Are western lifestyles causing a rise in autoimmune diseases?
Could the food we eat and the air we breath be damaging our immune systems? The number of people with autoimmune diseases, from rheumatoid arthritis to type 1 diabetes, began to increase around 40 years ago in the west. Now, some are also emerging in countries that had never seen the diseases before.Ian Sample speaks to genetic scientist and consultant gastroenterologist James Lee about how this points to what western lifestyles might be doing to our health, and how genetics could reveal exactly how our immune systems are malfunctioningArchive: King 5 News, WXYZ Channel 7Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - January 20, 2022 Category: Science Authors: Presented by Ian Sample and produced by Madeleine Finlay Tags: Science Biology Genetics Source Type: news

U.S. FDA Approves New MENTOR ® MemoryGel BOOST™ Breast Implant
Irvine, Calif., (January 13, 2021) – Mentor Worldwide LLC, the number one global brand in breast aesthetics, and part of the Johnson & Johnson Medical Devices Companies** today announced that the U.S. Food and Drug Administration (FDA) approved the MENTOR® MemoryGel BOOST™ Breast Implant for breast augmentation in women at least 22 years old, and for women of all ages undergoing breast reconstruction. This product will be commercially available for surgeons in the United States in early 2022. Nearly 400,000 women undergo breast implant surgeries every year in the U.S.[1], and selecting an implant is a v...
Source: Johnson and Johnson - January 13, 2022 Category: Pharmaceuticals Tags: Latest News Source Type: news

Fast-food diets are confusing people's immune systems and leading to a rise in autoimmune diseases
People are suffering because their immune systems cannot tell the difference between a healthy cell and an attacking virus, experts at the Francis Crick Institute in London say. (Source: the Mail online | Health)
Source: the Mail online | Health - January 10, 2022 Category: Consumer Health News Source Type: news

Global spread of autoimmune disease blamed on western diet
New DNA research by London-based scientists hopes to find cure for rapidly spreading conditionsMore and more people around the world are suffering because theirimmune systems can no longer tell the difference between healthy cells and invading micro-organisms. Disease defences that once protected them are instead attacking their tissue and organs.Major international research efforts are being made to fight this trend – including an initiative at London’s Francis Crick Institute, where two world experts, James Lee and Carola Vinuesa, have set up separate research groups to help pinpoint the precise causes of aut...
Source: Guardian Unlimited Science - January 10, 2022 Category: Science Authors: Robin McKie Observer science editor Tags: Medical research Genetics Science Biology Health Society UK news Source Type: news

Consumer Health: What is Hashimoto's disease?
January is Thyroid Awareness Month, which makes this a good time to learn more about Hashimoto's disease. Hashimoto's disease, also known as Hashimoto's thyroiditis, is an autoimmune disorder where your immune system creates antibodies that damage your thyroid gland. The thyroid is a butterfly-shaped gland at the base of your neck. Your thyroid produces hormones that regulate your heart rate, blood pressure, body temperature and weight. Hashimoto's disease is the most common cause of hypothyroidism, or underactive… (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - January 7, 2022 Category: Databases & Libraries Source Type: news

FDA Approves Vyvgart (efgartigimod alfa-fcab) for the Treatment of Generalized Myasthenia Gravis
Breda, the Netherlands—Dec. 17, 2021 - argenx SE (Euronext& Nasdaq: ARGX), a global immunology company committed to improving the lives of people suffering from severe autoimmune diseases and cancer, today announced that the U.S. Food and... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - December 17, 2021 Category: Drugs & Pharmacology Source Type: news

B12 deficiency: The texture of your poo may be a warning sign that levels are low
OLDER adults, vegetarians, and those with autoimmune diseases are at higher risk of a vitamin B12 deficiency. However, anybody can fall short of the important vitamin, which may show up in the texture of your poo. (Source: Daily Express - Health)
Source: Daily Express - Health - December 15, 2021 Category: Consumer Health News Source Type: news

The Pain Was Squeezing His Head Like an Octopus. What Was It?
The diagnosis came from an unlikely source. (Source: NYT Health)
Source: NYT Health - December 15, 2021 Category: Consumer Health News Authors: Lisa Sanders, M.D. Tags: Face Teeth and Dentistry Jaw (Body Part) Autoimmune Diseases Joints (Body Part) Source Type: news

Glenmark's subsidiary Ichnos Sciences enters pact with Almirall for novel drug to treat autoimmune diseases
Under the agreement, Almirall is granted global rights to develop and commercialize this monoclonal antibody for autoimmune diseases. Ichnos will retain rights for antibodies acting on the IL-1RAP pathway for oncology indications. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - December 14, 2021 Category: Pharmaceuticals Source Type: news

