The influence of genetic predisposition to oxidative stress on painful diabetic peripheral neuropathy: A mendelian randomization study
This study employed a Mendelian Randomization (MR) approach to investigate the causal relationship between genetic predisposition to OS and PDPN. Genetic instruments associated with OS biomarkers were selected as exposures. Summary-level data on PDPN was obtained from the largest available genome-wide association study (GWAS). MR analyses were conducted using the inverse-variance weighted (IVW) method, with sensitivity analyses employing the MR-Egger, weighted median, and MR-PRESSO approaches. Genetic predisposition to increased glutathione S-transferase (GST) activity was associated with a reduced risk of PDPN (OR=0.66, 9...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Liyan Zou Duosheng Zhu Min Gong Jiangyi Yu Source Type: research
Buprenorphine Affects the Initiation and Severity of Interleukin Induced Acute Pancreatitis in Mice
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 23. doi: 10.1152/ajpgi.00083.2024. Online ahead of print.ABSTRACTAcute pancreatitis (AP) is a common disease with no targeted therapy and has varied outcomes ranging from spontaneous resolution to being lethal. While typically painful, AP can also be painless. Various agents, including opioids are used for pain control in AP; the risks, and benefits of which are often debated. Since experimental AP in mice is used to study the efficacy of potential therapies, we studied the effect of a commonly used opioid buprenorphine on the initiation and progression of AP. For this we a...
Source: Am J Physiol Gastroi... - April 23, 2024 Category: Gastroenterology Authors: Sarah Jahangir Biswajit Khatua Nabil Smichi Prasad Rajalingamgari Anoop Narayana Pillai Megan J Summers Bryce McFayden Sergiy Kostenko Naomi M Gades Vijay P Singh Source Type: research
SHBG gene polymorphisms and their influence on serum SHBG, total and free testosterone concentrations in men
CONCLUSION: In these men, analyzed SNPs were relatively prevalent and affected serum concentrations of total T and SHBG but not calculated or measured free T except for a higher trend in rs6259 homozygotes.PMID:38652149 | DOI:10.1210/clinem/dgae280 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 23, 2024 Category: Endocrinology Authors: Joeri Walravens Bas Sleumer Michel J Vos Gido Snaterse Nick Narinx Leen Antonio Tim Reyns Tom Fiers Ido P Kema Jean-Marc Kaufman Nico C van de Merbel Bruno Lapauw Source Type: research
BiliQML: A supervised machine-learning model to quantify biliary forms from digitized whole-slide liver histopathological images
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 23. doi: 10.1152/ajpgi.00058.2024. Online ahead of print.ABSTRACTThe progress of research focused on cholangiocytes and the biliary tree during development and following injury is hindered by limited available quantitative methodologies. Current techniques include two-dimensional standard histological cell-counting approaches, which are rapidly performed error-prone and lack architectural context; or three-dimensional analysis of the biliary tree in opacified livers, which introduce technical issues along with minimal quantitation. The present study aims to fill these quant...
Source: Am J Physiol Gastroi... - April 23, 2024 Category: Gastroenterology Authors: Dominick J Hellen Meredith E Fay David H Lee Caroline Klindt-Morgan Ashley Bennett Kimberly J Pachura Arash Grakoui Stacey S Huppert Paul A Dawson Wilbur A Lam Saul J Karpen Source Type: research
Trans-Ancestral Genetic Risk Factors for Treatment-Related Type 2 Diabetes Mellitus in Survivors of Childhood Cancer
CONCLUSION: Our findings suggest therapy-related genetic risks contribute to the increased T2D burden among non-Hispanic Black childhood cancer survivors. Additional study of how therapy-related genetic susceptibility contributes to this disparity is needed.PMID:38652878 | DOI:10.1200/JCO.23.02281 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Cindy Im Achal Neupane Jessica L Baedke Brian Lenny Angela Delaney Stephanie B Dixon Eric J Chow Sogol Mostoufi-Moab Tianzhong Yang Melissa A Richard M Monica Gramatges Philip J Lupo Noha Sharafeldin Smita Bhatia Gregory T Armstrong Melissa M Hudson Kirst Source Type: research
Interactions between folate metabolism-related nutrients and polymorphisms on colorectal cancer risk: a case-control study in the Basque country
Eur J Nutr. 2024 Apr 23. doi: 10.1007/s00394-024-03371-5. Online ahead of print.ABSTRACTFolate-mediated one-carbon metabolism (FOCM) plays an important role in colorectal carcinogenesis. Previous studies have assessed the role of folate-mediated one-carbon metabolism (FOCM)-related gene-diet interaction in the aetiology of colorectal cancer (CRC), however, the results remained inconclusive. Thus, this study aimed to investigate dietary factors and genetic variants related to FOCM, as well as potential nutrient-gene and nutrient-lifestyle interactions, on CRC risk. This observational study included 229 patients diagnosed wi...
