Current Issues in Molecular Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.The Role of Bioactives in Inflammation
Curr Issues Mol Biol. 2024 Feb 29;46(3):1921-1923. doi: 10.3390/cimb46030125.ABSTRACTAs a physiological defense mechanism, inflammation is a complex response to harmful stimuli [...].PMID:38534741 | PMC:PMC10969684 | DOI:10.3390/cimb46030125 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Po-Chih Hsu Guan-Ting Liu Jiunn-Sheng Wu Chan-Yen Kuo Source Type: research
Ultraviolet Radiation Biological and Medical Implications
Curr Issues Mol Biol. 2024 Feb 29;46(3):1924-1942. doi: 10.3390/cimb46030126.ABSTRACTUltraviolet (UV) radiation plays a crucial role in the development of melanoma and non-melanoma skin cancers. The types of UV radiation are differentiated by wavelength: UVA (315 to 400 nm), UVB (280 to 320 nm), and UVC (100 to 280 nm). UV radiation can cause direct DNA damage in the forms of cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts (6-4PPs). In addition, UV radiation can also cause DNA damage indirectly through photosensitization reactions caused by reactive oxygen species (ROS), which manifest as 8-hydroxy-2'-deoxyguani...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Tarek Al-Sadek Nabiha Yusuf Source Type: research
Effects of Letrozole Treatment and Vitamin C Supplementation on Morphology, Endoplasmic Reticulum Stress, Programmed Cell Death, and Oxidative Stress in the Small Intestine of Adult Male Rats
Curr Issues Mol Biol. 2024 Mar 1;46(3):1943-1954. doi: 10.3390/cimb46030127.ABSTRACTEstrogens are hormones that play an important role in the digestive tract, including in men. Letrozole is an inhibitor of cytochrome P450 aromatase, an enzyme converting androgens to estrogens. The use of letrozole may cause oxidative stress and endoplasmic reticulum stress in the cells. Factors modulating cellular stress may include vitamin C. The purpose of this study was to examine whether letrozole and/or vitamin C supplementation can affect the morphology of the small intestine, the parameters of endoplasmic reticulum stress, programme...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Anna Pilutin Sylwia Rzeszotek Aleksandra Wilk Klaudia Klimaszewska Julia Łukasiewicz Rufaro Lynnette Mafuta Thanushan Nagendran Rupia Ndambara Barbara Wiszniewska Source Type: research
An Examination of the Effects of Propolis and Quercetin in a Rat Model of Streptozotocin-Induced Diabetic Peripheral Neuropathy
In conclusion, the combined effects of propolis and quercetin in diabetic neuropathy may provide optimal morphological protection with neuroprotective effects by reducing hyperglycemia, and these may represent a key alternative supplement in regenerative medicine.PMID:38534744 | PMC:PMC10969614 | DOI:10.3390/cimb46030128 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Sibel T üredi Hakim Çelik Şeyda Nur Dağlı Seyhan Ta şkın U ğur Şeker Mustafa Deniz Source Type: research
Subjective Cognitive Decline and Genetic Propensity for Dementia beyond Apolipoprotein ε < sub > 4 < /sub > : A Systematic Review
Curr Issues Mol Biol. 2024 Mar 2;46(3):1975-1986. doi: 10.3390/cimb46030129.ABSTRACTSubjective cognitive decline (SCD) has been described as a probable early stage of dementia, as it has consistently appeared to precede the onset of objective cognitive impairment. SCD is related to many risk factors, including genetic predisposition for dementia. The Apolipoprotein (APOE) ε4 allele, which has been thoroughly studied, seems to explain genetic risk for SCD only partially. Therefore, we aimed to summarize existing data regarding genetic factors related to SCD, beyond APOE ε4, in order to improve our current understanding of...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Stefanos N Sampatakakis Maria Roma Nikolaos Scarmeas Source Type: research
Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases
Curr Issues Mol Biol. 2024 Mar 2;46(3):1987-2026. doi: 10.3390/cimb46030130.ABSTRACTMitochondria are thought to have become incorporated within the eukaryotic cell approximately 2 billion years ago and play a role in a variety of cellular processes, such as energy production, calcium buffering and homeostasis, steroid synthesis, cell growth, and apoptosis, as well as inflammation and ROS production. Considering that mitochondria are involved in a multitude of cellular processes, mitochondrial dysfunction has been shown to play a role within several age-related diseases, including cancers, diabetes (type 2), and neurodegene...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Sydney Bartman Giuseppe Coppotelli Jaime M Ross Source Type: research
