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[Influence of epigenetic in Sj ögren's syndrome].
[Influence of epigenetic in Sjögren's syndrome]. Rev Med Interne. 2017 Oct 17;: Authors: Bordron A, Charras A, Le Dantec C, Renaudineau Y Abstract Sjögren's syndrome (SS) is a systemic autoimmune epithelitis with a major female incidence, and characterized by a dry syndrome, impaired quality of life, visceral involvement, and lymphoma for the most aggressive cases. During this process, epithelial cells acquire the capacity to produce cytokines, chemokines, and autoantigens which can in turn be presented to the immune system. Consequently, this epithelitis is accompanied by lymphocytic infiltr...
Source: Revue de Medecine Interne - October 23, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

The Role of Innate lymphoid cells in health and disease
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - October 23, 2017 Category: Cytology Authors: Hamed Mohammadi, Nadia Sharafkandi, Maryam Hemmatzadeh, Gholamreza Azizi, Mohammad Karimi, Farhad Jadidi ‐Niaragh, Behzad Baradaran, Zohreh Babaloo Tags: REVIEW ARTICLE Source Type: research

Spectrophotometer is useful for assessing vitiligo and chemical leukoderma severity by quantifying color difference with surrounding normally pigmented skin
ConclusionΔE*ab has been frequently used in aesthetic dentistry; however, current study is the first to use it in the measurement of skin color. ΔE*ab seems to be a useful parameter to evaluate the color contrast between vitiligo/leukoderma and surrounding normally pigmented skin and can be used to evaluate disease severity and patient's quality of life. (Source: Skin Research and Technology)
Source: Skin Research and Technology - October 22, 2017 Category: Dermatology Authors: M. Hayashi, K. Okamura, Y. Araki, M. Suzuki, T. Tanaka, Y. Abe, S. Nakano, J. Yoshizawa, Y. Hozumi, M. Inoie, T. Suzuki Tags: ORIGINAL ARTICLE Source Type: research

Murine Gammaherpesvirus 68: A Small Animal Model for Gammaherpesvirus-Associated Diseases.
Authors: Dong S, Forrest JC, Liang X Abstract Murine gammaherpesvirus 68 (MHV68) is a naturally occurring pathogen of murid rodents that is genetically related to the human gammaherpesviruses Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV). Viral, immunologic, and disease parameters following experimental infection of laboratory mice with MHV68 closely resemble what occurs during primary EBV infection of humans, which suggests that MHV68 infection of mice offers a small animal model to study in general the pathogenesis of gammaherpesvirus infections. Diseases elicited by MHV68 infection in...
Source: Advances in Experimental Medicine and Biology - October 21, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Anti-complementary activity of two homogeneous polysaccharides from Eclipta prostrata.
Abstract Complement-mediated inflammation and tissue damage is an important drive to pathology in autoimmune diseases, targeting inhibit the complement activation is promising treatment strategy for these diseases. We performed anticomplement activity-guided fractionation of the water extract of Eclipta prostrata by ion-exchange and size-exclusion chromatography, yielding two bioactive polysaccharides EAP20-1 and EAP20-2. The molecular weights of EAP20-1 and EAP20-2 were respectively calculated to be 5.2 kDa and 6.3 kDa by HPGPC, both polysaccharides was composed by d-Gal, l-Glc, and Ara at different rat...
Source: Biochemical and Biophysical Research communications - October 21, 2017 Category: Biochemistry Authors: Wang H, Li N, Zhu C, Shi S, Jin H, Wang S Tags: Biochem Biophys Res Commun Source Type: research

MicroRNA-590 promotes pathogenic Th17  cell differentiation through targeting Tob1 and is associated with multiple sclerosis.
MicroRNA-590 promotes pathogenic Th17 cell differentiation through targeting Tob1 and is associated with multiple sclerosis. Biochem Biophys Res Commun. 2017 Nov 18;493(2):901-908 Authors: Liu Q, Gao Q, Zhang Y, Li Z, Mei X Abstract Although the exact pathogenesis of multiple sclerosis (MS) remains largely unclear, Th17 cells have been suggested as an essential regulator in the disease induction. Emerging evidence have demonstrated that noncoding RNAs, especially microRNAs (miRs), play a crucial role in modulation of Th17 cell differentiation and autoimmune disease development. Here, we...
Source: Biochemical and Biophysical Research communications - October 21, 2017 Category: Biochemistry Authors: Liu Q, Gao Q, Zhang Y, Li Z, Mei X Tags: Biochem Biophys Res Commun Source Type: research

