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Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers
Curr Issues Mol Biol. 2023 Oct 25;45(11):8552-8585. doi: 10.3390/cimb45110539.ABSTRACTNeuroinflammation has a significant impact on different pathologies, such as stroke or spinal cord injury, intervening in their pathophysiology: expansion, progression, and resolution. Neuroinflammation involves oxidative stress, damage, and cell death, playing an important role in neuroplasticity and motor dysfunction by affecting the neuronal connection responsible for motor control. The diagnosis of this pathology is performed using neuroimaging techniques and molecular diagnostics based on identifying and measuring signaling molecules...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Ane Larrea Ane Elexpe Eguzki ñe Díez-Martín Mar ía Torrecilla Egoitz Astigarraga Gabriel Barreda-G ómez Source Type: research
Mitochondrial DNA and Inflammation in Alzheimer's Disease
Curr Issues Mol Biol. 2023 Oct 25;45(11):8586-8606. doi: 10.3390/cimb45110540.ABSTRACTMitochondrial dysfunction and neuroinflammation are implicated in the pathogenesis of most neurodegenerative diseases, such as Alzheimer's disease (AD). In fact, although a growing number of studies show crosstalk between these two processes, there remain numerous gaps in our knowledge of the mechanisms involved, which requires further clarification. On the one hand, mitochondrial dysfunction may lead to the release of mitochondrial damage-associated molecular patterns (mtDAMPs) which are recognized by microglial immune receptors and cont...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Giacoma Galizzi Marta Di Carlo Source Type: research
< em > Astragalus membranaceus < /em > and < em > Cinnamomum cassia < /em > Stimulate the Hair Follicle Differentiation-Related Growth Factor by the Wnt/ β-Catenin Signaling Pathway
In conclusion, the YH complex consisting of A. membranaceus and C. cassia induced hair follicle differentiation and preserved the growing-anagen phase by increasing growth factors and the Wnt/β-catenin signaling pathway, leading to the restoration of hair loss. The YH complex can be a remedy for hair loss diseases, such as alopecia areata, androgenetic alopecia, telogen effluvium, and chemotherapy-induced alopecia.PMID:37998718 | PMC:PMC10670826 | DOI:10.3390/cimb45110541 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Mi Hye Kim Seong Chul Jin Hee Kyung Baek Woong Mo Yang Source Type: research
Simvastatin Attenuates Areca Nut Extract-Induced Subdermal Fibrosis in Mice by Targeting TGF- β Signaling Pathways
In this study, 8-week-old male BALB/c mice were randomly divided into three groups based on different time points. Each mouse was then treated with four different drug formulations. Post-treatment, specimens were collected for histopathological examination and staining to assess skin thickness, fibrosis, and collagen deposition. ANE treatment alone significantly increased skin thickness and collagen deposition compared to the control group after the 4-week time point. The combined administration of ANE and simvastatin, resulted in a notable reduction in skin thickness and collagen deposition. Western blot analysis revealed...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Chi-Hua Chang Ching-Ping Lin Yuk-Kwan Chen Yu-Fang Hsiao Yan-Hsiung Wang Source Type: research
Implications of Activating the ANT2/mTOR/PGC-1 α Feedback Loop: Insights into Mitochondria-Mediated Injury in Hypoxic Myocardial Cells
