What ’s the Latest in Drug-Delivery Devices?
To simplify drug delivery for patients and practitioners, drug-delivery devices are becoming more complex. Many of today’s devices include special features designed to ease self-dosing and encourage patient adherence with novel regimens. Wearable devices are further easing use by promoting active lifestyles. And some devices are offering connectivity to support digital health monitoring. With so many possibilities, where do device developers and pharmaceutical companies begin? MD+DI asked Eric Resnick, vice president and chief technology officer, innovation and technology, West Pharmaceutical Services Inc...
Source: MDDI - May 22, 2019 Category: Medical Devices Authors: Daphne Allen Tags: Packaging Source Type: news

Association of childhood abuse with incident systemic lupus erythematosus in adulthood in a longitudinal cohort of women - Feldman CH, Malspeis S, Leatherwood C, Kubzansky L, Costenbader KH, Roberts AL.
We examined if childhood abuse was associated with heightened risk of incident systemic lupus erythematosus... (Source: SafetyLit)
Source: SafetyLit - May 18, 2019 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Scientists capture first-ever video of body's safety test for t-cells
(University of Texas at Austin) For the first time, immunologists have captured on video what happens when T-cells undergo a type of assassin-training program before they get unleashed in the body. A new imaging technique that allowed for the videos, described today in the journal Nature Communications, holds promise for the fight against autoimmune disorders such as Type 1 diabetes. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 17, 2019 Category: Infectious Diseases Source Type: news

Girl, 5, suffers from rare disease triggered by the sun that could leave her covered in rashes
Kaia Ettingoff, five, of Wayne, Pennsylvania, was diagnosed in January 2018 with juvenile dermatomyositis, a rare autoimmune disorder that leaves her with rashes and muscle inflammation. (Source: the Mail online | Health)
Source: the Mail online | Health - May 16, 2019 Category: Consumer Health News Source Type: news

Medical News Today: Could gut bacteria explain the link between stress and autoimmune disease?
A mouse study shows that persistent social stress alters gut bacteria in ways that raise the likelihood of immune system attacks on the body's own tissues. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 16, 2019 Category: Consumer Health News Tags: Immune System / Vaccines Source Type: news

Lupus Takes Bigger Toll on Longevity for Blacks
THURSDAY, May 16, 2019 -- Lupus, a chronic autoimmune disease that attacks the skin, joints and organs, can shorten the lives of its victims, but new research shows it can shorten the lives of black patients the most. Health data from two counties... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - May 16, 2019 Category: General Medicine Source Type: news

Multiple sclerosis: Discovery of a mechanism responsible for chronic inflammation
(Institut Pasteur) Multiple sclerosis (MS) is an autoimmune disease. The defense system that usually protects patients from external aggression turns on its own cells and attacks them for reasons that are not yet known. Scientists from the Institut Pasteur have shown that ancient viruses are involved in the acute inflammatory defense response that may contribute to the disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 10, 2019 Category: International Medicine & Public Health Source Type: news

FDA OKs First Treatment for Children With LEMS FDA OKs First Treatment for Children With LEMS
Amifampridine (Ruzurgi) is an oral potassium channel blocker indicated for children and adolescents aged 6 years to less than 17 years with the rare autoimmune disease.FDA Approvals (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - May 8, 2019 Category: Allergy & Immunology Tags: Neurology & Neurosurgery News Alert Source Type: news

Justices Decline Review Of Exclusion Of Experts In Chemical Exposure Suit
WASHINGTON, D.C. - With the denial of a petition for a writ of certiorari on April 29, the U.S. Supreme Court let stand a Second Circuit U.S. Court of Appeals' ruling upholding the exclusion of a man's causation experts in his case against his former employers alleging that he contracted an autoimmune disease from exposure to toxic substances at work (Timothy J. Rizzo v. Applied Materials, Inc., et al., No. 18-1153, U.S. Sup.). (Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News)
Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News - May 8, 2019 Category: Medical Law Source Type: news

3D 'mini-gut' model reflects autoimmune response to gluten in celiac patient tissue
(Massachusetts General Hospital) In pursuit of a novel tool for the research and treatment of celiac disease, scientists at the Mucosal Immunology and Biology Research Center at Massachusetts General Hospital have validated the use of intestinal organoids. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 7, 2019 Category: International Medicine & Public Health Source Type: news

