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Must-read article: America ’s Misguided War on Childhood Lead Exposures
This article is essential reading for all pediatricians, emergency practitioners, and toxicologists. (Source: The Poison Review)
Source: The Poison Review - March 23, 2018 Category: Toxicology Authors: Leon Gussow Tags: Best of TPR Medical blood level lead toxicity Source Type: news

A diagnosis you can ’t afford to miss
4 out of 5 stars Antibody-Mediated Encephalitis. Dalmau J, Graus F. N Engl J Med 2018 Mar 1;378:840-851. Reference TPR has posted before about anti-NMDA receptor encephalitis, a must-know, can’t-miss, humbling diagnosis that is distressingly easy to overlook. Although it is not a toxicologic condition, all toxicologists and emergency physicians should be thoroughly familiar with its presentation and clinical course. Let me explain why. NMDAR encephalitis often begins with behavioral changes, mood swings, and memory deficits in relatively young patients. According to this somewhat technical but excellent review, ...
Source: The Poison Review - March 2, 2018 Category: Toxicology Authors: Leon Gussow Tags: Medical anbitody-mediated encephalitis anti-NMDA receptor encephalitis brain on fire diagnosis Source Type: news

Flubromazolam: a potent designer benzodiazepine
Flubromazolam 3 out of 5 stars Flubromazolam — A new life-threatening designer benzodiazepine. Lukasik-Glebocka M et al. Clin Toxicol 2016;54:66-68. Abstract Last month, the Peoria (IL) Journal-Star reported that local police had seized samples of two rarely seen designer sedatives: flubromazolam (alleged street name “liquid Xanax“) and etizolam. This paper from Poland presents a case report of flubromazolam exposure. A 27-year-old male known to use psychotropic drugs was brought to hospital after being found unconscious at home. On arrival he was comatose with a Glasgow Coma Scale of 3. On...
Source: The Poison Review - February 28, 2018 Category: Toxicology Authors: Leon Gussow Tags: Medical benzodiazepine analog designer drug etizolam flubromazolam liquid xanax sedative-hypnotic Source Type: news

Can we improve prognostic indications in acetaminophen-induced hepatic failure?
The objective was to compare the markers of hypoglycemia (glucose
Source: The Poison Review - February 9, 2018 Category: Toxicology Authors: Leon Gussow Tags: Medical acetaminophen poisoning hepatic failure king's college criteria liver transplantation Source Type: news

Can smoking marijuana cause meningitis?
Cryptococcus neoformans (wikipedia.org) 2.5 out of 5 stars Cryptococcal meningitis in a daily cannabis smoker without evidence of immunodeficiency. Shapiro BB et al. BMJ Case Rep 2018 Jan 26 [Epub ahead of print] Abstract Can smoking marijuana cause meningitis? The question is not unreasonable. A wide range of pathogenic fungi — including Aspergillus and various Cryptococcus species — have been isolated from dispensary-grade medical marijuana samples. Concern that these pathogens could cause pneumonia or central nervous system infections has focussed on those with immunodeficiency, such...
Source: The Poison Review - February 2, 2018 Category: Toxicology Authors: Leon Gussow Tags: Medical cannabis cryptococcus fungal infection marijuana meningitis Source Type: news

Anterograde amnesia and hippocampal lesions: is fentanyl the culprit?
Hippocampus (wikipedia.org) 3 out of 5 stars An Unusual Amnesic Syndrome Associated With Combined Fentanyl and Cocaine Use. Duru LB et al. Ann Intern Med 30 Jan 2018 [Epub ahead of print] Reference Last year we reviewed an MMWR report describing 14 cases of anterograde amnesia associated with substance abuse and bilateral ischemia of the hippocampi, as well as an additional paper giving somewhat more detailed clinical information on the initial four cases. This letter describes an additional case that occurred in West Virginia. A 30-year-old man with a history of heroin use was found at home to be difficult to ar...
Source: The Poison Review - January 31, 2018 Category: Toxicology Authors: Leon Gussow Tags: Medical cocaine fentanyl hippocampus hippocampus ischemia norfentanyl opiate opioid Source Type: news

Comprehensive up-to-date review of toxic alcohol poisoning
3.5 out of 5 stars Toxic Alcohols. Kraut JA, Mullins ME. N Engl J Med 2018 Jan 18;378:270-280. Reference This is a good general review and update of clinical issues regarding the major toxic alcohols: methanol, ethylene glycol, isopropanol, diethylene glycol, and propylene glycol. The article is chockablock with information, and would I think be somewhat difficult to follow if one was not already familiar with these agents. For those wishing to learn the subject de novo, a good introductory book chapter in a toxicology or emergency medicine text would be better. But this is a very good refresher for those already...
Source: The Poison Review - January 30, 2018 Category: Toxicology Authors: Leon Gussow Tags: Medical diethylene glycol isopropanol methanol propylene glycol Review toxic alcohol Source Type: news

