Fifty years of paracetamol (acetaminophen) poisoning: the development of risk assessment and treatment 1973-2023 with particular focus on contributions published from Edinburgh and Denver - Bateman DN, Dart RC, Dear JW, Prescott LF, Rumack BH.
INTRODUCTION: Fifty years ago, basic scientific studies and the availability of assay methods made the assessment of risk in paracetamol (acetaminophen) poisoning possible. The use of the antidote acetylcysteine linked to new methods of risk assessment tra... (Source: SafetyLit)
Source: SafetyLit - January 15, 2024 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Researchers offer hypothesis for long COVID brain fog
A group in France has offered an explanation for long COVID brain fog, with the concept based on a visual brain pattern they discovered on patient PET scans, according to a study published October 13 in Medical Hypotheses. “We hypothesize that the hypometabolism pattern observed in long COVID patients with brain fog using F-18 FDG-PET might primarily be a signature of astrocyte-related glutamatergic dysregulation,” wrote lead study author Eric Guedj, MD, PhD, of Marseille University Hospital.That is, brain inflammation triggered by COVID-19 infections may disrupt how astrocyte cells regulate glutamate, a neurotransmitt...
Source: AuntMinnie.com Headlines - October 19, 2023 Category: Radiology Authors: Will Morton Tags: Clinical News Molecular Imaging Nuclear Medicine Source Type: news
Developing new antidotes for poisons with existing effective treatments: a case study of fomepizole in paracetamol poisoning - Dear JW, Bateman DN.
INTRODUCTION: Acetylcysteine is the only effective and licensed therapy for paracetamol poisoning. However, acetylcysteine loses efficacy if treatment is delayed 8-12 hours after paracetamol ingestion, and there is also uncertainty as to whether the dose s... (Source: SafetyLit)
Source: SafetyLit - September 27, 2023 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
FDA Declares Hangover a Disease
If you’ve ever woken up with a pounding headache, nausea, and dizziness after having a cocktail (or two) too many the night before – you may feel like you’re dying!
Of course, you also know that the symptoms of a hangover will soon pass…and by the end of the day, you’ll feel like yourself again.
But according to the FDA, if you are hungover, you don’t just feel sick. You have a disease…
I couldn’t make this stuff up if I tried.
Earlier this year, in their never-ending efforts to stop supplement makers from offering safe, natural, and tested solutions, the Federal government labeled the dreaded “m...
Source: Al Sears, MD Natural Remedies - August 9, 2023 Category: Complementary Medicine Authors: Jacob Tags: Health Source Type: news
Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease - Chidiac AS, Buckley NA, Noghrehchi F, Cairns R.
INTRODUCTION: Paracetamol is one of the most used medicines worldwide and is the most common important poisoning in high-income countries. In overdose, paracetamol causes dose-dependent hepatotoxicity. Acetylcysteine is an effective antidote, however despi... (Source: SafetyLit)
Source: SafetyLit - July 19, 2023 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Acute kidney injury after treatment of paracetamol overdose using new N-acetylcysteine guideline - Strehle EM, Haar I.
For several decades, UK children and young people (CYP) have been treated with the standard N-acetylcysteine (NAC) protocol following a paracetamol overdose (POD).1 Some patients develop liver impairment, but acute kidney injury (AKI) is uncommon.2 In 2021... (Source: SafetyLit)
Source: SafetyLit - March 1, 2023 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
The Hunt for N-Acetylcysteine: Medicine or Dietary Supplement? The Hunt for N-Acetylcysteine: Medicine or Dietary Supplement?
Psychiatrist Dinah Miller notes that the supplement abruptly became difficult to find in 2021 owing to"a cat-and-mouse chase" between manufacturers, advocacy agencies, and the FDA.MDedge (Source: Medscape Psychiatry Headlines)
Source: Medscape Psychiatry Headlines - October 4, 2022 Category: Psychiatry Tags: Psychiatry Commentary Source Type: news
Mucus Too Sticky? NAC Injections May Help
(MedPage Today) -- BARCELONA -- Patients with heavy mucus secretions that they couldn't readily expectorate obtained some relief with IV N-acetylcysteine (NAC), a researcher said here.
