N-acetylcysteine Protects Against Myocardial Ischemia-Reperfusion Injury Through Anti-ferroptosis in Type 1 Diabetic Mice
Cardiovasc Toxicol. 2024 Apr 22. doi: 10.1007/s12012-024-09852-7. Online ahead of print.ABSTRACTThe hearts of subjects with diabetes are vulnerable to ischemia-reperfusion injury (IRI). In contrast, experimentally rodent hearts have been shown to be more resistant to IRI at the very early stages of diabetes induction than the heart of the non-diabetic control mice, and the mechanism is largely unclear. Ferroptosis has recently been shown to play an important role in myocardial IRI including that in diabetes, while the specific mechanisms are still unclear. Non-diabetic control (NC) and streptozotocin-induced diabetic (DM) ...
Source: Cardiovascular Toxicology - April 22, 2024 Category: Cardiology Authors: Dongcheng Zhou Yuhui Yang Jiajia Chen Jiaqi Zhou Jianfeng He Danyong Liu Anyuan Zhang Bixian Yuan Yuxin Jiang Weiyi Xia Ronghui Han Zhengyuan Xia Source Type: research
The effect of colchicine on cancer risk in patients with immune-mediated inflammatory diseases: a time-dependent study based on the Taiwan ’s National Health Insurance Research Database
ConclusionColchicine was associated with the lower aHR of the all cancer and colorectal cancer formation in patients with the IMIDs. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 22, 2024 Category: Research Source Type: research
Effect of N-acetylcysteine on hair follicle changes in mouse model of cyclophosphamide-induced alopecia: histological and biochemical study
AbstractChemotherapy-induced alopecia (CIA) represents one of the most severe side effects of chemotherapy, which forces some patients to reject cancer treatment. The exact pathophysiological mechanisms of CIA are not clearly understood, which makes it difficult to discover efficient preventive or therapeutic procedures for this adverse effect. N-acetylcysteine (NAC) has a strong antioxidant activity as it stimulates glutathione synthesis and acts as an oxygen radical scavenger. The current study tried to investigate the efficacy of NAC in preserving biochemical parameters and hair follicle structure against cyclophosphami...
Source: Histochemistry and Cell Biology - April 20, 2024 Category: Biomedical Science Source Type: research
Celecoxib and sulindac sulfide elicit anticancer effects on PIK3CA-mutated head and neck cancer cells through endoplasmic reticulum stress, reactive oxygen species, and mitochondrial dysfunction
Biochem Pharmacol. 2024 Apr 18;224:116221. doi: 10.1016/j.bcp.2024.116221. Online ahead of print.ABSTRACTGain-of-function mutation in the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) catalytic subunit alpha gene (PIK3CA) is a significant factor in head and neck cancer (HNC). Patients with HNC harboring PIK3CA mutations receive therapeutic benefits from the use of non-steroidal anti-inflammatory drugs (NSAIDs). However, the molecular mechanisms underlying these effects remain unknown. Here, we examined the Detroit562 and FaDu cell lines as HNC models with and without a hyperactive PIK3CA mutation (H1047R), respecti...
Source: Biochemical Pharmacology - April 19, 2024 Category: Drugs & Pharmacology Authors: Nga Thi Thanh Nguyen Sang Yoon Lee Source Type: research
Protective Effect of < em > N < /em > -Acetylcysteine on Rooster Semen Cryopreservation
Biopreserv Biobank. 2024 Apr 18. doi: 10.1089/bio.2023.0103. Online ahead of print.ABSTRACTCryopreservation of avian semen is a useful reproductive technique in the poultry industry. However, during cooling, elevated reactive oxygen species (ROS) levels have destructive effects on both quality and function of thawed sperm. The aim of the current study is to investigate the antioxidant effects of N-acetylcysteine (NAC) during rooster semen cryopreservation. Semen samples were collected from ten Ross 308 broiler breeder roosters (32 weeks) and mixed. The mixed samples were divided into five equal parts and cryopreserved in L...
Source: Biopreservation and Biobanking - April 18, 2024 Category: Biomedical Science Authors: Farhad Hakimi Mohamad Amir Karimi Torshizi Maryam Hezavehei Mohsen Sharafi Source Type: research
Antioxidant supplementation may effect DNA methylation patterns, apoptosis, and ROS levels in developing mouse embryos
This study was designed to address the question: does antioxidant-containing embryo culture media affect DNA methyltransferases, global DNA methylation, inner cell mass/trophoblast differentiation, intracellular reactive oxygen species (ROS) levels, and apoptosis? Mouse zygotes were cultured in embryo culture media containing MitoQ,N-acetyl-l-cysteine (NAC), acetyl-l-carnitine (ALC), α-lipoic acid (ALA), or the mixture of NAC + ALC + ALA (AO) until the blastocyst stage, whereas in vivo-developed blastocysts were used as control. Protein expression levels of Dnmt1, 3a, 3b, and 3l enzymes were analyzed by immunofluoresc...
