Effect of < em > Bombyx mori < /em > on the Liver Protection of Non-Alcoholic Fatty Liver Disease Based on In Vitro and In Vivo Models
We examined the hepatoprotective effects of SW using in vitro and high-fat and high-fructose (HFHF) diet-induced obese in vivo model mice by real-time PCR, immunoblot analysis, and fecal microbiota analysis. SW significantly reduced lipid accumulation and expression of the lipogenic genes in HepG2 cells and the livers of HFHF-induced mice. SW caused significant reductions in triglycerides, and total cholesterol in serum and upregulation of fatty acid oxidation markers compared to the HFHF group. Besides, SW significantly induced phosphorylation of AMPK and ACC in both models, suggesting roles in AMPK activation and the ACC...
Source: Current Issues in Molecular Biology - April 30, 2021 Category: Molecular Biology Authors: Miey Park Chaewon Kang Hae-Jeung Lee Source Type: research

Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches
Curr Issues Mol Biol. 2021 Apr 27;43(1):2. doi: 10.3390/cimb43010002.ABSTRACTColorectal cancer (CRC) has the fourth-highest incidence of all cancer types, and its incidence has steadily increased in the last decade. The general transcription factor III (GTF3) family, comprising GTF3A, GTF3B, GTF3C1, and GTFC2, were stated to be linked with the expansion of different types of cancers; however, their messenger (m)RNA expressions and prognostic values in colorectal cancer need to be further investigated. To study the transcriptomic expression levels of GTF3 gene members in colorectal cancer in both cancerous tissues and cell ...
Source: Current Issues in Molecular Biology - April 30, 2021 Category: Molecular Biology Authors: Gangga Anuraga Wan-Chun Tang Nam Nhut Phan Hoang Dang Khoa Ta Yen-Hsi Liu Yung-Fu Wu Kuen-Haur Lee Chih-Yang Wang Source Type: research

Effect of < em > Bombyx mori < /em > on the Liver Protection of Non-Alcoholic Fatty Liver Disease Based on In Vitro and In Vivo Models
We examined the hepatoprotective effects of SW using in vitro and high-fat and high-fructose (HFHF) diet-induced obese in vivo model mice by real-time PCR, immunoblot analysis, and fecal microbiota analysis. SW significantly reduced lipid accumulation and expression of the lipogenic genes in HepG2 cells and the livers of HFHF-induced mice. SW caused significant reductions in triglycerides, and total cholesterol in serum and upregulation of fatty acid oxidation markers compared to the HFHF group. Besides, SW significantly induced phosphorylation of AMPK and ACC in both models, suggesting roles in AMPK activation and the ACC...
Source: Current Issues in Molecular Biology - April 30, 2021 Category: Molecular Biology Authors: Miey Park Chaewon Kang Hae-Jeung Lee Source Type: research

Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches
Curr Issues Mol Biol. 2021 Apr 27;43(1):2. doi: 10.3390/cimb43010002.ABSTRACTColorectal cancer (CRC) has the fourth-highest incidence of all cancer types, and its incidence has steadily increased in the last decade. The general transcription factor III (GTF3) family, comprising GTF3A, GTF3B, GTF3C1, and GTFC2, were stated to be linked with the expansion of different types of cancers; however, their messenger (m)RNA expressions and prognostic values in colorectal cancer need to be further investigated. To study the transcriptomic expression levels of GTF3 gene members in colorectal cancer in both cancerous tissues and cell ...
Source: Current Issues in Molecular Biology - April 30, 2021 Category: Molecular Biology Authors: Gangga Anuraga Wan-Chun Tang Nam Nhut Phan Hoang Dang Khoa Ta Yen-Hsi Liu Yung-Fu Wu Kuen-Haur Lee Chih-Yang Wang Source Type: research