Startup launches with $86M to solve drug delivery problems with AI
METiS Therapeutics, based in Cambridge and China, is using machine learning and quantum simulations to develop small-molecule and RNA drugs for orphan diseases, central nervous system disorders and autoimmune diseases. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - December 7, 2021 Category: American Health Authors: Rowan Walrath Source Type: news

Intestinal Worms Inspire New Experimental Therapeutics
Immunologists and parasitologists are working to revive the idea that helminths, and more specifically the molecules they secrete, could help treat allergies and autoimmune disease. (Source: The Scientist)
Source: The Scientist - December 1, 2021 Category: Science Tags: Features Magazine Issue Source Type: news

High Prevalence of Celiac Disease in Autoimmune Hepatitis High Prevalence of Celiac Disease in Autoimmune Hepatitis
Do individuals with autoimmune hepatitis demonstrate a higher prevalence of celiac disease compared to the general population?Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 29, 2021 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Next-generation Precision Medicine Company Allorion Therapeutics Completes Series A Financing Round
Focusing on small molecule drug discovery and development for cancer and autoimmune diseases BOSTON, Nov. 24, 2021 -- (Healthcare Sales & Marketing Network) -- Allorion Therapeutics, a company focusing on next-generation precision medicine for oncology... Biopharmaceuticals, Venture Capital Allorion Therapeutics (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 24, 2021 Category: Pharmaceuticals Source Type: news

Rheumatoid arthritis finding may lead to new inflammation blockers
ROCHESTER, Minn. — Mayo Clinic researchers have linked the T cell dysfunction seen in rheumatoid arthritis with a metabolic deficiency in a new Nature Immunology publication. In "helper" T cells from patients with rheumatoid arthritis, low levels of a specific amino acid lead to cellular miscommunication, but supp lying it may provide a new therapeutic strategy for autoimmune disease. Rheumatoid arthritis is an autoimmune disorder characterized by chronic inflammation, including high levels of a cytokine called… (Source: Mayo Clinic Minnesota News)
Source: Mayo Clinic Minnesota News - November 22, 2021 Category: Hospital Management Source Type: news

Rheumatoid arthritis test: The 11 early signs of arthritis - from bad sleep to weight loss
RHEUMATOID ARTHRITIS is a type of autoimmune disease where the body's immune system attacks the lining of the joints - but what are the key symptoms that could indicate early signs of this inflammatory disease? (Source: Daily Express - Health)
Source: Daily Express - Health - November 18, 2021 Category: Consumer Health News Source Type: news

Employers: Help your employees access affordable, advanced therapies for life-threatening and chronic illnesses
U.S. health care costs continue to increase, and many patients can ’t afford to buy the medicines they need. Patients with chronic and debilitating conditions, such as cancer, autoimmune disorders, diabetes and multiple sclerosis (MS), often face greater financial burden due to high out-of-pocket costs or lack of access to the therapies and treatments they need. Take cancer for example. The disease is one of the leading causes of death worldwide. According to an IQVIA Institute for Human Data Science… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - November 17, 2021 Category: American Health Authors: Laura Newpoff Source Type: news

Sharing Mayo Clinic: Reversing a dire disorder on the road to renewed health
Advanced testing at Mayo Clinic Laboratories that confirmed a diagnosis of myasthenia gravis put Lorinda McKinley on the road to renewed health after she nearly lost it all to the rare autoimmune disease. When Lorinda McKinley arrived at Mayo Clinic ’s Spine Center in February seeking a second opinion for neck surgery, her eyelids were droopy, her jaw routinely fell open, and she couldn’t lift her arms above her head. Based on the results of an… (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - November 14, 2021 Category: Databases & Libraries Source Type: news

COVID Vaccine Response Found Mostly Robust in RA, SLE Patients COVID Vaccine Response Found Mostly Robust in RA, SLE Patients
A trial found that immunosuppressed adults with autoimmune disease had a robust antibody response to the mRNA vaccine with no excess adverse events.Medscape Medical News (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - November 11, 2021 Category: Drugs & Pharmacology Tags: Rheumatology News Source Type: news

A Doctor Asks Two Strange Questions That Reveal a Mysterious Disease
She had a persistent cough that cracked a rib, and her body ached all the time. What was it? (Source: NYT Health)
Source: NYT Health - November 10, 2021 Category: Consumer Health News Tags: Tests (Medical) Coughs Doctors Steroids Arthritis Joints (Body Part) Autoimmune Diseases Source Type: news

