Impact of Helicobacter pylori Infection and Treatment on Colorectal Cancer in a Large, Nationwide Cohort
CONCLUSION: H. pylori positivity may be associated with small but statistically significant higher CRC incidence and mortality; untreated individuals, especially those with confirmed active infection, appear to be most at risk.PMID:38427927 | DOI:10.1200/JCO.23.00703 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 1, 2024 Category: Cancer & Oncology Authors: Shailja C Shah M Constanza Camargo Mark Lamm Ranier Bustamante Christianne L Roumie Otis Wilson Alese E Halvorson Robert Greevy Lin Liu Samir Gupta Joshua Demb Source Type: research
Improved risk stratification scheme for mismatch repair proficient stage II colorectal cancers using the digital pathology biomarker QuantCRC
CONCLUSIONS: Incorporation of QuantCRC into risk stratification provides a powerful predictor of RFS that has potential to guide subsequent treatment and surveillance for stage II MMRP CRCs.PMID:38421684 | DOI:10.1158/1078-0432.CCR-23-3211 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 29, 2024 Category: Cancer & Oncology Authors: Christina Wu Reetesh K Pai Heidi Kosiorek Imon Banerjee Ashlyn Pfeiffer Catherine E Hagen Christopher P Hartley Rondell P Graham Mohamad B Sonbol Tanios Bekaii-Saab Hao Xie Frank A Sinicrope Bhavik Patel Thomas Westerling-Bui Sameer Shivji James Conner Ca Source Type: research
Small molecules that disrupt RAD54-BLM interaction hamper tumor proliferation in colon cancer chemoresistance models
J Clin Invest. 2024 Feb 29:e161941. doi: 10.1172/JCI161941. Online ahead of print.ABSTRACTRAD54 and BLM helicase play pivotal roles during homologous recombination repair (HRR) ensuring genome maintenance. BLM amino acids (181-212) interacts with RAD54 and enhances its chromatin remodelling activity. Functionally, this interaction heightens HRR, leading to a decrease in residual DNA damage in colon cancer cells. This contributes to chemoresistance in colon cancer cells against cisplatin, camptothecin and oxaliplatin, eventually promoting tumorigenesis in preclinical colon cancer mouse models. ChIP-seq analysis and validati...
Source: Clinical Colorectal Cancer - February 29, 2024 Category: Cancer & Oncology Authors: Ekjot Kaur Ritu Agrawal Rimpy Arun Vinoth Madhavan Vivek Srivastava Dilip Kumar Pragyan Parimita Rath Nitin Kumar Sreekanth Vedagopuram Nishant Pandey Swati Priya Patrick Legembre Samudrala Gourinath Avinash Bajaj Sagar Sengupta Source Type: research
Clinical Evaluation of the Effect of Encorafenib on Bupropion, Rosuvastatin, and Coproporphyrin I and Considerations for Statin Coadministration
CONCLUSION: The results from these clinical studies suggest that encorafenib does not cause clinically relevant CYP2B6 induction or inhibition but is an inhibitor of BCRP and may also inhibit OATP1B1/3 to a lesser extent. Based on these results, it may be necessary to consider switching statins or reducing statin dosage accordingly for coadministration with encorafenib.CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov NCT03864042, registered 6 March 2019.PMID:38424308 | DOI:10.1007/s40262-024-01352-9 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 29, 2024 Category: Cancer & Oncology Authors: Joseph Piscitelli Micaela B Reddy Lance Wollenberg Laurence Del Frari Jason Gong Linda Wood Yizhong Zhang Kyle Matschke Jason H Williams Source Type: research
JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors
In this study we investigate the effectiveness of inhibiting JAK/STAT3 in diverse CRC models, establish in which contexts high pathway expression is prognostic and perform in depth analysis underlying phenotypes. In this study we investigated the use of JAK inhibitors for anti-cancer activity in CRC cell lines, mouse model organoids and patient-derived organoids. Immunohistochemical staining of the TransSCOT clinical trial cohort, and 2 independent large retrospective CRC patient cohorts was performed to assess the prognostic value of JAK/STAT3 expression. We performed mutational profiling, bulk RNASeq and NanoString GeoMx...
