Re-Do Plastic Reconstruction for Locally Advanced and Recurrent Colorectal Cancer Following a beyond Total Mesorectal Excision (TME) Operation-Key Considerations
This study demonstrated the lack of reporting on re-do reconstruction techniques following repeat exenteration for recurrent CRC. Based on this finding, we conducted a point-by-point discussion of certain key aspects that should be taken into consideration when approaching this patient cohort.PMID:38592018 | DOI:10.3390/jcm13051228 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Emmanuel Giannas Konstantinos Kavallieros Theodoros Nanidis John Giannas Paris Tekkis Christos Kontovounisios Source Type: research
Stereotactic Navigation-Assisted Laparoscopic Resection of Challenging Low Pelvic Tumors: A Case Series
Conclusions: The application of laparoscopic stereotactic navigation surgery to complex low pelvic tumors is feasible and could impact oncological surgical quality by enabling tumor targeting and ensuring resection margins. Further wider series are needed to confirm stereotactic navigation's impact on challenging low pelvic tumors.PMID:38592109 | DOI:10.3390/jcm13051233 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Guglielmo Niccol ò Piozzi Jung-Myun Kwak Ji-Seon Kim Se-Jin Baek Jin Kim Seon-Hahn Kim Source Type: research
Achieving Textbook Outcomes in Colorectal Cancer Surgery Is Associated with Improved Long-Term Survival: Results of the Multicenter Prospective Cohort Study
Conclusions: Elective colorectal resections result in successful TO for 52.5% of patients. The likelihood of failure to achieve TO is increased in patients with a high ASA score, while minimally invasive surgery is associated with higher TO rates. Patients who fail to achieve successful surgical outcomes experience reduced long-term outcomes.PMID:38592180 | DOI:10.3390/jcm13051304 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Marius Kryzauskas Augustinas Bausys Vilius Abeciunas Austeja Elzbieta Degutyte Klaudija Bickaite Rimantas Bausys Tomas Poskus Source Type: research
Validation of a Tool-Based Visual Anorectal Examination Advanced Simulator for the Early Detection of Colorectal Cancer
This study aims to establish the initial face, content, and construct validity of a tool-based visual anorectal examination advanced simulator model for proctoscopy and rigid sigmoidoscopy. This innovative, highly realistic simulated environment aims to enhance the training of healthcare professionals and improve the efficiency of detecting and diagnosing distal colorectal disease.PMID:38592245 | DOI:10.3390/jcm13051423 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Niamh Grayson Reza Haghighi Osgouei Renke Huang Paris Tekkis Fernando Bello Christos Kontovounisios Source Type: research
Modified neoadjuvant rectal score as a novel prognostic model for rectal cancer patients who underwent chemoradiotherapy
CONCLUSION: We established a novel prognostic model, for rectal cancer patients that have undergone neoadjuvant chemoradiotherapy, using a combination of apoptosis-detecting immunohistochemistry and neoadjuvant rectal scores.PMID:38592641 | DOI:10.1007/s10147-024-02520-4 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Kazushige Kawai Kosuke Ozaki Daisuke Nakano Akira Dejima Ichiro Ise Sakiko Nakamori Hiroki Kato Soichiro Natsume Misato Takao Tatsuro Yamaguchi Soichiro Ishihara Source Type: research
Panitumumab-Induced Periorbital Dermatitis: A Case Report
Clin Cosmet Investig Dermatol. 2024 Apr 3;17:763-767. doi: 10.2147/CCID.S459067. eCollection 2024.ABSTRACTPanitumumab is a recombinant, fully humanized immunoglobulin G2 monoclonal antibody targeting the epidermal growth factor receptor (EGFR). It is approved for the first- and second-line treatment of advanced wild-type KRAS colorectal cancer. Although common cutaneous side effects include acneiform dermatitis, folliculitis, and xerosis, ocular toxicities have occasionally been reported. Herein, we report the case of an 81-year-old Thai female with chemorefractory advanced stage sigmoid colon cancer who developed isolated...
Source: Clinical Colorectal Cancer - April 8, 2024 Category: Cancer & Oncology Authors: Napapat Pongbangpho Kumutnart Chanprapaph Wimolsiri Iamsumang Source Type: research
Number of older biological siblings and early-onset colorectal cancer risk
Clin Gastroenterol Hepatol. 2024 Apr 6:S1542-3565(24)00307-0. doi: 10.1016/j.cgh.2024.03.025. Online ahead of print.NO ABSTRACTPMID:38588764 | DOI:10.1016/j.cgh.2024.03.025 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 8, 2024 Category: Cancer & Oncology Authors: Noah C Peeri Peter S Liang Kelli O'Connell David A Katzka Elizabeth D Kantor Mengmeng Du Source Type: research
Microsatellite Instability Detection in Cancer: A Multiplex qPCR Approach that Obviates the Need for Matching Normal Samples
CONCLUSIONS: This study validates VarTrace as a swift, accurate, and economical assay for MSI detection in samples with low tumor percentages without the need for matching normal DNA. VarTrace's capacity for highly sensitive MSI analysis holds potential for enhancing the efficiency of clinical work flows and broadening the availability of this test.PMID:38581343 | DOI:10.1093/clinchem/hvae045 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Wei Chen Yan Helen Yan Blake Young Alessandro Pinto Qi Jiang Nanjia Song Adam Yaseen Weijie Yao David Yu Zhang Jinny Xuemeng Zhang Source Type: research
Genomic ancestry and cancer among Latin Americans
Clin Transl Oncol. 2024 Apr 6. doi: 10.1007/s12094-024-03415-6. Online ahead of print.ABSTRACTLatin American populations, characterized by intricate admixture patterns resulting from the intermingling of ancestries from European, Native American (NA) Asian, and African ancestries which result in a vast and complex genetic landscape, harboring unique combinations of novel variants. This genetic diversity not only poses challenges in traditional population genetics methods but also opens avenues for a deeper understanding of its implications in health. In cancer, the interplay between genetic ancestry, lifestyle factors, and...