Ichnos Sciences Appoints Sonia Quaratino, M.D., Ph.D., To Its Board Of Directors
NEW YORK, Nov. 9, 2021 -- (Healthcare Sales & Marketing Network) -- Ichnos Sciences Inc., a global biotechnology company developing innovative biologics in oncology and autoimmune diseases, announced that Sonia Quaratino, M.D., Ph.D., has been appointed a... Biopharmaceuticals, Oncology, Personnel Ichnos Sciences (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 9, 2021 Category: Pharmaceuticals Source Type: news

Vitamin D and Omega-3 Reduce Autoimmune Issues
Vitamin D and Omega-3 Supplements Reduce Autoimmune Disease Risk (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - November 8, 2021 Category: General Medicine Source Type: news

Vitamin D and Omega-3 Supplements Reduce Autoimmune Disease Risk Vitamin D and Omega-3 Supplements Reduce Autoimmune Disease Risk
The effect was strongest with vitamin D, with significant risk reduction beginning more than 2 years after the start of daily supplementation.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - November 8, 2021 Category: Cardiology Tags: Allergy & Clinical Immunology News Source Type: news

NC firm to coordinate study on Covid vaccines, autoimmune disease
The study will assess the antibody response to an additional Covid-19 vaccine dose in people with an autoimmune disease who did not respond to an initial vaccine regimen. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - November 7, 2021 Category: American Health Authors: Zac Ezzone Source Type: news

NC firm to coordinate study on Covid vaccines, autoimmune disease
The study will assess the antibody response to an additional Covid-19 vaccine dose in people with an autoimmune disease who did not respond to an initial vaccine regimen. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - November 7, 2021 Category: Biotechnology Authors: Zac Ezzone Source Type: news

Janssen to Present the Strength and Promise of its Hematologic Malignancies Portfolio and Pipeline at ASH 2021
RARITAN, N.J., November 4, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than 45 company-sponsored abstracts, including 11 oral presentations, plus more than 35 investigator-initiated studies will be featured at the American Society of Hematology (ASH) Annual Meeting and Exposition. ASH is taking place at the Georgia World Congress Center in Atlanta and virtually from December 11-14, 2021.“We are committed to advancing the science and treatment of hematologic malignancies and look forward to presenting the latest research from our robust portfolio and pipeline du...
Source: Johnson and Johnson - November 5, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

RTP firm to coordinate study on Covid vaccines, autoimmune disease
The study will assess the antibody response to an additional Covid-19 vaccine dose in people with an autoimmune disease who did not respond to an initial vaccine regimen. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - November 4, 2021 Category: Biotechnology Authors: Zac Ezzone Source Type: news

Alopecia Tied to a Threefold Increased Risk for Dementia Alopecia Tied to a Threefold Increased Risk for Dementia
Alopecia areata, an autoimmune disease that causes hair loss, including baldness, has been linked to a significantly increased risk for dementia, new research shows.Medscape Medical News (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - November 3, 2021 Category: Dermatology Tags: Psychiatry News Source Type: news

Company raises $55M to advance therapies for celiac, other autoimmune disorders
Biotech company Mozart Therapeutics has raised $55 million in Series A funding. Mozart is targeting autoimmune and inflammatory diseases through a network of what are called CD8 regulatory T cells. The work is built on the research of T cell biology expert Mark M. Davis. Mozart said the Series A will help the company to progress its treatment to the clinic while advancing oth er programs as well. "Mozart is doing something truly unique to change the treatment paradigm for patients with autoimmune… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - October 29, 2021 Category: Pharmaceuticals Authors: Rick Morgan Source Type: news

Company raises $55M to advance therapies for celiac, other autoimmune disorders
Biotech company Mozart Therapeutics has raised $55 million in Series A funding. Mozart is targeting autoimmune and inflammatory diseases through a network of what are called CD8 regulatory T cells. The work is built on the research of T cell biology expert Mark M. Davis. Mozart said the Series A will help the company to progress its treatment to the clinic while advancing oth er programs as well. "Mozart is doing something truly unique to change the treatment paradigm for patients with autoimmune… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - October 29, 2021 Category: Biotechnology Authors: Rick Morgan Source Type: news

Mozart Therapeutics raises $55M to advance disease therapies
Seattle-based biotech company Mozart Therapeutics has raised $55 million in Series A funding. Mozart is targeting autoimmune and inflammatory diseases through a network of what are called CD8 regulatory T cells. The work is built on the research of T cell biology expert Mark M. Davis. Mozart said the Series A will help the company to progress its treatment to the clinic while advancing oth er programs as well. "Mozart is doing something truly unique to change the treatment paradigm for patients… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - October 26, 2021 Category: American Health Authors: Rick Morgan Source Type: news

