Atlas, Sofinnova lead $45M investment in cancer startup
The founders of a small Cambridge startup helping to develop more effective drugs for cancer, autoimmune disorders and liver diseases like NASH are planning to double staff after closing a $45 million Series A venture capital investment. The startup, HotSpot Therapeutics Inc., has developed a platform it calls SpotFinder, which it says can better identify protein targets or "hotspots," to enable drugmakers to develop more potent medications for a variety of diseases. "What's exciting about HotSpot… (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - July 17, 2018 Category: Health Management Authors: Allison DeAngelis Source Type: news

Those metal fillings in your mouth could be putting you at risk of an autoimmune disease
(Natural News) Are your dental fillings wreaking havoc on your immune system and setting the stage for disease to set in? New research shows that might just be the case. The metals used to make dental amalgams can come with a host of ill effects on health and research has shown that these metals can,... (Source: NaturalNews.com)
Source: NaturalNews.com - July 12, 2018 Category: Consumer Health News Source Type: news

The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4+ T cells
The activation of T cells requires the guanine nucleotide exchange factor VAV1. Using mice in which a tag for affinity purification was attached to endogenous VAV1 molecules, we analyzed by quantitative mass spectrometry the signaling complex that assembles around activated VAV1. Fifty VAV1-binding partners were identified, most of which had not been previously reported to participate in VAV1 signaling. Among these was CD226, a costimulatory molecule of immune cells. Engagement of CD226 induced the tyrosine phosphorylation of VAV1 and synergized with T cell receptor (TCR) signals to specifically enhance the production of i...
Source: Signal Transduction Knowledge Environment - July 10, 2018 Category: Science Authors: Gaud, G., Roncagalli, R., Chaoui, K., Bernard, I., Familiades, J., Colacios, C., Kassem, S., Monsarrat, B., Burlet-Schiltz, O., de Peredo, A. G., Malissen, B., Saoudi, A. Tags: STKE Research Articles Source Type: news

Antibody identifier could speed development of therapies for cancer, other diseases
A research team led by a UCLA bioengineer has developed a model to predict the extent to which new laboratory-designed antibodies will be able to combat specific human diseases. This is the first time that a comprehensive model has accounted for the many ways that antibodies communicate with other parts of the immune system and could speed up research and development of new therapies for cancer, infectious diseases and autoimmune disorders.Antibodies are proteins in the blood that are an important part of the immune system. These “Y”-shaped molecules find and neutralize unwanted and potentially dangerous pathog...
Source: UCLA Newsroom: Health Sciences - July 9, 2018 Category: Universities & Medical Training Source Type: news

12 Signs of celiac disease you should never ignore
(Natural News) People with celiac disease cannot eat the protein called gluten because it harms their small intestine. Apparently, although this autoimmune disease is now common, with a prevalence of approximately one person out of 100 in the world, most of them are unaware that they have it. Here are 12 signs of celiac disease... (Source: NaturalNews.com)
Source: NaturalNews.com - July 3, 2018 Category: Consumer Health News Source Type: news

Stress Disorders Tied to Autoimmune Disease
People with post-traumatic stress disorder or related conditions were more likely to develop autoimmune illnesses. (Source: NYT Health)
Source: NYT Health - June 26, 2018 Category: Consumer Health News Authors: NICHOLAS BAKALAR Tags: Post-Traumatic Stress Disorder Autoimmune Diseases Immune System Mental Health and Disorders Source Type: news

UCLA researchers develop synthetic T cells that mimic form, function of human version
This study was funded by the National Institute for Dental and Craniofacial Research. The authors report no commercial conflicts of interest. (Source: UCLA Newsroom: Health Sciences)
Source: UCLA Newsroom: Health Sciences - June 26, 2018 Category: Universities & Medical Training Source Type: news

Researchers develop synthetic T cells, mimics form and function of human version
(University of California - Los Angeles) UCLA researchers have developed synthetic T lymphocytes, or T cells, that are near-perfect facsimiles of human T cells. Their artificial cell could be a key step toward more effective drugs to treat cancer and autoimmune diseases and could lead to a better understanding of human immune cells' behavior. The researchers were able to replicate T cell's shape, size and flexibility, which enable it to perform its basic functions of targeting and homing in on infections. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 26, 2018 Category: Cancer & Oncology Source Type: news