Tox Tunes #114: Mr. Pharmacist (The Fall)
Although The Fall had been making music since the late 1970s and is considered one of the most durable and long-lasting groups to emerge from the British post-punk scene, they had really never been on my radar. When the group’s vocalist and founder Mark E. Smith died this week, his obituary in the New York Times noted: At various points in the band’s four-decade career, the Fall might sound like punk, hard rock, psychedelia, funk, blues-rock, jazz-rock, electropop or sheer noise. “If it’s me and your granny on bongos, it’s the Fall,” Mr. Smith once declared. The BBC disc jockey...
Source: The Poison Review - January 29, 2018 Category: Toxicology Authors: Leon Gussow Tags: Medical Mark E. Smith Mr. Pharmacist the fall tox tunes Source Type: news

Tox Tunes #113: Legend of a Mind (Moody Blues)
“Legend of a Mind” is about Timothy Leary, the one-time Harvard professor of psychology and 1960s LSD-mountebank Timothy Leary, whom Richard Nixon once called the “most dangerous man in America.” Timothy Leary’s Dead No, no, he’s outside looking in He’ll fly his astral plane Takes you trips around the bay Brings you back the same day Timothy Leary, Timothy Leary Despite this funereal first verse, the song long pre-dated Leary’s death in 1996, and appeared on The Moody Blues 1968 progressive rock album In Search of the Lost Chord. “Legend of a Mind” was writte...
Source: The Poison Review - January 15, 2018 Category: Toxicology Authors: Leon Gussow Tags: Medical In search of the lost chord Legend of a Mind Moody Blues Ray Thomas Timothy Leary tox tunes Source Type: news

Fatal ingestion of e-cigarette nicotine liquid
lucadp/shutterstock.com 2.5 out of 5 stars Death from Ingestion of E-Liquid. Morley S et al. J Emerg Med 2017 Dec;53:862-864. Abstract This short case report is presented in a somewhat confusing fashion but nevertheless brings up interesting points. A 32-year-old man was brought to hospital after having a cardiac arrest in the field 1 hour after ingesting approximately 20 ml of e-cigarette nicotine liquid containing 72 mg/ml of nicotine (total dose approximately 1440 mg.) He was resuscitated but had developed anoxic encephalopathy and died 3 days later. A plasma nicotine level drawn 24 hours after admission was 1600 n...
Source: The Poison Review - January 9, 2018 Category: Toxicology Authors: Leon Gussow Tags: Medical e-cigarette liquid fatality liquid nicotine toxicity Source Type: news

The 8th Annual Alexander Awards: The Best Tox Reading of 2017
Alexander Gettler Once again, last year’s outstanding examples of long-form journalism dealing with topics related to medical toxicology were dominated by coverage of the opioid crisis, its origins and the resulting carnage. The must-read article of the year was “The Family That Built a Empire of Pain,” Patrick Radden Keefe’s massive history of the Sacklers, one of America’s richest clans, much of whose wealth comes from their ownership of Purdue Pharma and the marketing and distribution of Oxycontin. The article, which appeared in the New Yorker, notes that the clan’s patriarch, Ar...
Source: The Poison Review - January 2, 2018 Category: Toxicology Authors: Leon Gussow Tags: Medical 2017 Alexander awards opioids Purdue Pharma Sackler Source Type: news

Is there a better way to administer IV N-acetylcysteine?
3 out of 5 stars Fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose. McNulty R et al. Clin Toxicol 2017 Dec 8 [Epub ahead of print] Abstract Current recommendations for dosing intravenous N-acetylcysteine (Acetadote) for treating acute acetaminophen (paracetamol) poisoning involves a somewhat complex three-bag protocol, using 3 direct concentrations of the antidote given over a 21-hour period. Unfortunately, this protocol results in a high incidence of (usually mild) adverse events, including cutaneous effects, nausea and vomiting, and anaphylactoid reactions. Severe rea...
Source: The Poison Review - December 14, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical Acetadote acetaminophen antidote N-acetylcysteine paracetamol three-bag protocol toxicity two-bag protocol Source Type: news

