Phosphoproteomic Analysis Identified Mutual Phosphorylation of FAK and Src as a Mechanism of Osimertinib Resistance in < em > EGFR < /em > -Mutant Lung Cancer
CONCLUSIONS: Phosphoproteomic analysis may help elucidate the mechanisms of resistance to molecular-targeted therapies in lung cancer. Mutual phosphorylation of FAK and Src is involved in osimertinib resistance. Thus, FAK and Src inhibition may be novel treatment strategies for osimertinib-resistant NSCLC.PMID:38646155 | PMC:PMC11031815 | DOI:10.1016/j.jtocrr.2024.100668 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Takehiro Tozuka Rintaro Noro Keisuke Yoshida Satoshi Takahashi Mariko Hirao Kuniko Matsuda Yasuhiro Kato Shinji Nakamichi Susumu Takeuchi Masaru Matsumoto Akihiko Miyanaga Shinobu Kunugi Kazufumi Honda Jun Adachi Masahiro Seike Source Type: research
Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial
DISCUSSION: AD-GRS and APOE4 may have different impacts on potential intervention effects on amyloid, that is, less accumulation in the higher-risk group (AD-GRS) versus lower-risk group (APOE).HIGHLIGHTS: First study of neuroimaging and AD genetics in a multidomain lifestyle intervention. Possible intervention effect on brain amyloid deposition may rely on genetic risk. AD-GRS and APOE4 allele may have different impacts on amyloid during intervention.PMID:38647197 | DOI:10.1002/alz.13843 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Gazi Saadmaan Maria Carolina Dalmasso Alfredo Ramirez Mikko Hiltunen Nina Kemppainen Jenni Lehtisalo Francesca Mangialasche Tiia Ngandu Juha Rinne Hilkka Soininen Ruth Stephen Miia Kivipelto Alina Solomon Source Type: research
Phosphoproteomic Analysis Identified Mutual Phosphorylation of FAK and Src as a Mechanism of Osimertinib Resistance in EGFR-Mutant Lung Cancer
CONCLUSIONS: Phosphoproteomic analysis may help elucidate the mechanisms of resistance to molecular-targeted therapies in lung cancer. Mutual phosphorylation of FAK and Src is involved in osimertinib resistance. Thus, FAK and Src inhibition may be novel treatment strategies for osimertinib-resistant NSCLC.PMID:38646155 | PMC:PMC11031815 | DOI:10.1016/j.jtocrr.2024.100668 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Takehiro Tozuka Rintaro Noro Keisuke Yoshida Satoshi Takahashi Mariko Hirao Kuniko Matsuda Yasuhiro Kato Shinji Nakamichi Susumu Takeuchi Masaru Matsumoto Akihiko Miyanaga Shinobu Kunugi Kazufumi Honda Jun Adachi Masahiro Seike Source Type: research
Involvement of kinesins in skeletal dysplasia - a review
Am J Physiol Cell Physiol. 2024 Apr 22. doi: 10.1152/ajpcell.00613.2023. Online ahead of print.ABSTRACTSkeletal dysplasias are group of rare genetic diseases resulting from mutations in genes encoding structural proteins of the cartilage extracellular matrix (ECM), signaling molecules, transcription factors, epigenetic modifiers, and several intracellular proteins. Cell division, organelle maintenance, and intracellular transport are all orchestrated by the cytoskeleton associated proteins, and intracellular processes effected through microtubule-associated movement are important for the function of skeletal cells. Amongst...
Source: American Journal of Physiology. Cell Physiology - April 22, 2024 Category: Cytology Authors: Roufaida Bouchenafa Francesca Manuela de Sousa Brito Katarzyna Anna Pirog Source Type: research
Involvement of kinesins in skeletal dysplasia - a review
Am J Physiol Cell Physiol. 2024 Apr 22. doi: 10.1152/ajpcell.00613.2023. Online ahead of print.ABSTRACTSkeletal dysplasias are group of rare genetic diseases resulting from mutations in genes encoding structural proteins of the cartilage extracellular matrix (ECM), signaling molecules, transcription factors, epigenetic modifiers, and several intracellular proteins. Cell division, organelle maintenance, and intracellular transport are all orchestrated by the cytoskeleton associated proteins, and intracellular processes effected through microtubule-associated movement are important for the function of skeletal cells. Amongst...