Curr Issues Mol Biol. 2023 Oct 27;45(11):8633-8651. doi: 10.3390/cimb45110543.ABSTRACTMitochondrial dysfunction is known to play a critical role in the development of cardiomyocyte death during acute myocardial infarction (AMI). However, the exact mechanisms underlying this dysfunction are still under investigation. Adenine nucleotide translocase 2 (ANT2) is a key functional protein in mitochondria. We aimed at exploring the potential benefits of ANT2 inhibition against AMI. We utilized an oxygen-glucose deprivation (OGD) cell model and an AMI mice model to detect cardiomyocyte injury. We observed elevated levels of reacti...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Meng Zhang Yuanzhan Yang Zhu Zhu Zixuan Chen Dongyang Huang Source Type: research
Machine Learning Analysis of Alzheimer's Disease Single-Cell RNA-Sequencing Data across Cortex and Hippocampus Regions
Curr Issues Mol Biol. 2023 Oct 28;45(11):8652-8669. doi: 10.3390/cimb45110544.ABSTRACTAdvancements in molecular biology have revolutionized our understanding of complex diseases, with Alzheimer's disease being a prime example. Single-cell sequencing, currently the most suitable technology, facilitates profoundly detailed disease analysis at the cellular level. Prior research has established that the pathology of Alzheimer's disease varies across different brain regions and cell types. In parallel, only machine learning has the capacity to address the myriad challenges presented by such studies, where the integration of lar...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Marios G Krokidis Aristidis G Vrahatis Konstantinos Lazaros Konstantina Skolariki Themis P Exarchos Panagiotis Vlamos Source Type: research
Tight Junction Claudins and Occludin Are Differentially Regulated and Expressed in Genomically Defined Subsets of Colon Cancer
Curr Issues Mol Biol. 2023 Oct 28;45(11):8670-8686. doi: 10.3390/cimb45110545.ABSTRACTMetastatic colon cancer remains incurable despite improvements in survival outcomes. New therapies based on the discovery of colon cancer genomic subsets could improve outcomes. Colon cancers from genomic studies with publicly available data were examined to define the expression and regulation of the major tight junction proteins claudins and occludin in genomic groups. Putative regulations of the promoters of tight junction genes by colon-cancer-deregulated pathways were evaluated in silico. The effect of claudin mRNA expression levels ...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Ioannis A Voutsadakis Source Type: research
Autophagy Modulation and Its Implications on Glioblastoma Treatment
Curr Issues Mol Biol. 2023 Oct 29;45(11):8687-8703. doi: 10.3390/cimb45110546.ABSTRACTAutophagy is a vital cellular process that functions to degrade and recycle damaged organelles into basic metabolites. This allows a cell to adapt to a diverse range of challenging conditions. Autophagy assists in maintaining homeostasis, and it is tightly regulated by the cell. The disruption of autophagy has been associated with many diseases, such as neurodegenerative disorders and cancer. This review will center its discussion on providing an in-depth analysis of the current molecular understanding of autophagy and its relevance to br...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Johnny Chen Andrea Salinas Rodriguez Maximiliano Arath Morales Xiaoqian Fang Source Type: research
Altered Blood Molecular Markers of Cardiovascular Function in Rats after Intrauterine Hypoxia and Drug Therapy
Curr Issues Mol Biol. 2023 Oct 30;45(11):8704-8715. doi: 10.3390/cimb45110547.ABSTRACTMany children and adults who have suffered prenatal hypoxia at an early age develop many serious diseases. This disease is an actual problem of pediatric cardiology and little studied. The aim was to analyze the cardioprotective effect of L-arginine, Thiotriazoline, Angioline, and Mildronate on the cardiovascular system of rats after prenatal hypoxia. Methods: The experiments were carried out on 50 female white rats; intraperitoneal sodium nitrite solution was administered daily to pregnant female rats after 16 days at a dose of 50 mg/kg....
