Prediction of transformation in the histopathological growth pattern of colorectal liver metastases after chemotherapy using CT-based radiomics
This study included 181 patients with 298 CRLMs who underwent preoperative contrast-enhanced CT followed by partial hepatectomy between January 2007 and July 2022 at two institutions. HGPs were categorized as pure desmoplastic HGP (pdHGP) or non-pdHGP. The samples were allocated to training, internal validation, and external validation cohorts comprising 153, 65, and 29 CRLMs, respectively. Radiomics analysis was performed on pre-enhanced, arterial phase, portal venous phase (PVP), and fused images. The model was used to predict prechemotherapy HGPs in 112 CRLMs, and HGP transformation was analysed by comparing these findi...
Source: Clinical Colorectal Cancer - February 28, 2024 Category: Cancer & Oncology Authors: Shengcai Wei Xinyi Gou Yinli Zhang Jingjing Cui Xiaoming Liu Nan Hong Weiqi Sheng Jin Cheng Yi Wang Source Type: research
Exosomal non-coding RNAs in colorectal cancer metastasis
Clin Chim Acta. 2024 Feb 26:117849. doi: 10.1016/j.cca.2024.117849. Online ahead of print.ABSTRACTColorectal cancer (CRC) is a type of gastrointestinal cancer with high morbidity and mortality rates, and is often accompanied by distant metastases. Metastasis is a major cause of shortened survival time and poor treatment outcomes for patients with CRC. However, the molecular mechanisms underlying the metastasis of CRC remain unclear. Exosomes are a class of small extracellular vesicles that originate from almost all human cells and can transmit biological information (e.g., nucleic acids, lipids, proteins, and metabolites) ...
Source: Clinical Colorectal Cancer - February 28, 2024 Category: Cancer & Oncology Authors: Xiaoqian Yu Chiwen Bu Xuejie Yang Wenying Jiang Xiaoyun He Ru Sun Hongbin Guo Li Shang Chunlin Ou Source Type: research
Ureter Metastasis From Colorectal Cancer Revealed on 18F-FDG PET/CT
Clin Nucl Med. 2024 Feb 27. doi: 10.1097/RLU.0000000000005127. Online ahead of print.ABSTRACTThe involvement of the ureter as a site of metastasis of colorectal cancer is quite rare. Here we present FDG PET/CT findings of the right ureter metastasis from colon cancer in a patient after colectomy 6 years ago. 18F-FDG PET/CT showed increased 18F-FDG uptake in the right ureter with SUVmax of 4.3. The pathology and immunohistochemistry confirmed the diagnosis of ureter metastasis from colon cancer.PMID:38409759 | DOI:10.1097/RLU.0000000000005127 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 27, 2024 Category: Cancer & Oncology Authors: JiaNing Zhang Lan Yang LingGe Wei ZiYu Guo Peng Xie Source Type: research
Delphi consensus for the third-line treatment of metastatic colorectal cancer
CONCLUSION: The experts agreed with most of the proposed items on 3L treatment of mCRC, prioritizing therapeutic options that increase survival and preserve QoL, while facilitating the possibility that patients can continue to be treated later.PMID:38411748 | DOI:10.1007/s12094-023-03369-1 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 27, 2024 Category: Cancer & Oncology Authors: Pilar Garc ía-Alfonso Ruth Vera Enrique Aranda Elena Élez Fernando Rivera Source Type: research
Primary Tumor Resection Before Systemic Therapy in Patients With Colon Cancer and Unresectable Metastases: Combined Results of the SYNCHRONOUS and CCRe-IV Trials
