Study reveals amyloid clumps of a truncated p53 structure related to endometrial cancer
(Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem (INBEB)) Brazilian scientists have discovered that a truncated variant of the tumor suppressor protein p53 is present as amyloid aggregates in endometrial cancer cells. Published in the Journal of Biological Chemistry, the study points to new perspectives for treating tumors in which p53 variants are important components of these clusters, given that alterations in the p53 protein are associated with more aggressive versions of these tumors, with a high mortality rate. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 3, 2019 Category: Cancer & Oncology Source Type: news

Loss of a DNA repair system creates a unique vulnerability in many cancer types
(Broad Institute of MIT and Harvard) Cancer cells adapt to potentially fatal mutations and other molecular malfunctions by adjusting one or more other genes' activity, in the process becoming dependent on those genes for their survival and growth. The resulting genetic dependencies may provide targets for developing new precision-guided drugs or other cancer treatment strategies.Reporting in Nature, researchers describe one such vulnerability shared by a large subset of colon, gastric, endometrial, and ovarian cancer cell lines. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 10, 2019 Category: Cancer & Oncology Source Type: news

Taxane + Platinum Feasible for Adjuvant Tx in Endometrial Cancer
Tolerability, survival similar to that for doxorubicin + cisplatin for postoperative adjuvant chemotherapy (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - March 27, 2019 Category: Cancer & Oncology Tags: Gynecology, Oncology, Pharmacy, Journal, Source Type: news

Weight Loss Still a Challenge in Endometrial Cancer Setting Weight Loss Still a Challenge in Endometrial Cancer Setting
A more militarist approach to weight loss may help women with endometrial cancer shed pounds and improve their prognosis.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - March 27, 2019 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Taxane & #43; Platinum Feasible for Adjuvant Tx in Endometrial Cancer
WEDNESDAY, March 27, 2019 -- Taxane plus platinum regimens may be a reasonable alternative to doxorubicin plus cisplatin as postoperative adjuvant chemotherapy for endometrial cancer that carries a high risk for progression, according to a study... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 27, 2019 Category: Pharmaceuticals Source Type: news

Two Surgeries at Once: Endometrial Cancer & Stress Incontinence Two Surgeries at Once: Endometrial Cancer & Stress Incontinence
Women who require surgery for endometrial cancer enjoy a better quality of life if concomitant stress urinary incontinence is surgically repaired at the same time.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - March 26, 2019 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Does Bariatric Surgery Lower the Risk for Incident Cancer? Does Bariatric Surgery Lower the Risk for Incident Cancer?
Dr Lowenfels comments on a study that suggests weight loss surgery may lower the risk for obesity-associated cancers (endometrial, colon, pancreatic, and postmenopausal breast).Medscape General Surgery (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 22, 2019 Category: Consumer Health News Tags: General Surgery Viewpoint Source Type: news

Nigeria: Talcum Powder May Cause Cancer, Experts Warn
[Guardian] Researchers are unanimous that talc or talcum powder can cause lung, ovarian, stomach and endometrial (uterine) cancers. They said talc consisting of asbestos is generally accepted as being able to cause cancer if it is inhaled or/and used regularly in the genital area. Evidence on asbestos-free talc is however less clear. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - March 22, 2019 Category: African Health Source Type: news

Potential Game Changer for Endometrial Cancer
(MedPage Today) -- A 30% response rate in recurrent/advanced disease, 49% in MSI-H tumors (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - March 20, 2019 Category: Hematology Source Type: news

GSK reports positive data from trial of endometrial cancer drug
GlaxoSmithKline said on Tuesday a study testing its experimental drug dostarlimab in women with recurrent or advanced endometrial cancer showed promising results. (Source: Reuters: Health)
Source: Reuters: Health - March 19, 2019 Category: Consumer Health News Tags: healthNews Source Type: news