Case series: treating cannabinoid hyperemesis syndrome with capsaicin cream
3 out of 5 stars Resolution of cannabis hyperemesis syndrome with topical capsaicin in the emergency department: a case series. Dezieck L et al. Clin Toxicol 2017 Sep;55:908-913. Abstract  Cannabis hyperemesis syndrome (CHS) is a form of cyclic vomiting characterized by: chronic marijuana use recurrent vomiting, and lack of alternate explanation for symptoms A striking feature is that although CHS-induced nausea and vomiting are frequently resistant to standard antiemetics such as ondansetron, patients often report that very hot showers or baths relieve their symptoms. Several years ago, Jeff Lapoint ...
Source: The Poison Review - December 5, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical cannabinoid hyperemesis syndrome capsaicin treatment TRPV1 receptor Source Type: news

Tox Tunes #112: Chinese Rocks (Johnny Thunders & the Heartbreakers)
In a recent article discussing his favorite songs, food/travel guru Anthony Bourdain comments: “My early honeymoon period with heroin; this song made an other ill considered lifestyle option seem like a good idea.” Bourdain probably wasn’t paying close attention to the lyrics, which describe something other than a wise personal choice: I’m living on a Chinese Rock All my best things are in hock I’m living on a Chinese Rock Everything is in the pawn shop “Chinese Rock” is heroin. According to a commenter on Genius.com, there was an alternate third verse that the Heartbreakers someti...
Source: The Poison Review - December 4, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical chinese rocks Dee Dee Ramone heroin Johnny Thunders & the Heartbreakers Richard Hell tox tunes Source Type: news

Decontamination following deliberate mass-casualty exposures
[wikipedia.org]4 out of 5 stars Decontamination. Houston M, Hendrickson RG. Crit Care Clin 2005:21:653-672. Abstract Looking to finish some Lifelong Learning and Self-Assessment (LLSA) tests before the end of the year so I can re-certify in emergency medicine, I discovered that the subspecialty Medical Toxicology reading list modules can be used to comply with these requirements. At this time there are 3 active toxicology reading lists: 2017, 2015 and 2013. In the coming weeks, I will review selected articles from these lists. This  review comes from the October 2005 issue of Critical Care Clinics,...
Source: The Poison Review - November 29, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical biological chemical decontamination lifelong learning and self-assessment LLSA nuclear radiological terrorism weapon Source Type: news

Are ibuprofen plus acetaminophen as good as opioids in treating acute extremity pain
3.5 out of 5 stars Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial. Chang AK et al. JAMA 2017;318:1661-1667. Abstract As Dr. Demetrios Kyriacou points out in a must-read editorial accompanying this paper, a growing body of evidence clearly indicates that even short-term opioid use for painful injuries or procedures carries a significant risk of leading to chronic use and potential abuse. We are now realizing the importance of avoiding even limited use of drugs such as oxycodone and hydrocodone in opioid-naive patients...
Source: The Poison Review - November 22, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical acute pain analgesic emergency department opioid Source Type: news

Absolute must-watch: 60 Minutes on how pharmaceutical distributors fueled the opioid crisis
In a blockbuster investigation carried out along with the Washington Post, 60 Minutes’ Bill Whitaker looks into allegations that powerful pharmaceutical distributors helped advance the current opioid crisis by fulfilling patently suspicious orders for prescription opioids. The piece cites one example where a pharmacy in a West Virginia town with a population of several hundred ordered and received millions of opioid pills. The main source for the piece is Joe Rannazzisi, former head of the Drug Enforcement Agency’s Office of Diversion Control. Rannazzisi charges that as his office was planning to prosecute some...
Source: The Poison Review - October 16, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical 60 minutes DEA drug enforcement agency opioid crisis washington post Source Type: news

Tox Tunes #111: Girl on LSD (Tom Petty)
Although this Tom Petty song is somewhat obscure, I’m embarrassed to say I hadn’t know about it until an article in The Cannabist after the singer’s death last week brought it to my attention. The song appeared as the B-side to “You Don’t Know How It Feels” and was scheduled to be on Petty’s 1994 album Wildflowers, but the record company (Warners) objected because of its content. The New York Times has posted a guide with links to 14 essential Petty tracks. By the way, in a brilliant cold open to “Saturday Night Live” yesterday following the mass sho...
Source: The Poison Review - October 9, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical girl on LSD tom petty tox tunes Source Type: news

ACMT Position Statement: Toxicology Issues in Determining Brain Death
4 out of 5 stars ACMT Position Statement: Determining Brain Death in Adults After Drug Overdose. Neavyn MJ et al. J Med Toxicol 2017;13:271-273. Full Text The American Academy of Neurology guidelines on determining brain death in adults states that the clinician can not make such a determination unless he or she can  “[e]xclude the presence of a CNS-depressant drug effect by history, drug screen, calculation of clearance using 5 times the drug’s half-life (assuming normal hepatic and renal function), or, if available, drug plasma levels below the therapeutic range.” Excluding drug effect in...
Source: The Poison Review - September 27, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical american college of medical toxicology baclofen brain death position statement Source Type: news