Source: Clinical Colorectal Cancer - February 29, 2024 Category: Cancer & Oncology Authors: Kathryn A F Pennel Phimmada Hatthakarnkul Colin S Wood Guang-Yu Lian Sara S F Al-Badran Jean A Quinn Assya Legrini Jitwadee Inthagard Peter G Alexander Hester van Wyk Ahmad Kurniawan Umar Hashmi Michael A Gillespie Megan Mills Aula Ammar Jennifer Hay Ditt Source Type: research
Improved risk stratification scheme for mismatch repair proficient stage II colorectal cancers using the digital pathology biomarker QuantCRC
CONCLUSIONS: Incorporation of QuantCRC into risk stratification provides a powerful predictor of RFS that has potential to guide subsequent treatment and surveillance for stage II MMRP CRCs.PMID:38421684 | DOI:10.1158/1078-0432.CCR-23-3211 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 29, 2024 Category: Cancer & Oncology Authors: Christina Wu Reetesh K Pai Heidi Kosiorek Imon Banerjee Ashlyn Pfeiffer Catherine E Hagen Christopher P Hartley Rondell P Graham Mohamad B Sonbol Tanios Bekaii-Saab Hao Xie Frank A Sinicrope Bhavik Patel Thomas Westerling-Bui Sameer Shivji James Conner Ca Source Type: research
Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response
CONCLUSIONS: Our study emphasizes the critical impact of the screening methods for determining correlation between PDO drug screens and mCRC patient outcomes. Our 5-step optimization strategy provides a basis for future research on the clinical utility of PDO screens.PMID:38414064 | DOI:10.1186/s13046-024-02980-6 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 28, 2024 Category: Cancer & Oncology Authors: Lidwien P Smabers Emerens Wensink Carla S Verissimo Esmee Koedoot Katerina-Chara Pitsa Maarten A Huismans Celia Higuera Bar ón Mayke Doorn Liselot B Valkenburg-van Iersel Geert A Cirkel Anneta Brousali Ren é Overmeer Miriam Koopman Manon N Braat Bas Pen Source Type: research
Value of glucose transport protein 1 expression in detecting lymph node metastasis in patients with colorectal cancer
CONCLUSION: GLUT-1 expression was significantly correlated with the SUVmax of 18F-FDG-PET/CT for primary tumors and lymph nodes. Clinicians should consider GLUT-1 expression in preoperative endoscopic biopsy in interpreting PET/CT findings.PMID:38414613 | PMC:PMC10895641 | DOI:10.12998/wjcc.v12.i5.931 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 28, 2024 Category: Cancer & Oncology Authors: Hongsik Kim Song-Yi Choi Tae-Young Heo Kyeong-Rok Kim Jisun Lee Min Young Yoo Taek-Gu Lee Joung-Ho Han Source Type: research
Prediction of transformation in the histopathological growth pattern of colorectal liver metastases after chemotherapy using CT-based radiomics
This study included 181 patients with 298 CRLMs who underwent preoperative contrast-enhanced CT followed by partial hepatectomy between January 2007 and July 2022 at two institutions. HGPs were categorized as pure desmoplastic HGP (pdHGP) or non-pdHGP. The samples were allocated to training, internal validation, and external validation cohorts comprising 153, 65, and 29 CRLMs, respectively. Radiomics analysis was performed on pre-enhanced, arterial phase, portal venous phase (PVP), and fused images. The model was used to predict prechemotherapy HGPs in 112 CRLMs, and HGP transformation was analysed by comparing these findi...
Source: Clinical Colorectal Cancer - February 28, 2024 Category: Cancer & Oncology Authors: Shengcai Wei Xinyi Gou Yinli Zhang Jingjing Cui Xiaoming Liu Nan Hong Weiqi Sheng Jin Cheng Yi Wang Source Type: research
Exosomal non-coding RNAs in colorectal cancer metastasis
Clin Chim Acta. 2024 Feb 26:117849. doi: 10.1016/j.cca.2024.117849. Online ahead of print.ABSTRACTColorectal cancer (CRC) is a type of gastrointestinal cancer with high morbidity and mortality rates, and is often accompanied by distant metastases. Metastasis is a major cause of shortened survival time and poor treatment outcomes for patients with CRC. However, the molecular mechanisms underlying the metastasis of CRC remain unclear. Exosomes are a class of small extracellular vesicles that originate from almost all human cells and can transmit biological information (e.g., nucleic acids, lipids, proteins, and metabolites) ...
