Advances in understanding and exploiting Siglec-glycan interactions
Curr Opin Chem Biol. 2024 Apr 16;80:102454. doi: 10.1016/j.cbpa.2024.102454. Online ahead of print.ABSTRACTSialic-acid-binding immunoglobulin-type lectins (Siglecs) are a family of cell-surface immunomodulatory receptors that recognize sialic-acid-containing glycans. The majority of Siglecs have an inhibitory motif in their intercellular domain and can regulate the cellular activation of immune cells. Importantly, the immunomodulatory role of Siglecs is regulated by engagement with distinct sialoglycan ligands. However, there are still many unanswered questions about the precise ligand(s) recognized by individual Siglec fa...
Source: Current Opinion in Chemical Biology - April 17, 2024 Category: Biochemistry Authors: Zeinab Jame-Chenarboo Taylor E Gray Matthew S Macauley Source Type: research
Overview: Research on the Genetic Architecture of the Developing Cerebral Cortex in Norms and Diseases
Methods Mol Biol. 2024;2794:1-12. doi: 10.1007/978-1-0716-3810-1_1.ABSTRACTThe human brain is characterized by high cell numbers, diverse cell types with diverse functions, and intricate connectivity with an exceedingly broad surface of the cortex. Human-specific brain development was accomplished by a long timeline for maturation from the prenatal period to the third decade of life. The long timeline makes complicated architecture and circuits of human cerebral cortex possible, and it makes human brain vulnerable to intrinsic and extrinsic insults resulting in the development of variety of neuropsychiatric disorders. Unra...
Source: Mol Biol Cell - April 17, 2024 Category: Molecular Biology Authors: Mariko Y Momoi Source Type: research
< em > Lentzea sokolovensis < /em > sp. nov., < em > Lentzea kristufekii < /em > sp. nov. and < em > Lentzea miocenica < /em > sp. nov., rare actinobacteria from Miocene lacustrine sediment of the Sokolov Coal Basin, Czech Republic
Int J Syst Evol Microbiol. 2024 Apr;74(4). doi: 10.1099/ijsem.0.006335.ABSTRACTThe taxonomic position of three actinobacterial strains, BCCO 10_0061T, BCCO 10_0798T, and BCCO 10_0856T, recovered from bare soil in the Sokolov Coal Basin, Czech Republic, was established using a polyphasic approach. The multilocus sequence analysis based on 100 single-copy genes positioned BCCO 10_0061T in the same cluster as Lentzea waywayandensis, strain BCCO 10_0798T in the same cluster as Lentzea flaviverrucosa, Lentzea californiensis, Lentzea violacea, and Lentzea albidocapillata, and strain BCCO 10_0856T clustered together with Lentzea ...
Source: International Journal of Systematic and Evolutionary Microbiology - April 17, 2024 Category: Microbiology Authors: Ana Catalina Lara Lucie Kotrbov á Moritz Keller Imen Nouioui Meina Neumann-Schaal Yvonne Mast Alica Chro ňáková Source Type: research
A range-wide ectoparasite survey for allegheny woodrats (neotoma magister)
J Parasitol. 2024 Apr 1;110(2):179-185. doi: 10.1645/23-118.ABSTRACTAllegheny woodrats (Neotoma magister) are karst-specializing rodents that are rare or in conservation need in many states within their current range. Parasitism and habitat fragmentation have been suggested as primary reasons for declining populations. The presence, prevalence, and impact of ectoparasites, including fleas, ticks, and bots, is not fully understood rangewide. We collected Allegheny woodrat ectoparasites across 8 states in their range, identifying parasites via morphological and genetic means. Across contributions from 8 states, we discovered...
Source: The Journal of Parasitology - April 17, 2024 Category: Parasitology Authors: Karen E Powers Ralph P Eckerlin Robert R Sheehy Richard J Reynolds Source Type: research
Construction of ceRNA network mediated by circRNAs screening from microarray and identification of novel biomarkers for myasthenia gravis
CONCLUSIONS: We found that circFRMD4, circPIGB and circNUP214 can be considered as valuable potential novel biomarkers for AchR + MG. CircFRMD4 participate in the development of AchR + MG via targeting binding with miR-145-5p.PMID:38631652 | DOI:10.1016/j.gene.2024.148463 (Source: Gene)
Source: Gene - April 17, 2024 Category: Genetics & Stem Cells Authors: Xiaotong Kong Tao Wu Hanlu Cai Zhimin Chen Yu Wang Ping He Peifang Liu Lei Li Shanshan Peng Fanfan Xu Jianjian Wang Huixue Zhang Lihua Wang Source Type: research
Exploring Ribosomal Genes as Potential Biomarkers of the Immune Microenvironment in Respiratory Syncytial Virus Infection
This study aimed to identify genes associated with immune dysfunction using bioinformatics methods to gain insights into the role of dysregulated immune genes in RSV disease progression, and to predict potential therapeutic drugs by targeting dysregulated immune-related genes. 423 immune-related differential genes (DEIRGs) were filtered from the blood samples of 87 healthy individuals and 170 RSV patients. According to CIBERSORT analysis, the blood of RSV patients showed increased infiltration of various immune cells. Subsequently, ten immune-related hub genes were screened via Protein-Protein Interaction Networks. Six sig...