Effect of < em > Bombyx mori < /em > on the Liver Protection of Non-Alcoholic Fatty Liver Disease Based on In Vitro and In Vivo Models
We examined the hepatoprotective effects of SW using in vitro and high-fat and high-fructose (HFHF) diet-induced obese in vivo model mice by real-time PCR, immunoblot analysis, and fecal microbiota analysis. SW significantly reduced lipid accumulation and expression of the lipogenic genes in HepG2 cells and the livers of HFHF-induced mice. SW caused significant reductions in triglycerides, and total cholesterol in serum and upregulation of fatty acid oxidation markers compared to the HFHF group. Besides, SW significantly induced phosphorylation of AMPK and ACC in both models, suggesting roles in AMPK activation and the ACC...
Source: Current Issues in Molecular Biology - April 30, 2021 Category: Molecular Biology Authors: Miey Park Chaewon Kang Hae-Jeung Lee Source Type: research

Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches
Curr Issues Mol Biol. 2021 Apr 27;43(1):2. doi: 10.3390/cimb43010002.ABSTRACTColorectal cancer (CRC) has the fourth-highest incidence of all cancer types, and its incidence has steadily increased in the last decade. The general transcription factor III (GTF3) family, comprising GTF3A, GTF3B, GTF3C1, and GTFC2, were stated to be linked with the expansion of different types of cancers; however, their messenger (m)RNA expressions and prognostic values in colorectal cancer need to be further investigated. To study the transcriptomic expression levels of GTF3 gene members in colorectal cancer in both cancerous tissues and cell ...
Source: Current Issues in Molecular Biology - April 30, 2021 Category: Molecular Biology Authors: Gangga Anuraga Wan-Chun Tang Nam Nhut Phan Hoang Dang Khoa Ta Yen-Hsi Liu Yung-Fu Wu Kuen-Haur Lee Chih-Yang Wang Source Type: research

Publisher's Note: Continued Publication of < em > Current Issues in Molecular Biology < /em > by MDPI
Curr Issues Mol Biol. 2021 Mar 18;43(1):1. doi: 10.3390/cimb43010001.ABSTRACTCurrent Issues in Molecular Biology (ISSN 1467-3045) was launched in 1999 and has published international and multidisciplinary articles on all aspects of molecular biology spanning from basic mechanisms to applications in fields primarily, but not exclusively, relevant to microbiology and virology [...].PMID:33886529 | DOI:10.3390/cimb43010001 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - April 22, 2021 Category: Molecular Biology Authors: Franck Vazquez Shu-Kun Lin Source Type: research

Publisher's Note: Continued Publication of < em > Current Issues in Molecular Biology < /em > by MDPI
Curr Issues Mol Biol. 2021 Mar 18;43(1):1. doi: 10.3390/cimb43010001.ABSTRACTCurrent Issues in Molecular Biology (ISSN 1467-3045) was launched in 1999 and has published international and multidisciplinary articles on all aspects of molecular biology spanning from basic mechanisms to applications in fields primarily, but not exclusively, relevant to microbiology and virology [...].PMID:33886529 | DOI:10.3390/cimb43010001 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - April 22, 2021 Category: Molecular Biology Authors: Franck Vazquez Shu-Kun Lin Source Type: research

Publisher's Note: Continued Publication of < em > Current Issues in Molecular Biology < /em > by MDPI
Curr Issues Mol Biol. 2021 Mar 18;43(1):1. doi: 10.3390/cimb43010001.ABSTRACTCurrent Issues in Molecular Biology (ISSN 1467-3045) was launched in 1999 and has published international and multidisciplinary articles on all aspects of molecular biology spanning from basic mechanisms to applications in fields primarily, but not exclusively, relevant to microbiology and virology [...].PMID:33886529 | DOI:10.3390/cimb43010001 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - April 22, 2021 Category: Molecular Biology Authors: Franck Vazquez Shu-Kun Lin Source Type: research

