CD177 drives the transendothelial migration of Treg cells enriched in human colorectal cancer

CONCLUSIONS: These results demonstrated that Treg cells with higher CD177 levels exhibited an enhanced activation status and transendothelial migration capacity. Our findings suggest that CD177 may serve as an immunotherapeutic target and that overexpression of CD177 may improve the efficacy of chimeric antigen receptor T (CAR-T) cell therapy.PMID:38596253 | PMC:PMC11003710 | DOI:10.1002/cti2.1506

Source: Clinical Colorectal Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Shouyu Ke Yi Lei Yixian Guo Feng Xie Yimeng Yu Haigang Geng Yiqing Zhong Danhua Xu Xu Liu Fengrong Yu Xiang Xia Zizhen Zhang Chunchao Zhu Wei Ling Bin Li Wenyi Zhao Source Type: research