Immune cells that create and sustain chronic inflammatory bowel disease identified
(University of Alabama at Birmingham) In preclinical experiments, Laurie Harrington and colleagues have discovered a subset of immune cells that create and sustain chronic inflammatory bowel disease. These cells could become potential therapeutic targets to ameliorate or cure Crohn's disease and ulcerative colitis. Furthermore, if this subset of CD4 T cells plays a similar role in other autoimmune diseases, such as Type 1 diabetes or rheumatoid arthritis, they could also be targets for therapy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 26, 2018 Category: International Medicine & Public Health Source Type: news

GMR Funds a Womens Health Education Series at Steger-South Chicago Heights Public Library
Jamie Paicely, Library Director Jamie Paicely, Director of Steger-South Chicago Heights Public Library in Steger, Illinois, received funding for Women’s Health Wednesdays, a series of one-hour community health sessions for women. Background: Steger-South Chicago Heights Public Library is located in a racially diverse community: 45% White, 25% Black or African American, and 25% Hispanic or Latino. “Our library users tend to be mostly black and Hispanic.” The community also is low-income. “Our school district is 76.82% free or reduced lunch students.” Jamie wants to increase her patrons&rsq...
Source: The Cornflower - June 25, 2018 Category: Databases & Libraries Authors: Darlene Kaskie Tags: Blog Consumer Health Funding News from the Region Outreach Public Libraries Success Stories public libraries and health Source Type: news

Sharing Mayo Clinic: Tackling a rare autoimmune disease
When Kelli Anderson first decided to get her odd symptoms evaluated, she thought she had something resembling the flu. She never dreamed doctors at Mayo Clinic would diagnose her with an uncommon disorder that was attacking her kidneys. Shortly before she turned 24, Kelli Anderson began experiencing strange physical symptoms she couldn't explain. "I just [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - June 24, 2018 Category: Databases & Libraries Source Type: news

‘ This Is How I Save My Life ’ Excerpt From Amy B. Scher
Amy B. Scher’s “This Is How I Save My Life” is the true story of a fiery young woman diagnosed with late-stage, chronic Lyme disease whose journey takes her from near-death in California to a trip around the world in search of her ultimate salvation. This excerpt coincides with the book’s release in paperback from Gallery Books, an imprint CBS sister company Simon & Schuster. I am twenty-eight years old when I arrive in magnificent India. I am here with my parents, an updated vaccine record, and a visa, searching for something I cannot find at home: a cure. In a tiny hospital on the outskirts of...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - June 21, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health Simon and Schuster Source Type: news

Johnson & Johnson hits the Big Apple with latest JLabs site
Johnson & Johnson (NYSE:JNJ) opened its latest life science incubator in New York City, the healthcare giant said today. The 30,000-square-foot JLabs @ NYC is a collaboration between Johnson & Johnson Innovation, New York State and the New York Genome Center. Sited at the genome center in SoHo, the incubator is home to 26 startups and has room for four more, New Brunswick, N.J.-based J&J said. “Johnson & Johnson has deep entrepreneurial roots in New York and we are pleased to see our unique JLabs model applied in this rich ecosystem to foster the creation of new healthcare innovations that have t...
Source: Mass Device - June 21, 2018 Category: Medical Devices Authors: Brad Perriello Tags: Funding Roundup Research & Development johnsonandjohnson Source Type: news

Stress Disorders Tied to Increased Risk of Autoimmune Diseases Stress Disorders Tied to Increased Risk of Autoimmune Diseases
People who suffer from posttraumatic stress disorder (PTSD) and other stress-related psychiatric issues may be at higher risk for development of autoimmune diseases, a Swedish study suggests.Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - June 21, 2018 Category: Allergy & Immunology Tags: Psychiatry News Source Type: news

Finnish scientists analyzed the proteome of T helper 17 cells
(University of Turku) T helper 17 (Th17) cells belong to a group of T cells with essential functions in autoimmune diseases and inflammation. Regulatory T cells (iTregs) are T cells with a suppressive function to maintain self-tolerance and prevent autoimmune responses. Researchers from Turku Centre for Biotechnology and Aalto University together utilised the advanced technology called label-free quantitative proteomics to identify the proteomes of Th17 and iTreg cells. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 20, 2018 Category: International Medicine & Public Health Source Type: news