Increased prevalence of diabetes mellitus in bullous pemphigoid patients during the last decade
This article is protected by copyright. All rights reserved. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - October 21, 2017 Category: Dermatology Authors: Luca Fania, Giovanni Di Zenzo, Biagio Didona, Maria Antonietta Pilla, Luciano Sobrino, Annarita Panebianco, Cinzia Mazzanti, Damiano Abeni Tags: Letter to Editor Source Type: research

Amelioration of ongoing experimental autoimmune encephalomyelitis with fluoxetine
In patients with multiple sclerosis, the selective serotonin reuptake inhibitor, fluoxetine, resulted in less acute disease activity. We tested the immune modulating effects of fluoxetine in a mouse model of multiple sclerosis, i.e. experimental autoimmune encephalomyelitis (EAE). We show that fluoxetine delayed the onset of disease and reduced clinical paralysis in mice with established disease. Fluoxetine had abrogating effects on proliferation of immune cells and inflammatory cytokine production by both antigen-presenting cells and T cells. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - October 21, 2017 Category: Allergy & Immunology Authors: Roopa Bhat, Sidharth Mahapatra, Robert C. Axtell, Lawrence Steinman Source Type: research

The Heart in Rheumatic, Autoimmune and Inflammatory Diseases
Editor: Udi Nussinovitch MD PhD (Source: European Heart Journal)
Source: European Heart Journal - October 21, 2017 Category: Cardiology Source Type: research

HDL functionality in type 1 diabetes
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by absence of insulin secretion due to destruction of the pancreatic beta-cells. Patients with T1D exhibit an increased risk for cardiovascular disease (CVD) compared with non-diabetic subjects. It has been established that low concentration of high ‐density lipoprotein cholesterol (HDL-C), an independent risk marker of CVD, coincides with a reduced protective capacity against oxidative stress. However, conflicting results have been reported on the prevalence of low HDL-C levels in T1D. (Source: Atherosclerosis)
Source: Atherosclerosis - October 21, 2017 Category: Cardiology Authors: Shiva Ganjali, Geesje M. Dallinga-Thie, Luis E. Simental-Mend ía, Maciej Banach, Matteo Pirro, Amirhossein Sahebkar Tags: Review article Source Type: research

Case Report: Cutaneous Metastasis of Lung Carcinoma
Cutaneous lesions can represent a primary dermatologic process, or be a sign of a systemic disorder. Of emergency department visits for skin complaints, infection/cellulitis is the most common diagnosis (representing  > 50% of cases), followed by dermatitis and urticaria (1). However, certain skin lesions are signs of a systemic disease, such as in patients with autoimmune disorders (the characteristic butterfly rash of systemic lupus erythematosus) and systemic infections (Kaposi sarcoma associated with human im munodeficiency virus/AIDS). (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - October 21, 2017 Category: Emergency Medicine Authors: Breanne B. Jacobs, Stephen Sanders Tags: Visual Diagnosis in Emergency Medicine Source Type: research

An Overview of Vesicobullous Conditions Affecting the Oral Mucosa.
Authors: Hayes E, Challacombe SJ Abstract Vesicobullous diseases are characterised by the presence of vesicles or bullae at varying locations in the mucosa. The most common occurring in the oral cavity are mucous membrane pemphigoid (MMP) and pemphigus vulgaris (PV). Both are autoimmune diseases with a peak age onset of over 60 years and females are more commonly affected than men. This paper reviews the structure of the oral mucosa, with specific reference to the basement membrane zone, as well as bullous conditions affecting the mucosa, including PV and pemphigoid, their aetiology, clinical presentation, and mana...
Source: Primary dental care : journal of the Faculty of General Dental Practitioners UK - October 20, 2017 Category: Dentistry Tags: Prim Dent J Source Type: research

Oral Lichen Planus.
Authors: Ion DI, Setterfield JF Abstract Lichen planus (LP) is a relatively common autoimmune T-cell-mediated disease of unknown aetiology affecting the mucous membranes, skin and nails. Its prevalence varies between 0.5 and 2.2% of the population in epidemiological studies with a peak incidence in the 30-60 years range and with a female predominance of 2:1. Mucosal lichen planus tends to follow a chronic course with acute exacerbations. Spontaneous remission of oral lichen planus (OLP) is uncommon, and indeed mucosal LP may become worse with time. In contrast, cutaneous lichen planus may follow a milder clinical c...
Source: Primary dental care : journal of the Faculty of General Dental Practitioners UK - October 20, 2017 Category: Dentistry Tags: Prim Dent J Source Type: research