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Sara Corchero-Palacios Iker Alegria-Lertxundi Marian M de Pancorbo Marta Arroyo-Izaga Source Type: research
Forensic efficiency and population genetic construction of Guizhou Gelao minority from Southwest China revealed by a panel of 23 autosomal STR loci
Forensic Sci Res. 2024 Jan 5;9(2):owad058. doi: 10.1093/fsr/owad058. eCollection 2024 Jun.ABSTRACTShort tandem repeats (STRs) are the most common genetic markers in forensic and human population genetics due to their high polymorphism, rapid detection, and reliable genotyping. To adapt the rapid growth of forensic DNA database and solve problems in disputed cases, a panel of 23 autosomal STR loci with high discriminating ability was constructed recently. The Tai-Kadai-speaking Gelao is the most ancient indigenous minority in Guizhou province, however, the forensic efficiency and population genetic structure remain poorly e...
Source: Cell Research - April 23, 2024 Category: Cytology Authors: Siyu Chai Shuhua Li Ruxin Zhu Li Luo Kaiqin Chen Yinlei Lei Weihong Wan Xijie Hu Shiquan Liu Pengyu Chen Source Type: research
Genomic Testing Identifies Monogenic Causes in Patients with Very Early-Onset Inflammatory Bowel Disease: A Multi-center Survey in an Iranian Cohort
Clin Exp Immunol. 2024 Apr 23:uxae037. doi: 10.1093/cei/uxae037. Online ahead of print.ABSTRACTPatients with very early-onset inflammatory bowel disease (VEO-IBD) may present because of underlying monogenic inborn errors of immunity (IEI). Strong differences have been observed in the causes of monogenic IBD among ethnic populations. This multi-center study was carried out on 16 Iranian patients with VEO-IBD. We reviewed clinical and basic immunologic evaluation including flow cytometry and immunoglobulin levels. All patients underwent clinical whole exome sequencing (WES). Sixteen patients (8 females and 8 males) with a me...
Source: Clinical and Developmental Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Golnaz Eslamian Mahnaz Jamee Tooba Momen Pejman Rohani Sarehossadat Ebrahimi Mehrnaz Mesdaghi Soodeh Ghadimi Mahboubeh Mansouri Seyed Alireza Mahdaviani Mahnaz Sadeghi-Shabestari Morteza Fallahpour Bibi Shahin Shamsian Narges Eslami Samin Sharafian Naghi Source Type: research
Flow cytometric minimal residual disease measurement accounting for cytogenetics in children with non ‐high‐risk acute lymphoblastic leukemia treated according to the ALL‐MB 2008 protocol
ConclusionOur data show that combining clinical risk factors with MFC-MRD measurement is the most useful tool for risk group stratification of children with BCP-ALL in the reduced-intensity protocols. However, this algorithm can be supplemented with cytogenetic data for part of the ImR group. (Source: Cancer Medicine)
Source: Cancer Medicine - April 23, 2024 Category: Cancer & Oncology Authors: Alexander Popov,
Guenter Henze,
Grigory Tsaur,
Oleg Budanov,
Julia Roumiantseva,
Mikhail Belevtsev,
Tatiana Verzhbitskaya,
Liudmila Movchan,
Svetlana Lagoyko,
Liudmila Zharikova,
Yulia Olshanskaya,
Tatiana Riger,
Alena Valochnik,
Natalia Miak Tags: RESEARCH ARTICLE Source Type: research
GSE264393 Multiscale topology classifies and quantifies cell types in subcellular spatial transcriptomics [human snRNA-seq]
Contributors : Katherine Benjamin ; Aneesha Bhandari ; Jessica D Kepple ; Rui Qi ; Zhouchun Shang ; Yanan Xing ; Yanru An ; Nannan Zhang ; Yong Hou ; Tanya L Crockford ; Oliver MacCallion ; Fadi Issa ; Joanna Hester ; Ulrike Tillmann ; Heather A Harrington ; Katherine R BullSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSpatial transcriptomics has the potential to transform our understanding of RNA expression in tissues. Classical array-based technologies produce multiple-cell-scale measurements requiring deconvolution to recover single cell information. However, rapid a...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE264347 Emergence of metabolic coupling to the heterotroph Alteromonas promotes dark survival in Prochlorococcus
