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Cetylev (Acetylcysteine Effervescent Tablets for Oral Solution) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 1, 2017 Category: Drugs & Pharmacology Source Type: news

Acetylcysteine Solution (N-acetyl-L-cysteine) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - April 4, 2017 Category: Drugs & Pharmacology Source Type: news

A girl with self-harm treated with N-acetylcysteine (NAC) - Rus CP.
Deliberate and recurrent self-harm could be regarded as addictive behaviour that can be treated with medication. In addiction, the dopaminergic mesolimbic reward system is activated. Pain caused by cutting stimulates the reward system through the opioid sy... (Source: SafetyLit)
Source: SafetyLit - March 31, 2017 Category: Global & Universal Tags: Suicide and Self-Harm Source Type: news

Do not get a serum acetaminophen level less than 4 hours after an acute ingestion
4 out of 5 stars Can a serum acetaminophen concentration obtained less than 4 hours post-ingestion determine which patients do not require treatment with acetylcysteine? Yarema MC et al. Clin Toxicol 2017 Feb;55:102-108. Abstract For decades the decision whether or not to treat acute acetaminophen [APAP] toxicity with N-acetylcysteine (NAC) has been guided by a serum APAP level drawn 4 or more hours after ingestion. The thought was that before 4 hours the level might be misleading because absorption of the drug might not be complete. This paper addresses the question of whether an earlier level can be suffic...
Source: The Poison Review - February 9, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical acetaminophen antidote APAP N-acetylcysteine rumack-matthew nomogram treatment Source Type: news

A potential pharmaceutical intervention for co-occurring PTSD and substance use disorder
(Medical University of South Carolina) Veterans with co-occurring PTSD and substance abuse disorder (SUD) who received the antioxidant N-acetylcysteine in addition to group cognitive behavioral therapy (CBT) for their SUD had fewer PTSD symptoms and less craving and depression than those who underwent CBT alone, according to the findings of a randomized, controlled pilot trial recently reported by researchers at the Medical University of South Carolina and the Ralph H. Johnson VA Medical Center in the Journal of Clinical Psychiatry. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 16, 2016 Category: Global & Universal Source Type: news

N-acetylcysteine shows early promise in reducing alcohol use in marijuana-dependent teens
N-acetylcysteine (NAC) reduced alcohol use in a small cohort of marijuana-dependent adolescents who exhibited reductions in marijuana use, report researchers. In this secondary analysis of data from an earlier trial of NAC in marijuana-dependent adolescents, researchers show that reduced marijuana use was associated with reductions in alcohol consumption in the NAC-treated, but not placebo-treated teens. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 14, 2016 Category: Science Source Type: news

N-acetylcysteine shows early promise in reducing alcohol use in marijuana-dependent teens
(Medical University of South Carolina) N-acetylcysteine (NAC) reduced alcohol use in a small cohort of marijuana-dependent adolescents who exhibited reductions in marijuana use, report researchers at the Medical University of South Carolina in the December 2016 Addictive Behaviors. In this secondary analysis of data from an earlier trial of NAC in marijuana-dependent adolescents, MUSC researchers show that reduced marijuana use was associated with reductions in alcohol consumption in the NAC-treated, but not placebo-treated teens. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 14, 2016 Category: Global & Universal Source Type: news

The Use of N-Acetylcysteine in Acetaminophen Overdose The Use of N-Acetylcysteine in Acetaminophen Overdose
Explore alternative methods for the delivery of N-acetylcysteine to reduce hepatotoxicity in acetaminophen poisoning.Pediatric Pharmacotherapy (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 23, 2016 Category: Consumer Health News Tags: Pediatrics Journal Article Source Type: news

Glutathione Benefits: Boosting Levels For Long, Healthy Life
Many people who live to be 100 or more have something in common. And it’s not that they’ve followed conventional “wisdom” about healthy diet and exercise. It’s that their bodies make more of a powerful antioxidant called glutathione than the average person. It’s what keeps them from being ravaged by the toxic world we live in. Glutathione is an important antioxidant produced by the body By now you know your body is under attack every day from the air you breathe, the chemicals you use, and the processed foods you eat. These toxins cause your body to produce free radicals. Here’s w...
Source: Al Sears, MD Natural Remedies - September 2, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Health Source Type: news