Multiple sclerosis and sexual dysfunction: A  need for further education and interdisciplinary care.
CONCLUSIONS: Additional education for providers regarding the approach to assessment and management of sexual dysfunction, their potential role in treatment, and available specialized resources is needed. The role of interdisciplinary care with collaboration among providers should be considered. Further research should evaluate the impact of specific assessment tools and treatments on sexual dysfunction in PwMS. PMID: 29036844 [PubMed - as supplied by publisher] (Source: NeuroRehabilitation)
Source: NeuroRehabilitation - October 20, 2017 Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research

Frequency and distribution of CD4+CXCR5+ follicular B helper T  cells within involved tissues in IgG4‑related ophthalmic disease.
Frequency and distribution of CD4+CXCR5+ follicular B helper T cells within involved tissues in IgG4‑related ophthalmic disease. Mol Med Rep. 2017 Oct 12;: Authors: Yang H, Wei R, Liu Q, Shi Y, Li J Abstract Immonoglobulin G4‑related ophthalmic disease (IgG4‑ROD) is a IgG4‑RD and exhibits two main characteristics: Fibrosis that is not necessarily marked histopathologically; and frequent formation of germinal centers (GCs). Follicular B helper T (Tfh) cells are now recognized as the true helper cells for B cells in antibody responses. In the present study, the profile and distribution of Tf...
Source: Molecular Medicine Reports - October 20, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Gastrointestinal bleeding associated with chronic excessive use overdosing with topical ketoprofen patch in elderly patient.
CONCLUSIONS: Extensive care should be taken to avoid ulcerative intestinal hemorrhage to elderly patients receiving multiple doses of non-steroidal anti-inflammatory drug patch for multiple days. PMID: 29043859 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - October 20, 2017 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The molecular basis for peptide repertoire selection in the human leucocyte antigen (HLA) C*06:02 molecule [Immunology]
Human leukocyte antigen (HLA)-C*06:02 is identified as the allele associated with the highest risk for the development of the autoimmune skin disease psoriasis. However, the diversity and mode of peptide presentation by the HLA-C*06:02 molecule remains unclear. Here, we describe the endogenous peptide repertoire of ∼3,000 sequences for HLA-C*06:02 that defines the peptide-binding motif for this HLA allomorph. We found that HLA-C*06:02 predominantly presents nonamer peptides with dominant arginine anchors at the P2 and P7 positions and a preference for small hydrophobic residues at the C terminus (PΩ). To determin...
Source: Journal of Biological Chemistry - October 20, 2017 Category: Chemistry Authors: Jesse I. Mobbs, Patricia T. Illing, Nadine L. Dudek, Andrew G. Brooks, Daniel G. Baker, Anthony W. Purcell, Jamie Rossjohn, Julian P. Vivian Tags: Protein Structure and Folding Source Type: research

Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody [Immunology]
The neonatal Fc receptor FcRn plays a critical role in the trafficking of IgGs across tissue barriers and in retaining high circulating concentrations of both IgG and albumin. Although generally beneficial from an immunological perspective in maintaining IgG populations, FcRn can contribute to the pathogenesis of autoimmune disorders when an abnormal immune response targets normal biological components. We previously described a monoclonal antibody (DX-2507) that binds to FcRn with high affinity at both neutral and acidic pH, prevents the simultaneous binding of IgG, and reduces circulating IgG levels in preclinical animal...
Source: Journal of Biological Chemistry - October 20, 2017 Category: Chemistry Authors: Jon A. Kenniston, Brandy M. Taylor, Gregory P. Conley, Janja Cosic, Kris J. Kopacz, Allison P. Lindberg, Stephen R. Comeau, Kateri Atkins, Jameson Bullen, Christopher TenHoor, Burt A. Adelman, Daniel J. Sexton, Thomas E. Edwards, Andrew E. Nixon Tags: Immunology Source Type: research

In search of regulatory circuits that control the biological activity of vitamin D [Genomics and Proteomics]
Although the cytochrome P450 CYP27B1 plays a critical role in vitamin D biology, the molecular mechanisms involved in regulation of CYP27B1 have remained undefined. A new study has identified a kidney-specific control module distal to the Cyp27b1 gene that mediates the basal activity and hormonal regulation of Cyp27b1. This work provides a novel mechanism indicating differential regulation of Cyp27b1 in renal and non-renal cells and has implications for vitamin D biology in multiple sclerosis and perhaps other autoimmune diseases as well. (Source: Journal of Biological Chemistry)
Source: Journal of Biological Chemistry - October 20, 2017 Category: Chemistry Authors: Sylvia Christakos Tags: Editors ' Picks Highlights Source Type: research

