Management of Rectal Cancer in Lynch Syndrome: Balancing Risk Reduction and Quality of Life
Clin Colon Rectal Surg. 2023 Aug 10;37(3):180-184. doi: 10.1055/s-0043-1770730. eCollection 2024 May.ABSTRACTPatients with Lynch syndrome are predisposed to developing colorectal cancer and a variety of extracolonic malignancies, at a young age. The management of rectal cancer in the setting of Lynch syndrome is a complex clinical scenario that requires the expertise of a multidisciplinary management team. In this review, we delve into the approach for rectal cancer in these patients, and specifically focus on several key aspects of treatment. Some unique aspects of rectal cancer in Lynch syndrome include the decision betw...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Bradley A Krasnick Matthew F Kalady Source Type: research
The Natural History of Hereditary Colorectal Cancer Syndromes: From Phenotype to Genotype? Where Do We Stand and What Does the Future Hold?
Clin Colon Rectal Surg. 2023 Aug 9;37(3):127-132. doi: 10.1055/s-0043-1770380. eCollection 2024 May.ABSTRACTApplying the concept of a "natural history" to hereditary colorectal cancer is an interesting exercise because the way the syndromes are approached has changed so drastically. However, the exercise is instructive as it forces us to think in depth about where we are, where we have been, and, most helpfully, about where we may be going. In this article the diagnosis, along with endoscopic and surgical management of hereditary colorectal cancer are discussed in the context of their history and the changes in genomics an...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: James Church Source Type: research
Colorectal Cancer Risk between Mendelian and Non-Mendelian Inheritance
Clin Colon Rectal Surg. 2023 Jul 31;37(3):140-145. doi: 10.1055/s-0043-1770382. eCollection 2024 May.ABSTRACTHereditary colorectal cancer has been an area of focus for research and public health practitioners due to our ability to quantify risk and then act based on such results by enrolling patients in surveillance programs. The wide access to genetic testing and whole-genome sequencing has resulted in identifying many low/moderate penetrance genes. Above all, our understanding of the family component of colorectal cancer has been improving. Polygenic scores are becoming part of the risk assessment for many cancers, and t...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Elizabeth A Hibler Brittany Szymaniak Mohammad Ali Abbass Source Type: research
The potential of machine learning models to identify malnutrition diagnosed by GLIM combined with NRS-2002 in colorectal cancer patients without weight loss information
CONCLUSIONS: Nutrition Risk Screening 2002 was the optimal initial nutritional risk screening tool in the GLIM process. The RF model outperformed other models, and an online prediction tool was developed to properly identify patients at high risk of malnutrition.PMID:38603972 | DOI:10.1016/j.clnu.2024.04.001 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 11, 2024 Category: Cancer & Oncology Authors: Tiantian Wu Hongxia Xu Wei Li Fuxiang Zhou Zengqing Guo Kunhua Wang Min Weng Chunling Zhou Ming Liu Yuan Lin Suyi Li Ying He Qinghua Yao Hanping Shi Chunhua Song Investigation on Nutrition Status and its Clinical Outcome of Common Cancers (INSCOC) Group Source Type: research
METTL3 recruiting M2-type immunosuppressed macrophages by targeting m6A-SNAIL-CXCL2 axis to promote colorectal cancer pulmonary metastasis
CONCLUSION: METTL3 facilitates pulmonary metastasis of colorectal cancer by targeting the m6A-Snail-CXCL2 axis to recruit M2-type immunosuppressive macrophages. This finding offers new research directions and potential therapeutic targets for colorectal cancer treatment.PMID:38605400 | DOI:10.1186/s13046-024-03035-6 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 11, 2024 Category: Cancer & Oncology Authors: Peng Ouyang Kang Li Wei Xu Caiyun Chen Yangdong Shi Yao Tian Jin Gong Zhen Bao Source Type: research
CD177 drives the transendothelial migration of Treg cells enriched in human colorectal cancer
CONCLUSIONS: These results demonstrated that Treg cells with higher CD177 levels exhibited an enhanced activation status and transendothelial migration capacity. Our findings suggest that CD177 may serve as an immunotherapeutic target and that overexpression of CD177 may improve the efficacy of chimeric antigen receptor T (CAR-T) cell therapy.PMID:38596253 | PMC:PMC11003710 | DOI:10.1002/cti2.1506 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Shouyu Ke Yi Lei Yixian Guo Feng Xie Yimeng Yu Haigang Geng Yiqing Zhong Danhua Xu Xu Liu Fengrong Yu Xiang Xia Zizhen Zhang Chunchao Zhu Wei Ling Bin Li Wenyi Zhao Source Type: research
Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression
J Exp Clin Cancer Res. 2024 Apr 10;43(1):108. doi: 10.1186/s13046-024-03032-9.ABSTRACTFerroptosis is a newly identified iron-dependent form of death that is becoming increasingly recognized as a promising avenue for cancer therapy. N6-methyladenosine (m6A) is the most abundant reversible methylation modification in mRNA contributing to tumorigenesis. However, the crucial role of m6A modification in regulating ferroptosis during colorectal cancer (CRC) tumorigenesis remains elusive. Herein, we find that m6A modification is increased during ferroptotic cell death and correlates with the decreased m6A demethylase fat mass and...