ESC: Is N-acetylcysteine the Key to Reducing Infarct Size? (CME/CE)
(MedPage Today) -- Pilot study shows benefit as measured by MRI (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - August 29, 2016 Category: Cardiology Source Type: news

NACIAM: N-Acetylcysteine Reduces Infarct Size NACIAM: N-Acetylcysteine Reduces Infarct Size
The addition of intravenous N-acetylcysteine to GTN reduced infarct size by approximately one third and doubled myocardial salvage in STEMI patients in this phase 2 study.Heartwire from Medscape (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - August 28, 2016 Category: Cardiology Tags: Cardiology News Source Type: news

Naciam: N-acetylcysteine offers a post-MI boost
The addition of intravenous (IV) N-acetylcysteine (NAC) to IV glyceryl trinitrate (GTN) significantly reduced infarct size by approximately one third in patients undergoing percutaneous coronary intervention (PCI) after ST-segment elevation acute myocardial infarction (STEMI), according to Hot Line research reported here. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - August 28, 2016 Category: Science Source Type: news

Acetaminophen Overdose Antidote Cetylev Recalled Acetaminophen Overdose Antidote Cetylev Recalled
Arbor Pharmaceuticals recalls three lots of acetylcysteine (Cetylev) effervescent tablets for oral solution because of an inadequate seal of the blister pack.News Alerts (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - August 19, 2016 Category: Drugs & Pharmacology Tags: Emergency Medicine News Alert Source Type: news

Voluntary Nationwide Recall of Cetylev ® (Acetylcysteine) Effervescent Tablets for Oral Solution Due to an Inadequate Seal of the Blister Pack
Arbor Pharmaceuticals, LLC (Arbor) today announced a voluntary recall of three (3) lots of Cetylev (acetylcysteine) effervescent tablets for oral solution, 500 mg, due to an inadequate seal of the blister pack. An inadequate seal could result in an increase of oxygen and moisture entering the blister cavity which can start the effervescent process. This results in enlarged and swelled tablets which could also completely dissolve within the blister pack. (Source: Food and Drug Administration)
Source: Food and Drug Administration - August 18, 2016 Category: Food Science Source Type: news

Voluntary Nationwide Recall of Cetylev ® (Acetylcysteine) Effervescent Tablets for Oral Solution Due to an Inadequate Seal of the Blister Pack
Arbor Pharmaceuticals, LLC (Arbor) today announced a voluntary recall of three (3) lots of Cetylev (acetylcysteine) effervescent tablets for oral solution, 500 mg, due to an inadequate seal of the blister pack. An inadequate seal could result in an increase of oxygen and moisture entering the blister cavity which can start the effervescent process. This results in enlarged and swelled tablets which could also completely dissolve within the blister pack. (Source: Food and Drug Administration)
Source: Food and Drug Administration - August 18, 2016 Category: Food Science Source Type: news

The role of N-acetylcysteine in the management of COPD: A review of recent literature
(Bentham Science Publishers) Recent studies indicate the clinical significant effects of N-Acetylcysteine such as reducing exacerbation frequency are seen at daily doses 1,200 mg or greater. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 3, 2016 Category: Global & Universal Source Type: news

Acetaminophen and N-acetylcysteine are removed by hemodialysis
3.5 out of 5 stars Massive acetaminophen overdose: effect of hemodialysis on acetaminophen and acetylcysteine kinetics. Ghannoum M et al. Clin Toxicol 2016 Jul;54:519-22. Abstract As we’ve discussed before, massive acetaminophen [APAP] overdose may be a somewhat different beast from the usual, run-of-the-mill case that reliably responds to N-acetylcysteine [NAC] (if administered at an early stage.)There is evidence that a very large intake of APAP (some say>500 mg/kg) can poison mitochondria, causing severe effects that manifest even before onset of hepatotoxicity. “Massive overdose” is ...
Source: The Poison Review - June 30, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical acetaminophen acetylcysteine hemodialysis massive overdose Source Type: news

