Versatile drug may protect baby from hazards of intraamniotic infections
The drug N-acetylcysteine has been shown to decrease mortality and short-term neonatal morbidity in pregnancies complicated by infections or inflammation. (Source: Yale Science and Health News)
Source: Yale Science and Health News - February 15, 2019 Category: Universities & Medical Training Source Type: news
Treatment of military acoustic accidents with N-Acetyl-L-cysteine (NAC) - Rosenhall U, Skoog B, Muhr P.
OBJECTIVE: To study if the antioxidant (AO) N-Acetyl-L-cysteine (NAC) reduces the risk of hearing loss after acoustic accidents in humans. DESIGN: A retrospective, observational study. STUDY SAMPLE: Personnel of the Swedish Armed Forces (SAF) expos... (Source: SafetyLit)
Source: SafetyLit - January 21, 2019 Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
Pattern of paracetamol poisoning: influence on outcome and complications - Castanares-Zapatero D, Dinant V, Ruggiano I, Willem H, Laterre PF, Hantson P.
Acute paracetamol poisoning due to a single overdose may be effectively treated by the early administration of N-acetylcysteine (NAC) as an antidote. The prognosis may be different in the case of intoxication due to multiple ingestions or when the antidote... (Source: SafetyLit)
Source: SafetyLit - October 5, 2018 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Paracetamol self-poisoning: when oral N-acetylcysteine saves life? A case report - Benlamkaddem S, Iken I, Houari N, Elbouazzaoui A, Boukatta B, Sba ï H, Achour S, Kanjaa N.
We report a case of a 24-year-old Arab female who ha... (Source: SafetyLit)
Source: SafetyLit - June 11, 2018 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
New PRESERVE Analysis Backs Normal Saline Hydration in PCI New PRESERVE Analysis Backs Normal Saline Hydration in PCI
Normal saline was better than IV sodium bicarbonate or oral N-acetylcysteine for preserving renal function, but observers question whether the evidence should change PCI guidelines.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 3, 2018 Category: Consumer Health News Tags: Cardiology News Source Type: news
Acetadote (Acetylcysteine Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - April 20, 2018 Category: Drugs & Pharmacology Source Type: news
Retrospective study of paracetamol poisoning in children aged 0-6 years found no cases of liver injury - Dan-Nielsen S, Bisgaard AS, Jans SR, Arianto L, Heedeland RL, J ørgensen MH.
This study focused on children aged 0-6 years with suspected single-dose paracetamol poisoning, which has not been investigated in Denmark. We evaluated the incidence of liver injuries and the use of activated charcoal and N-acetylcysteine treatment. ... (Source: SafetyLit)
Source: SafetyLit - March 28, 2018 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Can we improve prognostic indications in acetaminophen-induced hepatic failure?
The objective was to compare the markers of hypoglycemia (glucose < 50 mg/dL,) coagulopathy, and lactic acidosis (lactate above hospital’s “normal” range) in predicting a composite endpoint of death or liver transplantation.
The authors identified 334 unique cases. 19 of these were listed for transplant, and 13 actually received liver transplant. (2 transplanted patients subsequently died.) Although 96 patients (29%) met the King’s College Criteria, it is not clear how many of these who were not transplanted died. There were 40 deaths in all.
After some statistical manipulation which was not at...
Source: The Poison Review - February 9, 2018 Category: Toxicology Authors: Leon Gussow Tags: Medical acetaminophen poisoning hepatic failure king's college criteria liver transplantation Source Type: news
Is there a better way to administer IV N-acetylcysteine?
3 out of 5 stars
Fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose. McNulty R et al. Clin Toxicol 2017 Dec 8 [Epub ahead of print]
Abstract
Current recommendations for dosing intravenous N-acetylcysteine (Acetadote) for treating acute acetaminophen (paracetamol) poisoning involves a somewhat complex three-bag protocol, using 3 direct concentrations of the antidote given over a 21-hour period. Unfortunately, this protocol results in a high incidence of (usually mild) adverse events, including cutaneous effects, nausea and vomiting, and anaphylactoid reactions. Severe reactions s...
Source: The Poison Review - December 14, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical Acetadote acetaminophen antidote N-acetylcysteine paracetamol three-bag protocol toxicity two-bag protocol Source Type: news
Cold remedy reduces cancer aggressiveness by up to 80%
Researchers from the University of Salford found N-Acetylcysteine (NAC) significantly lowers levels of the breast cancer aggressiveness marker MCT4, offering an inexpensive, safe therapy. (Source: the Mail online | Health)
Source: the Mail online | Health - November 22, 2017 Category: Consumer Health News Source Type: news
Sodium Bicarbonate, Acetylcysteine Don't Prevent Kidney Injury After Angiography
Neither sodium bicarbonate nor acetylcysteine appears to reduce risk for acute kidney injury in high-risk patients undergoing angiography, according to a randomized trial published... (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - November 13, 2017 Category: Primary Care Source Type: news
No Benefit From Bicarbonate, Acetylcysteine Postangiography No Benefit From Bicarbonate, Acetylcysteine Postangiography
In the PRESERVE trial, neither intravenous sodium bicarbonate nor oral N-acetylcysteine significantly reduced adverse outcomes compared with sodium chloride or placebo.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - November 13, 2017 Category: Cardiology Tags: Cardiology News Source Type: news
N-acetylcysteine for nonsuicidal self-injurious behavior in adolescents: an open-label pilot study - Cullen KR, Klimes-Dougan B, Westlund Schreiner M, Carstedt P, Marka N, Nelson K, Miller MJ, Reigstad K, Westervelt A, Gunlicks-Stoessel M, Eberly LE.
BACKGROUND: Nonsuicidal self-injury (NSSI) is common in adolescents and young adults, and few evidence-based treatments are available for this significant problem. N-acetylcysteine (NAC) is a widely available nutritional supplement that has been studied in... (Source: SafetyLit)
Source: SafetyLit - October 23, 2017 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Multi-mechanism approach to treating neonatal hypoxic ischemia
(Medical University of South Carolina) Male sex is a risk factor for worse outcome following neonatal insult, including hypoxic ischemia. While N-acetylcysteine and hypothermia promote functional improvement in female rodents, similar improvement in males requires the addition of vitamin D, report investigators at the Medical University of South Carolina in the September 1, 2017 issue of Neuropharmacology. Multi-mechanism approaches are needed to treat neonatal hypoxic ischemia, and those approaches appear to be different depending on sex. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 1, 2017 Category: International Medicine & Public Health Source Type: news
Cetylev (Acetylcysteine Effervescent Tablets for Oral Solution) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 1, 2017 Category: Drugs & Pharmacology Source Type: news