Transcriptome and Metabolome Analyses Provide Insight into the Glucose-Induced Adipogenesis in Porcine Adipocytes
In this study, we combined transcriptome and metabolome analyses to reveal the underlying regulatory mechanisms of high glucose (HG) on adipogenesis by comparing differentially expressed genes (DEGs) and differentially accumulated metabolites (DAMs) identified in porcine adipocytes. Results showed that HG (20 mmol/L) significantly increased fat accumulation in porcine adipocytes compared to low glucose (LG, 5 mmol/L). A total of 843 DEGs and 365 DAMs were identified. Functional enrichment analyses of DEGs found that multiple pathways were related to adipogenesis, lipid metabolism, and immune-inflammatory responses. PPARγ,...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Susu Jiang Guohua Zhang Jian Miao Dianhu Wu Ximei Li Jiawei Li Jianxiong Lu Shuangbao Gun Source Type: research
Use of Collagen in Cosmetic Products
Curr Issues Mol Biol. 2024 Mar 4;46(3):2043-2070. doi: 10.3390/cimb46030132.ABSTRACTCollagen (CLG) belongs to the family of fibrillar proteins and is composed of left-handed α polypeptide chains, which, twisting around themselves and their axis, form a right-handed superhelix. In the chemical structure, it contains mainly proline, hydroxyproline, glycine, and hydroxylysine. It occurs naturally in the dermis in the form of fibers that provide the skin with proper density and elasticity. The review aimed to present the types of collagen protein, factors affecting its structure and its unusual role in the functioning of the ...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Barbara Jadach Zofia Mielcarek Tomasz Osma łek Source Type: research
Melanocortin Derivatives Induced Vascularization and Neuroglial Proliferation in the Rat Brain under Conditions of Cerebral Ischemia
In this study the neuroprotective activity of melanocortin-like ACTH(4-7)PGP and ACTH(6-9)PGP peptides was investigated in rat brain at 24 h after transient middle cerebral artery occlusion (tMCAO). The severity of ischemic damage, changes in the proliferative activity of neuroglial cells and vascularization of rat brain tissue were analyzed. The administration of peptides resulted in a significant increase in the volume density of neurons in the perifocal zone of infarction compared to rats subjected to ischemia and receiving saline. Immunohistochemical analysis of the proliferative activity of neuroglia cells using PCNA ...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Vasily V Stavchansky Vadim V Yuzhakov Larisa E Sevan'kaeva Natalia K Fomina Anastasia E Koretskaya Alina E Denisova Ivan V Mozgovoy Leonid V Gubsky Ivan B Filippenkov Nikolay F Myasoedov Svetlana A Limborska Lyudmila V Dergunova Source Type: research
Development of Multiplex Molecular Assays for Simultaneous Detection of Dengue Serotypes and Chikungunya Virus for Arbovirus Surveillance
Curr Issues Mol Biol. 2024 Mar 6;46(3):2093-2104. doi: 10.3390/cimb46030134.ABSTRACTThe major arboviruses mainly belong to the Bunyaviridae, Togaviridae, and Flaviviridae families, among which the chikungunya virus and dengue virus have emerged as global public health problems. The main objective of this study was to develop specific, sensitive, and cost-effective molecular multiplex RT-PCR and RT-qPCR assays for the rapid and simultaneous detection of CHIKV and the four serotypes of DENV for arbovirus surveillance. Specific primers for all viruses were designed, and one-step multiplex RT-PCR (mRT-PCR) and RT-qPCR (mRT-qPC...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Louis Robert W Belem Sylvester Agha Ibemgbo Michel Kir éopori Gomgnimbou Dileep Kumar Verma Antoinette Kabor é Ankit Kumar Ibrahim Sangar é Sujatha Sunil Source Type: research
Testosterone Inhibits Secretion of the Pro-Inflammatory Chemokine CXCL1 from Astrocytes