FDA grants Jacobus Pharma approval for rare disease drug
Jacobus Pharmaceutical Co Inc on Monday won U.S. approval for the first drug to treat children with Lambert-Eaton myasthenic syndrome, a rare autoimmune disorder. (Source: Reuters: Health)
Source: Reuters: Health - May 7, 2019 Category: Consumer Health News Tags: healthNews Source Type: news

A selenium/myo-inositol combination can naturally heal Hashimoto’s disease
(Natural News) Hashimoto’s disease is one of the most common causes of hypothyroidism in the U.S., affecting at least one out of 20 people. A recent study, however, showed that the combination of selenium and myoinositol can work wonders with people who have this autoimmune condition. The study, which appeared in the journal European Review for Medical... (Source: NaturalNews.com)
Source: NaturalNews.com - May 6, 2019 Category: Consumer Health News Source Type: news

Exploring new treatments for autoimmune diseases
(Michigan Medicine - University of Michigan) A new grant will allow Michigan Medicine researchers to explore personalized approaches to treating autoimmune diseases such as scleroderma, lupus, rheumatoid arthritis and others. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 6, 2019 Category: International Medicine & Public Health Source Type: news

A selenium/myo-inositol combination can naturally heal Hashimoto’s disease
(Natural News) Hashimoto’s disease is one of the most common causes of hypothyroidism in the U.S., affecting at least one out of 20 people. A recent study, however, showed that the combination of selenium and myoinositol can work wonders with people who have this autoimmune condition. The study, which appeared in the journal European Review for Medical... (Source: NaturalNews.com)
Source: NaturalNews.com - May 3, 2019 Category: Consumer Health News Source Type: news

Researchers ready B cells for novel cell therapy
(Seattle Children's) Scientists at Seattle Children's Research Institute are paving the way to use gene-edited B cells -- a type of white blood cell in the immune system -- to treat a wide range of potential diseases that affect children, including hemophilia and other protein deficiency disorders, autoimmune diseases, and infectious diseases. If successful, their research would open the door to offering this experimental cell therapy as the first-of-its-kind in clinical trials at Seattle Children's in as soon as five years. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 2, 2019 Category: Infectious Diseases Source Type: news

Stem Cell Transplant An Effective Tool in Autoimmune Disease Stem Cell Transplant An Effective Tool in Autoimmune Disease
Patients with severe and refractory autoimmune disease such as multiple sclerosis can have marked improvements with hematopoietic stem cell transplant, as long as they are well selected, say experts.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - April 23, 2019 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

The Benefits of an Anti-Inflammatory Diet
TUESDAY, April 23, 2019 -- The body's immune system is designed to fight off threats, like infection-causing germs, through a process called inflammation. But a steady state of inflammation can lead to everything from diabetes to autoimmune diseases... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 23, 2019 Category: General Medicine Source Type: news

Rare disease gives new insight into regulatory T cell function
(Karolinska Institutet) An international study led from Karolinska Institutet in Sweden provides new insights into the regulatory T cells' role in protecting against autoimmune disease. By mapping the targets of the immune system in patients with the rare disease IPEX, they were able to show that regulatory T cells control immunotolerance in the gut. The results are published in the Journal of Allergy and Clinical Immunology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 23, 2019 Category: International Medicine & Public Health Source Type: news

$17 million grant will explore immune cells in inaccessible tissues of the human body
(University of Alabama at Birmingham) Researchers will receive $17.8 million in federal funding to attack a key 'knowledge gap' in human immunology -- how B cells and antibody-secreting cells that reside in tissues and organs differ from those found in blood. It is an exploration never undertaken in a systematic way, studying many individual people. These unknown differences may alter resistance to infections, contribute to autoimmune disease and play a role in rejection of transplanted organs, including proposed xenotransplants from pigs. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 22, 2019 Category: Infectious Diseases Source Type: news

MedImmune spinoff scores breakthrough status for rare autoimmune disease treatment
Viela Bio Inc. has earned a breakthrough therapy designation from the Food and Drug Administration for a product to treat neuromyelitis optica spectrum disorder, a life-threatening autoimmune disease that impacts the central nervous system. The FDA granted breakthrough status to the company’s candidate, inebilizumab, following positive results from a pivotal study that was “the largest monotherapy study ever conducted in NMOSD,” said Dr. Jorn Drappa, chief medical officer and head of research… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - April 19, 2019 Category: Biotechnology Authors: Sara Gilgore Source Type: news

