Management of Desmoid Disease in Familial Adenomatous Polyposis
Clin Colon Rectal Surg. 2023 Jul 25;37(3):185-190. doi: 10.1055/s-0043-1770731. eCollection 2024 May.ABSTRACTDesmoid disease, though technically a benign condition, is nevertheless a leading cause of morbidity and mortality in patients with familial adenomatous polyposis (FAP). Desmoid disease impacts approximately 30% of FAP patients, with several known risk factors. It runs the gamut in terms of severity-ranging from small, slow-growing asymptomatic lesions to large, focally destructive, life-threatening masses. Desmoids usually occur following surgery, and several patient risk factors have been established, including fe...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Joshua Sommovilla Dale Shepard David Liska Source Type: research
Colorectal Cancer Genetics: An Evolutionary Tale of Us
Clin Colon Rectal Surg. 2023 Aug 31;37(3):125-126. doi: 10.1055/s-0043-1770379. eCollection 2024 May.NO ABSTRACTPMID:38606048 | PMC:PMC11006443 | DOI:10.1055/s-0043-1770379 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Mohammad Ali Abbass Source Type: research
Management of Rectal Cancer in Lynch Syndrome: Balancing Risk Reduction and Quality of Life
Clin Colon Rectal Surg. 2023 Aug 10;37(3):180-184. doi: 10.1055/s-0043-1770730. eCollection 2024 May.ABSTRACTPatients with Lynch syndrome are predisposed to developing colorectal cancer and a variety of extracolonic malignancies, at a young age. The management of rectal cancer in the setting of Lynch syndrome is a complex clinical scenario that requires the expertise of a multidisciplinary management team. In this review, we delve into the approach for rectal cancer in these patients, and specifically focus on several key aspects of treatment. Some unique aspects of rectal cancer in Lynch syndrome include the decision betw...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Bradley A Krasnick Matthew F Kalady Source Type: research
The Natural History of Hereditary Colorectal Cancer Syndromes: From Phenotype to Genotype? Where Do We Stand and What Does the Future Hold?
Clin Colon Rectal Surg. 2023 Aug 9;37(3):127-132. doi: 10.1055/s-0043-1770380. eCollection 2024 May.ABSTRACTApplying the concept of a "natural history" to hereditary colorectal cancer is an interesting exercise because the way the syndromes are approached has changed so drastically. However, the exercise is instructive as it forces us to think in depth about where we are, where we have been, and, most helpfully, about where we may be going. In this article the diagnosis, along with endoscopic and surgical management of hereditary colorectal cancer are discussed in the context of their history and the changes in genomics an...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: James Church Source Type: research
Colorectal Cancer Risk between Mendelian and Non-Mendelian Inheritance
Clin Colon Rectal Surg. 2023 Jul 31;37(3):140-145. doi: 10.1055/s-0043-1770382. eCollection 2024 May.ABSTRACTHereditary colorectal cancer has been an area of focus for research and public health practitioners due to our ability to quantify risk and then act based on such results by enrolling patients in surveillance programs. The wide access to genetic testing and whole-genome sequencing has resulted in identifying many low/moderate penetrance genes. Above all, our understanding of the family component of colorectal cancer has been improving. Polygenic scores are becoming part of the risk assessment for many cancers, and t...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Elizabeth A Hibler Brittany Szymaniak Mohammad Ali Abbass Source Type: research
Chemoprevention in Inherited Colorectal Cancer Syndromes
Clin Colon Rectal Surg. 2023 Jul 19;37(3):172-179. doi: 10.1055/s-0043-1770384. eCollection 2024 May.ABSTRACTCancer prevention in hereditary gastrointestinal predisposition syndromes relies primarily on intensive screening (e.g., colonoscopy) or prophylactic surgery (e.g., colectomy). The use of chemopreventive agents as an adjunct to these measures has long been studied both in the general population and in hereditary cancer patients, in whom the risk of malignancy, and therefore the potential risk reduction, is considerably greater. However, to date only few compounds have been found to be effective, safe, and tolerable ...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Ophir Gilad Charles Muller Sonia S Kupfer Source Type: research
Hereditary Colorectal Cancer Syndromes Registry: What, How, and Why?
Clin Colon Rectal Surg. 2023 Jul 31;37(3):198-202. doi: 10.1055/s-0043-1770733. eCollection 2024 May.ABSTRACTCaring for patients with colorectal cancer inherited cancer syndromes is complex, and it requires a well-thought integration process between a multidisciplinary team, an accessible database, and a registry coordinator. This requires an aligned vision between the administrative business team and the clinical team. Although we can manage most of the cancers that those patients develop according to oncologic guidance, the future risk of patients and their families might add emotional and psychological burdens on them i...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Mohammad Ali Abbass Vitaliy Poylin Scott Strong Source Type: research
Current Trends in Vaccine Development for Hereditary Colorectal Cancer Syndromes
Clin Colon Rectal Surg. 2023 Jul 31;37(3):146-156. doi: 10.1055/s-0043-1770383. eCollection 2024 May.ABSTRACTThe coming of age for cancer treatment has experienced exponential growth in the last decade with the addition of immunotherapy as the fourth pillar to the fundamentals of cancer treatment-chemotherapy, surgery, and radiation-taking oncology to an astounding new frontier. In this time, rapid developments in computational biology coupled with immunology have led to the exploration of priming the host immune system through vaccination to prevent and treat certain subsets of cancer such as melanoma and hereditary color...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Charles M Bowen Krishna M Sinha Eduardo Vilar Source Type: research
The Evolution of Genetic Testing from Focused Testing to Panel Testing and from Patient Focused to Population Testing: Are We There Yet?