Getting to grips with autoimmunity
Why does the body attack itself? EU-funded researchers have discovered new details about how faults in a specific gene trigger such activity, increasing our understanding of the roots of autoimmune diseases like arthritis and lupus and raising hopes of finding new treatment approaches. (Source: EUROPA - Research Information Centre)
Source: EUROPA - Research Information Centre - June 20, 2018 Category: Research Source Type: news

Vaccine Guidelines in the Works for the Immunosuppressed Vaccine Guidelines in the Works for the Immunosuppressed
Provisional vaccine guidelines for people with autoimmune inflammatory rheumatic disease are in the final stages of review and will be released later this year.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 19, 2018 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Vaccine Guidelines in the Works to Bolster Immunity Vaccine Guidelines in the Works to Bolster Immunity
Provisional vaccine guidelines for people with autoimmune inflammatory rheumatic disease are in the final stages of review and will be released later this year.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 19, 2018 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Stress disorders tied to increased risk of autoimmune diseases
(Reuters Health) - People who suffer from posttraumatic stress disorder (PTSD) and other stress-related psychiatric issues may be more likely to develop autoimmune diseases than individuals who don't, a Swedish study suggests. (Source: Reuters: Health)
Source: Reuters: Health - June 19, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Fecal Transplant Promising Primary Therapy for C diff Fecal Transplant Promising Primary Therapy for C diff
Fecal microbiota transplantation can be used for the first-line treatment of C difficile, and it might also have an effect on neurologic and autoimmune diseases, such as autism and alopecia areata.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 19, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Woman whose lupus sent her into heart and kidney failure describes agonizing five-year battle
Nichole Woodward, 27, of Nebraska developed lupus suddenly five years ago, losing her hair, nearly 20lbs and going in to heart and kidney failure. Now, her autoimmune disease is at last under control. (Source: the Mail online | Health)
Source: the Mail online | Health - June 19, 2018 Category: Consumer Health News Source Type: news

Severe Stress May Send Immune System Into Overdrive
Trauma or intense stress may up your odds of developing an autoimmune disease, a new study suggests. (Source: WebMD Health)
Source: WebMD Health - June 19, 2018 Category: Consumer Health News Source Type: news

Severe Stress May Send Immune System Into Overdrive
TUESDAY, June 19, 2018 -- Trauma or intense stress may up your odds of developing an autoimmune disease, a new study suggests. Comparing more than 106,000 people who had stress disorders with more than 1 million people without them, researchers... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 19, 2018 Category: General Medicine Source Type: news

Having stress-related disorder associated with increased risk of developing autoimmune disease
(JAMA Network) Stress-related disorders brought on by traumatic or stressful life events were associated with increased risk of developing an autoimmune disease. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - June 19, 2018 Category: International Medicine & Public Health Source Type: news

Tattoo health warning for people with weakened immune systems
A woman with cystic fibrosis and lung transplants suffered chronic pain for three years after she had a tattoo on her thighGetting a tattoo if you have a weakened immune system could put you at risk of complications, doctors have warned. The caution comes after a woman with cystic fibrosis and lung transplants developed thigh and knee pain after having body art inked on her leg.Doctors say those taking immunosuppressant drugs should take precautions if considering body art. These medicines are often given after an organ transplant or to treat autoimmune conditions such as Crohn ’s disease, lupus or rheumatoid arthrit...
Source: Guardian Unlimited Science - June 18, 2018 Category: Science Authors: Nicola Davis Tags: Tattoos Medical research Immunology Biochemistry and molecular biology Health Cystic fibrosis Diabetes Source Type: news

Science Saturday: Autoimmune disorders unmasked
Editor?s note: Recently Mayo Clinic launched a first-in-the-U.S. clinical test to help patients get the right diagnosis faster when it comes to diseases like multiple sclerosis (MS). This is the story of how tests like that are developed at Mayo. Diseases of the human body evolve and change, but their effect on patients is fixed. [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - June 16, 2018 Category: Databases & Libraries Source Type: news