Discovery may help explain why women get autoimmune diseases far more often than men
(Michigan Medicine - University of Michigan) New evidence points to a key role for a molecular switch called VGLL3 in autoimmune diseases, and the major gap in incidence between women and men. Building on past research showing that women have more VGLL3 in their skin cells than men, a team studied it further in mice. They show that having too much VGLL3 in skin cells pushes the immune system into overdrive, leading to an autoimmune response and symptoms similar to lupus. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 18, 2019 Category: Biology Source Type: news

Anti-inflammatory drug halts strokes in children with rare disease
NIH researchers have identified a treatment that significantly decreases the risk of stroke in children with a rare genetic disease called DADA2 (deficiency of adenosine deaminase type 2), which can ultimately hinder blood flow to the brain and result in strokes. The treatment works by blocking the inflammatory effects of a protein - tumor necrosis factor - that is over-produced in people with DADA2 and other autoimmune and autoinflammatory diseases. Researchers published their findings in the April 18, 2019, issue ofThe New England Journal of Medicine. (Source: NHGRI Homepage Highlights)
Source: NHGRI Homepage Highlights - April 17, 2019 Category: Genetics & Stem Cells Source Type: news

Vitamin D implicated in autoimmunity
Vitamin D is involved in regulating immune responses through T cell activation, which may explain the link between low levels and increased risk of autoimmune disease, according to research published inFrontiers in Immunology.Medical Xpress (Source: Society for Endocrinology)
Source: Society for Endocrinology - April 16, 2019 Category: Endocrinology Source Type: news

CD30: From witness to culprit
(Helmholtz Zentrum M ü nchen - German Research Center for Environmental Health) Cells of certain blood cancers such as Hodgkin's lymphoma carry the protein CD30 on their surface. The molecule is not only an indicator of a few cancers of the immune system but also increases the risk of their occurrence, according to a report in the journal Blood by researchers of the Helmholtz Zentrum M ü nchen. A greatly increased number of CD30-bearing cells are produced after certain viral infections, e.g. Epstein-Barr virus (EBV) infection, and in autoimmune diseases. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2019 Category: Cancer & Oncology Source Type: news

Alberta women with breast implant illness urge doctors to warn others of risk
Women across Alberta are joining together to bring attention to breast implant illness, which they say caused them such severe autoimmune disease symptoms that they thought they were dying. (Source: CBC | Health)
Source: CBC | Health - April 11, 2019 Category: Consumer Health News Tags: News/Canada/Edmonton Source Type: news

Many Misdiagnosed With MS
THURSDAY, April 11, 2019 -- Almost one in five multiple sclerosis patients may be misdiagnosed with the autoimmune disease, according to a new study. Of 241 previously diagnosed multiple sclerosis (MS) patients referred to two major Los Angeles... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 11, 2019 Category: General Medicine Source Type: news

Ask What Is an Example of an Autoimmune Disease
What Is an Example of an Autoimmune Disease? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - April 9, 2019 Category: General Medicine Source Type: news

Acupuncture reduces the risk of coronary heart disease in people with rheumatoid arthritis
(Natural News) One of the most widely used methods for relieving pain is acupuncture. It is especially recommended to people with rheumatoid arthritis – a chronic autoimmune disease that causes inflammation, swelling and pain in the joints and other body organs. Because of its scope, people suffering from RA have a high risk of developing other... (Source: NaturalNews.com)
Source: NaturalNews.com - April 7, 2019 Category: Consumer Health News Source Type: news

Ask What Is the Most Common Autoimmune Disease
What Is the Most Common Autoimmune Disease? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - April 4, 2019 Category: General Medicine Source Type: news

Ask What Autoimmune Diseases Affect the Eyes
What Autoimmune Diseases Affect the Eyes? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - April 4, 2019 Category: General Medicine Source Type: news

ask how do you get autoimmune disease
How do you get autoimmune disease? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - April 4, 2019 Category: General Medicine Source Type: news

Ask Do Autoimmune Diseases Run in Families
Do Autoimmune Diseases Run in Families? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - April 4, 2019 Category: General Medicine Source Type: news