Methotrexate-associated osteonecrosis of the jaw: A report of two cases
We present 2 cases of ONJ in patients with long-standing arthritis treated with methotrexate in the absence of a lymphoproliferative disorder and antiresorptive or antiangiogenic medications. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - October 20, 2017 Category: ENT & OMF Source Type: research

Phagocytosis Deficiency of Macrophages in NOD.H-2(h4) Mice Accelerates the Severity of Iodine-Induced Autoimmune Thyroiditis.
In conclusion, deficiencies in the apoptosis clearance of macrophages in NOD.H-2(h4) mice may constitute an early pathogenic mechanism in AIT that is not influenced by iodine intake. PMID: 29052174 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - October 20, 2017 Category: Biology Authors: He X, Xiong C, Liu A, Zhao W, Xia X, Peng S, Li C, Zhou M, Li Y, Shi X, Shan Z, Teng W Tags: Biol Trace Elem Res Source Type: research

The Rare Complication and Diagnostic Challenges of Pulmonary Eosinophilia in Graft versus Host Disease Patients after Hematopoietic Stem Cell Transplantation
ConclusionWe propose that in post-HSCT patients with GvHD presenting with respiratory symptoms, GGO on CT, BAL eosinophilia of  >  10%, and negative respiratory cultures, an autoimmune eosinophilic process may be occurring. Earlier recognition and initiation of corticosteroids in these patients may improve their outcomes as an autoimmune diagnosis was often delayed in favor of antibiotics. (Source: Lung)
Source: Lung - October 20, 2017 Category: Respiratory Medicine Source Type: research

IgG4-related orbital disease masquerading as thyroid eye disease, vice versa, or both?
Abstract A 40 year-old male presented after one year of unilateral, progressive, steroid-responsive, orbital inflammatory disease causing proptosis, extraocular muscle (EOM) restriction, and compressive optic neuropathy. The development of anti-thyroidal antibodies prompted the diagnosis of thyroid eye disease (TED); however, the prolonged active phase, remarkable reversibility of ophthalmic features with high-dose corticosteroids, unilaterally of disease, uncharacteristic EOM involvement (including both obliques), and the absence of autoimmune thyroid disease provoked consideration of alternative diagnoses. ...
Source: Orbit - October 20, 2017 Category: Opthalmology Authors: Khandji J, Campbell AA, Callahan AB, Sirinek P, Kazim M Tags: Orbit Source Type: research

Supramolecular aggregation of aquaporin-4 is different in muscle and brain: correlation with tissue susceptibility in neuromyelitis optica.
In conclusion, our results provide evidence that AQP4 supramolecular structure is different in brain and skeletal muscle, which is likely to result in different tissues susceptibility to the NMO disease. PMID: 29055082 [PubMed - as supplied by publisher] (Source: J Cell Mol Med)
Source: J Cell Mol Med - October 20, 2017 Category: Molecular Biology Authors: Rosito S, Nicchia GP, Palazzo C, Lia A, Buccoliero C, Pisani F, Svelto M, Trojano M, Frigeri A Tags: J Cell Mol Med Source Type: research

The value of the BIOCHIP mosaic-based indirect immunofluorescence technique in the diagnosis of pemphigus and bullous pemphigoid in Turkish patients
Autoimmune bullous diseases (ABD) are a rarely seen group of diseases, of which pemphigus and bullous pemphigoid (BP) are the major groups. Diagnosis is generally based on the combination of clinical features, histopathologic and immunofluorescence (IF) findings, and/or enzyme-linked immunosorbent assay (ELISA). Aims of the work wereto determine the value of the innovative BIOCHIP mosaic-based indirect IF technique in the diagnosis of pemphigus and BP in Turkish patients. A total of 63 patients (45 pemphigus and 18 BP) in the active phase of the disease alongside 35 healthy controls were included in the study. All sera fro...
Source: Acta Dermatovenerologica Croatica - October 19, 2017 Category: Dermatology Source Type: research