Source: Histochemistry and Cell Biology - April 17, 2024 Category: Biomedical Science Source Type: research
Metabolic activation and cytochrome P450 inhibition of piperlonguminine mediated by CYP3A4
This study characterized the O-dealkylated metabolite (M1) through chemical synthesis. The IC50 shift assay showed time-dependent inhibition of CYP3A4, 2C9, 2E1, 2C8 and 2D6 by PLG. This research contributes to the understanding of PLG-induced enzyme inhibition and bioactivation.PMID:38626834 | DOI:10.1016/j.ijbiomac.2024.131502 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 16, 2024 Category: Biochemistry Authors: Yuqian Chi Xiaoliang Zhu Yaxuan Chen Xin Li Ziyi Jiang Xiaoyang Jian Mengyuan Lian Xiaodi Wu Lei Wang Mengmeng Sun Xiaowei Shi Source Type: research
Analysis of Gizzerosine in Foodstuffs by HPLC Involving Pre-column Derivatization with o-Phthaldialdehyde
Adv Exp Med Biol. 2024;1446:237-250. doi: 10.1007/978-3-031-54192-6_11.ABSTRACTGizzerosine [2-amino-9-(4-imidazolyl)-7-azanonanoic acid] is a toxic amino acid formed from histamine and lysine at high temperatures, and may be present in foodstuffs (e.g., fishmeal and meat-bone meal) for animals including cats and dogs. Here we developed a simple, rapid, sensitive, specific, and automated method for the analysis of gizzerosine in foodstuffs by high-performance liquid chromatography (HPLC) involving pre-column derivatization with o-phthaldialdehyde (OPA) in the presence of N-acetylcysteine (instead of the usual 2-mercaptoetha...
Source: Advances in Experimental Medicine and Biology - April 16, 2024 Category: Research Authors: Peng Li Guoyao Wu Source Type: research
Metabolic activation and cytochrome P450 inhibition of piperlonguminine mediated by CYP3A4
This study characterized the O-dealkylated metabolite (M1) through chemical synthesis. The IC50 shift assay showed time-dependent inhibition of CYP3A4, 2C9, 2E1, 2C8 and 2D6 by PLG. This research contributes to the understanding of PLG-induced enzyme inhibition and bioactivation.PMID:38626834 | DOI:10.1016/j.ijbiomac.2024.131502 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 16, 2024 Category: Biochemistry Authors: Yuqian Chi Xiaoliang Zhu Yaxuan Chen Xin Li Ziyi Jiang Xiaoyang Jian Mengyuan Lian Xiaodi Wu Lei Wang Mengmeng Sun Xiaowei Shi Source Type: research
Analysis of Gizzerosine in Foodstuffs by HPLC Involving Pre-column Derivatization with o-Phthaldialdehyde
Adv Exp Med Biol. 2024;1446:237-250. doi: 10.1007/978-3-031-54192-6_11.ABSTRACTGizzerosine [2-amino-9-(4-imidazolyl)-7-azanonanoic acid] is a toxic amino acid formed from histamine and lysine at high temperatures, and may be present in foodstuffs (e.g., fishmeal and meat-bone meal) for animals including cats and dogs. Here we developed a simple, rapid, sensitive, specific, and automated method for the analysis of gizzerosine in foodstuffs by high-performance liquid chromatography (HPLC) involving pre-column derivatization with o-phthaldialdehyde (OPA) in the presence of N-acetylcysteine (instead of the usual 2-mercaptoetha...
Source: Advances in Experimental Medicine and Biology - April 16, 2024 Category: Research Authors: Peng Li Guoyao Wu Source Type: research
Cold atmospheric plasma attenuates skin cancer via ROS induced apoptosis
CONCLUSIONS: These evidences suggest the protective effect of CAP in CSCC, and CAP has the potential clinical application of CSCC.PMID:38622261 | DOI:10.1007/s11033-024-09486-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Changqing Liu Jingjing Zha Tao Sun Ling Kong Xinru Zhang Dong Wang Guohua Ni Source Type: research
Cold atmospheric plasma attenuates skin cancer via ROS induced apoptosis
CONCLUSIONS: These evidences suggest the protective effect of CAP in CSCC, and CAP has the potential clinical application of CSCC.PMID:38622261 | DOI:10.1007/s11033-024-09486-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Changqing Liu Jingjing Zha Tao Sun Ling Kong Xinru Zhang Dong Wang Guohua Ni Source Type: research
Cold atmospheric plasma attenuates skin cancer via ROS induced apoptosis
CONCLUSIONS: These evidences suggest the protective effect of CAP in CSCC, and CAP has the potential clinical application of CSCC.PMID:38622261 | DOI:10.1007/s11033-024-09486-6 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 15, 2024 Category: Molecular Biology Authors: Changqing Liu Jingjing Zha Tao Sun Ling Kong Xinru Zhang Dong Wang Guohua Ni Source Type: research
Eight weeks of treatment with mineralocorticoid receptor blockade does not alter vascular function in individuals with and without type 2 diabetes
In conclusion, we found no effect of MR blockade endothelial function in individuals with and without type 2 diabetes. As the individuals with type 2 diabetes did not have vascular dysfunction, these results might not apply to individuals with vascular dysfunction. (Source: Physiological Reports)
Source: Physiological Reports - April 13, 2024 Category: Physiology Authors: Stine H. Finsen,
Mie R. Hansen,
Pernille B. L. Hansen,
Stefan P. Mortensen Tags: ORIGINAL ARTICLE Source Type: research
