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The Influence of Neurotrophins on the Brain-Lung Axis: Conception, Pregnancy, and Neonatal Period
Curr Issues Mol Biol. 2024 Mar 15;46(3):2528-2543. doi: 10.3390/cimb46030160.ABSTRACTNeurotrophins (NTs) are four small proteins produced by both neuronal and non-neuronal cells; they include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). NTs can exert their action through both genomic and non-genomic mechanisms by interacting with specific receptors. Initial studies on NTs have identified them only as functional molecules of the nervous system. However, recent research have shown that some tissues and organs (such as the lungs, skin, and skeletal and ...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Federica D'Amico Cecilia Lugar à Giovanni Luppino Carlo Giuffrida Ylenia Giorgianni Eleonora Maria Patan è Sara Manti Antonella Gambadauro Mariarosaria La Rocca Tiziana Abbate Source Type: research

The NLRP3 Inflammasome Gene Is Overexpressed in Hidradenitis Suppurativa Lesions: A Preliminary Study on the Role of Pyroptosis in Disease Pathogenesis
This study aimed to investigate the role of the P2X7 receptor (P2X7R) and NLRP3 inflammasome in HS pathogenesis. RNA sequencing and real-time PCR were performed to assess the gene expression levels of P2X7R and NLRP3 in the skin biopsies of HS patients and healthy controls (HC). The results of our study revealed a significantly increased expression of the NLRP3 gene in both the lesional and perilesional skin of HS patients compared to healthy controls. Moreover, the mRNA levels of NLRP3 were significantly higher in lesional skin compared to non-lesional skin in HS patients, indicating the spread of inflammation to adjacent...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Piotr K Krajewski Weronika Szuka ła Jacek C Szepietowski Source Type: research

Genetic and Environmental Factors in Autoimmune Thyroid Disease: Exploring Associations with Selenium Levels and Novel Loci in a Latvian Cohort
Curr Issues Mol Biol. 2024 Mar 17;46(3):2553-2565. doi: 10.3390/cimb46030162.ABSTRACTThe interplay of genetic, immune and environmental factors strongly contributes to the development of autoimmune thyroid disease (AITD), which can be classified as Graves' disease (GD) or Hashimoto thyroiditis (HT). One of the most studied exogenous factors in the pathogenesis of AITD is selenium, which, in the form of selenoproteins, strengthens the antioxidative defence system of thyroid cells against superoxide production. Furthermore, it modulates inflammatory cytokine release and autoantibody production. The aim of this study was to a...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Sabine Upmale-Engela Ieva Vaivode Raitis Peculis Helena Litvina Tatjana Zake Andrejs Skesters Deniss Gogins Vita Rovite Ilze Konrade Source Type: research

Autosomal Recessive Rod-Cone Dystrophy with Mild Extra-Ocular Manifestations Due to a Splice-Affecting Variant in BBS9 
Curr Issues Mol Biol. 2024 Mar 18;46(3):2566-2575. doi: 10.3390/cimb46030163.ABSTRACTBardet-Biedl syndrome (BBS), one of the most common forms of syndromic inherited retinal diseases (IRDs), is characterized by the combination of retinal degeneration with additional extra-ocular manifestations, including obesity, intellectual disability, kidney disease, polydactyly and other skeletal abnormalities. We observed an Israeli patient with autosomal recessive apparently non-syndromic rod-cone dystrophy (RCD). Extra-ocular findings were limited to epilepsy and dental problems. Genetic analysis with a single molecule molecular inv...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Iris Deitch Sofia Itskov Daan Panneman Aasem Abu Shtaya Tal Saban Yael Goldberg Miriam Ehrenberg Frans P M Cremers Susanne Roosing Tamar Ben-Yosef Source Type: research

Effects of rpl1001 Gene Deletion on Cell Division of Fission Yeast and Its Molecular Mechanism
This study focuses on the growth, spore production, cell morphology, the dynamics of microtubules, chromosomes, actin, myosin, and mitochondria of fission yeast (Schizosaccharomyces pombe) to investigate the impact of rpl1001 deletion on cell mitosis. RNA-Seq and bioinformatics analyses were also used to reveal key genes, such as hsp16, mfm1 and isp3, and proteasome pathways. The results showed that rpl1001 deletion resulted in slow cell growth, abnormal spore production, altered cell morphology, and abnormal microtubule number and length during interphase. The cell dynamics of the rpl1001Δ strain showed that the formatio...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Wen Yu Rongmei Yuan Mengnan Liu Ke Liu Xiang Ding Yiling Hou Source Type: research