Organic psychosis and nystagmus? consider dextromethorphan toxicity
2 out of 5 stars Dextromethorphan in Cough Syrup: The Poor Man’s Psychosis. Martinak B et al. Psychopharmacol Bull 2017 Sep 15:47:59-63. Full Text Dextromethorphan (DXM) is found in many over-the-counter cough and cold medications. At recommended therapeutic dosage (up to 120 mg per day in divided doses) DXM is safe and has no psychiatric effects. However, DXM and its major metabolite —dextrorphan — act as NMDA receptor antagonists, producing effects similar to those of phencyclidine (PCP) or ketamine when taken in large amounts. The intensity of psychiatric symptoms seen after DXM overdose...
Source: The Poison Review - September 26, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical cough and cold medicine dextromethorphan ketamine over-the-counter phencyclidine Source Type: news

Fentanyl, carfentanil and the opioid crisis: where do we stand now?
3.5 out of 5 stars Controversies and carfentanil: We have much to learn about the present state of opioid poisoning. Cole JB, Nelson LS. Am J Emerg Med 2017 Aug 24 [Epub ahead of print] Reference I have argued — both in a post on this blog and a column in Emergency Medicine News — that the idea of a “heroin overdose” is a completely outdated concept that is never coming back. The fact is, when a patient comes in today with a history of shooting or snorting heroin, none of us have any firm idea about exactly what drug or drugs were involved. The chance that such a patient was exposed only to heroin i...
Source: The Poison Review - September 19, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical carfentanil fentanyl opiates opioids Source Type: news

Great New Toxicology Podcast
In the first episode of “The Dantastic Mr. Tox & Howard Show,” Drs. Dan Rusyniak and Howard Greller — formerly of the Journal of Medical Toxicology Podcast — have a superb discussion about the current expanding opioid crisis with Dr. David Juurlink from Sunnybrook Health Sciences Centre in Toronto. Topics covered include opioid-induced hyperalgesia, the key difference between relieving pain and relieving suffering, and why tramadol is generally such a poor drug. The episode is smart, succinct, and highly recommended. I look forward to future podcasts. To listen, cli...
Source: The Poison Review - June 16, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical daniel rusyniak dantastic mr. tox & howard david juurlink howard greller podcast Source Type: news

Episode #15: How easy is it to get addicted to opioids?
TPR PODCAST EPISODE #15: HOW EASY IS IT TO GET ADDICTED TO OPIOIDS?     As has been well reported in medical papers, government studies and popular media, rates of overdose deaths from opioids have been increasing steadily over the last several decades. A recent article in the New York Times reported that there were likely more than 59,000 drug overdose deaths in 2016, an estimated 19% increase over the number in 2015. The total for 2017 is likely to be even higher.   Many deaths have been associated with prescription opioid analgesics, or have occurred among patients who became addicted to prescription opio...
Source: The Poison Review - June 11, 2017 Category: Toxicology Authors: Leon Gussow The Poison Review Tags: Podcast Source Type: news

Lipid rescue therapy for local anesthetic toxicity: is less more
DISCUSSION: Most of the “adverse events” associated with lipid rescue therapy have occurred after administration of relatively high doses. Although there have been no good studies demonstrating the maximum “safe” dose of intralipid for lipid rescue therapy, many authors recommended limiting the dose to that recommended by the FDA for nutritional support: 12.5 mL/kg (lean body mass) per day total. In specific cases it may be reasonable to consider extending the infusion beyond this, but such situations are likely rare. In this patient, who did not appear to have cardiovascular instability, it is...
Source: The Poison Review - May 25, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical adverse event intralipid lipid rescue therapy local anesthetic toxicity mepivacaine Source Type: news

Hemodialysis and the intubated salicylate-toxic patient
3.5 out of 5 stars The association of hemodialysis and survival in intubated salicylate-poisoned patients. McCabe DJ, Lu JJ. Am J Emerg Med 2017 Apr 10 [Epub ahead of print] Abstract [Disclosure: the co-authors of this paper are members of the Toxikon Consortium in Chicago, as am I.] This retrospective observational study looked at cases from the Illinois Poison Center over 12 years (2003 thru 2015) to identify intubated patients with recorded serum salicylate levels> 50 mg/dL. The goal was “to describe the impact of hemodialysis on survival rates of salicylate-intoxicated patients . . .”...
Source: The Poison Review - May 20, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical aspirin poisoning enhanced elimination hemodialysis salicylate toxicity Source Type: news