Natural molecule could improve Parkinson's
The natural molecule, n-acetylcysteine (NAC), with strong antioxidant effects, shows potential benefit as part of the management for patients with Parkinson's disease, according to a study... (Source: Parkinson's Disease News From Medical News Today)
Source: Parkinson's Disease News From Medical News Today - June 20, 2016 Category: Neurology Tags: Parkinson's Disease Source Type: news

Natural molecule could improve Parkinson's
The natural molecule, n-acetylcysteine (NAC), with strong antioxidant effects, shows potential benefit as part of the management for patients with Parkinson's disease, according to a study published in the journal PLOS ONE. Combining clinical evaluations of a patient's mental and physical abilities with brain imaging studies that tracked the levels of dopamine, (Source: World Pharma News)
Source: World Pharma News - June 16, 2016 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Nutrients To Energize Your Mitochondria
For more than a decade now, I’ve been boosting my patients’ mitochondria with two super-nutrients — CoQ10 and pyrroloquinoline quinone, or PQQ. You see, if you keep your mitochondria healthy, your body will have all the energy it’ll ever need to stay strong and ward off the diseases of aging. The problem is that mainstream medicine is lagging way behind, so you won’t hear about this from your doctor. But along with your telomeres, the cellular time keepers at the ends of your chromosomes, your mitochondria are key components in the anti-aging equation. Keeping them safe and charged is essenti...
Source: Al Sears, MD Natural Remedies - May 18, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Health Source Type: news

Mitochondrial Function: The Other Half Of The Anti-Aging Story
Telomere science changed everything we knew about aging. But today, I want to talk to you about the other half of the anti-aging equation. Regular readers will already know by protecting your telomeres, you can slow — and even reverse — the aging process. You see, your telomeres are like little countdown clocks that protect the DNA in your cells. They shorten with each cell division. And the shorter they get the faster you develop the signs of aging. So by protecting and nourishing them, you can literally turn back the years. I was one of the first doctors to put telomere science to the test. And for years, I&...
Source: Al Sears, MD Natural Remedies - March 9, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Anti-Aging mitochondria telomere Source Type: news

Risperidone, aripiprazole treat irritability in children with ASD
Risperidone and aripiprazole, followed by N-acetylcysteine, appear most effective in treating irritability and aggression in youth with autism spectrum disorders (ASD), according to a systematic... (Source: Family Practice News)
Source: Family Practice News - March 2, 2016 Category: Primary Care Source Type: news

Risperidone, aripiprazole treat irritability in children with ASD
Risperidone and aripiprazole, followed by N-acetylcysteine, appear most effective in treating irritability and aggression in youth with autism spectrum disorders (ASD), according to a systematic... (Source: Pediatric News)
Source: Pediatric News - March 2, 2016 Category: Journals (General) Source Type: news

Cetylev (Acetylcysteine Effervescent Tablets for Oral Solution) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - February 22, 2016 Category: Drugs & Pharmacology Source Type: news

Arbor Pharmaceuticals Announces FDA Approval of Cetylev
Atlanta, GA, February 9, 2016 -- Arbor Pharmaceuticals announced today that the U.S. Food and Drug Administration (FDA) approved its New Drug Application (NDA) for Cetylev (acetylcysteine effervescent tablets for oral solution). Cetylev is an... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - February 9, 2016 Category: Drugs & Pharmacology Source Type: news

Global research productivity of N-acetylcysteine use in paracetamol overdose: A bibliometric analysis (1976-2012) - Zyoud SH, Al-Jabi SW, Sweileh WM, Awang R, Waring WS.
PURPOSE: The main objective of this study was to examine the publication pattern of N-acetylcysteine (NAC) research output for paracetamol overdose at the global level. METHODS: Data were searched for documents that contained specific words regardi... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - October 10, 2015 Category: Global & Universal Tags: Poisoning Source Type: news

Popular Antioxidant Seems to Spread Skin Cancer Cells in Mouse Research
But link between N-acetylcysteine and melanoma progression needs more study (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - October 8, 2015 Category: Cancer & Oncology Source Type: news

