Colorectal Cancer Risk between Mendelian and Non-Mendelian Inheritance

Clin Colon Rectal Surg. 2023 Jul 31;37(3):140-145. doi: 10.1055/s-0043-1770382. eCollection 2024 May.ABSTRACTHereditary colorectal cancer has been an area of focus for research and public health practitioners due to our ability to quantify risk and then act based on such results by enrolling patients in surveillance programs. The wide access to genetic testing and whole-genome sequencing has resulted in identifying many low/moderate penetrance genes. Above all, our understanding of the family component of colorectal cancer has been improving. Polygenic scores are becoming part of the risk assessment for many cancers, and the data about polygenic risk scores for colorectal cancer is promising. The challenge is determining how we incorporate this data in clinical care.PMID:38606051 | PMC:PMC11006447 | DOI:10.1055/s-0043-1770382
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Source Type: research