Bio-Chemoinformatics-Driven Analysis of nsp7 and nsp8 Mutations and Their Effects on Viral Replication Protein Complex Stability
This study provides an intensive analysis of the mutations of nsp7 and nsp8 and their possible implications for viral complex stability.PMID:38534781 | PMC:PMC10968879 | DOI:10.3390/cimb46030165 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Bryan John J Subong Takeaki Ozawa Source Type: research

Clinical-Genomic Analysis of 1261 Patients with Ehlers-Danlos Syndrome Outlines an Articulo-Autonomic Gene Network (Entome)
Curr Issues Mol Biol. 2024 Mar 19;46(3):2620-2643. doi: 10.3390/cimb46030166.ABSTRACTSystematic evaluation of 80 history and 40 history findings diagnosed 1261 patients with Ehlers-Danlos syndrome (EDS) by direct or online interaction, and 60 key findings were selected for their relation to clinical mechanisms and/or management. Genomic testing results in 566 of these patients supported EDS relevance by their differences from those in 82 developmental disability patients and by their association with general rather than type-specific EDS findings. The 437 nuclear and 79 mitochondrial DNA changes included 71 impacting joint...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Golder N Wilson Vijay S Tonk Source Type: research

An Elevated IL10 mRNA Combined with Lower TNFA mRNA Level in Active Rheumatoid Arthritis Peripheral Blood
In conclusion, our results showed that active disease is associated with an elevated IL10 and lower TNFA mRNA level in peripheral blood cells of RA patients.PMID:38534783 | PMC:PMC10969346 | DOI:10.3390/cimb46030167 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Georgi Vasilev Viktoria Vasileva Mariana Ivanova Spaska Stanilova Irena Manolova Lyuba Miteva Source Type: research

Micro(nano)plastics and Their Potential Impact on Human Gut Health: A Narrative Review
Curr Issues Mol Biol. 2024 Mar 21;46(3):2658-2677. doi: 10.3390/cimb46030168.ABSTRACTMicroplastics and nanoplastics (MNPs) are becoming an increasingly severe global problem due to their widespread distribution and complex impact on living organisms. Apart from their environmental impact, the effects of MNPs on living organisms have also continued to attract attention. The harmful impact of MNPs has been extensively documented in marine invertebrates and larger marine vertebrates like fish. However, the research on the toxicity of these particles on mammals is still limited, and their possible effects on humans are poorly ...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Carlo Covello Federica Di Vincenzo Giovanni Cammarota Marco Pizzoferrato Source Type: research

Cellular Organelle-Related Transcriptomic Profile Abnormalities in Neuronopathic Types of Mucopolysaccharidosis: A Comparison with Other Neurodegenerative Diseases
Curr Issues Mol Biol. 2024 Mar 21;46(3):2678-2700. doi: 10.3390/cimb46030169.ABSTRACTMucopolysaccharidoses (MPS) are a group of diseases caused by mutations in genes encoding lysosomal enzymes that catalyze reactions of glycosaminoglycan (GAG) degradation. As a result, GAGs accumulate in lysosomes, impairing the proper functioning of entire cells and tissues. There are 14 types/subtypes of MPS, which are differentiated by the kind(s) of accumulated GAG(s) and the type of a non-functional lysosomal enzyme. Some of these types (severe forms of MPS types I and II, MPS III, and MPS VII) are characterized by extensive central n...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Karolina Wi śniewska Lidia Gaffke Magdalena Żabińska Grzegorz W ęgrzyn Karolina Pierzynowska Source Type: research