Fewer Complications After MIRS Introduced for Endometrial Cancer
Introduction of minimally invasive robotic surgery linked to reduced odds of severe complications (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - March 18, 2019 Category: Cancer & Oncology Tags: Gynecology, Oncology, Surgery, Journal, Source Type: news

Fewer Complications After MIRS Introduced for Endometrial Cancer
MONDAY, March 18, 2019 -- The introduction of minimally invasive robotic surgery (MIRS) is associated with a significantly lower risk for severe complications among patients with early-stage endometrial cancer, according to a study published online... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 18, 2019 Category: Pharmaceuticals Source Type: news

Could Robotic-Assisted Surgery Reduce Complications for Endometrial Cancer Patients?
Researchers studied the use of minimally invasive robotic surgery for hysterectomy and its risk for complications in the treatment of endometrial cancer in Denmark. (Source: CancerNetwork)
Source: CancerNetwork - March 8, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Fewer Complications With Robotic Surgery in Early Endometrial Cancer (CME/CE)
(MedPage Today) -- Introduction in Denmark correlated with more minimally invasive surgeries and fewer serious complications in early-stage disease (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - March 5, 2019 Category: Hematology Source Type: news

Pembrolizumab cost  effective for some endometrial cancers
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - March 1, 2019 Category: Drugs & Pharmacology Source Type: news

Fewer Complications With Robotic Surgery in Endometrial Cancer
(MedPage Today) -- Improved outcomes and greater uptake of minimally invasive surgery in those patients, Danish study shows (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - February 27, 2019 Category: Hematology Source Type: news

Podcast: Laparoscopy versus laparotomy for the management of presumed early stage endometrial cancer
Recent decades have seen greater and greater use of laparoscopy, or keyhole surgery, when people need an operation on their abdomen. There are now dozens of Cochrane Reviews of this, for a wide variety of conditions and, in October 2018, the one forlaparoscopy versus laparotomy, or open surgery, for women with early stage endometrial cancer was updated. The review is led by Khadra Galaal from the Royal Cornwall Hospital in Truro in the UK and she tells us the latest findings in this podcast." Worldwide, cancer of the womb or'endometrial cancer'is the fifth most common cancer among women under 65 years of age, with a h...
Source: Cochrane News and Events - February 26, 2019 Category: Information Technology Authors: Lydia Parsonson Source Type: news

Millennials Getting More Obesity-Related Cancers, Study Finds
This study shows the incidence of cancer associated with obesity has been rising dramatically in groups of individuals born in more recent decades,” said MD Anderson Cancer Center’s Dr. George Chang, who was not associated with the analysis. However, Chang warns against overgeneralizing on the basis of an epidemiological study. “The study was not set up to establish causation,” Chang said. “We know there are many factors that are associated with both obesity and cancer, such as lack of exercise and poor diet. How much each of those factors contribute to cancer is less clear.” Obesity is ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - February 4, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Cancer CNN Millennials Source Type: news

Some Cancers Are Rising in Young People. Scientists Think They Know Why
The rates of new cancer cases and cancer deaths have fallen in the U.S. over the past few decades. But certain cancers are becoming more common among younger Americans, and researchers think obesity may be to blame, finds a new report from the American Cancer Society and the National Cancer Institute. Rates of six different cancers that are associated with obesity increased among adults ages 25-49 between 1995 and 2014, according to the research, which was published in the journal Lancet Public Health and based on information in the Cancer in North America database. These cancers include multiple myeloma, colorectal, endom...
Source: TIME: Health - February 4, 2019 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Cancer healthytime Source Type: news

Some Cancers Are Rising in Millennials. Obesity Might Be the Reason Why
The rates of new cancer cases and cancer deaths have fallen in the U.S. over the past few decades. But certain cancers are becoming more common among younger Americans, and researchers think obesity may be to blame, finds a new report from the American Cancer Society and the National Cancer Institute. Obesity rates have been rising across age groups for years. According to the latest federal numbers, almost 36% of American adults ages 20-39 are obese, and that number may soon be even higher. Recent research suggests that if obesity trends continue, 57% of children in the U.S. will be obese by the time they turn 35. Rates ...
Source: TIME: Health - February 4, 2019 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Cancer healthytime Source Type: news