Curr Issues Mol Biol. 2024 Mar 6;46(3):2105-2118. doi: 10.3390/cimb46030135.ABSTRACTAstrocytes play an important role in the regulation of the inflammatory response in the CNS, e.g., in demyelinating diseases. Since the chemokine CXCL1 is known to be secreted by astrocytes and to have a pro-inflammatory effect on immune cells in the CNS, we verified the effect of testosterone on its secretion in vitro (in the astrocytic cell line DI TNC1). Testosterone reduced the increase in CXCL1 production caused by the pro-inflammatory agent lysophosphatidylcholine and restored the basal production level of CXCL1. The androgen receptor...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Malgorzata Turniak-Kusy Maciej Studzian Piotr Szpakowski Piotr Kuchta Kaja Smietanka Claudia Mattern Lukasz Pulaski Bartosz Bielecki Source Type: research
Anti-Tumor Potential of Post-Translational Modifications of PD-1
Curr Issues Mol Biol. 2024 Mar 6;46(3):2119-2132. doi: 10.3390/cimb46030136.ABSTRACTProgrammed cell death protein-1 (PD-1) is a vital immune checkpoint molecule. The location, stability, and protein-protein interaction of PD-1 are significantly influenced by post-translational modification (PTM) of proteins. The biological information of PD-1, including its gene and protein structures and the PD-1/PD-L1 signaling pathway, was briefly reviewed in this review. Additionally, recent research on PD-1 post-translational modification, including the study of ubiquitination, glycosylation, phosphorylation, and palmitoylation, was s...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Xiaoming Xi Wuli Zhao Source Type: research
Study on Chemical Composition and Biological Activity of < em > Psidium guajava < /em > Leaf Extracts
In this study, the use of concentrated P. guajava leaf extract molecules as a functional natural material was evaluated by confirming the extract's antioxidative, antibacterial, tyrosinase activity inhibition, and collagenase activity inhibition effects and its trans-2-nonenal removal ability. As a result of the analysis of the antioxidant and antibacterial components of concentrated P. guajava leaf extract molecules through GC-MS, a large amount of aromatic hydrocarbon molecules were detected. When different concentrations of ethanol were used for extraction, the leaf extract concentrated with 70% ethanol showed the most ...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Hyonam Park Bohee Kim Yuri Kang Woonjung Kim Source Type: research
Effects of Chronic Sleep Restriction on Transcriptional Sirtuin 1 Signaling Regulation in Male Mice White Adipose Tissue
Curr Issues Mol Biol. 2024 Mar 7;46(3):2144-2154. doi: 10.3390/cimb46030138.ABSTRACTChronic sleep restriction (CSR) is a prevalent issue in modern society that is associated with several pathological states, ranging from neuropsychiatric to metabolic diseases. Despite its known impact on metabolism, the specific effects of CSR on the molecular mechanisms involved in maintaining metabolic homeostasis at the level of white adipose tissue (WAT) remain poorly understood. Therefore, this study aimed to investigate the influence of CSR on sirtuin 1 (SIRT1) and the peroxisome proliferator-activated receptor γ (PPARγ) signaling ...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Marco Rendine Paolo Cocci Luisa de Vivo Michele Bellesi Francesco Alessandro Palermo Source Type: research
Increased Apolipoprotein A1 Expression Correlates with Tumor-Associated Neutrophils and T Lymphocytes in Upper Tract Urothelial Carcinoma
In this study, we examined the relationship between UTUC-derived factors and tumor-associated neutrophils or T lymphocytes. The culture supernatant from UTUC tumor tissue modulated neutrophils to inhibit T cell proliferation. Among the dominant factors secreted by UTUC tumor tissue, apolipoprotein A1 (Apo-A1) exhibited a positive correlation with NLR. Moreover, tumor-infiltrating neutrophils were inversely correlated with tumor-infiltrating T cells. Elevated Apo-A1 levels in UTUC were also inversely associated with the population of tumor-infiltrating T cells. Our findings indicate that elevated Apo-A1 expression in UTUC c...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Chih-Chia Chang Chia-Bin Chang Chiung-Ju Chen Chun-Liang Tung Chi-Feng Hung Wei-Hong Lai Cheng-Huang Shen Chang-Yu Tsai Ya-Yan Lai Ming-Yang Lee Shu-Fen Wu Pi-Che Chen Source Type: research