Source: Clinical Colorectal Cancer - February 28, 2024 Category: Cancer & Oncology Authors: Xiaoqian Yu Chiwen Bu Xuejie Yang Wenying Jiang Xiaoyun He Ru Sun Hongbin Guo Li Shang Chunlin Ou Source Type: research
Ureter Metastasis From Colorectal Cancer Revealed on 18F-FDG PET/CT
Clin Nucl Med. 2024 Feb 27. doi: 10.1097/RLU.0000000000005127. Online ahead of print.ABSTRACTThe involvement of the ureter as a site of metastasis of colorectal cancer is quite rare. Here we present FDG PET/CT findings of the right ureter metastasis from colon cancer in a patient after colectomy 6 years ago. 18F-FDG PET/CT showed increased 18F-FDG uptake in the right ureter with SUVmax of 4.3. The pathology and immunohistochemistry confirmed the diagnosis of ureter metastasis from colon cancer.PMID:38409759 | DOI:10.1097/RLU.0000000000005127 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 27, 2024 Category: Cancer & Oncology Authors: JiaNing Zhang Lan Yang LingGe Wei ZiYu Guo Peng Xie Source Type: research
Delphi consensus for the third-line treatment of metastatic colorectal cancer
CONCLUSION: The experts agreed with most of the proposed items on 3L treatment of mCRC, prioritizing therapeutic options that increase survival and preserve QoL, while facilitating the possibility that patients can continue to be treated later.PMID:38411748 | DOI:10.1007/s12094-023-03369-1 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 27, 2024 Category: Cancer & Oncology Authors: Pilar Garc ía-Alfonso Ruth Vera Enrique Aranda Elena Élez Fernando Rivera Source Type: research
Primary Tumor Resection Before Systemic Therapy in Patients With Colon Cancer and Unresectable Metastases: Combined Results of the SYNCHRONOUS and CCRe-IV Trials
CONCLUSION: Among patients with colon cancer and synchronous unresectable metastases, PTR before systemic chemotherapy was not associated with prolonged OS.PMID:38412408 | DOI:10.1200/JCO.23.01540 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 27, 2024 Category: Cancer & Oncology Authors: Nuh N Rahbari Sebastiano Biondo Ricardo Frago Manuel Fei ßt Esther Kreisler Inga Rossion Monica Serrano Dirk J äger Monika Lehmann Florian Sommer Axel Dignass Claus Bolling Ilka Vogel Ulrich Bork Markus W B üchler Gunnar Folprecht Meinhard Kieser Flori Source Type: research
Tumor-derived exosomal ADAM17 promotes pre-metastatic niche formation by enhancing vascular permeability in colorectal cancer
CONCLUSIONS: Our results suggest that exosomal ADAM17 plays a pivotal role in the hematogenous metastasis of CRC. Thus, this protein may serve as a valuable blood-based biomarker and potential drug target for CRC metastasis intervention.PMID:38413999 | PMC:PMC10898123 | DOI:10.1186/s13046-024-02991-3 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 27, 2024 Category: Cancer & Oncology Authors: Keyu Li Wenhua Xue Zhihua Lu Suo Wang Jiayao Zheng Kuangyi Lu Ming Li Yang Zong Feng Xu Jiamin Dai Yang Yang Jinbing Sun Source Type: research
Ureter Metastasis From Colorectal Cancer Revealed on 18F-FDG PET/CT
Clin Nucl Med. 2024 Feb 27. doi: 10.1097/RLU.0000000000005127. Online ahead of print.ABSTRACTThe involvement of the ureter as a site of metastasis of colorectal cancer is quite rare. Here we present FDG PET/CT findings of the right ureter metastasis from colon cancer in a patient after colectomy 6 years ago. 18F-FDG PET/CT showed increased 18F-FDG uptake in the right ureter with SUVmax of 4.3. The pathology and immunohistochemistry confirmed the diagnosis of ureter metastasis from colon cancer.PMID:38409759 | DOI:10.1097/RLU.0000000000005127 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - February 27, 2024 Category: Cancer & Oncology Authors: JiaNing Zhang Lan Yang LingGe Wei ZiYu Guo Peng Xie Source Type: research