Popular Antioxidant Seems to Spread Skin Cancer Cells in Mouse Research
But link between N-acetylcysteine and melanoma progression needs more study (Source: WebMD Health)
Source: WebMD Health - October 7, 2015 Category: Consumer Health News Source Type: news

Popular Antioxidant Seems to Spread Skin Cancer Cells in Mouse Research
But link between N-acetylcysteine and melanoma progression needs more study (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - October 7, 2015 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Oncology, Research, Nutrition, News, Source Type: news

Popular Antioxidant Seems to Spread Skin Cancer Cells in Mouse Research
But link between N-acetylcysteine and melanoma progression needs more studySource: HealthDay Related MedlinePlus Pages: Antioxidants, Cancer Alternative Therapies, Skin Cancer (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - October 7, 2015 Category: Consumer Health News Source Type: news

Pfizer closes $15B Hospira takeover
Pfizer (NYSE:PFE) yesterday closed its $15 billion acquisition of Hospira, its largest-ever buyout, expanding its portfolio of generic injectable drugs and copies of biotech medicines. Hospira makes generic versions of injectable drugs used in hospitals, pumps to deliver such medicine and also sells biosimilars or copies of biotech drugs. Pfizer paid $90 per share in cash, a 39% premium to Hospira’s closing stock price the day before the February bid. It’s Pfizer’s largest acquisition since the New York-based company failed to snare AstraZeneca (NYSE:AZN), which rebuffed a $118 bi...
Source: Mass Device - September 4, 2015 Category: Medical Equipment Authors: Brad Perriello Tags: Mergers & Acquisitions Pharmaceuticals Hospira Inc. Pfizer Inc. Source Type: news

FTC clears Pfizer’s $15B Hospira buy
Pfizer (NYSE:PFE) said Monday it won approval from the Federal Trade Commission for its $15 billion acquisition of Hospira (NYSE:HSP). The clearance came with a caveat –Pfizer must divest itself of its Acetylcysteine, Clindamycin, Voriconazole and Melphalan sterile injectable assets, according to the company. The news from the FTC came August 21, according to an SEC filing from Hospira, and leaves the company with only 1 post-clearance waiting period in a single foreign jurisdiction, though the region was not specified. Pfizer also announced that Brazil has given the merger the thumbs up. “We are...
Source: Mass Device - August 27, 2015 Category: Medical Equipment Authors: Fink Densford Tags: Business/Financial News Mergers & Acquisitions Hospira Inc. Pfizer Inc. Source Type: news

Early metabolic acidosis and coma in massive acetaminophen overdose
3.5 out of 5 stars Coma and Severe Acidosis: Remember to Consider Acetaminophen. Villano JH et al. J Med Toxicol 2015 July 8 [Epub ahead of print] Reference This paper, from UC-San Diego, contains an excellent case discussion that makes numerous important points about a patient who presents with decreased mental status and high-anion-gap metabolic acidosis. The patient was a 28-year-old male who was brought to the emergency department because he was found to be unresponsive in his jail cell 16 hours after being arrested for murder. Initial evaluation revealed tachycardia (111/min,) mild hypothermia (95.5oF,) and a depresse...
Source: The Poison Review - August 7, 2015 Category: Toxicology Authors: Leon Tags: Medical acetaminophen overdose APAP elevated anion gap metabolic acidosis Source Type: news

Paracetamol poisoning: beyond the nomogram - Bateman DN.
Paracetamol poisoning is the commonest overdose seen in the UK. The management of patients with paracetamol poisoning has been little changed for the past 40 years, with a weight related dose of antidote (acetylcysteine) and treatment based on nomograms ... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - July 12, 2015 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Episode #9: TPR Podcast on hemodialysis in poisonings
Episode 9: EXTRIP Review   Written by Theresa Kim, MD   Outline EXTRIP Guideline Methodology Methanol Theophylline Lithium Acetaminophen   EXTRIP Guideline Methodology Extracorporeal treatments (ie. hemodialysis, hemoperfusion) are commonly used in poisonings despite lack of formal human trials Goal of the EXTRIP workgroup was to form an international collaboration among experts from nephrology, toxicology, critical care, pharmacology, and over 30 professional societies to form consensus recommendations and suggestions based on available research and expert opinion Clinical evidence ranked using GRADE ...
Source: The Poison Review - June 1, 2015 Category: Toxicology Authors: LeonThe Poison Review Tags: Podcast Source Type: news