Novartis touts effectiveness, safety of autoimmune drug copies
ZURICH (Reuters) - Novartis on Friday touted safety and efficacy of its biosimilar copies of Johnson& Johnson's Remicade and Amgen Inc's Enbrel, citing a study it hopes will help convince doctors that switching from the original medicines is a viable alternative for treating autoimmune diseases. (Source: Reuters: Health)
Source: Reuters: Health - June 15, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Lilly's Lupus Treatment Succeeds in Mid-Stage Trial Lilly's Lupus Treatment Succeeds in Mid-Stage Trial
Eli Lilly& Co said its drug to treat autoimmune disease lupus met the main goal of a mid-stage trial, positioning the drugmaker to begin a bigger study later this year.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 14, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news

A Better Flu Shot May Be On the Horizon. Here ’s Why
Each year, influenza viruses bring aches, pains, fever and overall misery to millions of people. The flu also leads to hundreds of thousands of hospitalizations and thousands of deaths. In a new paper published in Genome Medicine, researchers say a blood test may be able to identify which people are more likely to fight off the flu and which may have a harder time. And information from that same test could lead to new treatments — including more effective vaccines — that might make more people more flu-resistant. For four years, Purvesh Khatri, an associate professor of medicine and biomedical data science at S...
Source: TIME: Health - June 14, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized healthytime public health Source Type: news

Surprising new research concludes that baking soda can prevent autoimmune disease on a cellular level
(Natural News) You’ve probably seen more than one list circulating online touting the many uses for baking soda. Is your fridge smelling bad? Did your drain get clogged? Do your shoes need freshening up? Baking soda has a lot of tricks up its sleeve, but one of the best ones doesn’t usually feature in lists... (Source: NaturalNews.com)
Source: NaturalNews.com - June 13, 2018 Category: Consumer Health News Source Type: news

Lilly's lupus treatment succeeds in mid-stage trial
(Reuters) - Eli Lilly& Co said its drug to treat autoimmune disease lupus met the main goal of a mid-stage trial, positioning the drugmaker to begin a bigger study later this year. (Source: Reuters: Health)
Source: Reuters: Health - June 13, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

What is the Developmental Outcomes of Patients with 22q11 Deletion Sequence?
Discussion 22q11.2 deletion sequence (22q11) is the most common micro-deletion syndrome. Most deletions are de novo. It affects ~1 in 2000-4000 live births. As it is autosomal, it affects males and females equally. Childhood mortality is low and often associated with congenital heart defects. Its phenotypic expression is highly variable. Some of the most common medical problems are: Congenital heart defects especially conotruncal abnormalities Palatal problems especially velopharyngeal incompetence and/or cleft lip/palate Immunodeficiency especially T-cell lymphopenia, but also abnormalities of IgG production, autoimmu...
Source: PediatricEducation.org - June 11, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

WATCH: Kelly Clarkson explains recent weight loss
The singer says she made a lifestyle change to address an autoimmune disease and a thyroid issue. (Source: ABC News: Health)
Source: ABC News: Health - June 8, 2018 Category: Consumer Health News Tags: GMA Source Type: news

Bezafibrate Normalizes Liver Enzymes in PBC
(MedPage Today) -- Fibrate shows promise for rare autoimmune liver disease (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - June 7, 2018 Category: Gastroenterology Source Type: news

Medical News Today: Immunosuppressants may reduce Parkinson's risk
A new study finds an association between autoimmune disease and a reduced risk of Parkinson's disease. The link seems to be immune-suppressing drugs. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 4, 2018 Category: Consumer Health News Tags: Parkinson's Disease Source Type: news

Immunosuppressants may reduce Parkinson's risk
A new study finds an association between autoimmune disease and a reduced risk of Parkinson's disease. The link seems to be immune-suppressing drugs. (Source: Parkinson's Disease News From Medical News Today)
Source: Parkinson's Disease News From Medical News Today - June 4, 2018 Category: Neurology Tags: Parkinson's Disease Source Type: news

Do-it-all veteran, mother-of-three and singer who was suddenly paralyzed by mysterious rare disease
Deanna Wheeler, 31, found herself almost instantaneously paralyzed last month, first from the waist down, then completely, by the rare autoimmune disorder, Guillain-Barre Syndrome. (Source: the Mail online | Health)
Source: the Mail online | Health - June 1, 2018 Category: Consumer Health News Source Type: news

