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Lower Vitamin D levels Linked to More Belly Fat
Low vitamin D levels have been linked to poor bone health, as well as increased risk for respiratory infection, autoimmune disorders and heart disease. (Source: WebMD Health)
Source: WebMD Health - May 21, 2018 Category: Consumer Health News Source Type: news

Experts Discuss Unique Side Effects of Immunotherapy
If you have mesothelioma and you’ve already received standard-of-care therapies, you may be considering an immunotherapy clinical trial. If you’re considering this option, a free immunotherapy teleconference is a great place to learn more. CancerCare recently hosted two one-hour education workshops featuring panels of immunotherapy experts. Part I of the teleconference presented an overview of immunotherapy. Part II of the teleconference, which is available online for free, focused exclusively on immunotherapy side effects. Understanding these issues and the role each patient plays in managing their own side ef...
Source: Asbestos and Mesothelioma News - May 21, 2018 Category: Environmental Health Authors: Matt Mauney Source Type: news

Humira does not improve aortic vascular inflammation in psoriasis patients
(University of Pennsylvania School of Medicine) An antibody used to treat the skin disease psoriasis and other chronic autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease has no effect on aortic inflammation -- a key marker of future risk of major cardiovascular events -- unlike other antibodies that target different aspects of the immune system. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 18, 2018 Category: International Medicine & Public Health Source Type: news

Medical News Today: What causes multiple sclerosis? Landmark study finds clue
Multiple sclerosis is an autoimmune disease, the causes of which remain mysterious. But a new study may now have uncovered a key factor in its development. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 16, 2018 Category: Consumer Health News Tags: Multiple Sclerosis Source Type: news

Broad Institute Spinout Aims To Bring Precision Medicine To Autoimmune Disease
Celsius Therapeutics will use techniques for constructing detailed profiles of individual cells to develop drugs for autoimmune diseases and cancer immunotherapies. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - May 15, 2018 Category: Pharmaceuticals Authors: Ellie Kincaid, Forbes Staff Source Type: news

Joint resolution: A link between Huntington's disease and rheumatoid arthritis
(University of California - San Diego) Using new analytic tools, researchers at University of California San Diego School of Medicine and the Icahn School of Medicine at Mount Sinai have decoded the epigenetic landscape for rheumatoid arthritis (RA), a common autoimmune disease that affects more than 1.3 million Americans. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 15, 2018 Category: International Medicine & Public Health Source Type: news

Immunicom's Immunotherapy Product Receives U.S. FDA Breakthrough Device Designation for the Treatment of Cancer
SAN DIEGO, May 14, 2018 -- (Healthcare Sales & Marketing Network) -- Immunicom, Inc., a medical technology company developing revolutionary non-pharmaceutical approaches for treating cancer and autoimmune diseases, has received Breakthrough Device designa... Devices, Oncology, FDA Immunicom, Immunopheresis (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - May 14, 2018 Category: Pharmaceuticals Source Type: news

How Humana And Walmart Can Overcome Organizational Autoimmune Disease
Walmart and Humana will need talented change agents —internal executives or outside consultants—who can lead innovation and improve processes because they are critical in the push to overcome organizational autoimmune disease. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - May 11, 2018 Category: Pharmaceuticals Authors: Leonard Achan, Contributor Source Type: news

Inflammatory Eye Disease: Complex, Scary
(MedPage Today) -- Often related to autoimmune, inflammatory diseases (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - May 10, 2018 Category: Rheumatology Source Type: news

This Osteoporosis Drug Has a Surprising Side-Effect. Scientists Say It Could Cure Baldness
Researchers may have discovered a new cure for baldness using a drug initially intended to treat osteoporosis. Scientists from the University of Manchester say the drug,WAY-316606, stimulated hair growth in the lab by targeting a protein that halts hair growth and contributes to baldness, BBC reports. They were originally testing Cyclosporine A, an immunosuppressive drug that has been used since the 1980s to stop rejections in organ transplants and mitigate symptoms of autoimmune diseases. While it was found to suppress hair loss, Cyclosporine A had side-effects that made it unsuitable. So the team went on looking for a dr...
Source: TIME: Health - May 10, 2018 Category: Consumer Health News Authors: Casey Quackenbush Tags: Uncategorized onetime overnight Research Source Type: news