Some Cancers Are Rising in Millennials. Obesity Might Be Why
The rates of new cancer cases and cancer deaths have fallen in the U.S. over the past few decades. But certain cancers are becoming more common among younger Americans, and researchers think obesity may be to blame, finds a new report from the American Cancer Society and the National Cancer Institute. Obesity rates have been rising across age groups for years. According to the latest federal numbers, almost 36% of American adults ages 20-39 are obese, and that number may soon be even higher. Recent research suggests that if obesity trends continue, 57% of children in the U.S. will be obese by the time they turn 35. Rates ...
Source: TIME: Health - February 4, 2019 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Cancer healthytime Source Type: news

23andMe Has a New Genetic Cancer Test. But the Results Don ’t Tell You the Whole Story
Consumer genetics company 23andMe is diving deeper into the medical space. On Jan. 22, the company announced that the Food and Drug Administration (FDA) approved its newest report, which can flag whether people have genetic variants that may raise their risk of developing colorectal cancer. The new test looks for two gene variants associated with MUTYH-associated polyposis, an inherited colorectal cancer syndrome. “If left unchecked, carrying both of these variants or having two copies of one increases the risk of developing colorectal cancer to between 43 and 100 percent,” according to 23andMe. The test will b...
Source: TIME: Health - January 23, 2019 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Cancer healthytime Source Type: news

World Cancer Day
is an international day marked on February 4 to raise awareness of cancer and to encourage its prevention, detection, and treatment. 2019 marks the launch of the 3-year ‘I Am and I Will’ campaign; an empowering call-to-action urging for personal commitment and represents the power of individual action taken now to impact the future.Cochrane Cancer supports and coordinates the work acrossmultiple Cochrane Review Groups dealing with the topic of Cancer. These  Cochrane Review Groups provide reliable evidence required to make important decisions on issues concerning cancer and related topics. Cochrane R...
Source: Cochrane News and Events - January 14, 2019 Category: Information Technology Authors: Muriah Umoquit Source Type: news

More Data Tie Obesity to Occult Endometrial Cancer
(MedPage Today) -- Bariatric surgery appeared to normalize neoplastic endometrium in some women (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - November 1, 2018 Category: Endocrinology Source Type: news

New study takes first step toward treating endometriosis
(Northwestern University) Researchers at Northwestern Medicine have taken the first step in bioengineering the human uterus to treat endometriosis, uterine-factor infertility and endometrial cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 1, 2018 Category: Cancer & Oncology Source Type: news

COUNTERPOINT: Should Radiation Therapy Be Routinely Used in the Adjuvant Treatment of Stage III Endometrial Cancer?
The routine use of adjuvant radiation therapy in stage III endometrial cancer patients is not supported by the current literature and should not be employed universally in this group of patients. (Source: CancerNetwork)
Source: CancerNetwork - September 19, 2018 Category: Cancer & Oncology Authors: John P. Diaz, MD, FACOG Source Type: news

POINT: Should Radiation Therapy Be Routinely Used in the Adjuvant Treatment of Stage III Endometrial Cancer?
Adjuvant radiation therapy provides a local control benefit in stage III endometrial carcinoma patients, as strongly suggested in retrospective and prospective series. (Source: CancerNetwork)
Source: CancerNetwork - September 18, 2018 Category: Cancer & Oncology Authors: Mark E. Bernard, MD, Marcus E. Randall, MD Source Type: news