Source: Biochemical Genetics - April 17, 2024 Category: Genetics & Stem Cells Authors: Lu Lin Zenghua Liao Chaoqian Li Source Type: research
Diagnostic Approach to Interstitial Lung Diseases Associated with Connective Tissue Diseases
Semin Respir Crit Care Med. 2024 Apr 17. doi: 10.1055/s-0044-1785674. Online ahead of print.ABSTRACTInterstitial lung disorders are a group of respiratory diseases characterized by interstitial compartment infiltration, varying degrees of infiltration, and fibrosis, with or without small airway involvement. Although some are idiopathic (e.g., idiopathic pulmonary fibrosis, idiopathic interstitial pneumonias, and sarcoidosis), the great majority have an underlying etiology, such as systemic autoimmune rheumatic disease (SARD, also called Connective Tissue Diseases or CTD), inhalational exposure to organic matter, medication...
Source: Respiratory Care - April 17, 2024 Category: Respiratory Medicine Authors: Ana C Zamora Lewis J Wesselius Michael B Gotway Henry D Tazelaar Alejandro Diaz-Arumir Vivek Nagaraja Source Type: research
X-linked Myotubular Myopathy Manifesting Carrier with Central and Peripheral Nervous System Involvement
Intern Med. 2024 Apr 16. doi: 10.2169/internalmedicine.3417-23. Online ahead of print.ABSTRACTX-linked myotubular myopathy (XLMTM) is a rare genetic disorder caused by X-linked mutations in the MTM1 gene. Although heterozygous females are typically asymptomatic, affected cases have recently been reported. We herein report a case of XLMTM manifesting carrier of the pathogenic c.206dupG mutation in MTM1 with uncommon extramuscular symptoms. She developed gaze nystagmus and cognitive impairment in addition to muscle weakness. Electrophysiological studies and brain magnetic resonance imaging indicated the involvement of the ce...
Source: Internal Medicine - April 17, 2024 Category: Internal Medicine Authors: Yosuke Takeuchi Teruaki Masuda Noriyuki Kimura Kaori Sumi Mika Jikumaru Nobuyuki Eura Ichizo Nishino Etsuro Matsubara Source Type: research
Genetic variants of ANRIL and coronary artery disease: Insights from a Turkish study population
CONCLUSIONS: In conclusion, selected ANRIL polymorphisms were associated with CAD presence/severity and CAD risk factors, T2DM, and hypertension. Notably, this study, the largest sample-sized study examining the effects of selected polymorphisms on CAD and its risk factors among Turkish individuals, supported the findings of previous studies conducted on different ethnicities.PMID:38631653 | DOI:10.1016/j.gene.2024.148475 (Source: Gene)
Source: Gene - April 17, 2024 Category: Genetics & Stem Cells Authors: Aybike Sena Ozuynuk-Ertugrul Cemre Buse Kirsan Aycan Fahri Erkan Berkay Ekici Evrim Komurcu-Bayrak Neslihan Coban Source Type: research
Genetic mapping reveals the complex genetic architecture controlling slow canopy wilting in soybean
Theor Appl Genet. 2024 Apr 17;137(5):107. doi: 10.1007/s00122-024-04609-w.ABSTRACTIn soybean [Glycine max (L.) Merr.], drought stress is the leading cause of yield loss from abiotic stress in rain-fed US growing areas. Only 10% of the US soybean production is irrigated; therefore, plants must possess physiological mechanisms to tolerate drought stress. Slow canopy wilting is a physiological trait that is observed in a few exotic plant introductions (PIs) and may lead to yield improvement under drought stress. Canopy wilting of 130 recombinant inbred lines (RILs) derived from Hutcheson × PI 471938 grown under drought stres...