Publisher's Note: Continued Publication of < em > Current Issues in Molecular Biology < /em > by MDPI
Curr Issues Mol Biol. 2021 Mar 18;43(1):1. doi: 10.3390/cimb43010001.ABSTRACTCurrent Issues in Molecular Biology (ISSN 1467-3045) was launched in 1999 and has published international and multidisciplinary articles on all aspects of molecular biology spanning from basic mechanisms to applications in fields primarily, but not exclusively, relevant to microbiology and virology [...].PMID:33886529 | DOI:10.3390/cimb43010001 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - April 22, 2021 Category: Molecular Biology Authors: Franck Vazquez Shu-Kun Lin Source Type: research

Publisher's Note: Continued Publication of < em > Current Issues in Molecular Biology < /em > by MDPI
Curr Issues Mol Biol. 2021 Mar 18;43(1):1. doi: 10.3390/cimb43010001.ABSTRACTCurrent Issues in Molecular Biology (ISSN 1467-3045) was launched in 1999 and has published international and multidisciplinary articles on all aspects of molecular biology spanning from basic mechanisms to applications in fields primarily, but not exclusively, relevant to microbiology and virology [...].PMID:33886529 | DOI:10.3390/cimb43010001 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - April 22, 2021 Category: Molecular Biology Authors: Franck Vazquez Shu-Kun Lin Source Type: research

Publisher's Note: Continued Publication of < em > Current Issues in Molecular Biology < /em > by MDPI
Curr Issues Mol Biol. 2021 Mar 18;43(1):1. doi: 10.3390/cimb43010001.ABSTRACTCurrent Issues in Molecular Biology (ISSN 1467-3045) was launched in 1999 and has published international and multidisciplinary articles on all aspects of molecular biology spanning from basic mechanisms to applications in fields primarily, but not exclusively, relevant to microbiology and virology [...].PMID:33886529 | DOI:10.3390/cimb43010001 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - April 22, 2021 Category: Molecular Biology Authors: Franck Vazquez Shu-Kun Lin Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

The Flexible Genome of Acidophilic Prokaryotes
This article reviews the diversity of elements that have been found to constitute the flexible genome of acidophiles. Special emphasis is put on the knowledge generated for Sulfolobus (archaea) and species of the bacterial genera Acidithiobacillus and Leptospirillum. Also, recent knowledge on the strategies used by acidophiles to contain deletereous exchanges while allowing innovation, and the emerging details of the molecular biology of these systems, are discussed. Major lacunae in our understanding of the mobilome of acidophilic prokaryotes and topics for further investigations are identified.PMID:33687344 | DOI:10.2177...
Source: Current Issues in Molecular Biology - March 9, 2021 Category: Molecular Biology Authors: Simon Beard Francisco J Ossandon Douglas E Rawlings Raquel Quatrini Source Type: research

Host Innate Immune Response and Viral Immune Evasion During Alphaherpesvirus Infection
Curr Issues Mol Biol. 2021;42:635-686. doi: 10.21775/cimb.042.635. Epub 2021 Feb 28.ABSTRACTBoth the development of the mammalian innate immune system and the antagonistic strategies acquired by alphaherpesviruses to dismantle it have been shaped by co-evolving virus-host interactions over millions of years. Here, we review mechanisms employed by mammalian cells to detect pathogen molecules, such as viral glycoproteins and nucleic acids, and induce innate immune signaling upon infection with alphaherpesviruses. We further explore strategies acquired by these viruses to bypass immune detection and activation, thereby suppor...
Source: Current Issues in Molecular Biology - February 28, 2021 Category: Molecular Biology Authors: Krystal K Lum Ileana M Cristea Source Type: research

