Current Issues in Molecular Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Influence of Neurotrophins on the Brain-Lung Axis: Conception, Pregnancy, and Neonatal Period
Curr Issues Mol Biol. 2024 Mar 15;46(3):2528-2543. doi: 10.3390/cimb46030160.ABSTRACTNeurotrophins (NTs) are four small proteins produced by both neuronal and non-neuronal cells; they include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). NTs can exert their action through both genomic and non-genomic mechanisms by interacting with specific receptors. Initial studies on NTs have identified them only as functional molecules of the nervous system. However, recent research have shown that some tissues and organs (such as the lungs, skin, and skeletal and ...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Federica D'Amico Cecilia Lugar à Giovanni Luppino Carlo Giuffrida Ylenia Giorgianni Eleonora Maria Patan è Sara Manti Antonella Gambadauro Mariarosaria La Rocca Tiziana Abbate Source Type: research

The NLRP3 Inflammasome Gene Is Overexpressed in Hidradenitis Suppurativa Lesions: A Preliminary Study on the Role of Pyroptosis in Disease Pathogenesis
This study aimed to investigate the role of the P2X7 receptor (P2X7R) and NLRP3 inflammasome in HS pathogenesis. RNA sequencing and real-time PCR were performed to assess the gene expression levels of P2X7R and NLRP3 in the skin biopsies of HS patients and healthy controls (HC). The results of our study revealed a significantly increased expression of the NLRP3 gene in both the lesional and perilesional skin of HS patients compared to healthy controls. Moreover, the mRNA levels of NLRP3 were significantly higher in lesional skin compared to non-lesional skin in HS patients, indicating the spread of inflammation to adjacent...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Piotr K Krajewski Weronika Szuka ła Jacek C Szepietowski Source Type: research

Genetic and Environmental Factors in Autoimmune Thyroid Disease: Exploring Associations with Selenium Levels and Novel Loci in a Latvian Cohort
Curr Issues Mol Biol. 2024 Mar 17;46(3):2553-2565. doi: 10.3390/cimb46030162.ABSTRACTThe interplay of genetic, immune and environmental factors strongly contributes to the development of autoimmune thyroid disease (AITD), which can be classified as Graves' disease (GD) or Hashimoto thyroiditis (HT). One of the most studied exogenous factors in the pathogenesis of AITD is selenium, which, in the form of selenoproteins, strengthens the antioxidative defence system of thyroid cells against superoxide production. Furthermore, it modulates inflammatory cytokine release and autoantibody production. The aim of this study was to a...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Sabine Upmale-Engela Ieva Vaivode Raitis Peculis Helena Litvina Tatjana Zake Andrejs Skesters Deniss Gogins Vita Rovite Ilze Konrade Source Type: research

Autosomal Recessive Rod-Cone Dystrophy with Mild Extra-Ocular Manifestations Due to a Splice-Affecting Variant in < em > BBS9 < /em >
Curr Issues Mol Biol. 2024 Mar 18;46(3):2566-2575. doi: 10.3390/cimb46030163.ABSTRACTBardet-Biedl syndrome (BBS), one of the most common forms of syndromic inherited retinal diseases (IRDs), is characterized by the combination of retinal degeneration with additional extra-ocular manifestations, including obesity, intellectual disability, kidney disease, polydactyly and other skeletal abnormalities. We observed an Israeli patient with autosomal recessive apparently non-syndromic rod-cone dystrophy (RCD). Extra-ocular findings were limited to epilepsy and dental problems. Genetic analysis with a single molecule molecular inv...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Iris Deitch Sofia Itskov Daan Panneman Aasem Abu Shtaya Tal Saban Yael Goldberg Miriam Ehrenberg Frans P M Cremers Susanne Roosing Tamar Ben-Yosef Source Type: research

Effects of < em > rpl1001 < /em > Gene Deletion on Cell Division of Fission Yeast and Its Molecular Mechanism
This study focuses on the growth, spore production, cell morphology, the dynamics of microtubules, chromosomes, actin, myosin, and mitochondria of fission yeast (Schizosaccharomyces pombe) to investigate the impact of rpl1001 deletion on cell mitosis. RNA-Seq and bioinformatics analyses were also used to reveal key genes, such as hsp16, mfm1 and isp3, and proteasome pathways. The results showed that rpl1001 deletion resulted in slow cell growth, abnormal spore production, altered cell morphology, and abnormal microtubule number and length during interphase. The cell dynamics of the rpl1001Δ strain showed that the formatio...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Wen Yu Rongmei Yuan Mengnan Liu Ke Liu Xiang Ding Yiling Hou Source Type: research