Prognostic and Predictive Value of Immunoscore in Stage III Colorectal Cancer: Pooled Analysis of Cases From the SCOT and IDEA-HORG Studies
CONCLUSION: IS is prognostic in stage III CRC treated with FOLFOX or CAPOX, including within clinically relevant tumor subgroups. Possible variation in IS prognostic value by age and MMR status, and prediction of benefit from extended adjuvant therapy merit validation.PMID:38484206 | DOI:10.1200/JCO.23.01648 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Enric Domingo Caroline Kelly Jennifer Hay Owen Sansom Noori Maka Karin Oien Tim Iveson Mark Saunders Rachel Kerr Ian Tomlinson Joanne Edwards Andrea Harkin Marta Nowak Viktor Koelzer Alistair Easton Ioannis Boukovinas Eleni Moustou Ippokratis Messaritakis Source Type: research
Type 2 diabetes mellitus and post-colonoscopy colorectal cancer: clinical and molecular characteristics and survival
CONCLUSION: The increased prevalence of proximally located PCCRCs and the poorer survival may suggest overlooked colorectal lesions as a predominant explanation for T2D-related PCCRC, although altered tumor progression cannot be ruled out.PMID:38483686 | DOI:10.1007/s10552-024-01861-9 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Mette L Boysen Frederikke S Troelsen Henrik T S ørensen Rune Erichsen Source Type: research
Prognostic and Predictive Value of Immunoscore in Stage III Colorectal Cancer: Pooled Analysis of Cases From the SCOT and IDEA-HORG Studies
CONCLUSION: IS is prognostic in stage III CRC treated with FOLFOX or CAPOX, including within clinically relevant tumor subgroups. Possible variation in IS prognostic value by age and MMR status, and prediction of benefit from extended adjuvant therapy merit validation.PMID:38484206 | DOI:10.1200/JCO.23.01648 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Enric Domingo Caroline Kelly Jennifer Hay Owen Sansom Noori Maka Karin Oien Tim Iveson Mark Saunders Rachel Kerr Ian Tomlinson Joanne Edwards Andrea Harkin Marta Nowak Viktor Koelzer Alistair Easton Ioannis Boukovinas Eleni Moustou Ippokratis Messaritakis Source Type: research
Fournier's gangrene due to rectal cancer: A case report
Mol Clin Oncol. 2024 Feb 12;20(4):30. doi: 10.3892/mco.2024.2728. eCollection 2024 Apr.ABSTRACTFournier's gangrene (FG) is an extremely rare necrotizing fasciitis that is insidious, rapidly spreading and life-threatening. FGs due to rectal cancer occur rarely and there is a lack of clinical reference. In the present study, a severe FG due to rectal cancer perforation was described and the features of this rare disease were summarized with a literature review. A 57-year-old man was admitted because of rectal cancer-induced FG. The patient was misdiagnosed with extensive perianal abscess until the intraoperative biopsy confi...
Source: Clinical Colorectal Cancer - March 13, 2024 Category: Cancer & Oncology Authors: Sen Hou Baosen Cheng Kai Shen Zhidong Gao Fan Liu Yingjiang Ye Source Type: research
A comprehensive multi-omics analysis identifies a robust scoring system for cancer-associated fibroblasts and intervention targets in colorectal cancer
CONCLUSION: We constructed a robust CAFGs score system with clinical significance using multiple CRC cohorts. In addition, we identified several molecules related to CAF identity and function that could be potential intervention targets for CRC patients.PMID:38478111 | DOI:10.1007/s00432-023-05548-7 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 13, 2024 Category: Cancer & Oncology Authors: Feng Wang Zhenlin Li Tianlei Xu Qian Zhang Tianyi Ma Sijia Li Xiaohui Wang Source Type: research
The choice of diagnostic modality influences the proportion of low muscle strength, low muscle mass, and sarcopenia in colorectal cancer patients
CONCLUSION: The proportion of low muscle strength, low muscle mass, and sarcopenia in CRC patients varied considerably depending on the diagnostic modalities used. Further studies are needed to provide modality-specific cut-off values, adjusted to sex, age and body size.PMID:38479906 | DOI:10.1016/j.clnesp.2024.01.001 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 13, 2024 Category: Cancer & Oncology Authors: Hedda Beate Berg Dena Treider Alavi Benedicte Beichmann Maiju Pesonen Christine Henriksen Ingvild Paur Siv Kj ølsrud Bøhn Peter M æhre Lauritzen Rune Blomhoff Hege Berg Henriksen Source Type: research
Association between adherence to a dietary approach to stop hypertension and the Mediterranean diets and risk of colorectal cancer: A matched case-control study
CONCLUSIONS: In conclusion, the current study's findings presented that adherence to a DASH diet could reduce the odds of CRC.PMID:38479910 | DOI:10.1016/j.clnesp.2024.02.003 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 13, 2024 Category: Cancer & Oncology Authors: Sazin Yarmand Nooshin Abdollahi Elham Tavassoli Nejad Fateme Souni Mohebat Vali Mehran Nouri Zainab Shateri Bahram Rashidkhani Source Type: research
Fournier's gangrene due to rectal cancer: A case report
Mol Clin Oncol. 2024 Feb 12;20(4):30. doi: 10.3892/mco.2024.2728. eCollection 2024 Apr.ABSTRACTFournier's gangrene (FG) is an extremely rare necrotizing fasciitis that is insidious, rapidly spreading and life-threatening. FGs due to rectal cancer occur rarely and there is a lack of clinical reference. In the present study, a severe FG due to rectal cancer perforation was described and the features of this rare disease were summarized with a literature review. A 57-year-old man was admitted because of rectal cancer-induced FG. The patient was misdiagnosed with extensive perianal abscess until the intraoperative biopsy confi...