FDA Looks Into Regulating CBD In Food, Beverages And More
(CNN) — The US Food and Drug Administration announced Tuesday that it will hold a public hearing next month to discuss developing a regulatory framework for the use of CBD in consumer products, including foods and beverages. CBD, the abbreviation for cannabidiol, is one of the non-psychoactive ingredients in cannabis, increasingly thought to offer wide-ranging health benefits, with few side effects and low risk of addiction or abuse. Tetrahydrocannabinol or THC is the main psychoactive component of the cannabis plant. Related: CBD – What Is It And Why Do People Use It? FDA Commissioner Dr. Scott Gottlieb said i...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - April 3, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CBD CNN Source Type: news

ask can Hashimotos cause other autoimmune diseases
Can Hashimoto's Cause Other Autoimmune Diseases? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - April 2, 2019 Category: General Medicine Source Type: news

Women Die From Heart Attacks More Often Than Men. Here ’s Why — and What Doctors Are Doing About It
Lilly Rocha was 37 years old in 2008 when she began having strange symptoms. When people asked her questions, she knew the answers but couldn’t articulate them. A tingling sensation on her left breast became painful. She thought she might have breast cancer, but her doctor assured her she was just experiencing stress from her demanding job. Her symptoms continued to get worse, and doctors continued to dismiss her. Three months later, at work, she became seriously ill. Luckily, her boss recognized the symptoms—chest and jaw pain and numbness in her left hand—and drove her to the nearest emergency room, whe...
Source: TIME: Health - April 1, 2019 Category: Consumer Health News Authors: Barbara Sadick Tags: Uncategorized heart health Source Type: news

What Does the Liver Do?
Discussion The liver is one of the largest organs in the body, weighing just over 3 pounds in an adult. It is found in the upper right abdomen, under the right dome of the diaphragm. Grossly, it has asymmetric lobes with the right being larger than the left. The lobes are separated by a fibrous connective tissue band that also anchors the liver in the abdominal cavity. The gallbladder is located on the inferior surface of the liver and stores bile, which is then released into the duodenum. Microscopically, the liver cells are arranged in lobules with canals carrying blood vessels and bile ducts. At any moment about 10-13% ...
Source: PediatricEducation.org - April 1, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Uterine artery embolization can be considered for well controlled symptomatic leiomyomas
(American Roentgen Ray Society) A new study published in the April 2019 issue of the American Journal of Roentgenology (AJR) investigates the safety of uterine artery embolization (UAE) for symptomatic leiomyomas in patients with various autoimmune diseases. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 29, 2019 Category: International Medicine & Public Health Source Type: news

Petitioner Says Exclusion Of Experts In Chemical Exposure Suit Warrants Review
WASHINGTON, D.C. - The Second Circuit U.S. Court of Appeals erred in affirming the exclusion of a man's causation experts in his case against his former employers alleging that he contracted an autoimmune disease from exposure to toxic substances at work, the former employee tells the U.S. Supreme Court in a Feb. 26 petition for a writ of certiorari (Timothy J. Rizzo v. Applied Materials, Inc., et al., No. 18-1153, U.S. Sup., 2019 U.S. S. Ct. Briefs LEXIS 825). (Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News)
Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News - March 26, 2019 Category: Medical Law Source Type: news

Pacific Mesothelioma Center Moves Closer to Treatment Breakthrough
Thoracic surgeon Dr. Robert Cameron and the Pacific Mesothelioma Center moved closer to a major treatment advance by obtaining U.S. patent approval for their novel mesenchymal stem cell research program. The patent approval in February makes the research program more attractive to potential investors who could accelerate development and change the way malignant mesothelioma is treated. “This is a big deal in the developmental path for MSC [mesenchymal stem cell] therapy,” Patent Adviser Dr. Walid Sabbagh told The Mesothelioma Center at Asbestos.com. “The patent is a pathway to really help these cancer pat...
Source: Asbestos and Mesothelioma News - March 25, 2019 Category: Environmental Health Authors: Matt Mauney Source Type: news

Autoimmune diseases are related to each other, some more than others
(The Endocrine Society) Researchers using the world's largest twin registry to study seven autoimmune diseases found the risk of developing the seven diseases is largely inherited, but that some diseases are more closely related than others. These results will be presented Sunday at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, La. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 24, 2019 Category: International Medicine & Public Health Source Type: news