Science confirms: Baking soda, a kitchen staple, can be used to treat various autoimmune diseases
(Natural News) Baking soda is a kitchen necessity, there’s no doubt about that. Whether you use it for baking, as a natural scrub for pots and pans, or as a deodorizer –the list of ways you can use baking soda in and around the home is truly an endless one. But did you know that... (Source: NaturalNews.com)
Source: NaturalNews.com - May 31, 2018 Category: Consumer Health News Source Type: news

New findings link estrogen and T cell immune response to autoimmune inflammation
Women are more prone to the development of autoimmune diseases. The female hormone estrogen is likely to affect the immune system. A team of scientists from Turku Center for Biotechnology and University of Georgia reported new findings related to the involvement of estrogen hormone receptor in autoimmune diseases. (Source: World Pharma News)
Source: World Pharma News - May 31, 2018 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Voices: 25 and Still Alive
“ I ’ m fine, ” I say. But I ’ m not fine. I almost died at 24 of a heart attack caused by a rare autoimmune disorder. (Source: NYT Health)
Source: NYT Health - May 31, 2018 Category: Consumer Health News Authors: JACLYN PEISER Tags: Heart Autoimmune Diseases Emergency Medical Treatment Source Type: news

New findings link estrogen and T cell immune response to autoimmune inflammation
(University of Turku) Women are more prone to the development of autoimmune diseases. The female hormone estrogen is likely to affect the immune system. A team of scientists from Turku Center for Biotechnology and University of Georgia reported new findings related to the involvement of estrogen hormone receptor in autoimmune diseases. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 31, 2018 Category: International Medicine & Public Health Source Type: news

Ebola Slows; No HPV Vax/Autoimmune Link; Zika Came Early?
(MedPage Today) -- News and commentary from the world of infectious diseases (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - May 30, 2018 Category: Infectious Diseases Source Type: news

Autoimmune disease doesn't have to take over your life
(Natural News) Scientists have discovered over 80 million autoimmune diseases, and over 80 million people in the U.S. alone suffer from one or more of these diseases. Being in such a state is a struggle as it is, but having to buy expensive medicine believing it will treat the disease is even more distressing. Autoimmune... (Source: NaturalNews.com)
Source: NaturalNews.com - May 30, 2018 Category: Consumer Health News Source Type: news

No Link Between HPV Vaccine, Autoimmune Diseases
Of nearly 181,000 girls who were vaccinated, about 680 were diagnosed with an autoimmune disease between one week and two months later. (Source: WebMD Health)
Source: WebMD Health - May 29, 2018 Category: Consumer Health News Source Type: news

No Link Between HPV Vaccine and Autoimmune Disorders No Link Between HPV Vaccine and Autoimmune Disorders
Large Canadian cohort study showed no link between the HPV4 vaccine and autoimmune disorders in girls; the findings are consistent with previous cohort studies.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 29, 2018 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

No Link Between HPV Vaccine, Autoimmune Diseases: Study
TUESDAY, May 29, 2018 -- Immunizing girls against human papillomavirus (HPV) doesn't increase their risk for autoimmune diseases, according to new research from Canada. HPV is the world's most common sexually transmitted disease, affecting up to 75... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - May 29, 2018 Category: General Medicine Source Type: news

No Link Between HPV Vaccine, Autoimmune Diseases: Study
(Source: Cancercompass News: Gynecological Cancer)
Source: Cancercompass News: Gynecological Cancer - May 29, 2018 Category: Cancer & Oncology Source Type: news

Deciphering the language of cells using observation chambers
(Ecole Polytechnique F é d é rale de Lausanne) EPFL researchers have developed an innovative label-free method for studying the behavior of single cells continuously and in real time. By placing a cell in a small chamber containing nanosensors and observing it over many hours, it is possible to identify the cell's unique personality and understand how it communicates. This powerful new technology could be used to select the most aggressive cells to combat an enemy. Potential applications include treatments for cancer and autoimmune diseases. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 28, 2018 Category: International Medicine & Public Health Source Type: news