Spectrum of autoimmune bullous diseases in northern Greece. A 4-year retrospective study and review of the literature
Bullous Diseases Unit at the 2nd Department of Dermatology and Venereology, Aristotle University of Thessaloniki was founded with the aim to provide the optimal diagnostic approach and treatment of patients with autoimmune bullous diseases (A ΙBD).  We processed all AIBD files of patients diagnosed from 2011 to 2014 in order to record all epidemiological data and therapeutic manipulations during monitoring. 57 patients were diagnosed with intraepidermal and 62 with subepidermal bullous diseases. There were 51 cases (89%) of pemphigus v ulgaris (PV) and 6 (11%) of pemphigus foliaceus (PF), whereas 45 (73%) patient...
Source: Acta Dermatovenerologica Croatica - October 19, 2017 Category: Dermatology Source Type: research

HLA-E*0101/0103X is associated with susceptibility to pemphigus vulgaris: a case-control study
Pemphigus vulgaris (PV) is a life-threatening, autoimmune blistering disease of the skin and mucous membranes. The relationship between PV and human leukocyte antigen (HLA) has been studied in several reports. Previous reports have demonstrated that HLA-E polymorphisms may have a role in the susceptibility to various autoimmune diseases. Our aim was to evaluate the role of HLA-E gene polymorphisms in the pathogenesis of PV in a Turkish population. A total of 49 patients with PV and 50 healthy subjects were enrolled into the study. We sequenced and analyzed the HLA-E gene from genomic DNA obtained from peripheral blood samp...
Source: Acta Dermatovenerologica Croatica - October 19, 2017 Category: Dermatology Source Type: research

Epidemiology of pemphigus in Turkey: One-year prospective study of 220 cases
Pemphigus is a group of rare and life-threatening autoimmune blistering diseases of the skin and mucous membranes. Although they occur worldwide, their incidence shows wide geographical variation, and prospective data on the epidemiology of pemphigus are very limited. Objective of this work is to evaluate the incidence and epidemiological and clinical features of patients with pemphigus in Turkey. All patients newly diagnosed with pemphigus between June 2013 and June 2014 were prospectively enrolled in 33 dermatology departments in 20 different provinces from all seven regions of Turkey. Disease parameters including demogr...
Source: Acta Dermatovenerologica Croatica - October 19, 2017 Category: Dermatology Source Type: research

Unusual Case of Posterior Reversible Encephalopathy Syndrome in a Patient with Anti-glomerular Basement Membrane Antibody Glomerulonephritis: A Case Report and Review of the Literature.
Authors: Cha B, Kim DY, Jang H, Hwang SD, Choi HJ, Kim MJ Abstract Posterior reversible encephalopathy syndrome (PRES) is characterized by a clinical and radiological entity with the sudden onset of seizures, headache, altered consciousness, and visual disturbances in patients with the findings of reversible vasogenic subcortical edema without infarction. Hypertension, renal disease, and autoimmune disease are co-morbid conditions of PRES. Nevertheless, there have only been a few case reports of PRES in a patient with anti-glomerular basement membrane antibody glomerulonephritis (anti-GBM GN). This paper presents t...
Source: Electrolyte and Blood Pressure - October 19, 2017 Category: Internal Medicine Tags: Electrolyte Blood Press Source Type: research

[Differential Diagnosis of Mediastinal and Hilar Lymphadenopathy with Focus on Occupational Diseases].
This article is intended to facilitate differential diagnosis by a systematic description of relevant pathologies, notably with occupational etiology. Clinical findings of relevant diseases, i. e. of tuberculosis, chronic beryllium disease, sarcoidosis, lung cancer, malignant lymphoma, Epstein-Barr virus infection, and histoplasmosis are compared.Case history, imaging and laboratory tests have important diagnostic impact. But also invasive methods can be necessary in order to exclude and prove malignancy, infection or autoimmune disease. PMID: 29046010 [PubMed - as supplied by publisher] (Source: Pneumologie)
Source: Pneumologie - October 19, 2017 Category: Respiratory Medicine Tags: Pneumologie Source Type: research

A randomized phase I study to evaluate the safety, tolerability, pharmacokinetics and food-effect of Iguratimod in healthy adult volunteers
ConclusionsThe maximum tolerated dose for iguratimod was confirmed to be 50  mg. The ingestion of food was able to increase the peak concentration of iguratimod and shorten the time to peak concentration. Therefore, based on our results, iguratimod can be administered with food. The PK profile and metabolic effects of iguratimod support further clinical development for its application in treating autoimmune diseases. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 19, 2017 Category: Drugs & Pharmacology Source Type: research