Reports of Breast Implant Illnesses Prompt Federal Review
The Food and Drug Administration is taking another look at breast implants because of renewed safety concerns. (Source: NYT Health)
Source: NYT Health - March 19, 2019 Category: Consumer Health News Authors: DENISE GRADY and RONI CARYN RABIN Tags: your-feed-science Implants Breasts Medical Devices Breast Cancer Women and Girls Plastic Surgery Autoimmune Diseases Allergan Inc Food and Drug Administration Mentor Worldwide LLC Sientra Inc. Source Type: news

Roche to present results of the largest safety study of its kind with Tecentriq (atezolizumab) in patients with metastatic bladder cancer
Roche today announced first results from SAUL, a Phase IIIb study evaluating the safety of Tecentriq ® in approximately 1000 patients with locally advanced or metastatic urothelial carcinoma (mUC) including several clinically relevant populations reflective of real-world clinical practice (patients with renal impairment, poor performance status (ECOG PS 2), treated asymptomatic CNS metastases, sta ble controlled autoimmune disease). (Source: Roche Investor Update)
Source: Roche Investor Update - March 18, 2019 Category: Pharmaceuticals Source Type: news

European Commission approves Roche ’s MabThera (rituximab) for a rare autoimmune disease
Roche today announced that the European Commission has approved MabThera ® (rituximab) for the treatment of adults with moderate to severe pemphigus vulgaris (PV), a rare condition characterised by progressive painful blistering of the skin and/or mucous membranes. (Source: Roche Media News)
Source: Roche Media News - March 15, 2019 Category: Pharmaceuticals Source Type: news

European Commission approves Roche ’s MabThera (rituximab) for a rare autoimmune disease
Roche today announced that the European Commission has approved MabThera ® (rituximab) for the treatment of adults with moderate to severe pemphigus vulgaris (PV), a rare condition characterised by progressive painful blistering of the skin and/or mucous membranes. (Source: Roche Investor Update)
Source: Roche Investor Update - March 15, 2019 Category: Pharmaceuticals Source Type: news

New proof that narcolepsy is an autoimmune disease
(University of Copenhagen The Faculty of Health and Medical Sciences) Researchers from the University of Copenhagen have discovered autoreactive cells in persons suffering from narcolepsy. This is a new, important proof that the sleep disorder is an autoimmune disease. This knowledge may lead to better treatment of the chronic condition, the researchers behind the new discovery believe. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 15, 2019 Category: Biology Source Type: news

Congenital Heart Block: Dangers Ahead
(MedPage Today) -- Risks high for cardiovascular and autoimmune diseases, as well as infections (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - March 6, 2019 Category: Cardiology Source Type: news

CAR T Cells Treat Lupus in Mice
T cells modified to target disease-contributing B cells improved survival in two mouse models of the autoimmune disease. (Source: The Scientist)
Source: The Scientist - March 6, 2019 Category: Science Tags: News & Opinion Source Type: news

Autoimmune rheumatic disease: Mayo Clinic Radio Health Minute
Rheumatoid arthritis, lupus and vasculitis are just a few examples of autoimmune rheumatic diseases. ?In this Mayo Clinic Radio Health Minute, Dr. Eric Matteson talks about the prevalence of these types of diseases and where treatment is headed. To listen, click the link below. Autoimmune rheumatic disease (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - March 6, 2019 Category: Databases & Libraries Source Type: news

Novel treatments offer new hope for patients with autoimmune disease
Autoimmune diseases, including type 1 diabetes and multiple sclerosis, arise when the body's immune cells attack itself. Current treatments eliminate these misfunctioning immune cells, but also destroy normal, protective immune cells, leaving patients susceptible to immune deficiency and opportunistic infections. Researchers at University of Utah Health have developed a new approach that targets the misfunctioning immune cells while leaving normal immune cells in place. (Source: World Pharma News)
Source: World Pharma News - March 5, 2019 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

UCLA-led study could point to ways to better control inflammation in autoimmune diseases
In autoimmune diseases such as psoriasis or lupus, the immune system goes into overdrive in response to people ’s own DNA being released from damaged cells — a reaction that can cause severe inflammation in the body.Until now, the molecular processes behind that immune response have not been fully understood by scientists, but a new UCLA-led study could help change that.Researchers at UCLA and three other institutions discovered that LL37 molecules, which are found in the immune system, play an important but unexpected role in revving up the body ’s self-defense response. The finding may bring scientists ...
Source: UCLA Newsroom: Health Sciences - March 5, 2019 Category: Universities & Medical Training Source Type: news