GSE246899 Effect of knockout ERO1 α on gene expression in mTORC1 activated mouse embryonic fibroblasts
Contributors : Zixi Wang ; Huaiyuan Zong ; Xiaojun ZhaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEndoplasmic reticulum oxidoreductase 1 alpha (ERO1 α) is an endoplasmic reticulum stress–related gene, which improves cell perseverance against challenges of high levels of protein misfolding during endoplasmic reticulum stress by retaining good activity of oxidative protein folding. Numerous studies have shown abnormal expression of ERo1α in va rious diseases, but its downstream target are not fully understood. Our work will help in the elucidation of the downstream molecular ...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE247272 CEBPA restricts alveolar type 2 cell plasticity during development and injury-repair
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
GSE246665 The role of miRNAs and lncRNAs in regulating transcription in gilthead sea bream (Sparus aurata) myoblasts in response to amino acids and insulin-like growth factor 1
Series Type : Non-coding RNA profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Sparus aurataThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Expression profiling by high throughput sequencing Sparus aurata Source Type: research
GSE246500 Analysis of intestinal epithelial cell responses to Cryptosporidium highlights the temporal effects of IFN- γ on parasite restriction
Contributors : Ryan D Pardy ; Katelyn A Walzer ; Bethan A Wallbank ; Jessica H Byerly ; Keenan M O'Dea ; Ian S Cohn ; Breanne E Haskins ; Justin L Roncaioli ; Eleanor J Smith ; Gracyn Y Buenconsejo ; Boris Striepen ; Christopher A HunterSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe production of IFN- γ is crucial for control of multiple enteric infections, but its impact on intestinal epithelial cells (IEC) is not well understood. Cryptosporidium parasites exclusively infect epithelial cells and the ability of interferons to activate the transcription factor STAT1 in IEC is re...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE246573 The role of miRNAs and lncRNAs in regulating transcription in gilthead sea bream (Sparus aurata) myoblasts in response to amino acids and insulin-like growth factor 1 [RNA-seq]
In this study, gilthead sea bream (Sparus aurata) fast muscle myoblasts were stimulated with two pro-growth treatments, amino acids (AA) and insulin-like growth factor 1 (Igf-1), to analyze the transcriptional response of genes, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) and their regulatory network. AA had a higher impact on gene transcription (1795 genes significantly changed) compared to Igf-1 (385 genes significantly changed). Both treatments stim-ulated the transcription of genes related to muscle differentiation (GO:0042692) and sarcomere components (GO:0030017), but AA stimulated more the DNA replication ...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Expression profiling by high throughput sequencing Sparus aurata Source Type: research
GSE246453 The role of miRNAs and lncRNAs in regulating transcription in gilthead sea bream (Sparus aurata) myoblasts in response to amino acids and insulin-like growth factor 1 [miRNA-seq]
In this study, gilthead sea bream (Sparus aurata) fast muscle myoblasts were stimulated with two pro-growth treatments, amino acids (AA) and insulin-like growth factor 1 (Igf-1), to analyze the transcriptional response of genes, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) and their regulatory network. AA had a higher impact on gene transcription (1795 genes significantly changed) compared to Igf-1 (385 genes significantly changed). Both treatments stim-ulated the transcription of genes related to muscle differentiation (GO:0042692) and sarcomere components (GO:0030017), but AA stimulated more the DNA replication ...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Sparus aurata Source Type: research
GSE243799 Influences of chronic hypoxia and hypoxic-inducible factor 2A on mouse myoblasts
Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe extracellular oxygen levels play a crucial role in the control of cellular metabolism and behaviors under various physiological and pathological conditions. When mammalian cells sense insufficient oxygen levels, one of the most important responses is to stabilize hypoxic-inducible factors. While the functions of HIF-1A and acute hypoxia signaling have been extensively studied in many cell types, the impacts of HIF-2A and chronic hypoxia on skeletal muscle myoblasts have not been fully understood. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE243906 RNAseq for Young Old mouse liver hepatocytes with and without high fat diet
Contributors : Peter D Adams ; Aaron Havas ; Xue LeiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOur Goal was to determine how hepatocytes of young and old mice differentially respond to 9-weeks of high fat diet vs normal chow. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE244653 An integrated toolkit for human microglia functional genomics
In this study will generated iMG from human iPSCs using our newly developed protocol. We used single cell RNA-Seq to study the transcriptomic profiles of our newly formed iMG. The single cell RNA-Seq data under this accession is from wild type iMG (Hashtag 7) and OTHER KO iMG (Hashtag 8) (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE246206 miRNA and mRNA Signatures in Human Acute Kidney Injury Tissue
Series Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
GSE243630 ATACseq for Young and Old mouse liver
Contributors : Aaron Havas ; Peter D Adams ; Neil A Robertson ; Brandon Sos ; Kun ZhangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusOur goal was to identify how aging affects chromatin accessability in the mouse liver. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
GSE241018 SMARCA4 loss and mutated β-catenin induce proliferative lesions in the murine embryonic cerebellum [scRNA-seq]
Contributors : Carolin G öbel ; Melanie Schoof ; Dörthe Holdhof ; Michael Spohn ; Ulrich SchüllerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlmost all medulloblastomas (MB) of the Wingless/Int-1 (WNT) type are characterized by hotspot mutations in CTNNB1, and mouse models have convincingly demonstrated the tumor-initiating role of these mutations. Additional alterations in SMARCA4 are detected in around 20% of WNT MB, but their functional role is mostly unknown. We therefore amended previously described Blbp cre::Ctnnb1(ex3)fl/wt mice by the introduction of a floxed Smarc...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE241542 A phosphate transporter in VIPergic neurons of the suprachiasmatic nucleus gates locomotor activity during the light/dark transition in mice
Contributors : Sara Pierre-Ferrer ; Ben Collins ; David Lukacsovich ; Shao'Ang Wen ; Yuchen Cai ; Jochen Winterer ; Jun Yan ; Lene Pedersen ; Csaba F öldy ; Steven A BrownSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe suprachiasmatic nucleus (SCN) encodes time of day through changes in daily firing, with neurons being generally more active during the day and more silent at night. However, molecular mechanisms by which the SCN encodes and times behavior are not fully understood. To identify factors that could encode day/night differences in activity we combined patch-cla...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE240713 Impact of Folate Status on the Sperm DNA Methylome of Mice with the 677C > T Variant in 5,10-Methylenetetrahydrofolate Reductase
Series Type : Methylation profiling by genome tiling array ; Methylation profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Methylation profiling by genome tiling array Methylation profiling by high throughput sequencing Mus musculus Source Type: research
GSE240742 Critical Role of Ferritin-Mediated Iron Homeostasis in the Maintenance of Hematopoietic Stem Cells and Leukemia Stem Cells
Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIron metabolism has emerged as a critical factor in cell viability, both in normal and pathological contexts. However, the intricate relationship between iron metabolism and the maintenance of adult stem cells and cancer stem cells remains incompletely understood. The ferritin complex, responsible for intracellular iron storage and buffering, plays a pivotal role in this process. Our research provides insights into the regulatory role of ferritin-mediated iron homeostasis in hematopoietic stem cells (HSCs). (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