Source: TAG. Theoretical and Applied Genetics - April 17, 2024 Category: Genetics & Stem Cells Authors: Ethan Menke Clinton J Steketee Qijian Song William T Schapaugh Thomas E Carter Benjamin Fallen Zenglu Li Source Type: research
Uncertainty in the mating strategy of honeybees causes bias and unreliability in the estimates of genetic parameters
CONCLUSIONS: Knowing only the dam of the DPQ(s) used in each mating may lead to erroneous assumptions on how DPQs were used and severely bias the estimates of genetic parameters and trends. Thus, we recommend keeping track of DPQs in the pedigree, and not only of the dams of DPQ(s). Records from DPQ colonies with queens open-mated to a heterogeneous drone population can be integrated by adding non-genetic effects to the statistical evaluation model.PMID:38632535 | DOI:10.1186/s12711-024-00898-3 (Source: Genet Sel Evol)
Source: Genet Sel Evol - April 17, 2024 Category: Genetics & Stem Cells Authors: Tristan Kistler Evert W Brascamp Benjamin Basso Piter Bijma Florence Phocas Source Type: research
Decoding triancestral origins, archaic introgression, and natural selection in the Japanese population by whole-genome sequencing
Sci Adv. 2024 Apr 19;10(16):eadi8419. doi: 10.1126/sciadv.adi8419. Epub 2024 Apr 17.ABSTRACTWe generated Japanese Encyclopedia of Whole-Genome/Exome Sequencing Library (JEWEL), a high-depth whole-genome sequencing dataset comprising 3256 individuals from across Japan. Analysis of JEWEL revealed genetic characteristics of the Japanese population that were not discernible using microarray data. First, rare variant-based analysis revealed an unprecedented fine-scale genetic structure. Together with population genetics analysis, the present-day Japanese can be decomposed into three ancestral components. Second, we identified u...
Source: Adv Data - April 17, 2024 Category: Epidemiology Authors: Xiaoxi Liu Satoshi Koyama Kohei Tomizuka Sadaaki Takata Yuki Ishikawa Shuji Ito Shunichi Kosugi Kunihiko Suzuki Keiko Hikino Masaru Koido Yoshinao Koike Momoko Horikoshi Takashi Gakuhari Shiro Ikegawa Kochi Matsuda Yukihide Momozawa Kaoru Ito Yoichiro Kam Source Type: research
Case series of retinal vein occlusions showing early recovery using oral l-methylfolate
Ther Adv Ophthalmol. 2024 Apr 15;16:25158414241240687. doi: 10.1177/25158414241240687. eCollection 2024 Jan-Dec.ABSTRACTThis case series describes the aggregate rate of recovery in five consecutive subjects (six eyes) with retinal vein occlusion (RVO) who received l-methylfolate and other vitamins via Ocufolin®, a medical food. Subjects were followed for 10-33 months by a single ophthalmologist. Ocufolin® was prescribed at the time of diagnosis and subjects remained on the regimen throughout the time of observation. Examinations were performed in an un-masked fashion at 3-month intervals with recording of best corrected ...
Source: Adv Data - April 17, 2024 Category: Epidemiology Authors: Steven Baker Dylan Baker Robert Baker Craig J Brown Source Type: research
The physiological quality of Vigna unguiculata L. seeds shows tolerance to salinity
The objective was to for a identify variety that is tolerant to salinity considering the physiological quality of seeds and seedling growth. A 2 × 4 factorial scheme was used, referring to the varieties Pingo-de-ouro and Coruja, and four electrical conductivities of water (0; 3.3; 6.6 and 9.9 dS m-1). The physiological quality of seeds and the growth of seedlings were analyzed, in addition to the cumulative germination. The Pingo-de-ouro variety showed no germination, length of the shoot and root, dry mass of the shoot and root compromised up to electrical conductivity of 6 dS m-1 in relation to 0.0 dS m-1. On the other h...
Source: Braz J Biol - April 17, 2024 Category: Biology Authors: F H A Andrade R T Silva M A Barbosa Neto S F Silva A F L Cardoso J S Lima J H B Silva A F S Cruz M I B Clemente E A Onias W E Pereira J T L Chaves S G S Borges A M F Oliveira P C A Linhares R R Silva Source Type: research
OsATL32 ubiquitinates the reactive oxygen species-producing OsRac5-OsRbohB module to suppress rice immunity
This study provides insights into the molecular mechanism by which the E3 ligase OsATL32 targets a ROS-producing module to undermine rice immunity.PMID:38629772 | DOI:10.1111/jipb.13666 (Source: Journal of Integrative Plant Biology)
Source: Journal of Integrative Plant Biology - April 17, 2024 Category: Biology Authors: Yuqing Yan Hui Wang Yan Bi Jiajing Wang Muhammad Noman Dayong Li Fengming Song Source Type: research