She collapsed on a flight to the Cleveland Clinic. A doctor from there happened to be on board.
Minutes into her flight to Cleveland for a visit to the renowned Cleveland Clinic, where she  hoped to find answers about her struggle with a rare autoimmune disease, Ashley Spencer  collapsed outside an airplane bathroom. Spencer, from the Philadelphia area, reportedly suffers from Churg-Strauss syndrome, also known as eosinophilic granulomatosis with polyangiitis, a disorder that causes inflammation in the blood vessels, slowing down blood flow to vital […]Related:‘I saved them because I’m a superhero!’: 4-year-old donates bone...
Source: Washington Post: To Your Health - May 7, 2018 Category: Consumer Health News Source Type: news

Arthritis Research UK joins forces with Medical Research Council to tackle childhood arthritis
This study will look at differences in genes, immune cells, blood proteins and other features that are seen in patients who respond well to treatments, and those who develop uveitis, a condition that causes eye inflammation and affects approximately 15% of children with arthritis.It is hoped the study will allow researchers to tailor personalised treatments and create a biomarkers test for childhood arthritis which would:Identify potential new treatmentsHelp doctors determine what the right treatment plan is for each patientIdentify which children are at risk of developing uveitisProject long-term outcomes for children wit...
Source: Arthritis Research UK - May 2, 2018 Category: Rheumatology Source Type: news

UPDATED: Van ’s Foods Voluntarily Recalls Gluten Free Waffles Due to Gluten, Undeclared Wheat & Undeclared Milk
Van ’s Foods is voluntarily recalling Van’s Gluten Free Waffles with a lot code date of #A640234710–WL2, BEST BY AUG 22, 2018 and UPC 0 89947 30206 4. The products are being recalled because a limited number of the wrong packaging were used during the production of Van’s Belgian Waffles. The pro duct inadvertently packaged in the Van’s Gluten Free Waffle box contains gluten, undeclared wheat and undeclared milk. People who have an allergy or severe sensitivity to milk, wheat or gluten run the risk of serious or life-threatening allergic reaction if they consume these products. These produ cts ...
Source: Food and Drug Administration - April 29, 2018 Category: Food Science Source Type: news

SPM in Real Life: Spring ’ 18
NEW MEMBERS: Spring ’18 Brief bios/plugs for new members (extracted from the Introduce Yourself Connect Community) Katherine Infantes-Cordova, a bilingual patient liaison passionate about improving the patient experience, is eager to take part in eliminating health inequities and empowering patients to be proactive in their health. Leah Jones has a background in consumer public relations and social media. Her company, Natiiv Facilitation, offers independent focus group moderation, event facilitation, and patient engagement projects. She advocates about fibroids and the challenges people struggling with their weight f...
Source: Society for Participatory Medicine - April 27, 2018 Category: General Medicine Authors: Danny van Leeuwen Tags: Newsletter Source Type: news

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity
Activated immune cells undergo a metabolic switch to aerobic glycolysis akin to the Warburg effect, thereby presenting a potential therapeutic target in autoimmune disease. Dimethyl fumarate (DMF), a derivative of the Krebs cycle intermediate fumarate, is an immunomodulatory drug used to treat multiple sclerosis and psoriasis. Although its therapeutic mechanism remains uncertain, DMF covalently modifies cysteine residues in a process termed succination. We found that DMF succinates and inactivates the catalytic cysteine of the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in mice and humans, both in vi...
Source: ScienceNOW - April 26, 2018 Category: Science Authors: Kornberg, M. D., Bhargava, P., Kim, P. M., Putluri, V., Snowman, A. M., Putluri, N., Calabresi, P. A., Snyder, S. H. Tags: Immunology, Medicine, Diseases reports Source Type: news

