Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response

CONCLUSIONS: Our study emphasizes the critical impact of the screening methods for determining correlation between PDO drug screens and mCRC patient outcomes. Our 5-step optimization strategy provides a basis for future research on the clinical utility of PDO screens.PMID:38414064 | DOI:10.1186/s13046-024-02980-6

Source: Clinical Colorectal Cancer - February 28, 2024 Category: Cancer & Oncology Authors: Lidwien P Smabers Emerens Wensink Carla S Verissimo Esmee Koedoot Katerina-Chara Pitsa Maarten A Huismans Celia Higuera Bar ón Mayke Doorn Liselot B Valkenburg-van Iersel Geert A Cirkel Anneta Brousali Ren é Overmeer Miriam Koopman Manon N Braat Bas Pen Source Type: research