After 7 days of treatment in a randomized trial conducted... (Source: MedPage Today Allergy)
Source: MedPage Today Allergy - September 5, 2022 Category: Allergy & Immunology Source Type: news
N-acetylcysteine as an antidote for paracetamol poisoning: a multicenter study - Codinach-Mart ín M, Ortega-Pérez J, Gispert-Ametller M, Salgado-García E, Rodríguez-Mariblanca A, Nogué-Xarau S, Puiguriguer-Ferrando J.
OBJECTIVES: To identify the most common problems related to use of N-acetylcysteine to reverse the toxic effects of paracetamol poisoning. MATERIAL AND METHODS: Retrospective descriptive observational study of clinical records for patients treated for para... (Source: SafetyLit)
Source: SafetyLit - June 27, 2022 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
acetylcysteine
Title: acetylcysteineCategory: MedicationsCreated: 2/25/2022 12:00:00 AMLast Editorial Review: 2/25/2022 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - February 25, 2022 Category: Drugs & Pharmacology Source Type: news
Antioxidant agent protects DNA from ionizing radiation
N-acetylcysteine is a promising compound for protecting cells from DNA damag...Read more on AuntMinnie.comRelated Reading:
Low-dose CT works just as well as standard to diagnose appendicitis
Most radiologists willing to perform PET/CT in pregnant women
Body position on x-ray affects radiation dose in children
Can 3D-printed shields protect patients during radiation therapy?
Antioxidant formula halves DNA damage from CT (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - November 30, 2021 Category: Radiology Source Type: news
Author Q & A: Ketamine as a treatment for depression
In this interview with Doctoral Researcher Rebecca Dean and Professor Andrea Cipriani we learn more about two reviews investigating the use of ketamine as a treatment for depression recently published through Cochrane ’s Common Mental Disorders Group.Tell us about this Cochrane ReviewThis review is an update of a Cochrane review published in 2015, investigating the use of ketamine and other glutamate receptor modulators as a treatment for unipolar depression (also known as major depressive disorder).Since 2015, a lot of research has been published in this area and the FDA has recently licensed esketamine (Spravato) for u...
Source: Cochrane News and Events - October 7, 2021 Category: Information Technology Authors: Lydia Parsonson Source Type: news
Biocompatible orthodontic cement with antibacterial capability and protein repellency
ConclusionsThe new cement with NAg, NAC and MPC had strong antibacterial capability, protein-repellent ability and acceptable biocompatibility. The new cement is promising to protect enamel from demineralization during orthodontic treatments. (Source: Dental Technology Blog)
Source: Dental Technology Blog - August 25, 2021 Category: Dentistry Source Type: news
Acetylcysteine Solution (Mucomyst) (N-acetyl-L-cysteine) - updated on RxList
Mucomyst (Acetylcysteine Solution) may treat pulmonary disease. Learn about side effects, dosage, drug interactions, warnings, precautions, and contraindications. (Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 18, 2021 Category: Drugs & Pharmacology Source Type: news
Identifying biological signatures of n-acetylcysteine for non-suicidal self-injury in adolescents and young adults - Sahasrabudhe SA, Silamongkol T, Park YW, Colette A, Eberly LE, Klimes-Dougan B, Coles LD, Cloyd JC, Öz G, Mueller BA, Kartha RV, Cullen KR.
The prevalence of non-suicidal self-injury (NSSI) is high in adolescents and young adults. However, there is a paucity of evidence-based treatments to address this clinical problem. An open-label, pilot study in the target population showed that treatment ... (Source: SafetyLit)
Source: SafetyLit - May 28, 2021 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