Drinking baking soda could be an inexpensive, safe way to combat autoimmune disease
(Medical College of Georgia at Augusta University) A daily dose of baking soda may help reduce the destructive inflammation of autoimmune diseases like rheumatoid arthritis, scientists say.They have some of the first evidence of how the cheap, over-the-counter antacid can encourage our spleen to promote instead an anti-inflammatory environment that could be therapeutic in the face of inflammatory disease, Medical College of Georgia scientists report in The Journal of Immunology. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 25, 2018 Category: Biology Source Type: news

Autoimmune Disease or Drug Hypersensitivity Reaction? Autoimmune Disease or Drug Hypersensitivity Reaction?
The case of a 51-year-old man with eosinophilic myocarditis was simpler than it seemed.Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 24, 2018 Category: Consumer Health News Tags: Rheumatology Expert Column Source Type: news

Epstein-Barr virus and autoimmune diseases
Researchers found a mechanism that may explain why the Epstein-Barr virus is associated with certain autoimmune illnesses such as lupus. (Source: NIH Research Matters from the National Institutes of Health (NIH))
Source: NIH Research Matters from the National Institutes of Health (NIH) - April 24, 2018 Category: Consumer Health News Source Type: news

Epstein-Barr Virus Transcription Factor Implicated in Seven Autoimmune Diseases Epstein-Barr Virus Transcription Factor Implicated in Seven Autoimmune Diseases
Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 20, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Epstein-Barr Virus Protein and Autoimmune Diseases
Epstein-Barr Virus Protein Can 'Switch On' Risk Genes for Autoimmune Diseases (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - April 19, 2018 Category: General Medicine Source Type: news

Compound treats psoriasis, may curb autoimmune diseases, researchers say
A compound from immune cells treats psoriasis in mice and might also be effective in treating multiple sclerosis, rheumatoid arthritis and lupus. (Source: Health News - UPI.com)
Source: Health News - UPI.com - April 18, 2018 Category: Consumer Health News Source Type: news

Bioelectronic Medicine: Targeting Inflammatory Disease with Electricity
We presented positive initial results in Crohn’s disease at the 2016 United European Gastroenterology meeting: six of the eight patients had seen a substantial reduction in their disease activity index scores, and three were in remission from the disease. As SetPoint looks ahead, several chronic disease areas are emerging as key bioelectronic medicine therapy targets, and our company is exploring a number of these. One of our preclinical programs explores bioelectronic medicine’s potential role as a treatment for MS.   New Target: Multiple Sclerosis In late 2017, SetPoint presented positive data from a s...
Source: Mass Device - April 17, 2018 Category: Medical Devices Authors: Anthony Arnold Tags: Bioelectronic Medicine Clinical Trials Neuromodulation/Neurostimulation SetPoint Medical Sponsored Content Source Type: news

Scientists identify potential targets for new autoimmune disease treatments
(eLife) Researchers have provided new insight into how a gene associated with autoimmunity contributes to disease in humans. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 17, 2018 Category: International Medicine & Public Health Source Type: news

A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22
The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases. Two papers in Science Immunology and Science Signaling on this human disease–associated variant lead us to propose a new "switch-of-function" model. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - April 17, 2018 Category: Science Authors: Vang, T., Nielsen, J., Burn, G. L. Tags: STKE Focus Source Type: news

Estrogen receptor {alpha} contributes to T cell-mediated autoimmune inflammation by promoting T cell activation and proliferation
It has long been appreciated that most autoimmune disorders are characterized by increased prevalence in females, suggesting a potential role for sex hormones in the etiology of autoimmunity. To study how estrogen receptor α (ERα) contributes to autoimmune diseases, we generated mice in which ERα was deleted specifically in T lymphocytes. We found that ERα deletion in T cells reduced their pathogenic potential in a mouse model of colitis and correlated with transcriptomic changes that affected T cell activation. ERα deletion in T cells contributed to multiple aspects of T cell function, includ...
Source: Signal Transduction Knowledge Environment - April 17, 2018 Category: Science Authors: Mohammad, I., Starskaia, I., Nagy, T., Guo, J., Yatkin, E., Väänänen, K., Watford, W. T., Chen, Z. Tags: STKE Research Articles Source Type: news