Contrast-Induced Nephropathy in PCI: Evidence-Based PreventionContrast-Induced Nephropathy in PCI: Evidence-Based Prevention
Do patients given N-acetylcysteine (NAC) plus sodium chloride or sodium bicarbonate have better clinical outcomes than those who only get NaCL or NaCO3? British Journal of Cardiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 17, 2015 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

ACEP Toxicology Section Antidote App (free)
This simple but very useful app, from the Toxicology Section of the American College of Emergency Physicians, provides basic information about uses and dosing of basic antidotes used in toxicology. Version 1.1 covers approximately 50 different antidotes from A (acetylcysteine) to T (thiamine). Of course, clinical judgment is still required when considering these treatments, and most situations requiring use of the antidotes listed would justify consultation with a poison center. For example, one of the potential indications listed for hyperbaric oxygen (HBO) therapy in carbon monoxide (CO) poisoning is myocardial ischemia....
Source: The Poison Review - March 27, 2015 Category: Toxicology Authors: Leon Tags: Medical ACEP american college of emergency physicians android antidotes app iOS Source Type: news

N-acetylcysteine overdose after acetaminophen poisoning - Mahmoudi GA, Astaraki P, Mohtashami AZ, Ahadi M.
N-acetylcysteine (NAC) is used widely and effectively in oral and intravenous forms as a specific antidote for acetaminophen poisoning. Here we report a rare case of iatrogenic NAC overdose following an error in preparation of the solution, and describe it... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - March 26, 2015 Category: Global & Universal Tags: Poisoning Source Type: news

Milk and dairy 'good for the brain' claim unproven
ConclusionThis small study found people with higher dairy, milk and calcium consumption had higher levels of glutathione in the frontal and parietal regions of the brain. Glutathione is an antioxidant that helps to "neutralise" potentially harmful chemicals in the brain. Research into glutathione and its role in neurodegenerative diseases is in the early stages. It is known that the levels reduce with age and in certain conditions such as Alzheimer’s disease and Parkinson’s disease, but it is not known whether this is part of what leads to the disease or a consequence of the disease. This study does n...
Source: NHS News Feed - March 26, 2015 Category: Consumer Health News Tags: Neurology Food/diet Source Type: news

Paracetamol poisonings in the Czech and Slovak Republic and N-acetylcysteine treatment. Data analysis - Urban M, Cagáňová B, Plačková S, Kurcová I, Pelclova D.
OBJECTIVES: Paracetamol overdose belongs to frequent calls to Toxicological Information Centre (TIC) in the Czech Republic and to the National Toxicological Information Centre (NTIC) in Slovakia. The aim of the study was to evaluate outcomes and side effec... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - February 5, 2015 Category: Global & Universal Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

What’s better for amatoxin poisoning: silibinin or leprechaun luck?
Amanita phalloides 2 out of 5 stars Survival Following Investigational Treatment of Amanita Mushroom Poisoning: Thistle or Shamrock? Gores KM et al. Chest 2014 Oct 1 [Epub ahead of print] Abstract Amatoxins are potent RNA inhibitors, shutting down protein synthesis and producing hepatonecrosis and, occasionally, renal injury. There is not generally accepted treatment for amatoxin-induced hepatotoxicity aside from supportive care, early multi dose activated charcoal, and liver transplant if indicated. There are, however, a number of unproven therapies that have been used and advocated in the past. This case report, fro...
Source: The Poison Review - November 18, 2014 Category: Toxicology Authors: Leon Tags: Medical amanita phalloides amatoxin milk thistle mushroom poisoning silibinin Source Type: news