Hemp seed oil may possibly (but not probably) cause cannabinoid poisoning
2.5 out of 5 stars Cannabinoid Poisoning by Hemp Seed Oil in a Child. Chinello M et al. Pediatr Emerg Care 2017;33:344-345. Abstract This interesting but non-dispositive short case report from Italy suggests that, in rare instances, commercially marketed hemp seed oil can cause mild cannabinoid toxicity. A 2-year-7-month old male was brought to hospital with altered mental status and several hours of “decreased alertness, refusal to walk, and no verbal response.” Additional findings included: “paleness, stupor, [and] low reactivity to stimulation.” Pulse rate was 129 bpm. There was no ataxia. The p...
Source: The Poison Review - May 10, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical cannabinoid cannabis hemp seed oil pediatric subacute poisoning Source Type: news

Tox Tunes #110: Nutmeg (John Legend & Stephen Colbert)
Started thinking about this song again earlier in the week as I prepared to take part in an hour-long discussion of the spice on Connecticut Public Radio’s Colin McEnroe Show. The discussion touched on many aspects the spice: historical, economic, culinary, medicinal, and toxicological. To listen to the show, click here. To read my 2011 Emergency Medicine News column about nutmeg, click here. (Source: The Poison Review)
Source: The Poison Review - May 7, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical john legend nutmeg stephen colbert tox tunes Source Type: news

TPR Podcast Episode #14: VX and the Assassination of Kim Jong-Nam
  On February 13, 2017 Kim Jong Nam — half-brother to North Korean leader Kim Jong Un — was attacked by two women in Malaysia’s Kuala Lumpur International airport. The attacks smeared some substance on his face. Within 10 or 15 minutes Mr. Kim collapsed in the airport medical clinic and died apparently in the ambulance on way to hospital.   Days later, Malaysian authorities announced that the nerve agent VX was detected in samples taken from Mr. Kim’s face.   Security camera footage from the airport showing the attack on Mr. Kim and its aftermath can be viewed here. In the video, the ...
Source: The Poison Review - March 30, 2017 Category: Toxicology Authors: Leon Gussow The Poison Review Tags: Podcast Source Type: news

Tox Tunes #109: I Killed Robert Johnson (The Stone Foxes)
More myths and legends are attached to the life of Robert Johnson (1911 – 1938) than surround any other American blues artist. It’s said that he sold his soul to the devil down at a Mississippi crossroads in return for the ability to play guitar with a technique that musicians like Eric Clapton are still trying to replicate. It’s said that his death at age 27 established a precedent for other great American musicians who also died at that same age, including Jimi Hendrix, Janis Joplin, Jim Morrison, and Al “Blind Owl” Wilson. And it is said that Johnson was poisoned with strychnine in Greenwoo...
Source: The Poison Review - March 6, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical american delta blues i killed robert johnson nux vomica sonte foxes strychnine tox tunes Source Type: news

Labetalol in acute cocaine toxicity: is it safe?
3 out of 5 stars Acute Toxicity from Topical Cocaine for Epistaxis: Treatment with Labetalol. Richards JR et al. J Emerg Med 2017 Mar;52:311-313. Abstract There has long been a debate among toxicologists — still unresolved — as to whether it is safe to use a beta-blocker to treat cocaine-related hypertension and tachycardia. The (theoretical) concern is that since cocaine is both an α- and a β-agonist, blocking the β-receptors could lead to unopposed α stimulation with increased severe hypertension. Some authors contend that in this setting, labetalol would be safe since it blocks bot...
Source: The Poison Review - March 1, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical beta blocker cocaine epistaxis labetalol safety toxicity Source Type: news

Tox Tunes #108: Commit a Crime (Howlin ’ Wolf)
You put poison in my coffee, instead of milk or cream You put poison in my coffee, instead of milk or cream You bout the evilest woman, that I ever seen You mixed my drinks with a can of Red Devil lye You mixed my drinks with a can of Red Devil lye Then you sit down, watch me, hopin’ that I might die This is one of the great dysfunctional relationship songs in all of the blues. Howling’ Wolf (Chester Burnett 1910 – 1976) also recorded a great version of the song — under the title “What a Woman” and with Eric Clapton playing lead guitar — on the 1970 London Sessi...
Source: The Poison Review - February 26, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical commit a crime eric clapton howling' wolf london sessions rolling stones tox tunes Source Type: news

Did the nerve agent VX kill Kim Jong Nam?
Last night Malaysian authorities announced that they identified the nerve agent VX taken off the face of Kim Jong Nam, who was murdered on February 13 at Kuala Lumpur International Airport. As the History Channel video above indicates, nerve agents are potent acetylcholinesterase inhibitors that utilize the same mechanism as organophosphate insecticides such as parathion. Conceptually, the effect of VX exposure is simple: wherever in the body acetylcholine acts as a neurotransmitter, nerve agents cause unregulated, chaotic activity. There are generally 3 such sites: muscarinic sites: connections between ner...
Source: The Poison Review - February 24, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical assassination Kim Jong Nam Kuala Lumpur International Airport malaysia murder nerve agent North Korea VX Source Type: news