CONCLUSION: Among patients with colon cancer and synchronous unresectable metastases, PTR before systemic chemotherapy was not associated with prolonged OS.PMID:38412408 | DOI:10.1200/JCO.23.01540 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 27, 2024 Category: Cancer & Oncology Authors: Nuh N Rahbari Sebastiano Biondo Ricardo Frago Manuel Fei ßt Esther Kreisler Inga Rossion Monica Serrano Dirk J äger Monika Lehmann Florian Sommer Axel Dignass Claus Bolling Ilka Vogel Ulrich Bork Markus W B üchler Gunnar Folprecht Meinhard Kieser Flori Source Type: research
Tumor-derived exosomal ADAM17 promotes pre-metastatic niche formation by enhancing vascular permeability in colorectal cancer
CONCLUSIONS: Our results suggest that exosomal ADAM17 plays a pivotal role in the hematogenous metastasis of CRC. Thus, this protein may serve as a valuable blood-based biomarker and potential drug target for CRC metastasis intervention.PMID:38413999 | PMC:PMC10898123 | DOI:10.1186/s13046-024-02991-3 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 27, 2024 Category: Cancer & Oncology Authors: Keyu Li Wenhua Xue Zhihua Lu Suo Wang Jiayao Zheng Kuangyi Lu Ming Li Yang Zong Feng Xu Jiamin Dai Yang Yang Jinbing Sun Source Type: research
Ureter Metastasis From Colorectal Cancer Revealed on 18F-FDG PET/CT
Clin Nucl Med. 2024 Feb 27. doi: 10.1097/RLU.0000000000005127. Online ahead of print.ABSTRACTThe involvement of the ureter as a site of metastasis of colorectal cancer is quite rare. Here we present FDG PET/CT findings of the right ureter metastasis from colon cancer in a patient after colectomy 6 years ago. 18F-FDG PET/CT showed increased 18F-FDG uptake in the right ureter with SUVmax of 4.3. The pathology and immunohistochemistry confirmed the diagnosis of ureter metastasis from colon cancer.PMID:38409759 | DOI:10.1097/RLU.0000000000005127 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 27, 2024 Category: Cancer & Oncology Authors: JiaNing Zhang Lan Yang LingGe Wei ZiYu Guo Peng Xie Source Type: research
Delphi consensus for the third-line treatment of metastatic colorectal cancer
CONCLUSION: The experts agreed with most of the proposed items on 3L treatment of mCRC, prioritizing therapeutic options that increase survival and preserve QoL, while facilitating the possibility that patients can continue to be treated later.PMID:38411748 | DOI:10.1007/s12094-023-03369-1 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 27, 2024 Category: Cancer & Oncology Authors: Pilar Garc ía-Alfonso Ruth Vera Enrique Aranda Elena Élez Fernando Rivera Source Type: research
Primary Tumor Resection Before Systemic Therapy in Patients With Colon Cancer and Unresectable Metastases: Combined Results of the SYNCHRONOUS and CCRe-IV Trials
CONCLUSION: Among patients with colon cancer and synchronous unresectable metastases, PTR before systemic chemotherapy was not associated with prolonged OS.PMID:38412408 | DOI:10.1200/JCO.23.01540 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 27, 2024 Category: Cancer & Oncology Authors: Nuh N Rahbari Sebastiano Biondo Ricardo Frago Manuel Fei ßt Esther Kreisler Inga Rossion Monica Serrano Dirk J äger Monika Lehmann Florian Sommer Axel Dignass Claus Bolling Ilka Vogel Ulrich Bork Markus W B üchler Gunnar Folprecht Meinhard Kieser Flori Source Type: research
Tumor-derived exosomal ADAM17 promotes pre-metastatic niche formation by enhancing vascular permeability in colorectal cancer
CONCLUSIONS: Our results suggest that exosomal ADAM17 plays a pivotal role in the hematogenous metastasis of CRC. Thus, this protein may serve as a valuable blood-based biomarker and potential drug target for CRC metastasis intervention.PMID:38413999 | DOI:10.1186/s13046-024-02991-3 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 27, 2024 Category: Cancer & Oncology Authors: Keyu Li Wenhua Xue Zhihua Lu Suo Wang Jiayao Zheng Kuangyi Lu Ming Li Yang Zong Feng Xu Jiamin Dai Yang Yang Jinbing Sun Source Type: research