Cambridge woman outraged after late sister's photos used in Ontario MPP's anti-vaccination posts
A Cambridge woman is demanding an apology from Ontario MPP Randy Hillier after a photo and personal information of her late sister, who died from a rare autoimmune disease, were used without permission in his anti-vaccination social media posts. (Source: CBC | Health)
Source: CBC | Health - October 21, 2021 Category: Consumer Health News Tags: News/Canada/Kitchener-Waterloo Source Type: news

GSK taps at-home test maker Viome Life Sciences to research cancer, autoimmune diseases
The partnership expands on the companies ’ earlier collaboration announced in late 2019. (Source: mobihealthnews)
Source: mobihealthnews - October 20, 2021 Category: Information Technology Source Type: news

FDA Approves Avacopan for Rare ANCA Autoimmune Disease FDA Approves Avacopan for Rare ANCA Autoimmune Disease
ChemoCentryx said it plans to price its new medicine at an annual cost of $150,000 to $200,000 for US patients.Orphan Drug Approvals (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - October 8, 2021 Category: Dermatology Tags: Rheumatology News Alert Source Type: news

IpiNovyx Bio gets seed funds from Eli Lilly, others
The company develops treatments for autoimmune and inflammatory diseases. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - October 5, 2021 Category: American Health Authors: I-Chun Chen Source Type: news

Young woman, 25, reveals the terrifying moment she was diagnosed with skin cancer
A young woman who has been battling with an incurable autoimmune disease since the age of 17 has spoken of the terrifying moment she was diagnosed with skin cancer at 25. (Source: the Mail online | Health)
Source: the Mail online | Health - October 1, 2021 Category: Consumer Health News Source Type: news

Can Breakthrough Infections Lead to Long COVID? For an Unlucky Few, Yes
When health experts talk about the remarkable efficacy of COVID-19 vaccines, they typically point to their ability to prevent severe disease and death. Fully vaccinated people can still get “breakthrough” infections from the virus that causes COVID-19—but compared to an unvaccinated person, they’re more than 10 times less likely to be hospitalized or die from their illness, according to U.S. Centers for Disease Control and Prevention (CDC) research. Officials often point to these impressive figures as evidence that we can tame COVID-19 into a mostly mild illness that behaves like a routine cold or f...
Source: TIME: Health - September 30, 2021 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news

Woman who dropped to four stone with rare autoimmune disease says OnlyFans money 'saved my life'
Ex legal worker Rachael Huckle, from Wrexham, says money made from racy cosplay photos have paid for private treatment for pemphigus, which causes blisters in the digestive system. (Source: the Mail online | Health)
Source: the Mail online | Health - September 24, 2021 Category: Consumer Health News Source Type: news

Cell therapy partnership between Bay Area biotechs offers hope to cancer patients
Imagine a world in which physicians can confidently cure cancer. Two Bay Area life sciences companies are working together to make this vision a reality. Atara Biotherapeutics Inc., founded in 2012, is developing a pipeline of cell therapies to treat various types of cancer and autoimmune diseases. Bayer is licensing Atara’s cutting-edge cell therapies that t arget certain types of aggressive tumors including mesothelioma, pancreatic, ovarian and non-small-cell lung cancer. “With cancer therapies,… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - September 16, 2021 Category: Pharmaceuticals Authors: Lauren Lawley Head Source Type: news

Kyverna Therapeutics Appoints Ian Clark as Chairman of the Board and Karen Walker as Chief Technology Officer
Former Genentech CEO Ian Clark will guide Kyverna's vision to transform the treatment of autoimmune diseases through engineered cell therapies Seasoned pharmaceutical executive Karen Walker will lead technical development of Kyverna's T-cell therapies ... Biopharmaceuticals, Personnel Kyverna Therapeutics, cell therapy (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - September 15, 2021 Category: Pharmaceuticals Source Type: news

Association Between Atopic Dermatitis and Autoimmune Diseases Association Between Atopic Dermatitis and Autoimmune Diseases
This large population-based study explored the association between atopic dermatitis and a wide spectrum of autoimmune diseases. Which autoimmune disorders had the strongest association?The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 15, 2021 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

Study finds more than HALF of patients hospitalized with COVID-19 develop autoantibodies
Over half of patients hospitalized with COVID-19 develop 'rogue antibodies' that attack their own body tissues - potentially causing autoimmune disease - a new Stanford study finds. (Source: the Mail online | Health)
Source: the Mail online | Health - September 14, 2021 Category: Consumer Health News Source Type: news

