< em > Ginkgo biloba < /em > : Antioxidant Activity and In Silico Central Nervous System Potential
Curr Issues Mol Biol. 2023 Dec 1;45(12):9674-9691. doi: 10.3390/cimb45120604.ABSTRACTGinkgo biloba (GB) extracts have been used in clinical studies as an alternative therapy for Alzheimer's disease (AD), but the exact bioaction mechanism has not yet been elucidated. In this work, an in silico study on GB metabolites was carried out using SwissTargetPrediction to determine the proteins associated with AD. The resulting proteins, AChE, MAO-A, MAO-B, β-secretase and γ-secretase, were studied by molecular docking, resulting in the finding that kaempferol, quercetin, and luteolin have multitarget potential against AD. These c...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Eduardo Su árez-González Jes ús Sandoval-Ramírez Jorge Flores-Hern ández Alan Carrasco-Carballo Source Type: research

Overexpression of < em > KvCHX < /em > Enhances Salt Tolerance in < em > Arabidopsis thaliana < /em > Seedlings
Curr Issues Mol Biol. 2023 Dec 1;45(12):9692-9708. doi: 10.3390/cimb45120605.ABSTRACTThe CHX (cation/H+ exchanger) family plays an important role in the transmembrane transport of cation/H+ in plants. The aim of this study was to identify and functionally analyze the KvCHX gene in the halophyte Kosteletzkya virginica to investigate its role in regulating the K+/Na+ ratio under salinity tolerance. Based on a partial gene sequence of EST from K. virginica, the full-length DNA sequence of the KvCHX gene was obtained using genome walking technology. Structural analysis and phylogenetic relationship analysis showed that the KvC...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Yuqi Guo Chengrong Zhu Zengyuan Tian Source Type: research

A Comparative Kidney Transcriptome Analysis of Bicarbonate-Loaded < em > insrr < /em > -Null Mice
Curr Issues Mol Biol. 2023 Dec 4;45(12):9709-9722. doi: 10.3390/cimb45120606.ABSTRACTThe maintenance of plasma pH is critical for life in all organisms. The kidney plays a critical role in acid-base regulation in vertebrates by controlling the plasma concentration of bicarbonate. The receptor tyrosine kinase IRR (insulin receptor-related receptor) is expressed in renal β-intercalated cells and is involved in alkali sensing due to its ability to autophosphorylate under alkalization of extracellular medium (pH > 7.9). In mice with a knockout of the insrr gene, which encodes for IRR, urinary bicarbonate secretion in respo...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: E A Gantsova O V Serova D Eladari D M Bobrovskiy A G Petrenko A V Elchaninov I E Deyev Source Type: research

Integrated Analysis of Transcriptome and Metabolome Profiles in the Longissimus Dorsi Muscle of Buffalo and Cattle
This study contributes to the breed genetic improvement and enhancement of buffalo meat quality.PMID:38132453 | PMC:PMC10741837 | DOI:10.3390/cimb45120607 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Guansheng Wu Xinjun Qiu Zizhuo Jiao Weijie Yang Haoju Pan Hong Li Zhengyu Bian Qiang Geng Hui Wu Junming Jiang Yuanyuan Chen Yiwen Cheng Qiaoling Chen Si Chen Churiga Man Li Du Lianbin Li Fengyang Wang Source Type: research

A Bioinformatics Toolkit for Next-Generation Sequencing in Clinical Oncology
Curr Issues Mol Biol. 2023 Dec 4;45(12):9737-9752. doi: 10.3390/cimb45120608.ABSTRACTNext-generation sequencing (NGS) has taken on major importance in clinical oncology practice. With the advent of targeted therapies capable of effectively targeting specific genomic alterations in cancer patients, the development of bioinformatics processes has become crucial. Thus, bioinformatics pipelines play an essential role not only in the detection and in identification of molecular alterations obtained from NGS data but also in the analysis and interpretation of variants, making it possible to transform raw sequencing data into mea...
Source: Current Issues in Molecular Biology - December 22, 2023 Category: Molecular Biology Authors: Simon Cabello-Aguilar Julie A Vendrell J érôme Solassol Source Type: research