Modified neoadjuvant rectal score as a novel prognostic model for rectal cancer patients who underwent chemoradiotherapy
CONCLUSION: We established a novel prognostic model, for rectal cancer patients that have undergone neoadjuvant chemoradiotherapy, using a combination of apoptosis-detecting immunohistochemistry and neoadjuvant rectal scores.PMID:38592641 | DOI:10.1007/s10147-024-02520-4 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Kazushige Kawai Kosuke Ozaki Daisuke Nakano Akira Dejima Ichiro Ise Sakiko Nakamori Hiroki Kato Soichiro Natsume Misato Takao Tatsuro Yamaguchi Soichiro Ishihara Source Type: research
Panitumumab-Induced Periorbital Dermatitis: A Case Report
Clin Cosmet Investig Dermatol. 2024 Apr 3;17:763-767. doi: 10.2147/CCID.S459067. eCollection 2024.ABSTRACTPanitumumab is a recombinant, fully humanized immunoglobulin G2 monoclonal antibody targeting the epidermal growth factor receptor (EGFR). It is approved for the first- and second-line treatment of advanced wild-type KRAS colorectal cancer. Although common cutaneous side effects include acneiform dermatitis, folliculitis, and xerosis, ocular toxicities have occasionally been reported. Herein, we report the case of an 81-year-old Thai female with chemorefractory advanced stage sigmoid colon cancer who developed isolated...
Source: Clinical Colorectal Cancer - April 8, 2024 Category: Cancer & Oncology Authors: Napapat Pongbangpho Kumutnart Chanprapaph Wimolsiri Iamsumang Source Type: research
Number of older biological siblings and early-onset colorectal cancer risk
Clin Gastroenterol Hepatol. 2024 Apr 6:S1542-3565(24)00307-0. doi: 10.1016/j.cgh.2024.03.025. Online ahead of print.NO ABSTRACTPMID:38588764 | DOI:10.1016/j.cgh.2024.03.025 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 8, 2024 Category: Cancer & Oncology Authors: Noah C Peeri Peter S Liang Kelli O'Connell David A Katzka Elizabeth D Kantor Mengmeng Du Source Type: research
Microsatellite Instability Detection in Cancer: A Multiplex qPCR Approach that Obviates the Need for Matching Normal Samples
CONCLUSIONS: This study validates VarTrace as a swift, accurate, and economical assay for MSI detection in samples with low tumor percentages without the need for matching normal DNA. VarTrace's capacity for highly sensitive MSI analysis holds potential for enhancing the efficiency of clinical work flows and broadening the availability of this test.PMID:38581343 | DOI:10.1093/clinchem/hvae045 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Wei Chen Yan Helen Yan Blake Young Alessandro Pinto Qi Jiang Nanjia Song Adam Yaseen Weijie Yao David Yu Zhang Jinny Xuemeng Zhang Source Type: research
Genomic ancestry and cancer among Latin Americans
Clin Transl Oncol. 2024 Apr 6. doi: 10.1007/s12094-024-03415-6. Online ahead of print.ABSTRACTLatin American populations, characterized by intricate admixture patterns resulting from the intermingling of ancestries from European, Native American (NA) Asian, and African ancestries which result in a vast and complex genetic landscape, harboring unique combinations of novel variants. This genetic diversity not only poses challenges in traditional population genetics methods but also opens avenues for a deeper understanding of its implications in health. In cancer, the interplay between genetic ancestry, lifestyle factors, and...