Must-watch: video showing murder of Kim Jong Nam
Discussion on toxicology discussion boards have brought up the following possibilities: Tetramine: Tetramethylenedisulfotetramine (TETS) is a rat poison that has been banned since 1984 but which — according to Wikipedia — is still used in China. It is a white powder that is slightly soluble both in water and DMSO, a solvent that could accelerate dermal absorption. TETS is a neurotoxin that acts as a GABA antagonist causing refractory status epileptics, coma, and death. There is no specific antidote. Aconite: This plant poison is used in several Chinese herbal medicines.Aconite is a sodium channel opener, ...
Source: The Poison Review - February 22, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical assassination Kim Jong Nam Kuala Lumpur International Airport malaysia murder North Korea Source Type: news

Do not get a serum acetaminophen level less than 4 hours after an acute ingestion
4 out of 5 stars Can a serum acetaminophen concentration obtained less than 4 hours post-ingestion determine which patients do not require treatment with acetylcysteine? Yarema MC et al. Clin Toxicol 2017 Feb;55:102-108. Abstract For decades the decision whether or not to treat acute acetaminophen [APAP] toxicity with N-acetylcysteine (NAC) has been guided by a serum APAP level drawn 4 or more hours after ingestion. The thought was that before 4 hours the level might be misleading because absorption of the drug might not be complete. This paper addresses the question of whether an earlier level can be suffic...
Source: The Poison Review - February 9, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical acetaminophen antidote APAP N-acetylcysteine rumack-matthew nomogram treatment Source Type: news

Amnesia and hippocampal ischemia in 4 opiate abusers: a case series
Hippocampus (wikipedia.org) 3.5 out of 5 stars Complete, bilateral hippocampal ischemia: a case series. Small JE et al. Neruocase 2016 Oct;22:411-415. Abstract Last week, we reviewed an MMWR investigation into a cluster of 14 cases of acute anterograde amnesia with MRI evidence of bilateral hippocampal ischemia identified in Massachusetts during the years 2012-2016. This constellation of features is distinctly unusual — especially when symmetric and accompanied by scant pathology outside the hippocampus —  but has in the past been associated with cocaine abuse and carbon monoxide p...
Source: The Poison Review - February 1, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical amnesia hippocampus ischemia memory opiate abuse Source Type: news

Amnesia and hippocmpal ischemia in 4 opiate abusers: a case series
Hippocampus (wikipedia.org) 3.5 out of 5 stars Complete, bilateral hippocampal ischemia: a case series. Small JE et al. Neruocase 2016 Oct;22:411-415. Abstract Last week, we reviewed an MMWR investigation into a cluster of 14 cases of acute anterograde amnesia with MRI evidence of bilateral hippocampal ischemia identified in Massachusetts during the years 2012-2016. This constellation of features is distinctly unusual — especially when symmetric and accompanied by scant pathology outside the hippocampus —  but has in the past been associated with cocaine abuse and carbon monoxide p...
Source: The Poison Review - February 1, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical amnesia hippocampus ischemia memory opiate abuse Source Type: news

Anterograde amnesia and bilateral hippocampus ischemia: is it caused by substance abuse?
Diffusion weighted MRI findings in patient with unusual amnestic syndrome — Massachusetts, 2012 [Source: MMWR]3.5 out of 5 stars Cluster of an Unusual Amnestic Syndrome — Massachusetts, 2012-2016. Barash JA et al. MMWR Morb Mortal Wkly Rep 2017;66:76-79 Full Text Late in 2015 a Boston neurologist reported a cluster of 4 cases of anterograde amnesia associated with MRI evidence of bilateral hippocampal ischemia. After a public health alert was issued an additional 10 cases were identified in the years 2012-2016, using the case definition of: “1) new onset amnesia in the absence of evidence t...
Source: The Poison Review - January 27, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical amnestic syndrome e opioid overdose hippocampus ischemia opiat Source Type: news

Is commercial kratom being spiked with a naturally occurring potent opioid
  3.5 out of 5 stars Suspected Adulteration of Commercial Kratom Products with 7-Hydroxymitragynine. Lydecker AG et al. J Med Toxicol 2016;12:341-349. Abstract This well done paper provides — among other things — a helpful short review kratom, a psychoactive product  derived from the Mitragyna speciosa plant. M speciosa contains more than 40 distinct alkaloids. The primary alkaloid — mitragynine — is an opioid agonist at the mu and delta receptors. Mitragynine has about 33% the opioid potency of morphine. A minor component of M speciosa —  7-h...
Source: The Poison Review - January 24, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical 7-hydroxymitragynine kratom mitragyna speciosa Source Type: news