Minimal functional driver gene heterogeneity among untreated metastases
Metastases are responsible for the majority of cancer-related deaths. Although genomic heterogeneity within primary tumors is associated with relapse, heterogeneity among treatment-naïve metastases has not been comprehensively assessed. We analyzed sequencing data for 76 untreated metastases from 20 patients and inferred cancer phylogenies for breast, colorectal, endometrial, gastric, lung, melanoma, pancreatic, and prostate cancers. We found that within individual patients, a large majority of driver gene mutations are common to all metastases. Further analysis revealed that the driver gene mutations that were not share...
Source: ScienceNOW - September 6, 2018 Category: Science Authors: Reiter, J. G., Makohon-Moore, A. P., Gerold, J. M., Heyde, A., Attiyeh, M. A., Kohutek, Z. A., Tokheim, C. J., Brown, A., DeBlasio, R. M., Niyazov, J., Zucker, A., Karchin, R., Kinzler, K. W., Iacobuzio-Donahue, C. A., Vogelstein, B., Nowak, M. A. Tags: Medicine, Diseases reports Source Type: news

Catheter-based intervention drains endometrial cysts
South Korean researchers found that by replacing an interventional needle with...Read more on AuntMinnie.comRelated Reading: USPSTF again nixes screening for ovarian cancer Women with endometriosis have higher heart disease risk Ultrasound should be 1st choice for female pelvic imaging The Practice of Ultrasound: Part 4 -- Female pelvic ultrasound Rigorous investigation using MRI can prove crucial for endometriosis (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - August 31, 2018 Category: Radiology Source Type: news

Postmenopausal Bleeding Common in Women With Endometrial Cancer
A meta-analysis finds that postmenopausal bleeding occurs in approximately 90% of women with endometrial cancer. (Source: CancerNetwork)
Source: CancerNetwork - August 31, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Oral Contraceptive Use and Risks of Cancer Oral Contraceptive Use and Risks of Cancer
While oral contraceptive use has been well studied in terms of breast, ovarian, and endometrial cancers, this analysis investigated the total effect of OC use on cancer risk across all organs.American Journal of Epidemiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 24, 2018 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Journal Article Source Type: news

Sentinel Lymph Node Mapping Most Cost - Effective for Uterine CA
Findings compared to routine, selective lymphadenectomy for low - risk endometrial cancer (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - August 21, 2018 Category: Cancer & Oncology Tags: Gynecology, Oncology, Radiology, Surgery, Journal, Source Type: news

Sentinel Lymph Node Mapping Most Cost-Effective for Uterine CA
TUESDAY, Aug. 21, 2018 -- Sentinel lymph node mapping has the lowest costs and highest quality-adjusted survival compared to both routine and selective lymphadenectomy for managing low-risk endometrial carcinoma, according to a study published in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - August 21, 2018 Category: Pharmaceuticals Source Type: news

Most Postmenopausal Bleeding Not Associated With Cancer
TUESDAY, Aug. 14, 2018 -- Most women with postmenopausal bleeding (PMB) will not be diagnosed with endometrial cancer, according to a review published online Aug. 6 in JAMA Internal Medicine. Megan A. Clarke, Ph.D., from the National Cancer... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - August 14, 2018 Category: Pharmaceuticals Source Type: news

Postmenopausal Bleeding and Endometrial Cancer
Postmenopausal Bleeding: Reliable Sign of Endometrial Cancer (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - August 9, 2018 Category: General Medicine Source Type: news

Postmenopausal Bleeding: Reliable Sign of Endometrial Cancer Postmenopausal Bleeding: Reliable Sign of Endometrial Cancer
Almost all women with endometrial cancer have postmenopausal bleeding (PMB), although only a small proportion of women with PMB will be diagnosed with endometrial cancer.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 8, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Postmenopausal Bleeding Should Prompt Endometrial Ca Evaluation
(MedPage Today) -- But patient counseling needed, as only 10% of such cases are cancer (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - August 7, 2018 Category: Hematology Source Type: news

How common is endometrial cancer in women with postmenopausal bleeding?
(JAMA Network) Postmenopausal bleeding is a common symptom among most women with endometrial cancer but most women with   postmenopausal bleeding won't be diagnosed with endometrial cancer, findings that raise questions about how to best manage postmenopausal bleeding for the early detection of endometrial cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 6, 2018 Category: Cancer & Oncology Source Type: news