Source: Am J Physiol Cell Ph... - April 22, 2024 Category: Cytology Authors: Roufaida Bouchenafa Francesca Manuela de Sousa Brito Katarzyna Anna Pirog Source Type: research
Construction of an Immunogenic Cell Death-Related Gene Signature and Genetic Subtypes for Predicting Prognosis, Immune Microenvironments, and Drug Sensitivity in Hepatocellular Carcinoma
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - April 22, 2024 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
GSE264519 High-throughput Fitness Experiments Reveal Specific Vulnerabilities of Human-Adapted Salmonella During Stress and Infection
Series Type : OtherOrganism : Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 ; Salmonella enterica subsp. enterica serovar Typhi str. Ty2 ; Salmonella enterica subsp. enterica serovar Typhimurium str. D23580 ; Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74This SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 22, 2024 Category: Genetics & Stem Cells Tags: Other Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhimurium str. D23580 Salmonella enterica subsp. enterica serovar Source Type: research
GSE131040 Maternal antioxidant treatment prevents behavioural and neurological changes in offspring exposed to prenatal social stress [RNA-seq]
Contributors : Hannah Scott ; Thomas J Phillips ; Ying Sze ; Alessio Alfieri ; Mark F Rogers ; Charles P Case ; Paula J BruntonSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusMaternal exposure to social stress during pregnancy is associated with an increased risk of psychiatric disorders in the offspring in later life. How the effects of maternal social stress are transmitted to the developing foetus is unclear. Using a rat model of maternal social stress during pregnancy, we explored the mechanisms by which maternal stress is conveyed to the foetus and the potential for targe...
Source: GEO: Gene Expression Omnibus - April 22, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research
GSE173164 To investigate the effects of NRF2 inhibitors (pyrimethamine and mitoxantrone) on gene expression in a human esophageal squamous cell carcinoma cell line (KYSE70)
Contributors : Chorlada Paiboonrungruang ; Zhaohui Xiong ; Xiaoxin ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo study the effects of NRF2 inhibitors (pyrimethamine or mitoxantrone) on human esophageal squamous cell carcinoma cells. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 22, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE210982 Deletion of cardiac-enriched lncRNA CARDINAL exacerbate TAC induced hypertrophy
Contributors : Yao W Lu ; Xin He ; Da-Zhi WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPathological cardiac hypertrophy is featured by enhanced protein synthesis. Translation inhibition is effective in treating cardiac hypertrophy, yet with systematic side effect. We identified a cardiac-enriched LncRNA CARDINAL, when deleted, exacerbate transaortic constriction (TAC) induced hypertrophy. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 22, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE210983 AAV9-medated cardiac expression of lncRNA CARDINAL ameliorate TAC induced hypertrophy
Contributors : Yao W Lu ; Xin He ; Da-Zhi WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPathological cardiac hypertrophy is featured by enhanced protein synthesis. Translation inhibition is effective in treating cardiac hypertrophy, yet with systematic side effect. We identified a cardiac-enriched LncRNA CARDINAL, when over-expressed in cardiomyocyte using AAV9 driven by cTNT promoter, ameliorate transaortic constriction (TAC) induced hypertrophy. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 22, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE210985 Analysis of cardiac-enriched lncRNA CARDINAL in TAC induced hypertrophy
Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 22, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE224207 Macrophage epigenetic memories of early life injury drive neonatal nociceptive priming. [ATAC-Seq]
This study reveals a novel mechanism by which acute post-surgical pain may transition to chronic pain in children. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 22, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
GSE231940 The chromatin binding of BMAL1 in eneriched PVN tissue at ZT8
Contributors : Rachel Van Drunen ; Kristin Eckel-Mahan ; Haichao Wei ; Jiaqian Wu ; Xian Chen ; Zhongming ZhaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusWhile BMAL1 chromatin binding has been explored in detail in the liver tissue and other tissue, research has not examined BMAL1 binding in regions such as the brain's hypothalmus. Chromatin immunoprecipitation-sequencing (ChIP-seq) allows us to capture the role of BMAL1 during its peak chromatin occupancy, ZT8, for binding to the genome of enriched PVN mouse tissue. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 22, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
GSE230384 Combined transcriptome and miRNA-based analysis of the molecular mechanism of collection preference in Italian honey bees
Contributor : Lina GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Apis melliferaA combined transcriptomic and miRNA-based analysis of the molecular mechanism of collection preference in Italian honey bees was conducted, mainly selecting the long-range sensor tentacles and the proximal sensor mouthparts. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 22, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Apis mellifera Source Type: research
