Limonin inhibits the stemness of cancer stem-like cells derived from colorectal carcinoma cells potentially via blocking STAT3 signaling
CONCLUSION: Taken together, these results indicate that limonin is a promising compound that targets CSCs and could be used to combat CRC recurrence and metastasis.PMID:38455137 | PMC:PMC10915944 | DOI:10.5306/wjco.v15.i2.317 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 8, 2024 Category: Cancer & Oncology Authors: Wei-Feng Zhang Cheng-Wei Ruan Jun-Bo Wu Guo-Liang Wu Xiao-Gan Wang Hong-Jin Chen Source Type: research
Survivin expression is associated with lymph node metastasis and short survival in patients with colorectal adenocarcinoma
CONCLUSION: Survivin immune expression is associated with worse prognoses in CRC patients. Survivin can be a potential disease biomarker and could be used in management plans for CRC patients.PMID:38455507 | PMC:PMC10915287 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 8, 2024 Category: Cancer & Oncology Authors: Haneen Al-Maghrabi Zuhoor Al-Mansouri Jaudah Al-Maghrabi Source Type: research
Implication of calcium supplementations in health and diseases with special focus on colorectal cancer
Crit Rev Clin Lab Sci. 2024 Mar 8:1-14. doi: 10.1080/10408363.2024.2322565. Online ahead of print.ABSTRACTCalcium is a fundamental and integrative element and helps to ensure optimal health by regulating various physiological and pathological processes. While there is substantiated evidence confirming the beneficial effects of calcium in the treatment, management, and prevention of various health conditions, including cancer, conflicting studies are imperative to acknowledge the potential negative role of calcium supplementation. The studies on calcium supplementation showed that a specific dose can help in the maintenance...
Source: Clinical Colorectal Cancer - March 8, 2024 Category: Cancer & Oncology Authors: Shahanavaj Khan S Needa Mosvi Saeed Vohra Nitesh Kumar Poddar Source Type: research
Phase 1/2 study of combined BCL-xL and MEK inhibition with navitoclax and trametinib in KRAS or NRAS mutant advanced solid tumors
CONCLUSIONS: Navitoclax in combination with trametinib was tolerable. Durable clinical responses were observed in patients with RAS-mutant GYN cancers, warranting further evaluation in this population.PMID:38456660 | DOI:10.1158/1078-0432.CCR-23-3135 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 8, 2024 Category: Cancer & Oncology Authors: Ryan B Corcoran Khanh T Do Jeong E Kim James M Cleary Aparna R Parikh Oladapo O Yeku Niya Xiong Colin D Weekes Jennifer Veneris Leanne G Ahronian Gianluca Mauri Jun Tian Bryanna L Norden Alexa G Michel Emily E Van Seventer Giulia Siravegna Kyle Camphausen Source Type: research
Colorectal Cancer Prevention and Chat Generative Pretrained Transformer (ChatGPT)
J Clin Gastroenterol. 2024 Mar 7. doi: 10.1097/MCG.0000000000001989. Online ahead of print.NO ABSTRACTPMID:38457428 | DOI:10.1097/MCG.0000000000001989 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 8, 2024 Category: Cancer & Oncology Authors: Hinpetch Daungsupawong Viroj Wiwanitkit Source Type: research
HER2 Gene Expression Levels Are Predictive and Prognostic in Patients With Metastatic Colorectal Cancer Enrolled in CALGB/SWOG 80405
CONCLUSION: HER2 gene expression was prognostic and predictive in CALGB/SWOG 80405. HER2 tumor expression may inform treatment selection for patients with low HER2 favoring bevacizumab- versus cetuximab-based therapies.PMID:38457761 | DOI:10.1200/JCO.23.01507 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 8, 2024 Category: Cancer & Oncology Authors: Francesca Battaglin Fang-Shu Ou Xueping Qu Howard S Hochster Donna Niedzwiecki Richard M Goldberg Robert J Mayer Karam Ashouri Tyler J Zemla Charles D Blanke Alan P Venook Omar Kabbarah Heinz-Josef Lenz Federico Innocenti Source Type: research
Colon stenting as a bridge to surgery in obstructive colorectal cancer management
Clin Endosc. 2024 Mar 8. doi: 10.5946/ce.2023.138. Online ahead of print.ABSTRACTColonic stent placement is a commonly used bridging strategy for surgery in patients with obstructive colorectal cancer. The procedure involves the placement of a self-expandable metallic stent (SEMS) across the obstructive lesion to restore intestinal patency and alleviate the symptoms of obstruction. By allowing patients to receive surgery in a planned and staged manner with time for preoperative optimization and bowel preparation, stent placement may reduce the need for emergency surgery, which is associated with higher complication rates a...