TPR Podcast Episode #13: Naloxone in the Age of Carfentanil
In this “Lucky 13” episode of the TPR podcast, Steven and Leon discuss naloxone, and address the following issues:   Does the concept of a “heroin overdose patient” have meaning anymore in this age of U-47700, fentanyl, and carfentanil? Given the adulteration of both heroin and counterfeit prescription medications with extremely potent synthetic opioids, do we have to reconsider our entire approach to opioid overdose patients? Can past medical literature guide us in our management of these patients?(Hint: the answer is no.) What medical toxicology paper do Steve and Leon — in an unusual ...
Source: The Poison Review - January 19, 2017 Category: Toxicology Authors: Leon Gussow The Poison Review Tags: Podcast Source Type: news

The 7th Annual Alexander Awards: The Best Tox Reading of 2016
Alexander Gettler When TPR began giving out the annual Alexander Awards for best long-form writing in the field of toxicology, the eligibility criteria included the requirement that “entries must be fully and freely accessible” on the web. After 2016 — a remarkably truth-impaired year scarred by fake news and unchallenged mendacity — supporting aggressive, unbiased, fearless journalism appears to us to be a civic duty. A number of our selections this year come from sources such as the New York Times and Los Angeles Times that have much of their content behind a paywall. Often the...
Source: The Poison Review - January 1, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical adder all Alexander awards ayahuasca cannabidiol carfentanil fentanyl Gettler opiates opioids oxycontin Source Type: news

Severe respiratory depression after snorting U-47700
3.5 out of 5 stars Two cases of intoxication with new synthetic opioid, U-47700. Domanski K et al. Clin Toxicol 2017 Jan;55:46-50. Abstract U-47700 was first synthesized by Upjohn in the 1970s — hence the “U”. The company was seeking to develop an analgesic as effective as morphine but not addictive. Work on this compound was abandoned when the addictive properties of the drug became apparent. U-47700 is a μ-receptor agonist that is approximately 7.5 times as potent as morphine. This paper reports two patients who presented to hospital after insufflating U-47700 (confirmed on laboratory ...
Source: The Poison Review - December 30, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical synthetic opioid U-47700 Source Type: news

Lipid therapy in oral poisoning: a not-so-systematic review
2 out of 5 stars No support for lipid rescue in oral poisoning: A systematic review and analysis of 160 published cases. Forsberg M et al. Hum Exp Toxicol 2016 Nov 24 [Epub ahead of print] Abstract The authors’ goal was “to present a systematic review and case analysis of practically all published reports on humans treated with lipid rescue for LAST [local anesthetic systemic toxicity] or oral poisoning.” The focus of the paper is on oral poisonings. The authors report that they identified 94 reported cases of oral poisoning with “alleged” positive response to lipid rescue therapy (LRT.) Two a...
Source: The Poison Review - December 27, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical intralipid intravenous lipid emulsion lipid rescue therapy systematic review Source Type: news

Synthetic cannabinoid AMB-FUBINACA responsible for July 2016 “zombie” episode
4 out of 5 stars “Zombie” Outbreak Caused by the Synthetic Cannabinoid AMB-FUBINACA in New York, Adams AJ et al. N Engl J Med 2016 Dec 14 [Epub ahead of print] Abstract  On July 12, 2016, the New York Times reported that in the course of one day, in the Bushwick and Bedford-Stuyvesant areas of Brooklyn, 33 people had been transported to hospitals after apparently overdosing on a synthetic cannabinoid. The major manifestations shown by the victims were altered mental status and lethargy. One observer described what he say at the scene: “’It’s like a scene out of a zombie movie, a...
Source: The Poison Review - December 18, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical AMB-FUBINACA Brooklyn synthetic cannabinoid zombie Source Type: news

Tox Tunes #107: Lullaby (The Cure)
There is, to be sure, whether the subtext of this song involves child abuse or drug addiction. The director of this video, Tim Pope, has stated that Lullaby is “an allegory of [The Cure frontman] Robert Smith’s druggy past.” Certainly, the lyrics would back back this up: On candy stripe legs the Spiderman comes Softly through the shadow of the evening sun Stealing past the windows of the blissfully dead Looking for the victim shivering in bed Searching out fear in the gathering gloom and Suddenly A movement in the corner of the room And there is nothing I can do When I realize with fright That the Sp...
Source: The Poison Review - December 12, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical lullaby the cure tox tunes Source Type: news