Contracting mono as a child raises autoimmune disease risks later on
The mono virus binds to susceptible DNA in certain people to reprogram their immune system cells and raise their risks for seven diseases, a Cincinnati Children's Hospital study revealed. (Source: the Mail online | Health)
Source: the Mail online | Health - April 16, 2018 Category: Consumer Health News Source Type: news

Contracting mono as a child raises autoimmune disease risks later in life
The mono virus binds to susceptible DNA in certain people to reprogram their immune system cells and raise their risks for seven diseases, a Cincinnati Children's Hospital study revealed. (Source: the Mail online | Health)
Source: the Mail online | Health - April 16, 2018 Category: Consumer Health News Source Type: news

Epstein-Barr virus protein can “switch on” risk genes for autoimmune diseases
EBV may trigger some cases of lupus, say NIH-supported researchers. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - April 16, 2018 Category: American Health Source Type: news

Apitope Announces Positive Results with Novel Treatment for Graves' Disease
Phase I data show early efficacy in the majority of patients and a very favourable safety profile HASSELT, Belgium and CHEPSTOW, Wales, April 16, 2018 -- (Healthcare Sales & Marketing Network) -- Apitope, a clinical stage biotech company developing pot... Biopharmaceuticals Apitope, Graves' Disease, Multiple Sclerosis, autoimmune disease (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - April 16, 2018 Category: Pharmaceuticals Source Type: news

Cool Digs: For a business that involves needles, Mend Acupuncture has a calming decor
Woven fabrics, soft lighting, calming colors and plenty of greenery make up the offices of Mend Acupuncture. The clinic opened in the Remington Row mixed-use development opened in 2016. A second location in Lutherville opened last year. Acupuncture is often used to manage health difficulties such as digestive problems, anxiety and depression, autoimmune disease and discomforts such as headaches and bac k pain. Many women also use acupuncture treatments for help with fertility and premenstrual syndrome.… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - April 16, 2018 Category: Biotechnology Authors: Carley Milligan Source Type: news

Epstein-Barr virus protein can 'switch on' risk genes for autoimmune diseases
(NIH/National Institute of Allergy and Infectious Diseases) Infection with Epstein-Barr virus (EBV), the cause of infectious mononucleosis, has been associated with subsequent development of systemic lupus erythematosus and other chronic autoimmune illnesses, but the mechanisms behind this association were unclear. Now, a novel computational method shows that a viral protein found in EBV-infected human cells may activate genes associated with increased risk for autoimmunity. Scientists supported by the National Institute of Allergy and Infectious Diseases report their findings today in Nature Genetics. (Source: EurekAlert!...
Source: EurekAlert! - Infectious and Emerging Diseases - April 16, 2018 Category: Infectious Diseases Source Type: news

Immune Checkpoint Inhibitor Therapy in Patients With Autoimmune Disease
In this article, we detail the experience with immune checkpoint inhibitors in patients with autoimmune disease. (Source: CancerNetwork)
Source: CancerNetwork - April 15, 2018 Category: Cancer & Oncology Authors: Daniel Y. Wang, MD Douglas B. Johnson, MD, MSCI Kathryn E. Beckermann, MD, PhD Tags: Immuno Oncology Oncology Journal Source Type: news

You Asked: What Is Inflammation, And Why Should I Care About It?
Your body can heal itself, which is pretty miraculous when you sit back and think about it. If you suffer a cut or infection—or if a disease, allergen or virus finds its way into you—your immune system reacts by sending specialized white blood cells to the affected area. These white blood cells can repair damage, stop the spread of infection or illness and in some cases eradicate the intruder. This whole response is called inflammation. “Inflammation is an activation of cells and cell-derived components that have the job of fighting invasions, and in some cases just sponging up or clearing out damaged cel...
Source: TIME: Health - April 11, 2018 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized healthytime medicine Source Type: news