Childhood trauma, dissociation, alexithymia, and anger in people with autoimmune diseases: a mediation model - Macarenco MM, Opariuc-Dan C, Nedelcea C.
BACKGROUND: Despite research linking dissociation, alexithymia, and anger with childhood trauma and ADs, the investigation addressing the relationships between the potential mediators has not yet been established within the literature. OBJECTIVE: T... (Source: SafetyLit)
Source: SafetyLit - September 14, 2021 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

How does Lichen Sclerosus et Atrophicus Present?
Discussion Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory disease with a strong autoimmune association. It can occur with other autoimmune diseases. Its specific cause is unknown. It affects females and males of all ages, but especially females 40-60 years. In the pediatric population it affects prepubertal females most often. Treatment includes steroid medications or anti-inflammatory medications. Other treatments may be offered including phototherapy, and much less commonly systemic steroids or immunosuppressive therapy. Circumcision may also be an option for some males. Childhood LSA generally improves b...
Source: PediatricEducation.org - September 6, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Prime Therapeutics rises to Minnesota's No. 2 largest private company as pharmacy costs rise
CEO Ken Paulus said the company ’s steady growth has largely been driven by increases in pharmacy spending, specifically for prescription medications used to treat complex conditions including oncology, autoimmune and rare diseases. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - September 2, 2021 Category: American Health Authors: Carter Jones Source Type: news

Prime Therapeutics rises to Minnesota's No. 2 largest private company as pharmacy costs rise
CEO Ken Paulus said the company ’s steady growth has largely been driven by increases in pharmacy spending, specifically for prescription medications used to treat complex conditions including oncology, autoimmune and rare diseases. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - September 2, 2021 Category: Biotechnology Authors: Carter Jones Source Type: news

Arthritis diet: Three healthy foods that can ‘trigger’ painful arthritis symptoms
ARTHRITIS comes in many forms but one of the most common is rheumatoid arthritis - an autoimmune disease. According to the Physicians Committee for Responsible Medicine, there are three healthy foods that can "trigger" arthritis. (Source: Daily Express - Health)
Source: Daily Express - Health - September 1, 2021 Category: Consumer Health News Source Type: news

COVID Vax Booster Trial Begun in People With Autoimmune Disease COVID Vax Booster Trial Begun in People With Autoimmune Disease
The trial will investigate the impact of a booster in patients with five autoimmune diseases who are either on or off immunosuppressives.Medscape Medical News (Source: Medscape Rheumatology Headlines)
Source: Medscape Rheumatology Headlines - August 30, 2021 Category: Rheumatology Tags: Rheumatology News Source Type: news

NIH launches study of extra COVID-19 vaccine dose in people with autoimmune disease
Trial also will test pausing immunosuppressive medication to improve antibody response. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - August 27, 2021 Category: American Health Source Type: news

What Causes Anisocoria?
Discussion Anisocoria is a common physical finding caused by the mechanical imbalance of the iris dilator (sympathetic innervation causing dilation) and sphincter muscles (parasympathetic innervation causes miosis). Which pupil is abnormal is important to determine. “Anisocoria greater in the light signifies an abnormal large pupil, whereas anisocoria in the dark indicates an abnormal small pupil.” The pupillary size should be noted along with any changes with accommodation, extra ocular movements and lighting. The time it takes to revert to the baseline pupillary size can also be helpful. Any ptosis, lacrimati...
Source: PediatricEducation.org - August 23, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits TH17 cell expansion
The cytokine interleukin-6 (IL-6) signals through three mechanisms called classic signaling, trans-signaling, and trans-presentation. IL-6 trans-signaling is distinctly mediated through a soluble form of its transmembrane receptor IL-6R (sIL-6R) and the coreceptor gp130 and is implicated in multiple autoimmune diseases. Although a soluble form of gp130 (sgp130) inhibits only IL-6 trans-signaling, it also blocks an analogous trans-signaling mechanism of IL-11 and its soluble receptor sIL-11R. Here, we report miniaturized chimeric soluble gp130 variants that efficiently trap IL-6:sIL-6R but not IL-11:sIL-11R complexes. We de...
Source: Signal Transduction Knowledge Environment - August 17, 2021 Category: Science Authors: Heise, D., Derrac Soria, A., Hansen, S., Dambietz, C., Akbarzadeh, M., Berg, A. F., Waetzig, G. H., Jones, S. A., Dvorsky, R., Ahmadian, M. R., Scheller, J., Moll, J. M. Tags: STKE Research Articles Source Type: news