy Space Heats Up
Guardant Health is one of the biggest names in liquid biopsy and after Monday its presence in the space can only increase. The Redwood City, CA-based company revealed results of a study conducted by it along with researchers from The University of Texas MD Anderson Cancer Center, the Samsung Medical Center, and other institutions. Results show the Guardant360 assay can accurately detect microsatellite instability status (MSI) as accurately as tissue biopsy. The company said this is the largest comparison of MSI testing to traditional tissue methods across multiple solid tumor types. Findings were reported in Cl...
Source: MDDI - August 5, 2019 Category: Medical Devices Authors: Omar Ford Tags: IVD Source Type: news

Ribociclib-Letrozole Regimen Tested in Ovarian, Endometrial Cancer
Researchers examined the results of ribociclib and letrozole as a treatment for patients with  estrogen receptor-positive ovarian cancer and endometrial cancer. (Source: CancerNetwork)
Source: CancerNetwork - July 23, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Many of the deadliest cancers receive the least amount of research funding
(Northwestern University) Many of the deadliest or most common cancers get the least amount of nonprofit research funding, reports a new Northwestern Medicine study. 'Embarrassing' or stigmatized cancers, like lung and liver, are underfunded. Colon, endometrial, liver and bile duct, cervical, ovarian, pancreatic and lung cancers were all poorly funded compared to how common they are and how many deaths they cause, the study found. In contrast, breast cancer, leukemia, lymphoma and pediatric cancers were all well-funded, respective to their impact on society. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 18, 2019 Category: Cancer & Oncology Source Type: news

Endometrial Safety of Vaginal Estrogens in Menopausal Women Endometrial Safety of Vaginal Estrogens in Menopausal Women
Does treatment of vulvar and vaginal atrophy with unopposed vaginal estrogens increase the risk for endometrial hyperplasia or cancer in menopausal women?Menopause (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 16, 2019 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Journal Article Source Type: news

Endometrial cancer clinical trial aims to pave the way for practice-changing therapy
(University of Colorado Anschutz Medical Campus) The University of Colorado Cancer Center is leading the way in the development of a new endometrial cancer clinical trial that may lead to practice-changing therapies. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 11, 2019 Category: International Medicine & Public Health Source Type: news

The Case for Tumor and Germline Testing in Endometrial Cancer Patients
A new study reinforces the need for universal mismatch repair protein immunohistochemistry screening of tumors from endometrial cancer patients, as well as germline genetic testing in accordance with guidelines. (Source: CancerNetwork)
Source: CancerNetwork - June 27, 2019 Category: Cancer & Oncology Authors: Christina Bennett, MS Source Type: news