At Women ’s Health Research at Yale, small steps lead to big results
With a seed grant form WHRY, Yale researchers led by Dr. Martin Kriegel demonstrated that an otherwise beneficial gut bacterium can trigger autoimmune disease. (Source: Yale Science and Health News)
Source: Yale Science and Health News - April 10, 2018 Category: Universities & Medical Training Source Type: news

Measuring autoimmunity in America
NIEHS clinical researcher Fred Miller discussed the increase in autoimmune diseases in the U.S., and the research to better understand why. (read more) (Source: Environmental Factor - NIEHS Newsletter)
Source: Environmental Factor - NIEHS Newsletter - April 3, 2018 Category: Environmental Health Source Type: news

The 7 Best Foods for Fighting Inflammation
The following story is excerpted from TIME’s special edition, 100 Most Healing Foods, which is available in stores, at the Meredith Shop and at Amazon. Inflammation is our body’s healthy response to fighting disease. But when it gets out of hand, inflammation can become chronic and lead to a whole host of health problems, from autoimmune diseases to cancer. Foods high in sugar and saturated fat are thought to contribute to inflammation, which is why some people who have inflammatory conditions and autoimmune disorders try out low-sugar diets. On the flip side, there are also foods to pile onto your plate that m...
Source: TIME: Health - April 2, 2018 Category: Consumer Health News Authors: Alexandra Sifferlin Tags: Uncategorized Diet/Nutrition healthytime Source Type: news

'Molecular scissors' could be key to cutting off diseases including HIV infection
(Ohio State University) One way to fight diseases including HIV infection and autoimmune disorders could involve changing how a naturally occurring enzyme called SAMHD1 works to influence the immune system, new research suggests. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 2, 2018 Category: Cancer & Oncology Source Type: news

Researchers find ways to impede progress of neurodegenerative diseases
(Kazan Federal University) As the paper posits, there is currently no doubt that hyperpolarization of mitochondria and concomitant oxidative stress are associated with the development of serious pathologies, such as Parkinson's disease, Alzheimer's disease, autoimmune syndromes, some cancers, and other conditions. Hyperpolarized mitochondria have an elevated transmembrane potential because of the excess of H+ ions in the intermembrane space in comparison with the matrix (pH 8). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 30, 2018 Category: International Medicine & Public Health Source Type: news

Adult-Onset Type 1 Diabetes, Other Autoimmune Diseases Linked Adult-Onset Type 1 Diabetes, Other Autoimmune Diseases Linked
The risk of developing additional autoimmune conditions rises with age of type 1 diabetes onset.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 27, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Woman with heart-shaped vitiligo patch on her face goes makeup-free
Denise Chamberlain, 42, from Anderson, Indiana was ten when a white spot appeared on her finger after the suspected autoimmune disease caused that area of her skin to lose pigment. (Source: the Mail online | Health)
Source: the Mail online | Health - March 27, 2018 Category: Consumer Health News Source Type: news

Gut microbe drives autoimmunity
A study found that a certain gut microbe can trigger autoimmune disease in mice that are prone to such disease and identified the same microbe in people with autoimmune diseases. (Source: NIH Research Matters from the National Institutes of Health (NIH))
Source: NIH Research Matters from the National Institutes of Health (NIH) - March 27, 2018 Category: Consumer Health News Source Type: news

Tildra approval to give sentimental push to Sun Pharma
​​The drug which will be sold under the brand name Ilumya is expected to treat adults for moderate to severe plaque psoriasis, an autoimmune disease. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - March 22, 2018 Category: Pharmaceuticals Source Type: news