Must-read: consider hemodialysis in cases of massive acetaminophen overdose
4 out of 5 stars Extracorporeal treatment of acetaminophen poisoning: Recommendations from the EXTRIP workgroup. Gosselin S et al. Clin Toxicol 2014 Aug 18:1-12. [Epub ahead of print] Abstract These recommendations come from the Extracorporeal Treatments in Poisoning (EXTRIP) workgroup, a project established to provide some guidance on the use of hemodialysis and other techniques in toxicology cases, an area where high-quality evidence simply does not exist. Although there has been some disagreement among toxicologists about the value of this effort, I have found the papers that come from EXTRIP extreme...
Source: The Poison Review - September 6, 2014 Category: Toxicology Authors: Leon Tags: Medical acetaminophen enhanced elimination extracorporeal treatment extracorporeal treatments in poisoning workgroup extrip massive overdose N-acetylcysteine paracetamol tylenol Source Type: news

Antioxidant No Help in IPF (CME/CE)
SAN DIEGO (MedPage Today) -- N-acetylcysteine (NAC) used on its own had no impact on outcomes in idiopathic pulmonary fibrosis (IPF), the PANTHER-IPF trial showed. (Source: MedPage Today Allergy)
Source: MedPage Today Allergy - May 19, 2014 Category: Allergy & Immunology Source Type: news

Antioxidant No Help in IPF
SAN DIEGO (MedPage Today) -- N-acetylcysteine (NAC) used on its own had no impact on outcomes in idiopathic pulmonary fibrosis (IPF), the PANTHER-IPF trial showed. (Source: MedPage Today Allergy)
Source: MedPage Today Allergy - May 19, 2014 Category: Allergy & Immunology Source Type: news

Acetylcysteine Solution 10 Percent/Roxane: Recall - Glass Particles in Product
Use of an inhaled product with glass particles has potential to cause choking which could be life-threatening. Aerosolization of small glass particles in airways could result in recurrent infections. (Source: FDA MedWatch)
Source: FDA MedWatch - February 15, 2014 Category: American Health Source Type: news

Acetylcysteine Solution 10 Percent: Recall - Glass Particles in Product
Use of an inhaled product with glass particles has potential to cause choking which could be life-threatening. Aerosolization of small glass particles in airways could result in recurrent infections. (Source: FDA MedWatch)
Source: FDA MedWatch - February 15, 2014 Category: American Health Source Type: news

Antioxidant for COPD Questioned
(MedPage Today) -- The antioxidant N-acetylcysteine may be popular in chronic obstructive pulmonary disease after cutting exacerbations in some trials, but don't expect to see it in guidelines any time soon, two pulmonologists argued. (Source: MedPage Today Allergy)
Source: MedPage Today Allergy - February 5, 2014 Category: Allergy & Immunology Source Type: news

Do we need to change the dosing regimen for IV N-acetylcysteine
1.5 out of 5 stars Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomized controlled trial. Bateman DM et al. Lancet 2013 Nov 28 [Epub ahead of print] Abstract The authors argue that since there is a high incidence of adverse events — nausea and vomiting, anaphylactoid reactions —  associated with the standard protocol for administering intravenous N-acetylcysteine (IV-NAC), a different dosing regimen might be safer and just as effective. In this somewhat complicated trial from Great Britain, subjects were randomized to 4...
Source: The Poison Review - December 22, 2013 Category: Toxicology Authors: Leon Tags: Medical acetaminophen adverse events N-acetylcysteine NAC rumack-matthew nomogram Source Type: news

Revised treatment for acetaminophen poisoning
Patients suffering acetaminophen poisoning could be helped by a small change in the way the antidote is delivered, say scientists from the University of Edinburgh in the UK.The study, published in The Lancet, shows that using the same antidote, acetylcysteine, over a shorter time period leads to fewer side effects.The Food and Drug Administration (FDA) says that acetaminophen, also known as paracetamol and Tylenol, is one of the most commonly used drugs in the US. It has a good record of safety and efficacy when used according to the directions on the packaging. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 2, 2013 Category: Consumer Health News Tags: Clinical Trials / Drug Trials Source Type: news

Shorter Acetaminophen-Poisoning Regimen Less Likely to Induce Discomfort (FREE)
By Joe Elia A shorter acetylcysteine treatment regimen for acetaminophen poisoning carries a lower risk for early vomiting than standard therapy, a Lancet study finds.Researchers randomized some 220 patients with acetaminophen overdose to either standard or modified regimens; they were … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - December 2, 2013 Category: Primary Care Source Type: news