Source: Clinical Colorectal Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Yaya Qiao Meng Su Huifang Zhao Huanle Liu Chenxi Wang Xintong Dai Lingling Liu Guangju Liu Huanran Sun Mingming Sun Jiyan Wang Zhen Li Jun Fan Quan Zhang Chunshen Li Fangmin Situ Jun Xue Zhenghu Jia Chunze Zhang Shuai Zhang Changliang Shan Source Type: research
CD177 drives the transendothelial migration of Treg cells enriched in human colorectal cancer
CONCLUSIONS: These results demonstrated that Treg cells with higher CD177 levels exhibited an enhanced activation status and transendothelial migration capacity. Our findings suggest that CD177 may serve as an immunotherapeutic target and that overexpression of CD177 may improve the efficacy of chimeric antigen receptor T (CAR-T) cell therapy.PMID:38596253 | PMC:PMC11003710 | DOI:10.1002/cti2.1506 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Shouyu Ke Yi Lei Yixian Guo Feng Xie Yimeng Yu Haigang Geng Yiqing Zhong Danhua Xu Xu Liu Fengrong Yu Xiang Xia Zizhen Zhang Chunchao Zhu Wei Ling Bin Li Wenyi Zhao Source Type: research
Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression
J Exp Clin Cancer Res. 2024 Apr 10;43(1):108. doi: 10.1186/s13046-024-03032-9.ABSTRACTFerroptosis is a newly identified iron-dependent form of death that is becoming increasingly recognized as a promising avenue for cancer therapy. N6-methyladenosine (m6A) is the most abundant reversible methylation modification in mRNA contributing to tumorigenesis. However, the crucial role of m6A modification in regulating ferroptosis during colorectal cancer (CRC) tumorigenesis remains elusive. Herein, we find that m6A modification is increased during ferroptotic cell death and correlates with the decreased m6A demethylase fat mass and...
Source: Clinical Colorectal Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Yaya Qiao Meng Su Huifang Zhao Huanle Liu Chenxi Wang Xintong Dai Lingling Liu Guangju Liu Huanran Sun Mingming Sun Jiyan Wang Zhen Li Jun Fan Quan Zhang Chunshen Li Fangmin Situ Jun Xue Zhenghu Jia Chunze Zhang Shuai Zhang Changliang Shan Source Type: research
Re-Do Plastic Reconstruction for Locally Advanced and Recurrent Colorectal Cancer Following a beyond Total Mesorectal Excision (TME) Operation-Key Considerations
This study demonstrated the lack of reporting on re-do reconstruction techniques following repeat exenteration for recurrent CRC. Based on this finding, we conducted a point-by-point discussion of certain key aspects that should be taken into consideration when approaching this patient cohort.PMID:38592018 | PMC:PMC10932044 | DOI:10.3390/jcm13051228 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Emmanuel Giannas Konstantinos Kavallieros Theodoros Nanidis John Giannas Paris Tekkis Christos Kontovounisios Source Type: research
Stereotactic Navigation-Assisted Laparoscopic Resection of Challenging Low Pelvic Tumors: A Case Series
Conclusions: The application of laparoscopic stereotactic navigation surgery to complex low pelvic tumors is feasible and could impact oncological surgical quality by enabling tumor targeting and ensuring resection margins. Further wider series are needed to confirm stereotactic navigation's impact on challenging low pelvic tumors.PMID:38592109 | PMC:PMC10931769 | DOI:10.3390/jcm13051233 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Guglielmo Niccol ò Piozzi Jung-Myun Kwak Ji-Seon Kim Se-Jin Baek Jin Kim Seon-Hahn Kim Source Type: research
Efficacy and Safety of Thermal Ablation after Endoscopic Mucosal Resection: A Systematic Review and Network Meta-Analysis
Conclusions: We demonstrated the efficacy and safety of thermal ablation after EMR for decreasing recurrence of adenoma.PMID:38592137 | PMC:PMC10932371 | DOI:10.3390/jcm13051298 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Hossein Haghbin Nuruddinkhodja Zakirkhodjaev Rawish Fatima Faisal Kamal Muhammad Aziz Source Type: research
Achieving Textbook Outcomes in Colorectal Cancer Surgery Is Associated with Improved Long-Term Survival: Results of the Multicenter Prospective Cohort Study
Conclusions: Elective colorectal resections result in successful TO for 52.5% of patients. The likelihood of failure to achieve TO is increased in patients with a high ASA score, while minimally invasive surgery is associated with higher TO rates. Patients who fail to achieve successful surgical outcomes experience reduced long-term outcomes.PMID:38592180 | PMC:PMC10931839 | DOI:10.3390/jcm13051304 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Marius Kryzauskas Augustinas Bausys Vilius Abeciunas Austeja Elzbieta Degutyte Klaudija Bickaite Rimantas Bausys Tomas Poskus Source Type: research
Validation of a Tool-Based Visual Anorectal Examination Advanced Simulator for the Early Detection of Colorectal Cancer
This study aims to establish the initial face, content, and construct validity of a tool-based visual anorectal examination advanced simulator model for proctoscopy and rigid sigmoidoscopy. This innovative, highly realistic simulated environment aims to enhance the training of healthcare professionals and improve the efficiency of detecting and diagnosing distal colorectal disease.PMID:38592245 | PMC:PMC10932247 | DOI:10.3390/jcm13051423 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Niamh Grayson Reza Haghighi Osgouei Renke Huang Paris Tekkis Fernando Bello Christos Kontovounisios Source Type: research
Modified neoadjuvant rectal score as a novel prognostic model for rectal cancer patients who underwent chemoradiotherapy
CONCLUSION: We established a novel prognostic model, for rectal cancer patients that have undergone neoadjuvant chemoradiotherapy, using a combination of apoptosis-detecting immunohistochemistry and neoadjuvant rectal scores.PMID:38592641 | DOI:10.1007/s10147-024-02520-4 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Kazushige Kawai Kosuke Ozaki Daisuke Nakano Akira Dejima Ichiro Ise Sakiko Nakamori Hiroki Kato Soichiro Natsume Misato Takao Tatsuro Yamaguchi Soichiro Ishihara Source Type: research