Dendrimers: Breaking the paradigm of current musculoskeletal autoimmune therapies
Abstract The advances achieved by cell‐based therapies to treat autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS), despite promising, are still insufficient for the current demands. RA and MS therapeutic approaches follow world guidelines to use disease modifying drugs and biological agents which, regardless of some good results in clinical outcomes, are well known for several systemic secondary side effects. Dendrimers are custom‐made nanoparticles with proved clinical potential, displaying proper size, chemistries, immunomodulatory and anti‐inflammatory properties. This has directed ...
Source: Journal of Tissue Engineering and Regenerative Medicine - October 19, 2017 Category: Biotechnology Authors: Daniel B. Rodrigues, Joaquim M. Oliveira, T írcia C. Santos, Rui L. Reis Tags: REVIEW Source Type: research

Inflammation, circadian rest-activity rhythms, and behavioral sequelae of chronic graft-versus-host disease
Publication date: November 2017 Source:Brain, Behavior, and Immunity, Volume 66, Supplement Author(s): E.S. Costanzo, M.B. Juckett, C.L. Coe, D.A. Dickson, K. Morris, P. Hematti, M.E. Rumble Chronic graft-versus-host-disease (cGVHD) is a common complication of hematopoietic stem cell transplantation that involves alloegeneic and autoimmune dysregulation affecting multiple organ systems. We hypothesized that disrupted circadian rest-activity rhythms and inflammation contribute to co-occurring behavioral symptoms in this population. Adults with cGVHD (N=55) wore a wrist actigraph for 7days, provided a blood sample, complete...
Source: Brain, Behavior, and Immunity - October 19, 2017 Category: Neurology Source Type: research

Desmoglein 3-Reactive B Cells “Hiding” in Pemphigus Lesions
Pemphigus vulgaris is an autoimmune blistering disease caused by anti-desmoglein 3 IgG autoantibodies. It is accepted that interactions between autoreactive B and T cells are key to humoral autoimmunity targeting desmoglein 3. This orchestrated process usually occurs in secondary lymphoid organs, including the spleen and lymph nodes. Thus, it seems likely that autoreactive B cells reside and produce autoantibodies in these tissues. Yuan et  al. analyzed lymphocytes in the lesional skin of patients with pemphigus vulgaris using several experimental techniques and concluded that desmoglein 3-reactive B cells were presen...
Source: Journal of Investigative Dermatology - October 18, 2017 Category: Dermatology Authors: Hayato Takahashi Tags: Commentary Source Type: research

A Case of IgG4-related Lung Pseudotumor and Pleural Inflammation with Autoimmune Hepatitis.
Authors: Nagashima K, Sano I, Kobayashi T, Eto K, Nagai K, Ninomiya R, Suzuki A, Oohata Y, Konishi K, Nakano T, Yamamoto F Abstract A 63-year-old man was admitted to our department following a secondary medical examination. Blood tests showed high levels of liver enzymes, IgG, IgG4, and antinuclear antibody. Computed tomography showed tumors in the bilateral lower lobes of the lungs and pleural thickening. After pleural and liver biopsy procedures, he was conclusively diagnosed with IgG4-related lung pseudotumor and pleural inflammation with autoimmune hepatitis. We started treatment with prednisolone 40 mg/day, an...
Source: Internal Medicine - October 18, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

[Severity of illness index in autoimmune diseases: Have there any usefulness in medical practice?]
CONCLUSION: The discrepancy between the ratio of practitioners who believe that scores have a place in daily practice and their actual use shows that the current scores do not meet the needs. The implementation of easily usable activity scores in inflammatory diseases remains a challenge for the internists. PMID: 29032100 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - October 18, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Human papillomavirus vaccination of adult women and risk of autoimmune and neurological diseases
ConclusionUnmasking of conditions at vaccination visits is a plausible explanation for the increased risk associated with qHPV in this study because coeliac disease is underdiagnosed in Scandinavian populations. In conclusion, our study of serious adverse event rates in qHPV‐vaccinated and qHPV‐unvaccinated adult women 18–44 years of age did not raise any safety issues of concern. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 18, 2017 Category: Internal Medicine Authors: A. Hviid, H. Svanstr öm, N. M. Scheller, O. Grönlund, B. Pasternak, L. Arnheim‐Dahlström Tags: Original Article Source Type: research