Source: Clinical Colorectal Cancer - March 8, 2024 Category: Cancer & Oncology Authors: Dong Hyun Kim Han Hee Lee Source Type: research
Prevalence, risk factors, and BRAF mutation of colorectal sessile serrated lesions among Vietnamese patients
CONCLUSION: The prevalence of SSLs was 4.2%. BRAF mutations were present in one-third of SSLs. Significant risk factors for SSLs included age ≥ 40, male sex, diabetes mellitus, and hypertension.PMID:38455129 | PMC:PMC10915949 | DOI:10.5306/wjco.v15.i2.290 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 8, 2024 Category: Cancer & Oncology Authors: Nhu Thi Hanh Vu Huy Minh Le Diem Thi-Ngoc Vo Hoang Anh Vu Nhan Quang Le Dung Dang Quy Ho Duc Trong Quach Source Type: research
Identification and validation of a pyroptosis-related prognostic model for colorectal cancer based on bulk and single-cell RNA sequencing data
CONCLUSION: We developed a pyroptosis-related prognostic model for CRC, affirming its correlation with immune infiltration. This model may prove useful for CRC prognostic evaluation.PMID:38455135 | PMC:PMC10915942 | DOI:10.5306/wjco.v15.i2.329 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 8, 2024 Category: Cancer & Oncology Authors: Li-Hua Zhu Jun Yang Yun-Fei Zhang Li Yan Wan-Rong Lin Wei-Qing Liu Source Type: research
Limonin inhibits the stemness of cancer stem-like cells derived from colorectal carcinoma cells potentially via blocking STAT3 signaling
CONCLUSION: Taken together, these results indicate that limonin is a promising compound that targets CSCs and could be used to combat CRC recurrence and metastasis.PMID:38455137 | PMC:PMC10915944 | DOI:10.5306/wjco.v15.i2.317 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 8, 2024 Category: Cancer & Oncology Authors: Wei-Feng Zhang Cheng-Wei Ruan Jun-Bo Wu Guo-Liang Wu Xiao-Gan Wang Hong-Jin Chen Source Type: research
Survivin expression is associated with lymph node metastasis and short survival in patients with colorectal adenocarcinoma
CONCLUSION: Survivin immune expression is associated with worse prognoses in CRC patients. Survivin can be a potential disease biomarker and could be used in management plans for CRC patients.PMID:38455507 | PMC:PMC10915287 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 8, 2024 Category: Cancer & Oncology Authors: Haneen Al-Maghrabi Zuhoor Al-Mansouri Jaudah Al-Maghrabi Source Type: research
Implication of calcium supplementations in health and diseases with special focus on colorectal cancer
Crit Rev Clin Lab Sci. 2024 Mar 8:1-14. doi: 10.1080/10408363.2024.2322565. Online ahead of print.ABSTRACTCalcium is a fundamental and integrative element and helps to ensure optimal health by regulating various physiological and pathological processes. While there is substantiated evidence confirming the beneficial effects of calcium in the treatment, management, and prevention of various health conditions, including cancer, conflicting studies are imperative to acknowledge the potential negative role of calcium supplementation. The studies on calcium supplementation showed that a specific dose can help in the maintenance...
Source: Clinical Colorectal Cancer - March 8, 2024 Category: Cancer & Oncology Authors: Shahanavaj Khan S Needa Mosvi Saeed Vohra Nitesh Kumar Poddar Source Type: research
Phase 1/2 study of combined BCL-xL and MEK inhibition with navitoclax and trametinib in KRAS or NRAS mutant advanced solid tumors
CONCLUSIONS: Navitoclax in combination with trametinib was tolerable. Durable clinical responses were observed in patients with RAS-mutant GYN cancers, warranting further evaluation in this population.PMID:38456660 | DOI:10.1158/1078-0432.CCR-23-3135 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 8, 2024 Category: Cancer & Oncology Authors: Ryan B Corcoran Khanh T Do Jeong E Kim James M Cleary Aparna R Parikh Oladapo O Yeku Niya Xiong Colin D Weekes Jennifer Veneris Leanne G Ahronian Gianluca Mauri Jun Tian Bryanna L Norden Alexa G Michel Emily E Van Seventer Giulia Siravegna Kyle Camphausen Source Type: research
Colorectal Cancer Prevention and Chat Generative Pretrained Transformer (ChatGPT)
J Clin Gastroenterol. 2024 Mar 7. doi: 10.1097/MCG.0000000000001989. Online ahead of print.NO ABSTRACTPMID:38457428 | DOI:10.1097/MCG.0000000000001989 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 8, 2024 Category: Cancer & Oncology Authors: Hinpetch Daungsupawong Viroj Wiwanitkit Source Type: research
HER2 Gene Expression Levels Are Predictive and Prognostic in Patients With Metastatic Colorectal Cancer Enrolled in CALGB/SWOG 80405
CONCLUSION: HER2 gene expression was prognostic and predictive in CALGB/SWOG 80405. HER2 tumor expression may inform treatment selection for patients with low HER2 favoring bevacizumab- versus cetuximab-based therapies.PMID:38457761 | DOI:10.1200/JCO.23.01507 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 8, 2024 Category: Cancer & Oncology Authors: Francesca Battaglin Fang-Shu Ou Xueping Qu Howard S Hochster Donna Niedzwiecki Richard M Goldberg Robert J Mayer Karam Ashouri Tyler J Zemla Charles D Blanke Alan P Venook Omar Kabbarah Heinz-Josef Lenz Federico Innocenti Source Type: research