The Ethyl Acetate Extract of Caulerpa microphysa Promotes Collagen Homeostasis and Inhibits Inflammation in the Skin
Curr Issues Mol Biol. 2024 Mar 21;46(3):2701-2712. doi: 10.3390/cimb46030170.ABSTRACTInflammation and collagen-degrading enzymes' overexpression promote collagen decomposition, which affects the structural integrity of the extracellular matrix. The polysaccharide and peptide extracts of the green alga Caulerpa microphysa (C. microphysa) have been proven to have anti-inflammatory, wound healing, and antioxidant effects in vivo and in vitro. However, the biological properties of the non-water-soluble components of C. microphysa are still unknown. In the present study, we demonstrated the higher effective anti-inflammatory fu...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Kuo-Yun Lu Li-Ching Cheng Zheng-Ci Hung Ze-Ying Chen Chuang-Wei Wang Hsin-Han Hou Source Type: research

Unveiling the Molecular Mechanism of Trastuzumab Resistance in SKBR3 and BT474 Cell Lines for HER2 Positive Breast Cancer
Curr Issues Mol Biol. 2024 Mar 21;46(3):2713-2740. doi: 10.3390/cimb46030171.ABSTRACTHER2-positive breast cancer is one of the most prevalent forms of cancer among women worldwide. Generally, the molecular characteristics of this breast cancer include activation of human epidermal growth factor receptor-2 (HER2) and hormone receptor activation. HER2-positive is associated with a higher death rate, which led to the development of a monoclonal antibody called trastuzumab, specifically targeting HER2. The success rate of HER2-positive breast cancer treatment has been increased; however, drug resistance remains a challenge. Th...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Anna Kokot Sachin Gadakh Indrajit Saha Ewa Gajda Micha ł Łaźniewski Somnath Rakshit Kaustav Sengupta Ayatullah Faruk Mollah Micha ł Denkiewicz Katarzyna G órczak J ürgen Claesen Tomasz Burzykowski Dariusz Plewczynski Source Type: research

The Opposite Functions of CD30 Ligand Isoforms
This study aims to elucidate the properties and signaling functions of the second CD30 ligand isoform. We have found mRNA expression of both isoforms in the PBMCs of all six healthy donors tested. Through methods in cell biology and biochemistry, we were able to discover that the second CD30 ligand isoform has no discernable pro-inflammatory function and, in fact, isoform 2 can restrict the capacity of the canonical isoform to signal through the CD30 receptor by preventing their interaction. This discovery has implications for the future development of therapeutics targeting the CD30/CD30 ligand signaling pair in cancer an...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Ignat Printsev Elyas Alalli Janine Bilsborough Source Type: research

Genetic Insights into the Extremely Dwarf Hibiscus syriacus var. micranthus : Complete Chloroplast Genome Analysis and Development of a Novel dCAPS Marker
This study explored the chloroplast (cp) genomes of three Hibiscus syriacus (HS) specimens endemic to Korea possessing unique ornamental and conservation values: the dwarf H. syriacus var. micranthus (HSVM), renowned for its small stature and breeding potential; HS 'Tamra', a cultivar from Korea's southernmost islands, noteworthy for its distinctive beauty; and HS Natural Monument no. 521 (N.M.521), a specimen of significant lifespan and height. Given the scarcity of evolutionary studies on these specimens, we assembled and analyzed their cp genomes. We successfully assembled genomes spanning 160,000 to 160,100 bp and iden...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Soon-Ho Kwon Hae-Yun Kwon Hanna Shin Source Type: research

The Role of Urothelial Cancer-Associated 1 in Gynecological Cancers
Curr Issues Mol Biol. 2024 Mar 21;46(3):2772-2797. doi: 10.3390/cimb46030174.ABSTRACTGynecological cancers (GC) represent some of the most frequently diagnosed malignancies in women worldwide. Long-non-coding RNAs (lncRNAs) are regulatory RNAs increasingly being recognized for their role in tumor progression and metastasis in various cancers. Urothelial cancer-associated 1 (UCA1) is a lncRNA, first found deregulated in bladder cancer, and many studies have exposed its oncogenic effects in more tumors since. However, the role of UCA1 in gynecological malignancies is still unclear. This review aims to analyze and define the ...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Eleni Nousiopoulou Kleio Vrettou Christos Damaskos Nikolaos Garmpis Anna Garmpi Panagiotis Tsikouras Nikolaos Nikolettos Konstantinos Nikolettos Iason Psilopatis Source Type: research