T Cell-Derived CD70 Delivers an Immune Checkpoint Function in Inflammatory T Cell Responses.
This study suggests that T cell-derived CD70 performs a critical negative feedback function to downregulate inflammatory T cell responses. PMID: 29046346 [PubMed - as supplied by publisher] (Source: Journal of Immunology)
Source: Journal of Immunology - October 18, 2017 Category: Allergy & Immunology Authors: O'Neill RE, Du W, Mohammadpour H, Alqassim E, Qiu J, Chen G, McCarthy PL, Lee KP, Cao X Tags: J Immunol Source Type: research

Design, isolation and evaluation of the binding efficiency of a DNA aptamer against interleukin 2 receptor alpha, in vitro.
Abstract High levels of CD25, as part of the IL-2 receptor, are expressed on the surface of the activated T lymphocytes and regulatory T cells, indicating that the soluble CD25 (sCD25) could be a clinically valuable tool for treating several diseases. Moreover, progress has been achieved in targeting the IL-2 receptor to treat autoimmune diseases, organ transplantation and certain hematological malignancies. In the current study, generation of an ssDNA aptamer (Apt51) against CD25 is reported. Apt51 bound to CD25 with high affinity (Kd=13.4nM) and specificity. Furthermore, Apt51 was truncated to two shortened vari...
Source: International Immunopharmacology - October 18, 2017 Category: Allergy & Immunology Authors: Shahdordizadeh M, Taghdisi SM, Sankian M, Ramezani M, Abnous K Tags: Int Immunopharmacol Source Type: research

Long-Term Systemic Corticosteroid Exposure: A Systematic Literature Review.
The objective of this study was to conduct a systematic literature review of recent publications on the burden of long-term corticosteroid exposure, specifically, to summarize the AEs and economic impact of long-term corticosteroid use and to reveal data gaps for additional research. METHODS: The Ovid search platform was used to access scientific literature databases. The search strategy targeted the use of corticosteroids and economic outcomes research. Articles were restricted to those published between 2007 and 2016 to cover publications since prior reviews; conference abstracts and articles assessing pediatrics we...
Source: Clinical Therapeutics - October 18, 2017 Category: Drugs & Pharmacology Authors: Rice JB, White AG, Scarpati LM, Wan G, Nelson WW Tags: Clin Ther Source Type: research

Systemic vasculitis is associated with a higher risk of lower extremity amputation in patients with severe peripheral arterial occlusive disease: a secondary analysis of a nationwide, population-based health claims database
AbstractPrevious research has shown that diabetes mellitus increases the risk of lower extremity amputation in patients with peripheral arterial occlusive disease. However, to our knowledge, no studies have investigated whether systemic autoimmune disease, in particular systemic vasculitis is associated with a higher risk of lower extremity amputation in these patients. To investigate the association between systemic autoimmune disease and lower extremity amputation in patients with severe peripheral arterial occlusive disease based on a secondary analysis of a nationwide, population-based health claims database. Using the...
Source: Rheumatology International - October 17, 2017 Category: Rheumatology Source Type: research

Evaluation of serum levels of C3 and C4 complement factors in patients with beta Thalassemia major in Khuzestan Province, Southwest Iran.
This study has shown a significant reduction in serum levels of C3 and C4 in patients compared to controls (P-value
Source: Journal of Immunoassay and Immunochemistry - October 17, 2017 Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research

Adult idiopathic cholestasis: a condition more common in the Canadian Inuit?
Authors: Minuk GY, Pollock G, Uhanova J Abstract Despite extensive investigations, some patients have no identifiable cause for their cholestatic liver enzyme abnormalities. The aim of this study was to document the clinical, laboratory, radiologic and histologic features of adult patients with idiopathic cholestasis (AIC). A computerised database of referred patients to a tertiary care hospital outpatient department for assessment of hepatobiliary disorders between 2005 and 2015 was employed to identify and describe features associated with AIC. Of 6,560 patient referrals, sufficient documentation to warrant a dia...
Source: International Journal of Circumpolar Health - October 17, 2017 Category: International Medicine & Public Health Tags: Int J Circumpolar Health Source Type: research

Clinicopathological Study of Autoimmune Hepatitis Cases That Were Difficult to Differentiate from Drug-Induced Liver Injury
Conclusion: This study showed that DDW-J scale was useful for differentiating AIH from DILI in cases with a DDW-J scale score of #x2267;5. The histologic features of AIH were characterized by cobblestone hepatocellular change, interface hepatitis, and plasma cell infiltration of the portal region.Dig Dis 2017;35:506-514 (Source: Digestive Diseases)
Source: Digestive Diseases - October 17, 2017 Category: Gastroenterology Source Type: research