Source: Clinical Colorectal Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Alejandro Ru íz-Patiño Leonardo Rojas Jairo Zuluaga Oscar Arrieta Luis Corrales Claudio Mart ín Sandra Franco Luis Raez Christian Rolfo Natalia S ánchez Andr és Felipe Cardona Source Type: research
Microsatellite Instability Detection in Cancer: A Multiplex qPCR Approach that Obviates the Need for Matching Normal Samples
CONCLUSIONS: This study validates VarTrace as a swift, accurate, and economical assay for MSI detection in samples with low tumor percentages without the need for matching normal DNA. VarTrace's capacity for highly sensitive MSI analysis holds potential for enhancing the efficiency of clinical work flows and broadening the availability of this test.PMID:38581343 | DOI:10.1093/clinchem/hvae045 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Wei Chen Yan Helen Yan Blake Young Alessandro Pinto Qi Jiang Nanjia Song Adam Yaseen Weijie Yao David Yu Zhang Jinny Xuemeng Zhang Source Type: research
Genomic ancestry and cancer among Latin Americans
Clin Transl Oncol. 2024 Apr 6. doi: 10.1007/s12094-024-03415-6. Online ahead of print.ABSTRACTLatin American populations, characterized by intricate admixture patterns resulting from the intermingling of ancestries from European, Native American (NA) Asian, and African ancestries which result in a vast and complex genetic landscape, harboring unique combinations of novel variants. This genetic diversity not only poses challenges in traditional population genetics methods but also opens avenues for a deeper understanding of its implications in health. In cancer, the interplay between genetic ancestry, lifestyle factors, and...
Source: Clinical Colorectal Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Alejandro Ru íz-Patiño Leonardo Rojas Jairo Zuluaga Oscar Arrieta Luis Corrales Claudio Mart ín Sandra Franco Luis Raez Christian Rolfo Natalia S ánchez Andr és Felipe Cardona Source Type: research
Microsatellite Instability Detection in Cancer: A Multiplex qPCR Approach that Obviates the Need for Matching Normal Samples
CONCLUSIONS: This study validates VarTrace as a swift, accurate, and economical assay for MSI detection in samples with low tumor percentages without the need for matching normal DNA. VarTrace's capacity for highly sensitive MSI analysis holds potential for enhancing the efficiency of clinical work flows and broadening the availability of this test.PMID:38581343 | DOI:10.1093/clinchem/hvae045 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Wei Chen Yan Helen Yan Blake Young Alessandro Pinto Qi Jiang Nanjia Song Adam Yaseen Weijie Yao David Yu Zhang Jinny Xuemeng Zhang Source Type: research
Genomic ancestry and cancer among Latin Americans
Clin Transl Oncol. 2024 Apr 6. doi: 10.1007/s12094-024-03415-6. Online ahead of print.ABSTRACTLatin American populations, characterized by intricate admixture patterns resulting from the intermingling of ancestries from European, Native American (NA) Asian, and African ancestries which result in a vast and complex genetic landscape, harboring unique combinations of novel variants. This genetic diversity not only poses challenges in traditional population genetics methods but also opens avenues for a deeper understanding of its implications in health. In cancer, the interplay between genetic ancestry, lifestyle factors, and...
Source: Clinical Colorectal Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Alejandro Ru íz-Patiño Leonardo Rojas Jairo Zuluaga Oscar Arrieta Luis Corrales Claudio Mart ín Sandra Franco Luis Raez Christian Rolfo Natalia S ánchez Andr és Felipe Cardona Source Type: research
Role of targeting ferroptosis as a component of combination therapy in combating drug resistance in colorectal cancer
World J Clin Oncol. 2024 Mar 24;15(3):375-377. doi: 10.5306/wjco.v15.i3.375.ABSTRACTColorectal cancer (CRC) is a form of cancer that is often resistant to chemotherapy, targeted therapy, radiotherapy, and immunotherapy due to its genomic instability and inflammatory tumor microenvironment. Ferroptosis, a type of non-apoptotic cell death, is characterized by the accumulation of iron and the oxidation of lipids. Studies have revealed that the levels of reactive oxygen species and glutathione in CRC cells are significantly lower than those in healthy colon cells. Erastin has emerged as a promising candidate for CRC treatment ...