Host Innate Immune Response and Viral Immune Evasion During Alphaherpesvirus Infection
Curr Issues Mol Biol. 2021 Feb 28;42:635-686. doi: 10.21775/cimb.042.635. Online ahead of print.ABSTRACTBoth the development of the mammalian innate immune system and the antagonistic strategies acquired by alphaherpesviruses to dismantle it have been shaped by co-evolving virus-host interactions over millions of years. Here, we review mechanisms employed by mammalian cells to detect pathogen molecules, such as viral glycoproteins and nucleic acids, and induce innate immune signaling upon infection with alphaherpesviruses. We further explore strategies acquired by these viruses to bypass immune detection and activation, th...
Source: Current Issues in Molecular Biology - February 28, 2021 Category: Molecular Biology Authors: Krystal K Lum Ileana M Cristea Source Type: research

Host Innate Immune Response and Viral Immune Evasion During Alphaherpesvirus Infection
Curr Issues Mol Biol. 2021 Feb 28;42:635-686. doi: 10.21775/cimb.042.635. Online ahead of print.ABSTRACTBoth the development of the mammalian innate immune system and the antagonistic strategies acquired by alphaherpesviruses to dismantle it have been shaped by co-evolving virus-host interactions over millions of years. Here, we review mechanisms employed by mammalian cells to detect pathogen molecules, such as viral glycoproteins and nucleic acids, and induce innate immune signaling upon infection with alphaherpesviruses. We further explore strategies acquired by these viruses to bypass immune detection and activation, th...
Source: Current Issues in Molecular Biology - February 28, 2021 Category: Molecular Biology Authors: Krystal K Lum Ileana M Cristea Source Type: research

Host Innate Immune Response and Viral Immune Evasion During Alphaherpesvirus Infection
Curr Issues Mol Biol. 2021 Feb 28;42:635-686. doi: 10.21775/cimb.042.635. Online ahead of print.ABSTRACTBoth the development of the mammalian innate immune system and the antagonistic strategies acquired by alphaherpesviruses to dismantle it have been shaped by co-evolving virus-host interactions over millions of years. Here, we review mechanisms employed by mammalian cells to detect pathogen molecules, such as viral glycoproteins and nucleic acids, and induce innate immune signaling upon infection with alphaherpesviruses. We further explore strategies acquired by these viruses to bypass immune detection and activation, th...
Source: Current Issues in Molecular Biology - February 28, 2021 Category: Molecular Biology Authors: Krystal K Lum Ileana M Cristea Source Type: research

Host Innate Immune Response and Viral Immune Evasion During Alphaherpesvirus Infection
Curr Issues Mol Biol. 2021 Feb 28;42:635-686. doi: 10.21775/cimb.042.635. Online ahead of print.ABSTRACTBoth the development of the mammalian innate immune system and the antagonistic strategies acquired by alphaherpesviruses to dismantle it have been shaped by co-evolving virus-host interactions over millions of years. Here, we review mechanisms employed by mammalian cells to detect pathogen molecules, such as viral glycoproteins and nucleic acids, and induce innate immune signaling upon infection with alphaherpesviruses. We further explore strategies acquired by these viruses to bypass immune detection and activation, th...
Source: Current Issues in Molecular Biology - February 28, 2021 Category: Molecular Biology Authors: Krystal K Lum Ileana M Cristea Source Type: research

Host Innate Immune Response and Viral Immune Evasion During Alphaherpesvirus Infection
Curr Issues Mol Biol. 2021 Feb 28;42:635-686. doi: 10.21775/cimb.042.635. Online ahead of print.ABSTRACTBoth the development of the mammalian innate immune system and the antagonistic strategies acquired by alphaherpesviruses to dismantle it have been shaped by co-evolving virus-host interactions over millions of years. Here, we review mechanisms employed by mammalian cells to detect pathogen molecules, such as viral glycoproteins and nucleic acids, and induce innate immune signaling upon infection with alphaherpesviruses. We further explore strategies acquired by these viruses to bypass immune detection and activation, th...
Source: Current Issues in Molecular Biology - February 28, 2021 Category: Molecular Biology Authors: Krystal K Lum Ileana M Cristea Source Type: research