Great video: tongue fasciculations in organophosphate poisoning
3.5 out of 5 stars Tongue Fasciculations in Organophosphate Poisoning. Chhabria BA, Bhalla A. . N Engl J Med 2016 Dec 8;375:e47 Full text with video The New England Journal of Medicine just posted a brief case of dichlorvos poisoning with a great video demonstrating organophosphate-induced tongue fasciculations. The case and video can be seen here. The NEJM also has video of tongue fasciculations caused by amyotrophic lateral sclerosis (Lou Gehrig’s Disease) that can be seen here. Here is another video of tongue fasciculations associated with amyotrophic lateral sclerosis: Other causes ...
Source: The Poison Review - December 8, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical amyotrophic lateral sclerosis lou gehrig's disease organophosphate poisoning tongue fasciculations Source Type: news

Loperamide abuse and cardiac dysrhythmia
3.5 out of 5 stars Cardiac Dysrhythmias After Loperamide Abuse — New York, 2008-2016. Eggleston W et al. MMWR 2016 Nov 18;65:1276-1277. Full Text Last week we reviewed a new paper showing that the number of cases of loperamide abuse reported to the National Poison Data System increased by 91% from the years 2000 to 2015. For reasons detailed in that review and in my recent Emergency Medicine News article on the topic, massive doses of loperamide can alleviate opioid withdrawal symptoms and also produce opioid-like effects. This very brief report has some interesting clinical and epidemiological nu...
Source: The Poison Review - November 25, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical cardiotoxicity ecg ekg electrocardiogram imodium loperamide Source Type: news

Treating “heroin” overdose: the past is no guide
1.5 out of 5 stars Do heroin overdose patients require observation after receiving naloxone? Tillman MW et al. Clin Toxicol 2016 Nov 16:1-7 [Epub ahead of print] Abstract The stated goal of this study was to search the medical literature in an attempt to answer 3 main questions: “What are the medical risks to a heroin user who refuses ambulance transfer after naloxone? “If the heroin user is treated in the emergency department after naloxone, how long must the be observed prior to discharge? “How effective in heroin users is naloxone administered by first responders and bystanders?” ...
Source: The Poison Review - November 22, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical antidote emergency department heroin naloxone narcan opiate opioid overdose pre-hospital treat-and-release Source Type: news

How to interpret urine drug tests for marijuana: a review
Linda Parton/shutterstock.com 4 out of 5 stars Interpretation of Workplace Tests for Cannabinoids. Kulig K. J Med Toxicol 2016 Sep 29 [Epub ahead of print] Abstract The interpretation of workplace urine drug tests for marijuana often becomes a point of contention in workman’s compensation cases or proceedings moving towards firing an employee. In may experience, the court or arbitrator not infrequently gets the science of these tests wrong. Such misinterpretation can be devastating for the employee who is at risk of losing his or her job and benefits. This concise review of the subject by Ken Kulig gets the science r...
Source: The Poison Review - November 19, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical marijuana occupational medicine THC THC acid THC-COOH THCa urine drug screen workman's compensation Source Type: news

Missing loperamide (Imodium) abuse can be a fatal mistake
3 out of 5 stars Epidemiologic Trends in Loperamide Abuse and Misuse. Vakkalanka JP et al. Ann Emerg Med 2016 Nov 4 [Epub ahead of print] Abstract This paper reviews loperamide exposures reported to the National Poison Data System  over the 6-year period from 2010 through 2015. Because of the well-recognized limitations involved in retrospective analysis of poison center data, there is not much clinically useful information revealed by their study. The authors did find — unsurprisingly — that reported exposures to loperamide went up from 2010 to 2015, increasing by 91%. As we’ve discus...
Source: The Poison Review - November 15, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical cardiotoxicity fatality imodium loperamide overdose prolonged QT syndrome Source Type: news

Does exposure to marijuana cause myocardial infarction?
2 out of 5 stars Prolonged cardiac arrest complicating a massive ST-segment elevation myocardial infarction associated with marijuana consumption. Orsini J et al. J Community Hosp Intern Med Perspect 2016 Sept 7;6(4):31695 Full Text The medical literature contains scattered, rare case reports and series describing myocardial infarction, acute coronary syndrome, and cardiac arrest associated with exposure to cannabis. (Extreme emphasis on the word “associated.”) This literature is limited by a number of crippling problems, including failure to screen completely for presence of other drugs, failure to collect com...
Source: The Poison Review - November 12, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical cannabis cardiotoxicity heart attack cardiac arrest marijuana myocardial infarction Source Type: news