NOS2 Polymorphism in Aspect of Left and Right-Sided Colorectal Cancer
Conclusions: In conclusion, the results support the hypothesis that the SNP rs2297518 of the NOS2 gene influences colorectal cancer development with regard to tumor localization.PMID:38398251 | PMC:PMC10888565 | DOI:10.3390/jcm13040937 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 24, 2024 Category: Cancer & Oncology Authors: Justyna Klusek Piotr Lewitowicz Ruslan Oblap Ewa Orlewska Bartosz Witczak Micha ł Tomasz Marzec Monika Koz łowska-Geller Łukasz Nawacki Monika Wawszczak-Kasza Kamila Koca ńda Artur J óźwik Stanis ław Głuszek Source Type: research
Current Approaches for Monitoring of Patients with Inflammatory Bowel Diseases: A Narrative Review
CONCLUSION: In light of growing clinical advances, we present a schematic evidence-based monitoring algorithm that can be easily applied in clinical practice which combines all major monitoring modalities, including noninvasive tools such as IUS and video-capsule endoscopy.PMID:38398321 | PMC:PMC10888591 | DOI:10.3390/jcm13041008 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 24, 2024 Category: Cancer & Oncology Authors: Alessandro Vitello Marcello Maida Endrit Shahini Fabio Salvatore Macaluso Ambrogio Orlando Mauro Grova Daryl Ramai Gaetano Serviddio Antonio Facciorusso Source Type: research
Early-Onset Colorectal Cancer: Are Neuroendocrine Tumors or Adenocarcinomas the Culprit? Analysis of the Largest U.S. Cancer Incidence Database, 2001-2020
Conclusions: Our study, covering ~98% of the U.S. population provides the first comparative analysis of early-onset CRC histopathological subtypes, showing that the rate of increase of NETs in young adults is much greater than that of ADC. Given that patients with NETs with malignant behavior can experience significant mortality, our findings are importance, highlighting the rapidly increasing NET incidence in young adults and encouraging early screening that can improve outcomes.PMID:38398411 | PMC:PMC10889361 | DOI:10.3390/jcm13041098 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 24, 2024 Category: Cancer & Oncology Authors: Yazan Abboud Madison Fraser Imran Qureshi Kaveh Hajifathalian Source Type: research
Paroxysmal Dystonic Posturing Mimicking Nocturnal Leg Cramps as a Presenting Sign in an Infant with DCC Mutation, Callosal Agenesis and Mirror Movements
Conclusions: This study underlines the importance of in-depth genetic investigations in young children with ACC and highlights the need for further detailed analyses of early motor symptoms in infants with DCC mutations.PMID:38398422 | PMC:PMC10889236 | DOI:10.3390/jcm13041109 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 24, 2024 Category: Cancer & Oncology Authors: Adriana Prato Lara Cirnigliaro Federica Maugeri Antonina Luca Loretta Giuliano Giuseppina Vitiello Edoardo Errichiello Enza Maria Valente Ennio Del Giudice Giovanni Mostile Renata Rizzo Rita Barone Source Type: research
The Impact of Mechanical Bowel Preparation and Oral Antibiotics in Colorectal Cancer Surgery (MECCA Study): A Prospective Randomized Clinical Trial
Conclusions: Preoperative antibiotic therapy in combination with mechanical bowel preparation seemed to be correlated with a lower SSI rate after colorectal cancer surgery.PMID:38398474 | PMC:PMC10889669 | DOI:10.3390/jcm13041162 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 24, 2024 Category: Cancer & Oncology Authors: Maximos Frountzas Victoria Michalopoulou Georgia Georgiou Despoina Kanata Maria Matiatou Despina Kimpizi Georgia Matthaiou Spilios Spiliotopoulos Dimitrios Vouros Konstantinos G Toutouzas George E Theodoropoulos Source Type: research