The Use of Primary Prevention Statin Therapy in Those Predisposed to Atherosclerosis
AbstractPurpose of ReviewMany guidelines exist for the use of statins in the primary prevention of atherosclerotic cardiovascular disease (ASCVD). Few have focused on disease specific states that predispose to ASCVD. This review is intended to focus on the recommendations and evidence in inflammatory diseases that predispose to an increased risk of ASCVD beyond what conventional cardiac risk scores would predict.Recent FindingsCertain autoimmune inflammatory diseases such as rheumatoid arthritis (RA), systemic lupus erythematous (SLE), and psoriasis/psoriatic arthritis have all been shown to increase the risk of ASCVD. Oth...
Source: Current Atherosclerosis Reports - October 17, 2017 Category: Cardiology Source Type: research

Characterization and implications of thyroid dysfunction induced by immune checkpoint inhibitors in real-life clinical practice: a long-term prospective study from a referral institution
ConclusionsImmune checkpoint blockade is burdened by a high incidence of autoimmune thyroid dysfunction, which is often severe. Therefore, early and careful monitoring and, eventually, treatment are crucial to prevent the negative impact of thyroid dysfunction on the clinical outcome. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 17, 2017 Category: Endocrinology Source Type: research

Management of phenytoin-induced gingival enlargement in a patient with antiphospholipid antibody syndrome: A rare case report
Shilpa Sarvesh Urolagin, Deepthi Swaroop, Charu Agrawal, Pathik Dholakia, Menaka Basavanneppa KaralwadJournal of Indian Society of Periodontology 2016 20(5):561-564 Antiphospholipid antibody (APLA) syndrome is a noninflammatory autoimmune disease, with innumerable clinical manifestations ranging from recurrent thrombosis and pregnancy morbidity to valvular lesions, transverse myelitis, thrombocytopenia, and hemolytic anemia. APLAs in antiphospholipid syndrome (APS) are well-known risk factors for cerebrovascular accidents. Stroke is the most common manifestation of APS in the central nervous system. Gingival enlargement i...
Source: Journal of Indian Society of Periodontology - October 17, 2017 Category: Dentistry Authors: Shilpa Sarvesh Urolagin Deepthi Swaroop Charu Agrawal Pathik Dholakia Menaka Basavanneppa Karalwad Source Type: research

Germinal center B cells are essential for collagen ‐induced arthritis
ConclusionTogether, we identify germinal center formation and anti‐collagen antibody production as the key pathogenic function of B cells in CIA. The role of B cells in RA is likely to be more complex. However, targeting the germinal center reaction could allow for more refined therapeutic interventions than general B cell depletion.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 17, 2017 Category: Rheumatology Authors: Albert Dahdah, Katrin Habir, Kutty Selva Nandakumar, Amit Saxena, Bingze Xu, Rikard Holmdahl, Stephen Malin Tags: Full Length Source Type: research

NF ‐κB2 Controls the Migratory Activity of Memory T Cells by Regulating Expression of CXCR4 in a Mouse Model of Sjögren's Syndrome
ConclusionOur results suggest that the RelB/NF‐κB2 pathway regulates T cell migration to autoimmune targets through TGFβ/TGFβR‐dependent regulation of CXCL12/CXCR4 signaling. This suggests that these signaling pathways are potential therapeutic targets for the treatment of autoimmune diseases. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 17, 2017 Category: Rheumatology Authors: Mie Kurosawa, Rieko Arakaki, Akiko Yamada, Takaaki Tsunematsu, Yasusei Kudo, Jonathan Sprent, Naozumi Ishimaru Tags: Original Article Source Type: research

Innate immunity and tolerance toward mitochondria
Publication date: Available online 17 October 2017 Source:Mitochondrion Author(s): Anthony Rongvaux Mitochondria are intracellular organelles that originate from a bacterial symbiont, and they retain multiple features of this bacterial ancestry. The immune system evolved to detect the presence of invading pathogens, including bacteria, to eliminate them by a diversity of antimicrobial mechanisms and to mount long-term protective immunity. Due to their bacterial ancestry, mitochondria are sensed by the innate immune system, and trigger inflammatory responses comparable to those induced by pathogenic bacteria. In both cases...
Source: Mitochondrion - October 17, 2017 Category: Biochemistry Source Type: research