Source: Clinical Colorectal Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Alejandro Ru íz-Patiño Leonardo Rojas Jairo Zuluaga Oscar Arrieta Luis Corrales Claudio Mart ín Sandra Franco Luis Raez Christian Rolfo Natalia S ánchez Andr és Felipe Cardona Source Type: research
Microsatellite Instability Detection in Cancer: A Multiplex qPCR Approach that Obviates the Need for Matching Normal Samples
CONCLUSIONS: This study validates VarTrace as a swift, accurate, and economical assay for MSI detection in samples with low tumor percentages without the need for matching normal DNA. VarTrace's capacity for highly sensitive MSI analysis holds potential for enhancing the efficiency of clinical work flows and broadening the availability of this test.PMID:38581343 | DOI:10.1093/clinchem/hvae045 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Wei Chen Yan Helen Yan Blake Young Alessandro Pinto Qi Jiang Nanjia Song Adam Yaseen Weijie Yao David Yu Zhang Jinny Xuemeng Zhang Source Type: research
Genomic ancestry and cancer among Latin Americans
Clin Transl Oncol. 2024 Apr 6. doi: 10.1007/s12094-024-03415-6. Online ahead of print.ABSTRACTLatin American populations, characterized by intricate admixture patterns resulting from the intermingling of ancestries from European, Native American (NA) Asian, and African ancestries which result in a vast and complex genetic landscape, harboring unique combinations of novel variants. This genetic diversity not only poses challenges in traditional population genetics methods but also opens avenues for a deeper understanding of its implications in health. In cancer, the interplay between genetic ancestry, lifestyle factors, and...
Source: Clinical Colorectal Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Alejandro Ru íz-Patiño Leonardo Rojas Jairo Zuluaga Oscar Arrieta Luis Corrales Claudio Mart ín Sandra Franco Luis Raez Christian Rolfo Natalia S ánchez Andr és Felipe Cardona Source Type: research
Microsatellite Instability Detection in Cancer: A Multiplex qPCR Approach that Obviates the Need for Matching Normal Samples
CONCLUSIONS: This study validates VarTrace as a swift, accurate, and economical assay for MSI detection in samples with low tumor percentages without the need for matching normal DNA. VarTrace's capacity for highly sensitive MSI analysis holds potential for enhancing the efficiency of clinical work flows and broadening the availability of this test.PMID:38581343 | DOI:10.1093/clinchem/hvae045 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Wei Chen Yan Helen Yan Blake Young Alessandro Pinto Qi Jiang Nanjia Song Adam Yaseen Weijie Yao David Yu Zhang Jinny Xuemeng Zhang Source Type: research
Genomic ancestry and cancer among Latin Americans
Clin Transl Oncol. 2024 Apr 6. doi: 10.1007/s12094-024-03415-6. Online ahead of print.ABSTRACTLatin American populations, characterized by intricate admixture patterns resulting from the intermingling of ancestries from European, Native American (NA) Asian, and African ancestries which result in a vast and complex genetic landscape, harboring unique combinations of novel variants. This genetic diversity not only poses challenges in traditional population genetics methods but also opens avenues for a deeper understanding of its implications in health. In cancer, the interplay between genetic ancestry, lifestyle factors, and...
Source: Clinical Colorectal Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Alejandro Ru íz-Patiño Leonardo Rojas Jairo Zuluaga Oscar Arrieta Luis Corrales Claudio Mart ín Sandra Franco Luis Raez Christian Rolfo Natalia S ánchez Andr és Felipe Cardona Source Type: research
Role of targeting ferroptosis as a component of combination therapy in combating drug resistance in colorectal cancer
World J Clin Oncol. 2024 Mar 24;15(3):375-377. doi: 10.5306/wjco.v15.i3.375.ABSTRACTColorectal cancer (CRC) is a form of cancer that is often resistant to chemotherapy, targeted therapy, radiotherapy, and immunotherapy due to its genomic instability and inflammatory tumor microenvironment. Ferroptosis, a type of non-apoptotic cell death, is characterized by the accumulation of iron and the oxidation of lipids. Studies have revealed that the levels of reactive oxygen species and glutathione in CRC cells are significantly lower than those in healthy colon cells. Erastin has emerged as a promising candidate for CRC treatment ...
Source: Clinical Colorectal Cancer - April 5, 2024 Category: Cancer & Oncology Authors: Xiao-Ting Xie Qiang-Hu Pang Lian-Xiang Luo Source Type: research
Ferroptosis biomarkers predict tumor mutation burden's impact on prognosis in HER2-positive breast cancer
CONCLUSION: Our model helps guide the prognosis of HER2+ breast cancer patients, and its combination with the TMB can aid in more accurate assessment of patient prognosis and provide new ideas for further diagnosis and treatment.PMID:38576597 | PMC:PMC10989258 | DOI:10.5306/wjco.v15.i3.391 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 5, 2024 Category: Cancer & Oncology Authors: Jin-Yu Shi Xin Che Rui Wen Si-Jia Hou Yu-Jia Xi Yi-Qian Feng Ling-Xiao Wang Shi-Jia Liu Wen-Hao Lv Ya-Fen Zhang Source Type: research