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Olena Popazova Igor Belenichev Oleh Yadlovskyi Valentyn Oksenych Aleksandr Kamyshnyi Source Type: research
mtDNA Single-Nucleotide Variants Associated with Type 2 Diabetes
Curr Issues Mol Biol. 2023 Oct 30;45(11):8716-8732. doi: 10.3390/cimb45110548.ABSTRACTType 2 diabetes (T2D) is a chronic systemic disease with a complex etiology, characterized by insulin resistance and mitochondrial dysfunction in various cell tissues. To explore this relationship, we conducted a secondary analysis of complete mtDNA sequences from 1261 T2D patients and 1105 control individuals. Our findings revealed significant associations between certain single-nucleotide polymorphisms (SNPs) and T2D. Notably, the variants m.1438A>G (rs2001030) (controls: 32 [27.6%], T2D: 84 [72.4%]; OR: 2.46; 95%CI: 1.64-3.78; p <...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Enrique Garcia-Gaona Alhel í García-Gregorio Camila Garc ía-Jiménez Mildred Alejandra L ópez-Olaiz Paola Mendoza-Ram írez Daniel Fernandez-Guzman Rolando Alberto Pillado-S ánchez Axel David Soto-Pacheco Laura Yareni-Zu ñiga Mar ía Guadalupe Sánc Source Type: research
An Analysis of the Biotin-(Strept)avidin System in Immunoassays: Interference and Mitigation Strategies
Curr Issues Mol Biol. 2023 Oct 31;45(11):8733-8754. doi: 10.3390/cimb45110549.ABSTRACTAn immunoassay is an analytical test method in which analyte quantitation is based on signal responses generated as a consequence of an antibody-antigen interaction. They are the method of choice for the measurement of a large panel of diagnostic markers. Not only are they fully automated, allowing for a short turnaround time and high throughput, but offer high sensitivity and specificity with low limits of detection for a wide range of analytes. Many immunoassay manufacturers exploit the extremely high affinity of biotin for streptavidin...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Amy H A Balzer Christopher B Whitehurst Source Type: research
Verbascoside Inhibits/Repairs the Damage of LPS-Induced Inflammation by Regulating Apoptosis, Oxidative Stress, and Bone Remodeling
Curr Issues Mol Biol. 2023 Oct 31;45(11):8755-8766. doi: 10.3390/cimb45110550.ABSTRACTOsteocytes play an important role as regulators of both osteoclasts and osteoblasts, and some proteins that are secreted from them play a role in bone remodeling and modeling. LPS affects bone structure because it is an inflammatory factor, despite verbascoside's potential for bone preservation and healing. Osteocytes may also be involved in the control of the bone's response to immunological changes in inflammatory situations. MLO-Y4 cells were cultured in either supplemented -MEM alone with a low serum to inhibit cell growth or media wi...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Sahika Pinar Akyer Ege R ıza Karagur Melek Tunc Ata Emine Kilic Toprak Aysegul Cort Donmez Baris Ozgur Donmez Source Type: research
Identification of m6A Modification Regulated by Dysregulated circRNAs in Decidua of Recurrent Pregnancy Loss
Curr Issues Mol Biol. 2023 Oct 31;45(11):8767-8779. doi: 10.3390/cimb45110551.ABSTRACTN6-methyladenosine (m6A) modification is a prevalent modification of messenger ribonucleic acid (mRNA) in eukaryote cells and is closely associated with recurrent pregnancy loss (RPL). Circular RNAs (circRNAs) play critical roles in embryo implantation, trophoblast invasion and immune balance, which are important events during pregnancy. However, how m6A modification is regulated by circRNAs and the potential regulatory mechanism of circRNAs on RPL occurrence remain largely unclassified. We displayed the expression profiles of circRNAs an...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Liyuan Cui Minfeng Shi Xinhang Meng Jinfeng Qian Songcun Wang Source Type: research
Molecular Linkage between Immune System Disorders and Atherosclerosis
This article unravels the molecular linkage between the aforementioned immune system disorders and atherosclerosis.PMID:37998729 | PMC:PMC10670175 | DOI:10.3390/cimb45110552 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Katarzyna Napi órkowska-Baran Oskar Schmidt Bart łomiej Szymczak Jakub Luba ński Agata Doligalska Zbigniew Bartuzi Source Type: research
Untangling Tau: Molecular Insights into Neuroinflammation, Pathophysiology, and Emerging Immunotherapies
Curr Issues Mol Biol. 2023 Nov 2;45(11):8816-8839. doi: 10.3390/cimb45110553.ABSTRACTNeuroinflammation, a core pathological feature observed in several neurodegenerative diseases, including Alzheimer's disease (AD), is rapidly gaining attention as a target in understanding the molecular underpinnings of these disorders. Glial cells, endothelial cells, peripheral immune cells, and astrocytes produce a variety of pro-inflammatory mediators that exacerbate the disease progression. Additionally, microglial cells play a complex role in AD, facilitating the clearance of pathological amyloid-beta peptide (Aβ) plaques and aggrega...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Ryder Davidson Reese I Krider Philip Borsellino Keith Noorda George Alhwayek Thomas A Vida Source Type: research