Wide range of drugs affect growth of gut microbes, study says
It ’s not just antibiotics that affect our microbes – a quarter of drugs designed to act on human cells do so tooA wide range of drugs from cancer therapies to antipsychotics affect the growth of microbes that are found in our gut, researchers say, highlighting that it is not only antibiotics that can have an impact on our internal flora.These microbes, whose genes taken together are known as the gut microbiome, play an important role in our health, including for our immune system and our digestion, and have been linked to a host of diseases such as autoimmune conditions, obesity and mood disorders.Continue rea...
Source: Guardian Unlimited Science - March 19, 2018 Category: Science Authors: Nicola Davis Tags: Microbiology Science Drugs Drug resistance Health Source Type: news

A Diagnostic Dilemma: Sometimes You ’ ll Never Know
Patient Presentation A 9-year-old male came to clinic with a 1 month history of painful joint swelling. One month ago he started having right ankle pain that was intermittent but consistent. One day ago his right wrist, right ankle and bilateral knees had some swelling but no erythema or warmth. He says that he has pain in them when he moves but not when he is resting and he denies any joint stiffness or gelling. He also had 1-2 days of multiple red skin lesions on his extremities and trunk, not overlying the affected joints. The skin lesions do not come and go and do not itch. They are mainly discrete circular lesions wi...
Source: PediatricEducation.org - March 19, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

FDA approves CSL Behring rare disease treatment
The Food and Drug Administration granted marketing clearance Friday for Hizentra, a treatment for chronic inflammatory demyelinating polyneuropathy developed by CSL Behring. Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare autoimmune disorder that affects the peripheral nerves and may cause permanent nerve damage. The condition, which afflicts an estimated 40,000 people in the United States, can cause nerve numbness or tingling, muscle weakness, fa tigue and other symptoms. An… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - March 16, 2018 Category: Biotechnology Authors: John George Source Type: news

NIH, industry and non-profits join forces to speed validation of disease targets: Goal is to develop new treatments earlier, beginning with Alzheimer ’s, type 2 diabetes, and autoimmune disorders
(Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Small Molecules Hold Promise to Prevent Type 1 Diabetes
Small molecules show potential in treating autoimmune disease and type 1 diabetes. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Unraveling how mesenchymal stem cells from gum tissue accelerate wound healing
(University of Pennsylvania) Researchers at the University of Pennsylvania set out to determine whether and how gum-derived stem cells play a role in accelerated wound healing. Their results, indicating that these cells secrete tiny vesicles packed with signaling proteins, point the way forward for therapeutic strategies that aim to harness the prowess of stem cells to treat delayed wound healing as well as other conditions that involve an overactive inflammatory response, such as autoimmune diseases. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 14, 2018 Category: International Medicine & Public Health Source Type: news

People desperate for relief from autoimmune and bowel diseases are trying DIY fecal transplants – with disastrous results
(Natural News) Various health trends come and go depending on how effective they are, but here’s one for the books: experts are warning people against DIY fecal transplants, which can reportedly address autoimmune and bowel diseases. This dangerous trend can increase an individual’s risk of hepatitis and HIV along with various conditions like multiple sclerosis, obesity, Parkinson’s, and even sleep... (Source: NaturalNews.com)
Source: NaturalNews.com - March 13, 2018 Category: Consumer Health News Source Type: news

p38{alpha} signaling in Langerhans cells promotes the development of IL-17-producing T cells and psoriasiform skin inflammation
Dendritic cells (DCs) contribute to psoriasis pathogenesis. In a mouse model of imiquimod-induced psoriasiform skin inflammation, we found that p38α activity in Langerhans cells (LCs), a skin-resident subset of DCs, promoted the generation of T cells that produce IL-17, a proinflammatory cytokine that is implicated in autoimmune disease. Deletion of p38α in LCs, but not in other skin or circulating DC subsets or T cells, decreased T cell–mediated psoriasiform skin inflammation in mice. The activity of p38α in LCs specifically promoted IL-17 production from and CD4+ T cells by increasing the abundanc...
Source: Signal Transduction Knowledge Environment - March 13, 2018 Category: Science Authors: Zheng, T., Zhao, W., Li, H., Xiao, S., Hu, R., Han, M., Liu, H., Liu, Y., Otsu, K., Liu, X., Huang, G. Tags: STKE Research Articles Source Type: news