Source: Clinical Colorectal Cancer - April 5, 2024 Category: Cancer & Oncology Authors: Xiao-Ting Xie Qiang-Hu Pang Lian-Xiang Luo Source Type: research
Ferroptosis biomarkers predict tumor mutation burden's impact on prognosis in HER2-positive breast cancer
CONCLUSION: Our model helps guide the prognosis of HER2+ breast cancer patients, and its combination with the TMB can aid in more accurate assessment of patient prognosis and provide new ideas for further diagnosis and treatment.PMID:38576597 | PMC:PMC10989258 | DOI:10.5306/wjco.v15.i3.391 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 5, 2024 Category: Cancer & Oncology Authors: Jin-Yu Shi Xin Che Rui Wen Si-Jia Hou Yu-Jia Xi Yi-Qian Feng Ling-Xiao Wang Shi-Jia Liu Wen-Hao Lv Ya-Fen Zhang Source Type: research
Appendiceal intussusception complicated by adenocarcinoma of the cecum: A case report
CONCLUSIONS: Physicians should consider the possibility of appendiceal intussusception in cases of atypical appendicitis, particularly when associated with neoplastic presentation.PMID:38576819 | PMC:PMC10989461 | DOI:10.12998/wjcc.v12.i8.1461 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 5, 2024 Category: Cancer & Oncology Authors: Yu Long Yi-Ning Xiang Fei Huang Lei Xu Xiao-Yun Li Yun-Huan Zhen Source Type: research
Hypertension as predictive factor for bevacizumab-containing first-line therapy in metastatic breast and colorectal cancer in BRECOL (GEICAM/2011-04) study
CONCLUSIONS: Neither the frequency of AHT nor the increase of BP levels were predictive of efficacy in MBC and mCRC patients treated with bevacizumab-containing chemotherapy.CLINICAL TRIAL REGISTRY: ClinicalTrials.gov Identifier: NCT01733628.PMID:38578537 | DOI:10.1007/s12094-024-03411-w (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 5, 2024 Category: Cancer & Oncology Authors: Álvaro Rodríguez-Lescure Javier Gallego Pilar Garcia-Alfonso Bartomeu Massuti Ra úl Márquez Lourdes Calvo Pedro S ánchez-Rovira Antonio Ant ón Jos é Ignacio Chacón Eva Ciruelos Jose Juan Ponce Ana Santaballa Manuel Valladares-Ayerbes Mar ía Rosar Source Type: research
Effectiveness of G-CSF in chemotherapy for digestive system tumors: a systematic review of the Clinical Practice Guidelines for the Use of G-CSF 2022 delineated by the Japan Society of Clinical Oncology
CONCLUSION: The use of G-CSF for primary prophylaxis in chemotherapy for colorectal cancer is inappropriate.PMID:38578596 | DOI:10.1007/s10147-024-02502-6 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 5, 2024 Category: Cancer & Oncology Authors: Mamoru Ito Yuta Okumura Kenta Nio Eishi Baba Yukinori Ozaki Hiroshi Nishio Eiki Ichihara Yuji Miura Makoto Endo Shingo Yano Dai Maruyama Tetsuhiro Yoshinami Nobuyuki Susumu Munetaka Takekuma Takashi Motohashi Nobuaki Ochi Toshio Kubo Keita Uchino Takahiro Source Type: research
Plasma proteomic characterization of colorectal cancer patients with FOLFOX chemotherapy by integrated proteomics technology
CONCLUSIONS: Our study sheds light on the pathways affected in CRC patients treated with FOLFOX chemotherapy and identifies potential biomarkers that could be valuable for prognosis prediction. Our findings showed the potential of mass spectrometry-based proteomics and machine learning as an unbiased and systematic approach for discovering biomarkers in CRC.PMID:38580967 | DOI:10.1186/s12014-024-09454-z (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 5, 2024 Category: Cancer & Oncology Authors: Xi Wang Keren Zhang Wan He Luobin Zhang Biwei Gao Ruijun Tian Ruilian Xu Source Type: research