Contributors : Allison Coe ; Rogier Braakman ; Steven J Biller ; Aldo Arellano ; Christina Bliem ; Nhi N Vo ; Konnor von Emster ; Elaina Thomas ; Michelle DeMers ; Claudia Steglich ; Jef Huisman ; Sallie W ChisholmSeries Type : Expression profiling by high throughput sequencingOrganism : Alteromonas macleodii ; Prochlorococcus marinus str. NATL2AProchlorococcus is found throughout the euphotic zone in the oligotrophic open ocean. Deep mixing and sinking in aggregates or while attached to particles can, however, transport cells below this sunlit zone, depriving them of light for extended periods of time and influen...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Alteromonas macleodii Prochlorococcus marinus str. NATL2A Source Type: research
GSE264288 The effect of CRISPLD2 on TGF β-induced fibroblast fibrosis
In this study, human cysteine-rich secreted protein LCCL domain protein 2 (CRISPLD2) was found increased reactivity in TGFβ induced fibroblasts, and we further confirmed that CRISPLD2 can participate in TGFβ induced fibroblast fibrosis from multiple perspectives and levels, and investigated the mechanism of CRISPLD2 in fibrosis, providing evidence for CRISPLD2 to become a clinical potentia l therapeutic target and a new biomarker. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE264321 Multiscale topology classifies and quantifies cell types in subcellular spatial transcriptomics [stereo-seq]
Contributors : Katherine Benjamin ; Aneesha Bhandari ; Jessica D Kepple ; Rui Qi ; Zhouchun Shang ; Yanan Xing ; Yanru An ; Nannan Zhang ; Yong Hou ; Tanya L Crockford ; Oliver MacCallion ; Fadi Issa ; Joanna Hester ; Ulrike Tillmann ; Heather A Harrington ; Katherine R BullSeries Type : OtherOrganism : Mus musculusSpatial transcriptomics has the potential to transform our understanding of RNA expression in tissues. Classical array-based technologies produce multiple-cell-scale measurements requiring deconvolution to recover single cell information. However, rapid advances in subcellular measurement of RNA exp...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Other Mus musculus Source Type: research
GSE264327 Nano-encapsulated senolytics cocktail ameliorates germ cell senescence in female mice
Contributors : Yiting Guan ; Hongyong ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLow-quality oocytes directly affect fertilization and embryo developmental ability, and further contributes to infertility in women. Dasatinib and quercetin, as a senolytics, has been explored extensively in various age-related diseases. Here, we report that nano-encapsulated senolytics cocktail (D+Q) efficaciously ameliorates the the quantity and quality of follicles and oocytes in vitro and in vivo. D+Q cocktail supplementation reduces the level of ROS in aged oocytes, decreases the frequenc...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE264332 Transcriptome analysis of RNA-sequencing data for 2-D08-treated SK-LMS-1 cells
Contributors : Hyunju Liu ; Hosouk JoungSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens2 ʹ,3ʹ,4ʹ-trihydroxyflavone (2-D08) is a synthetic flavone that mechanistically has been identified as a specific inhibitor of protein SUMOylation. Recent studies have demonstrated that 2-D08 has various biological functions, including anticancer. We aimed to obtain additional insights into the eff ects of 2-D08 and conducted transcriptome analyses using RNA-sequencing (RNA-seq) in SK-LMS-1 leiomyosarcoma cells. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