Clin Colon Rectal Surg. 2023 Jul 19;37(3):133-139. doi: 10.1055/s-0043-1770381. eCollection 2024 May.ABSTRACTThe field of cancer genetics has evolved significantly over the past 30 years. Genetic testing has become less expensive and more comprehensive which has changed practice patterns. It is no longer necessary to restrict testing to those with the highest likelihood of testing positive. In addition, we have learned that the criteria developed to determine who has the highest likelihood of testing positive are neither sensitive nor specific. As a result, the field is moving from testing only the highest risk patients id...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Lauren Gima Ilana Solomon Heather Hampel Source Type: research
Management of Desmoid Disease in Familial Adenomatous Polyposis
Clin Colon Rectal Surg. 2023 Jul 25;37(3):185-190. doi: 10.1055/s-0043-1770731. eCollection 2024 May.ABSTRACTDesmoid disease, though technically a benign condition, is nevertheless a leading cause of morbidity and mortality in patients with familial adenomatous polyposis (FAP). Desmoid disease impacts approximately 30% of FAP patients, with several known risk factors. It runs the gamut in terms of severity-ranging from small, slow-growing asymptomatic lesions to large, focally destructive, life-threatening masses. Desmoids usually occur following surgery, and several patient risk factors have been established, including fe...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Joshua Sommovilla Dale Shepard David Liska Source Type: research
Colorectal Cancer Genetics: An Evolutionary Tale of Us
Clin Colon Rectal Surg. 2023 Aug 31;37(3):125-126. doi: 10.1055/s-0043-1770379. eCollection 2024 May.NO ABSTRACTPMID:38606048 | PMC:PMC11006443 | DOI:10.1055/s-0043-1770379 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Mohammad Ali Abbass Source Type: research
Management of Rectal Cancer in Lynch Syndrome: Balancing Risk Reduction and Quality of Life
Clin Colon Rectal Surg. 2023 Aug 10;37(3):180-184. doi: 10.1055/s-0043-1770730. eCollection 2024 May.ABSTRACTPatients with Lynch syndrome are predisposed to developing colorectal cancer and a variety of extracolonic malignancies, at a young age. The management of rectal cancer in the setting of Lynch syndrome is a complex clinical scenario that requires the expertise of a multidisciplinary management team. In this review, we delve into the approach for rectal cancer in these patients, and specifically focus on several key aspects of treatment. Some unique aspects of rectal cancer in Lynch syndrome include the decision betw...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Bradley A Krasnick Matthew F Kalady Source Type: research
The Natural History of Hereditary Colorectal Cancer Syndromes: From Phenotype to Genotype? Where Do We Stand and What Does the Future Hold?
Clin Colon Rectal Surg. 2023 Aug 9;37(3):127-132. doi: 10.1055/s-0043-1770380. eCollection 2024 May.ABSTRACTApplying the concept of a "natural history" to hereditary colorectal cancer is an interesting exercise because the way the syndromes are approached has changed so drastically. However, the exercise is instructive as it forces us to think in depth about where we are, where we have been, and, most helpfully, about where we may be going. In this article the diagnosis, along with endoscopic and surgical management of hereditary colorectal cancer are discussed in the context of their history and the changes in genomics an...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: James Church Source Type: research
Colorectal Cancer Risk between Mendelian and Non-Mendelian Inheritance
Clin Colon Rectal Surg. 2023 Jul 31;37(3):140-145. doi: 10.1055/s-0043-1770382. eCollection 2024 May.ABSTRACTHereditary colorectal cancer has been an area of focus for research and public health practitioners due to our ability to quantify risk and then act based on such results by enrolling patients in surveillance programs. The wide access to genetic testing and whole-genome sequencing has resulted in identifying many low/moderate penetrance genes. Above all, our understanding of the family component of colorectal cancer has been improving. Polygenic scores are becoming part of the risk assessment for many cancers, and t...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Elizabeth A Hibler Brittany Szymaniak Mohammad Ali Abbass Source Type: research
The potential of machine learning models to identify malnutrition diagnosed by GLIM combined with NRS-2002 in colorectal cancer patients without weight loss information
CONCLUSIONS: Nutrition Risk Screening 2002 was the optimal initial nutritional risk screening tool in the GLIM process. The RF model outperformed other models, and an online prediction tool was developed to properly identify patients at high risk of malnutrition.PMID:38603972 | DOI:10.1016/j.clnu.2024.04.001 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 11, 2024 Category: Cancer & Oncology Authors: Tiantian Wu Hongxia Xu Wei Li Fuxiang Zhou Zengqing Guo Kunhua Wang Min Weng Chunling Zhou Ming Liu Yuan Lin Suyi Li Ying He Qinghua Yao Hanping Shi Chunhua Song Investigation on Nutrition Status and its Clinical Outcome of Common Cancers (INSCOC) Group Source Type: research