Source: Clinical Colorectal Cancer - March 13, 2024 Category: Cancer & Oncology Authors: Sen Hou Baosen Cheng Kai Shen Zhidong Gao Fan Liu Yingjiang Ye Source Type: research
Optimizing smartphone psychotherapy for depressive symptoms in patients with cancer: Multiphase optimization strategy using a decentralized multicenter randomized clinical trial (J-SUPPORT 2001 Study)
CONCLUSION: As the presence of any of the three intervention components did not contribute to a significant additive reduction of depressive symptoms, we cannot make evidence-based recommendations regarding the use of specific smartphone psychotherapy.PMID:38468404 | DOI:10.1111/pcn.13657 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 12, 2024 Category: Cancer & Oncology Authors: Tatsuo Akechi Toshiaki A Furukawa Hisashi Noma Hiroji Iwata Tatsuya Toyama Kenji Higaki Hiromichi Matsuoka Sadamoto Zenda Tsuguo Iwatani Kazuhisa Akahane Akira Inoue Yasuaki Sagara Megumi Uchida Fuminobu Imai Kanae Momino Gen Imaizumi Takuhiro Yamaguchi T Source Type: research
NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA stabilization
CONCLUSIONS: Our findings highlight the importance of NSUN2 in the initiation and progression of CRC via m5C-YBX1-dependent stabilization of the SKIL transcript, providing a promising targeted therapeutic strategy for CRC.PMID:38468490 | DOI:10.1002/ctm2.1621 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 12, 2024 Category: Cancer & Oncology Authors: Shaomin Zou Yizhi Huang Ziqing Yang Jieping Zhang Manqi Meng Yijing Zhang Junyan Feng Rui Sun Weiyao Li Wencong Wang Jes ús García-Foncillas López Lekun Fang Source Type: research
Lifestyle Factors and Cancer: A Narrative Review
Mayo Clin Proc Innov Qual Outcomes. 2024 Mar 4;8(2):166-183. doi: 10.1016/j.mayocpiqo.2024.01.004. eCollection 2024 Apr.ABSTRACTLifestyle factors and their impact on cancer prevention, prognosis, and survivorship are increasingly recognized in the medical literature. Lifestyle factors are primarily defined here as diet and physical activity. We conducted a narrative review of the primary published data, including randomized controlled trials and prospective studies, on the impact of primary lifestyle factors on oncogenesis and clinical outcomes in the preventative and survivorship setting. First, we discuss the oncogenic m...
Source: Clinical Colorectal Cancer - March 12, 2024 Category: Cancer & Oncology Authors: Reya Sharman Zoey Harris Brenda Ernst Dawn Mussallem Ashley Larsen Krisstina Gowin Source Type: research
Percutaneous microwave ablation for early-stage intrahepatic cholangiocarcinoma: A single-institutional cohort
CONCLUSION: In patients who do not qualify for surgical resection, MWA is a safe alternative therapy for the treatment of intrahepatic CCA.PMID:38469173 | PMC:PMC10927040 | DOI:10.25259/JCIS_59_2023 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 12, 2024 Category: Cancer & Oncology Authors: Sophia Humphrey Jack Bailey Newcomer Driss Raissi Gaby Gabriel Source Type: research
Acute Myeloid Leukemia Secondary to Treatment with Oxaliplatin Combined with Capecitabine for Colorectal Cancer
CONCLUSIONS: We suggest that clinicians conduct long-term epidemiological follow-up and epidemiological investigations on patients treated with oxaliplatin and capecitabine. In addition, clinicians should carefully check the complete blood cell count on routine follow-ups and observe the morphological changes of white blood cells in peripheral blood smears, even for asymptomatic patients who have undergone chemotherapy. In this way, we can observe the possibility of its development into secondary leukemia.PMID:38469787 | DOI:10.7754/Clin.Lab.2023.230946 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 12, 2024 Category: Cancer & Oncology Authors: Juan Xie Meiqing Li Peizhang Li Ying Wang Naiqi Pang Source Type: research
Polo-like kinase 1 inhibition in KRAS-mutated metastatic colorectal cancer
Clin Cancer Res. 2024 Mar 12. doi: 10.1158/1078-0432.CCR-24-0251. Online ahead of print.ABSTRACTInhibition of Polo-like kinase 1 (Plk1) is a promising new target and therapeutic strategy in metastatic colorectal cancer, especially those with KRAS mutations. New data support further development of onvansertib, and highlights the role of circulating tumor DNA in phase 1 clinical trials.PMID:38470499 | DOI:10.1158/1078-0432.CCR-24-0251 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 12, 2024 Category: Cancer & Oncology Authors: Justin Stebbing Andrea J Bullock Source Type: research
Tumor deposits in axillary adipose tissue in patients with breast cancer: Do they matter?
World J Clin Cases. 2024 Feb 26;12(6):1045-1049. doi: 10.12998/wjcc.v12.i6.1045.ABSTRACTTumor deposits (TDs) are defined as discrete, irregular clusters of tumor cells lying in the soft tissue adjacent to but separate from the primary tumor, and are usually found in the lymphatic drainage area of the primary tumor. By definition, no residual lymph node structure should be identified in these tumor masses. At present, TDs are mainly reported in colorectal cancer, with a few reports in gastric cancer. There are very few reports on breast cancer (BC). For TDs, current dominant theories suggest that these are the result of lym...
Source: Clinical Colorectal Cancer - March 11, 2024 Category: Cancer & Oncology Authors: Muhammed Mubarak Rahma Rashid Shaheera Shakeel Source Type: research