Women's Wellness: Endometrial cancer -- risk factors, screening, treatment
DEAR MAYO CLINIC:?My sister, who is 56, recently was diagnosed with early-stage endometrial cancer. I?m wondering if this kind of cancer runs in families. Could I be at risk for it, too? Are there other things that can raise a woman?s risk for endometrial cancer? Are there any screening tests available for it? ANSWER:?An increased [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - July 26, 2018 Category: Databases & Libraries Source Type: news

Extended Tamoxifen May Double Endometrial Cancer Risk
(MedPage Today) -- But observed malignancies were detected early and carried low mortality risk (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - July 10, 2018 Category: Hematology Source Type: news

Top oncologist to study effect of diet on cancer drugs
Siddhartha Mukherjee says trial is first in a series on ‘rethinking human diets for cancer’A groundbreaking clinical trial on whether diet could boost the effectiveness of cancer drugs is set to be launched by one of the world ’s leading oncologists.The work, led bySiddhartha Mukherjee atColumbia University Medical Center in New York, will investigate whether a high-fat, low-carbohydrate diet could improve outcomes for patients with lymphoma and endometrial cancer.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - July 6, 2018 Category: Science Authors: Hannah Devlin Science correspondent Tags: Cancer research Medical research Siddhartha Mukherjee Science Diets and dieting Health Source Type: news

Breast-cancer drug taken by thousands of women doubles the risk of womb cancer
Researchers from St Vincent's Hospital Group, Dublin, found that taking tamoxifen for 10 years rather than five raises the risk of endometrial cancer from 1.5 per cent to 3.5 per cent. (Source: the Mail online | Health)
Source: the Mail online | Health - July 5, 2018 Category: Consumer Health News Source Type: news

Extended tamoxifen therapy may increase risk of endometrial cancer
(Wiley) There is clear evidence that extended adjuvant tamoxifen therapy for 10 years reduces local recurrence and improves breast cancer-free survival in women with oestrogen receptor-positive breast cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 5, 2018 Category: Cancer & Oncology Source Type: news

Olaparib Plus Vistusertib Promising in Early Trial of Endometrial, Other Cancers
Dave LevitanJun 6, 2018The combination of the PARP inhibitor olaparib with the mTORC1/2 inhibitor vistusertib had promising activity across endometrial, ovarian, and triple-negative breast cancers. (Source: CancerNetwork)
Source: CancerNetwork - June 6, 2018 Category: Cancer & Oncology Authors: A Source Type: news

Gene sequencing study finds new cancers linked with Lynch syndrome
CHICAGO (Reuters) - Lynch syndrome, a rare hereditary disease typically associated with an increased risk of colorectal and endometrial cancers, appears to be linked with several additional types of cancer than previously thought, U.S. researchers said on Saturday. (Source: Reuters: Health)
Source: Reuters: Health - June 2, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

CVD Risk Elevated in Endometrial Ca Survivors (CME/CE)
(MedPage Today) -- Call for careful monitoring, risk management for up to 10 years after cancer diagnosis (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - May 14, 2018 Category: Cardiology Source Type: news

Long-Term Cardiovascular Risk for Endometrial Cancer Survivors
TUESDAY, May 8, 2018 -- Endometrial cancer survivors have an elevated risk of various adverse long-term cardiovascular outcomes, according to a study published online May 8 in the Journal of the National Cancer Institute. Sean Soisson, from the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 8, 2018 Category: Pharmaceuticals Source Type: news

Endometrial cancer telephone follow-up, a good call
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - May 1, 2018 Category: Drugs & Pharmacology Source Type: news

Can Diabetes Lead to Irregular Periods in Teens?
In the long-term, irregular periods can also increase the risk of endometrial cancer, the researchers pointed out in the new report. (Source: WebMD Health)
Source: WebMD Health - April 25, 2018 Category: Consumer Health News Source Type: news